UniProtKB - P09012 (SNRPA_HUMAN)
U1 small nuclear ribonucleoprotein A
SNRPA
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
- RNA binding Source: UniProtKB
- U1 snRNA binding Source: UniProtKB
- U1 snRNP binding Source: Ensembl
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
- regulation of mRNA polyadenylation Source: Ensembl
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | P09012 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: U1 small nuclear ribonucleoprotein AShort name: U1 snRNP A Short name: U1-A Short name: U1A |
Gene namesi | Name:SNRPA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000077312.8 |
HGNCi | HGNC:11151, SNRPA |
MIMi | 182285, gene |
neXtProti | NX_P09012 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: HPA
- spliceosomal complex Source: HGNC-UCL
- U1 snRNP Source: UniProtKB
Keywords - Cellular componenti
Nucleus, SpliceosomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 11 | T → V: Abolishes RNA binding. 1 Publication | 1 | |
Mutagenesisi | 13 | Y → F: Substantially reduces RNA binding. 1 Publication | 1 | |
Mutagenesisi | 15 | N → V: Abolishes RNA binding. 1 Publication | 1 | |
Mutagenesisi | 16 | N → V: Substantially reduces RNA binding. 1 Publication | 1 | |
Mutagenesisi | 52 | R → Q: Abolishes RNA binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6626 |
OpenTargetsi | ENSG00000077312 |
PharmGKBi | PA35993 |
Miscellaneous databases
Pharosi | P09012, Tbio |
Chemistry databases
DrugBanki | DB02175, Malonic acid |
Polymorphism and mutation databases
BioMutai | SNRPA |
DMDMi | 134092 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000081887 | 2 – 282 | U1 small nuclear ribonucleoprotein AAdd BLAST | 281 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 60 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 131 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 152 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | P09012 |
jPOSTi | P09012 |
MassIVEi | P09012 |
MaxQBi | P09012 |
PaxDbi | P09012 |
PeptideAtlasi | P09012 |
PRIDEi | P09012 |
ProteomicsDBi | 52184 |
TopDownProteomicsi | P09012 |
PTM databases
iPTMneti | P09012 |
MetOSitei | P09012 |
PhosphoSitePlusi | P09012 |
Expressioni
Gene expression databases
Bgeei | ENSG00000077312, Expressed in subventricular zone (inner) (primate) and 236 other tissues |
ExpressionAtlasi | P09012, baseline and differential |
Genevisiblei | P09012, HS |
Organism-specific databases
HPAi | ENSG00000077312, Low tissue specificity |
Interactioni
Subunit structurei
U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C.
Interacts with SFPQ; component of a snRNP-free complex with SFPQ.
1 PublicationBinary interactionsi
Hide detailsP09012
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 112510, 149 interactors |
CORUMi | P09012 |
DIPi | DIP-29407N |
IntActi | P09012, 96 interactors |
MINTi | P09012 |
STRINGi | 9606.ENSP00000243563 |
