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Protein

U1 small nuclear ribonucleoprotein A

Gene

SNRPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • RNA binding Source: UniProtKB
  • snRNA stem-loop binding Source: GO_Central
  • U1 snRNA binding Source: GO_Central
  • U1 snRNP binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein A
Short name:
U1 snRNP A
Short name:
U1-A
Short name:
U1A
Gene namesi
Name:SNRPA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000077312.8
HGNCiHGNC:11151 SNRPA
MIMi182285 gene
neXtProtiNX_P09012

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi11T → V: Abolishes RNA binding. 1 Publication1
Mutagenesisi13Y → F: Substantially reduces RNA binding. 1 Publication1
Mutagenesisi15N → V: Abolishes RNA binding. 1 Publication1
Mutagenesisi16N → V: Substantially reduces RNA binding. 1 Publication1
Mutagenesisi52R → Q: Abolishes RNA binding. 1 Publication1

Organism-specific databases

DisGeNETi6626
OpenTargetsiENSG00000077312
PharmGKBiPA35993

Chemistry databases

DrugBankiDB02175 Malonic acid

Polymorphism and mutation databases

BioMutaiSNRPA
DMDMi134092

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000818872 – 282U1 small nuclear ribonucleoprotein AAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei60N6-acetyllysineCombined sources1
Modified residuei131PhosphothreonineCombined sources1
Modified residuei152Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP09012
MaxQBiP09012
PaxDbiP09012
PeptideAtlasiP09012
PRIDEiP09012
ProteomicsDBi52184
TopDownProteomicsiP09012

PTM databases

iPTMnetiP09012
PhosphoSitePlusiP09012

Expressioni

Gene expression databases

BgeeiENSG00000077312 Expressed in 225 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_SNRPA
ExpressionAtlasiP09012 baseline and differential
GenevisibleiP09012 HS

Organism-specific databases

HPAiCAB004652
HPA046440
HPA054834

Interactioni

Subunit structurei

U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component of a snRNP-free complex with SFPQ.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112510, 97 interactors
CORUMiP09012
DIPiDIP-29407N
IntActiP09012, 72 interactors
MINTiP09012
STRINGi9606.ENSP00000243563

Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP09012
SMRiP09012
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP09012

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 89RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini208 – 282RRM 2PROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 206Pro-richAdd BLAST67

Sequence similaritiesi

Belongs to the RRM U1 A/B'' family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4206 Eukaryota
ENOG410XPZI LUCA
GeneTreeiENSGT00390000007046
HOGENOMiHOG000217519
HOVERGENiHBG000895
InParanoidiP09012
KOiK11091
OMAiALHNYKL
OrthoDBiEOG091G0NFU
PhylomeDBiP09012
TreeFamiTF313834

Family and domain databases

CDDicd12477 RRM1_U1A, 1 hit
cd12480 RRM2_U1A, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034407 U1A_RRM1
IPR034409 U1A_RRM2
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P09012-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVPETRPNH TIYINNLNEK IKKDELKKSL YAIFSQFGQI LDILVSRSLK
60 70 80 90 100
MRGQAFVIFK EVSSATNALR SMQGFPFYDK PMRIQYAKTD SDIIAKMKGT
110 120 130 140 150
FVERDRKREK RKPKSQETPA TKKAVQGGGA TPVVGAVQGP VPGMPPMTQA
160 170 180 190 200
PRIMHHMPGQ PPYMPPPGMI PPPGLAPGQI PPGAMPPQQL MPGQMPPAQP
210 220 230 240 250
LSENPPNHIL FLTNLPEETN ELMLSMLFNQ FPGFKEVRLV PGRHDIAFVE
260 270 280
FDNEVQAGAA RDALQGFKIT QNNAMKISFA KK
Length:282
Mass (Da):31,280
Last modified:January 23, 2007 - v3
Checksum:i9426E83EE5A22894
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R268M0R268_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
256Annotation score:
M0QZG7M0QZG7_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
184Annotation score:
M0R2B8M0R2B8_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
148Annotation score:
M0R221M0R221_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
142Annotation score:
M0R0G9M0R0G9_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
87Annotation score:
M0QXK2M0QXK2_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
128Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60784
, M60779, M60780, M60781, M60782, M60783 Genomic DNA Translation: AAA61245.1
X06347 mRNA Translation: CAA29653.1
BC000405 mRNA Translation: AAH00405.1
BC008290 mRNA Translation: AAH08290.1
CCDSiCCDS12565.1
PIRiJQ1528
RefSeqiNP_004587.1, NM_004596.4
UniGeneiHs.466775

Genome annotation databases

EnsembliENST00000243563; ENSP00000243563; ENSG00000077312
GeneIDi6626
KEGGihsa:6626
UCSCiuc002ooz.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60784
, M60779, M60780, M60781, M60782, M60783 Genomic DNA Translation: AAA61245.1
X06347 mRNA Translation: CAA29653.1
BC000405 mRNA Translation: AAH00405.1
BC008290 mRNA Translation: AAH08290.1
CCDSiCCDS12565.1
PIRiJQ1528
RefSeqiNP_004587.1, NM_004596.4
UniGeneiHs.466775