Miscellaneous databases
RNActi | P09012, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P09012 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P09012 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 89 | RRM 1PROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 208 – 282 | RRM 2PROSITE-ProRule annotationAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 140 – 206 | Pro-richAdd BLAST | 67 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4206, Eukaryota |
GeneTreei | ENSGT00390000007046 |
HOGENOMi | CLU_041869_1_3_1 |
InParanoidi | P09012 |
OMAi | QYPNLHE |
OrthoDBi | 1608132at2759 |
PhylomeDBi | P09012 |
TreeFami | TF313834 |
Family and domain databases
CDDi | cd12477, RRM1_U1A, 1 hit cd12480, RRM2_U1A, 1 hit |
DisProti | DP01857 |
Gene3Di | 3.30.70.330, 2 hits |
IDEALi | IID00018 |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034407, U1A_RRM1 IPR034409, U1A_RRM2 |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAVPETRPNH TIYINNLNEK IKKDELKKSL YAIFSQFGQI LDILVSRSLK
60 70 80 90 100
MRGQAFVIFK EVSSATNALR SMQGFPFYDK PMRIQYAKTD SDIIAKMKGT
110 120 130 140 150
FVERDRKREK RKPKSQETPA TKKAVQGGGA TPVVGAVQGP VPGMPPMTQA
160 170 180 190 200
PRIMHHMPGQ PPYMPPPGMI PPPGLAPGQI PPGAMPPQQL MPGQMPPAQP
210 220 230 240 250
LSENPPNHIL FLTNLPEETN ELMLSMLFNQ FPGFKEVRLV PGRHDIAFVE
260 270 280
FDNEVQAGAA RDALQGFKIT QNNAMKISFA KK
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R2B8 | M0R2B8_HUMAN | U1 small nuclear ribonucleoprotein ... | SNRPA | 148 | Annotation score: | ||
M0R221 | M0R221_HUMAN | U1 small nuclear ribonucleoprotein ... | SNRPA | 142 | Annotation score: | ||
M0R268 | M0R268_HUMAN | U1 small nuclear ribonucleoprotein ... | SNRPA | 256 | Annotation score: | ||
M0QZG7 | M0QZG7_HUMAN | U1 small nuclear ribonucleoprotein ... | SNRPA | 184 | Annotation score: | ||
M0QXK2 | M0QXK2_HUMAN | U1 small nuclear ribonucleoprotein ... | SNRPA | 128 | Annotation score: | ||
M0R0G9 | M0R0G9_HUMAN | U1 small nuclear ribonucleoprotein ... | SNRPA | 87 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60784 , M60779, M60780, M60781, M60782, M60783 Genomic DNA Translation: AAA61245.1 X06347 mRNA Translation: CAA29653.1 BC000405 mRNA Translation: AAH00405.1 BC008290 mRNA Translation: AAH08290.1 |
CCDSi | CCDS12565.1 |
PIRi | JQ1528 |
RefSeqi | NP_004587.1, NM_004596.4 |
Genome annotation databases
Ensembli | ENST00000243563; ENSP00000243563; ENSG00000077312 |
GeneIDi | 6626 |
KEGGi | hsa:6626 |
UCSCi | uc002ooz.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60784 , M60779, M60780, M60781, M60782, M60783 Genomic DNA Translation: AAA61245.1 X06347 mRNA Translation: CAA29653.1 BC000405 mRNA Translation: AAH00405.1 BC008290 mRNA Translation: AAH08290.1 |
CCDSi | CCDS12565.1 |
PIRi | JQ1528 |
RefSeqi | NP_004587.1, NM_004596.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AUD | NMR | - | A | 2-102 | [»] | |
1DRZ | X-ray | 2.30 | A | 2-98 | [»] | |
1DZ5 | NMR | - | A/B | 2-102 | [»] | |
1FHT | NMR | - | A | 2-117 | [»] | |
1M5K | X-ray | 2.40 | C/F | 1-100 | [»] | |
1M5O | X-ray | 2.20 | C/F | 1-100 | [»] | |
1M5P | X-ray | 2.60 | C/F | 1-100 | [»] | |
1M5V | X-ray | 2.40 | C/F | 1-100 | [»] | |
1NU4 | X-ray | 1.80 | A/B | 2-98 | [»] | |
1OIA | X-ray | 2.40 | A/B | 1-95 | [»] | |
1SJ3 | X-ray | 2.20 | P | 1-100 | [»] | |
1SJ4 | X-ray | 2.70 | P | 1-100 | [»] | |
1SJF | X-ray | 2.75 | A | 1-100 | [»] | |
1U6B | X-ray | 3.10 | A | 1-98 | [»] | |
1URN | X-ray | 1.92 | A/B/C | 2-98 | [»] | |
1VBX | X-ray | 2.70 | A | 1-100 | [»] | |
1VBY | X-ray | 2.90 | A | 1-100 | [»] | |
1VBZ | X-ray | 2.80 | A | 1-100 | [»] | |
1VC0 | X-ray | 2.50 | A | 1-100 | [»] | |
1VC5 | X-ray | 3.40 | A | 1-100 | [»] | |
1VC6 | X-ray | 2.80 | A | 1-100 | [»] | |
1ZZN | X-ray | 3.37 | A | 1-98 | [»] | |
2A3J | NMR | - | A | 3-80 | [»] | |
2NZ4 | X-ray | 2.50 | A/B/C/D | 5-98 | [»] | |
2OIH | X-ray | 2.40 | A | 2-100 | [»] | |
2OJ3 | X-ray | 2.90 | A | 2-100 | [»] | |
2U1A | NMR | - | A | 195-282 | [»] | |
3BO2 | X-ray | 3.31 | A | 4-98 | [»] | |
3BO3 | X-ray | 3.40 | A | 4-98 | [»] | |
3BO4 | X-ray | 3.33 | A | 4-98 | [»] | |
3CUL | X-ray | 2.80 | A/B | 1-96 | [»] | |
3CUN | X-ray | 3.00 | A/B | 1-98 | [»] | |
3EGZ | X-ray | 2.20 | A | 1-98 | [»] | |
3G8S | X-ray | 3.10 | A/B/C/D | 1-98 | [»] | |
3G8T | X-ray | 3.00 | A/B/C/D | 1-98 | [»] | |
3G96 | X-ray | 3.01 | A/B/C/D | 1-98 | [»] | |
3G9C | X-ray | 2.90 | A/B/C/D | 1-98 | [»] | |
3HHN | X-ray | 2.99 | B/D | 2-98 | [»] | |
3IIN | X-ray | 4.18 | A | 4-98 | [»] | |
3IRW | X-ray | 2.70 | P | 1-98 | [»] | |
3IWN | X-ray | 3.20 | C/D | 6-96 | [»] | |
3K0J | X-ray | 3.10 | A/B/C/D | 2-97 | [»] | |
3L3C | X-ray | 2.85 | A/B/C/D | 7-96 | [»] | |
3MUM | X-ray | 2.90 | P | 1-98 | [»] | |
3MUR | X-ray | 3.00 | P | 1-98 | [»] | |
3MUT | X-ray | 3.00 | P | 1-98 | [»] | |
3MUV | X-ray | 3.20 | P | 1-98 | [»] | |
3MXH | X-ray | 2.30 | P | 1-98 | [»] | |
3P49 | X-ray | 3.55 | B | 1-98 | [»] | |
3PGW | X-ray | 4.40 | A/P | 1-282 | [»] | |
3R1H | X-ray | 3.15 | A/D | 1-98 | [»] | |
3R1L | X-ray | 3.12 | A/D | 1-98 | [»] | |
3UCU | X-ray | 2.80 | P | 1-98 | [»] | |
3UCZ | X-ray | 2.80 | P | 1-98 | [»] | |
3UD3 | X-ray | 3.10 | P | 1-98 | [»] | |
3UD4 | X-ray | 2.70 | P | 1-98 | [»] | |
3UTR | model | - | B/D | 1-98 | [»] | |
4C4W | X-ray | 2.95 | A/B/E/F | 1-102 | [»] | |
4PR6 | X-ray | 2.30 | A | 4-96 | [»] | |
4PRF | X-ray | 2.40 | A | 1-100 | [»] | |
4W90 | X-ray | 3.12 | B | 6-96 | [»] | |
4W92 | X-ray | 3.21 | B | 6-96 | [»] | |
4YB1 | X-ray | 2.08 | P | 7-97 | [»] | |
5DDO | X-ray | 3.10 | C/G | 2-98 | [»] | |
5DDP | X-ray | 2.30 | C/D | 2-98 | [»] | |
5DDQ | X-ray | 2.40 | C/D | 2-98 | [»] | |
5DDR | X-ray | 2.60 | C/D | 2-98 | [»] | |
5FJ4 | X-ray | 2.95 | A/B/E/F | 1-102 | [»] | |
6LAS | X-ray | 2.71 | C/D/E | 6-96 | [»] | |
6LAU | X-ray | 3.11 | C/D/E | 6-96 | [»] | |