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AUDNMR-A2-102[»]
1DRZX-ray2.30A2-98[»]
1DZ5NMR-A/B2-102[»]
1FHTNMR-A2-117[»]
1M5KX-ray2.40C/F1-100[»]
1M5OX-ray2.20C/F1-100[»]
1M5PX-ray2.60C/F1-100[»]
1M5VX-ray2.40C/F1-100[»]
1NU4X-ray1.80A/B2-98[»]
1OIAX-ray2.40A/B1-95[»]
1SJ3X-ray2.20P1-100[»]
1SJ4X-ray2.70P1-100[»]
1SJFX-ray2.75A1-100[»]
1U6BX-ray3.10A1-98[»]
1URNX-ray1.92A/B/C2-98[»]
1VBXX-ray2.70A1-100[»]
1VBYX-ray2.90A1-100[»]
1VBZX-ray2.80A1-100[»]
1VC0X-ray2.50A1-100[»]
1VC5X-ray3.40A1-100[»]
1VC6X-ray2.80A1-100[»]
1ZZNX-ray3.37A1-98[»]
2A3JNMR-A3-80[»]
2NZ4X-ray2.50A/B/C/D5-98[»]
2OIHX-ray2.40A2-100[»]
2OJ3X-ray2.90A2-100[»]
2U1ANMR-A195-282[»]
3BO2X-ray3.31A4-98[»]
3BO3X-ray3.40A4-98[»]
3BO4X-ray3.33A4-98[»]
3CULX-ray2.80A/B1-96[»]
3CUNX-ray3.00A/B1-98[»]
3EGZX-ray2.20A1-98[»]
3G8SX-ray3.10A/B/C/D1-98[»]
3G8TX-ray3.00A/B/C/D1-98[»]
3G96X-ray3.01A/B/C/D1-98[»]
3G9CX-ray2.90A/B/C/D1-98[»]
3HHNX-ray2.99B/D2-98[»]
3IINX-ray4.18A4-98[»]
3IRWX-ray2.70P1-98[»]
3IWNX-ray3.20C/D6-96[»]
3K0JX-ray3.10A/B/C/D2-97[»]
3L3CX-ray2.85A/B/C/D7-96[»]
3MUMX-ray2.90P1-98[»]
3MURX-ray3.00P1-98[»]
3MUTX-ray3.00P1-98[»]
3MUVX-ray3.20P1-98[»]
3MXHX-ray2.30P1-98[»]
3P49X-ray3.55B1-98[»]
3PGWX-ray4.40A/P1-282[»]
3R1HX-ray3.15A/D1-98[»]
3R1LX-ray3.12A/D1-98[»]
3UCUX-ray2.80P1-98[»]
3UCZX-ray2.80P1-98[»]
3UD3X-ray3.10P1-98[»]
3UD4X-ray2.70P1-98[»]
3UTRmodel-B/D1-98[»]
4C4WX-ray2.95A/B/E/F1-102[»]
4PR6X-ray2.30A4-96[»]
4PRFX-ray2.40A1-100[»]
4W90X-ray3.12B6-96[»]
4W92X-ray3.21B6-96[»]
4YB1X-ray2.08P7-97[»]
5DDOX-ray3.10C/G2-98[»]
5DDPX-ray2.30C/D2-98[»]
5DDQX-ray2.40C/D2-98[»]
5DDRX-ray2.60C/D2-98[»]
5FJ4X-ray2.95A/B/E/F1-102[»]
ProteinModelPortaliP09012
SMRiP09012
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112510, 97 interactors
CORUMiP09012
DIPiDIP-29407N
IntActiP09012, 72 interactors
MINTiP09012
STRINGi9606.ENSP00000243563

Chemistry databases

DrugBankiDB02175 Malonic acid

PTM databases

iPTMnetiP09012
PhosphoSitePlusiP09012

Polymorphism and mutation databases

BioMutaiSNRPA
DMDMi134092

Proteomic databases

EPDiP09012
MaxQBiP09012
PaxDbiP09012
PeptideAtlasiP09012
PRIDEiP09012
ProteomicsDBi52184
TopDownProteomicsiP09012

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243563; ENSP00000243563; ENSG00000077312
GeneIDi6626
KEGGihsa:6626
UCSCiuc002ooz.4 human

Organism-specific databases

CTDi6626
DisGeNETi6626
EuPathDBiHostDB:ENSG00000077312.8
GeneCardsiSNRPA
HGNCiHGNC:11151 SNRPA
HPAiCAB004652
HPA046440
HPA054834
MIMi182285 gene
neXtProtiNX_P09012
OpenTargetsiENSG00000077312
PharmGKBiPA35993
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4206 Eukaryota
ENOG410XPZI LUCA
GeneTreeiENSGT00390000007046
HOGENOMiHOG000217519
HOVERGENiHBG000895
InParanoidiP09012
KOiK11091
OMAiALHNYKL
OrthoDBiEOG091G0NFU
PhylomeDBiP09012
TreeFamiTF313834

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiSNRPA human
EvolutionaryTraceiP09012
GeneWikiiSmall_nuclear_ribonucleoprotein_polypeptide_A
GenomeRNAii6626
PROiPR:P09012
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000077312 Expressed in 225 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_SNRPA
ExpressionAtlasiP09012 baseline and differential
GenevisibleiP09012 HS

Family and domain databases

CDDicd12477 RRM1_U1A, 1 hit
cd12480 RRM2_U1A, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034407 U1A_RRM1
IPR034409 U1A_RRM2
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSNRPA_HUMAN
AccessioniPrimary (citable) accession number: P09012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 217 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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