6LAX | X-ray | 2.70 | C/D/E | 6-96 | [»] | |
6LAZ | X-ray | 2.76 | C/D/E | 6-96 | [»] | |
6QX9 | electron microscopy | 3.28 | 1A | 1-282 | [»] | |
6SQN | X-ray | 2.05 | A/B/C | 2-98 | [»] | |
6SQQ | X-ray | 2.37 | AAA/BBB/CCC | 1-98 | [»] | |
6SQT | X-ray | 1.84 | AAA/BBB/CCC | 1-98 | [»] | |
6SQV | X-ray | 2.45 | AAA/BBB/CCC/DDD | 1-97 | [»] | |
6SR7 | X-ray | 1.86 | AAA/BBB/CCC/DDD | 1-98 | [»] | |
SMRi | P09012 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112510, 149 interactors |
CORUMi | P09012 |
DIPi | DIP-29407N |
IntActi | P09012, 96 interactors |
MINTi | P09012 |
STRINGi | 9606.ENSP00000243563 |
Chemistry databases
DrugBanki | DB02175, Malonic acid |
PTM databases
iPTMneti | P09012 |
MetOSitei | P09012 |
PhosphoSitePlusi | P09012 |
Polymorphism and mutation databases
BioMutai | SNRPA |
DMDMi | 134092 |
Proteomic databases
EPDi | P09012 |
jPOSTi | P09012 |
MassIVEi | P09012 |
MaxQBi | P09012 |
PaxDbi | P09012 |
PeptideAtlasi | P09012 |
PRIDEi | P09012 |
ProteomicsDBi | 52184 |
TopDownProteomicsi | P09012 |
Protocols and materials databases
Antibodypediai | 3308, 312 antibodies |
Genome annotation databases
Ensembli | ENST00000243563; ENSP00000243563; ENSG00000077312 |
GeneIDi | 6626 |
KEGGi | hsa:6626 |
UCSCi | uc002ooz.4, human |
Organism-specific databases
CTDi | 6626 |
DisGeNETi | 6626 |
EuPathDBi | HostDB:ENSG00000077312.8 |
GeneCardsi | SNRPA |
HGNCi | HGNC:11151, SNRPA |
HPAi | ENSG00000077312, Low tissue specificity |
MIMi | 182285, gene |
neXtProti | NX_P09012 |
OpenTargetsi | ENSG00000077312 |
PharmGKBi | PA35993 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4206, Eukaryota |
GeneTreei | ENSGT00390000007046 |
HOGENOMi | CLU_041869_1_3_1 |
InParanoidi | P09012 |
OMAi | QYPNLHE |
OrthoDBi | 1608132at2759 |
PhylomeDBi | P09012 |
TreeFami | TF313834 |
Enzyme and pathway databases
PathwayCommonsi | P09012 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
BioGRID-ORCSi | 6626, 217 hits in 855 CRISPR screens |
ChiTaRSi | SNRPA, human |
EvolutionaryTracei | P09012 |
GeneWikii | Small_nuclear_ribonucleoprotein_polypeptide_A |
GenomeRNAii | 6626 |
Pharosi | P09012, Tbio |
PROi | PR:P09012 |
RNActi | P09012, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000077312, Expressed in subventricular zone (inner) (primate) and 236 other tissues |
ExpressionAtlasi | P09012, baseline and differential |
Genevisiblei | P09012, HS |
Family and domain databases
CDDi | cd12477, RRM1_U1A, 1 hit cd12480, RRM2_U1A, 1 hit |
DisProti | DP01857 |
Gene3Di | 3.30.70.330, 2 hits |
IDEALi | IID00018 |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034407, U1A_RRM1 IPR034409, U1A_RRM2 |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SNRPA_HUMAN | |
Accessioni | P09012Primary (citable) accession number: P09012 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 234 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM