SNRPA

Functionⁱ

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.1 Publication

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16189514
- 25416956
RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19561594
snRNA stem-loop binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
U1 snRNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
U1 snRNP binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA splicing, via spliceosome
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of mRNA polyadenylation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: U1 small nuclear ribonucleoprotein A Short name: U1 snRNP A Short name: U1-A Short name: U1A
Gene namesⁱ	Name:SNRPA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000077312.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11151 SNRPA
MIMⁱ	182285 gene
neXtProtⁱ	NX_P09012

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	11	T → V: Abolishes RNA binding. 1 Publication	1
Mutagenesisⁱ	13	Y → F: Substantially reduces RNA binding. 1 Publication	1
Mutagenesisⁱ	15	N → V: Abolishes RNA binding. 1 Publication	1
Mutagenesisⁱ	16	N → V: Substantially reduces RNA binding. 1 Publication	1
Mutagenesisⁱ	52	R → Q: Abolishes RNA binding. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6626
Open Targets More...OpenTargetsⁱ	ENSG00000077312
PharmGKBⁱ	PA35993

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB02175 Malonic acid

DrugBankⁱ

DB02175 Malonic acid

Polymorphism and mutation databases

BioMutaⁱ	SNRPA
DMDMⁱ	134092

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000081887	2 – 282	U1 small nuclear ribonucleoprotein AAdd BLAST		281

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	60	N6-acetyllysineCombined sources	1
Modified residueⁱ	131	PhosphothreonineCombined sources	1
Modified residueⁱ	152	Omega-N-methylarginineCombined sources	1

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	P09012
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P09012
PaxDbⁱ	P09012
PeptideAtlas More...PeptideAtlasⁱ	P09012
PRIDEⁱ	P09012
ProteomicsDBⁱ	52184
TopDownProteomicsⁱ	P09012

PTM databases

iPTMnetⁱ	P09012
PhosphoSitePlusⁱ	P09012

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000077312 Expressed in 225 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_SNRPA
ExpressionAtlasⁱ	P09012 baseline and differential
Genevisibleⁱ	P09012 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004652 HPA046440 HPA054834

HPAⁱ

CAB004652
HPA046440
HPA054834

Interactionⁱ

Subunit structureⁱ

U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component of a snRNP-free complex with SFPQ.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		4	EBI-607085,EBI-607085
CIRBP	Q14011	3	EBI-607085,EBI-538850
ENOX2	Q16206-2	3	EBI-607085,EBI-10179508
GABPB1	Q06547	3	EBI-607085,EBI-618165
HNRNPK	P61978	4	EBI-607085,EBI-304185
LENG8	Q96PV6	5	EBI-607085,EBI-739546
METTL13	Q8N6R0	3	EBI-607085,EBI-1053295
MTUS2	Q5JR59	3	EBI-607085,EBI-742948
NDUFAF3	Q9BU61	5	EBI-607085,EBI-2114801
NDUFAF3	Q9BU61-2	3	EBI-607085,EBI-10298649
PCBP1	Q15365	5	EBI-607085,EBI-946095
PCBP2	Q15366	3	EBI-607085,EBI-945799
PTBP1	P26599	5	EBI-607085,EBI-350540
QKI	Q96PU8	3	EBI-607085,EBI-945792
RBM3	P98179	5	EBI-607085,EBI-2949699
RBMX	P38159	3	EBI-607085,EBI-743526
RBPMS2	Q6ZRY4	4	EBI-607085,EBI-11987469
SFPQ	P23246	4	EBI-607085,EBI-355453
SNRPA1	P09661	6	EBI-607085,EBI-876439
TRIM27	P14373	5	EBI-607085,EBI-719493
TRIR	Q9BQ61	4	EBI-607085,EBI-744881
U2AF2	P26368	5	EBI-607085,EBI-742339
U2AF2	P26368-2	4	EBI-607085,EBI-11097439

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16189514
- 25416956

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112510, 97 interactors
CORUMⁱ	P09012
Database of interacting proteins More...DIPⁱ	DIP-29407N
IntActⁱ	P09012, 72 interactors
Molecular INTeraction database More...MINTⁱ	P09012
STRINGⁱ	9606.ENSP00000243563

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	10 – 16	Combined sources	7
Beta strandⁱ	19 – 21	Combined sources	3
Helixⁱ	23 – 34	Combined sources	12
Helixⁱ	35 – 37	Combined sources	3
Beta strandⁱ	40 – 44	Combined sources	5
Helixⁱ	47 – 51	Combined sources	5
Beta strandⁱ	55 – 61	Combined sources	7
Helixⁱ	62 – 72	Combined sources	11
Turnⁱ	77 – 79	Combined sources	3
Beta strandⁱ	83 – 86	Combined sources	4
Helixⁱ	93 – 96	Combined sources	4
Helixⁱ	97 – 100	Combined sources	4
Beta strandⁱ	208 – 213	Combined sources	6
Helixⁱ	221 – 229	Combined sources	9
Beta strandⁱ	234 – 238	Combined sources	5
Beta strandⁱ	246 – 253	Combined sources	8
Helixⁱ	254 – 263	Combined sources	10
Turnⁱ	264 – 266	Combined sources	3
Helixⁱ	269 – 271	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P09012
SMRⁱ	P09012
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P09012

EvolutionaryTraceⁱ

P09012

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	10 – 89	RRM 1PROSITE-ProRule annotationAdd BLAST		80
Domainⁱ	208 – 282	RRM 2PROSITE-ProRule annotationAdd BLAST		75

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	140 – 206	Pro-richAdd BLAST		67

Sequence similaritiesⁱ

Belongs to the RRM U1 A/B'' family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG4206 Eukaryota ENOG410XPZI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007046
HOGENOMⁱ	HOG000217519
HOVERGENⁱ	HBG000895
InParanoidⁱ	P09012
KEGG Orthology (KO) More...KOⁱ	K11091
OMAⁱ	ALHNYKL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NFU
PhylomeDBⁱ	P09012
TreeFamⁱ	TF313834

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12477 RRM1_U1A, 1 hit cd12480 RRM2_U1A, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR034407 U1A_RRM1 IPR034409 U1A_RRM2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

P09012-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVPETRPNH TIYINNLNEK IKKDELKKSL YAIFSQFGQI LDILVSRSLK 
        60         70         80         90        100
MRGQAFVIFK EVSSATNALR SMQGFPFYDK PMRIQYAKTD SDIIAKMKGT 
       110        120        130        140        150
FVERDRKREK RKPKSQETPA TKKAVQGGGA TPVVGAVQGP VPGMPPMTQA 
       160        170        180        190        200
PRIMHHMPGQ PPYMPPPGMI PPPGLAPGQI PPGAMPPQQL MPGQMPPAQP 
       210        220        230        240        250
LSENPPNHIL FLTNLPEETN ELMLSMLFNQ FPGFKEVRLV PGRHDIAFVE 
       260        270        280 
FDNEVQAGAA RDALQGFKIT QNNAMKISFA KK

Length:282

Mass (Da):31,280

Last modified:January 23, 2007 - v3

Checksum:ⁱ9426E83EE5A22894

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0R268	M0R268_HUMAN	U1 small nuclear ribonucleoprotein ... U1 small nuclear ribonucleoprotein A	SNRPA	256	Annotation score:
M0QZG7	M0QZG7_HUMAN	U1 small nuclear ribonucleoprotein ... U1 small nuclear ribonucleoprotein A	SNRPA	184	Annotation score:
M0R2B8	M0R2B8_HUMAN	U1 small nuclear ribonucleoprotein ... U1 small nuclear ribonucleoprotein A	SNRPA	148	Annotation score:
M0R221	M0R221_HUMAN	U1 small nuclear ribonucleoprotein ... U1 small nuclear ribonucleoprotein A	SNRPA	142	Annotation score:
M0R0G9	M0R0G9_HUMAN	U1 small nuclear ribonucleoprotein ... U1 small nuclear ribonucleoprotein A	SNRPA	87	Annotation score:
M0QXK2	M0QXK2_HUMAN	U1 small nuclear ribonucleoprotein ... U1 small nuclear ribonucleoprotein A	SNRPA	128	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60784 M60783 Genomic DNA Translation: AAA61245.1 X06347 mRNA Translation: CAA29653.1 BC000405 mRNA Translation: AAH00405.1 BC008290 mRNA Translation: AAH08290.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12565.1
PIRⁱ	JQ1528
NCBI Reference Sequences More...RefSeqⁱ	NP_004587.1, NM_004596.4
UniGeneⁱ	Hs.466775

Genome annotation databases

Ensemblⁱ	ENST00000243563; ENSP00000243563; ENSG00000077312
GeneIDⁱ	6626
KEGGⁱ	hsa:6626
UCSC genome browser More...UCSCⁱ	uc002ooz.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P09012	U1 small nuclear ribonucleoprotein A (Fragment)		HUMAN		184	UniRef100_P09012
U1 small nuclear ribonucleoprotein A (Fragment)		HUMAN		148
U1 small nuclear ribonucleoprotein A (Fragment)		HUMAN		142

Protein	Similar proteins		Species	Score	Length	Source
P09012	U1 small nuclear ribonucleoprotein A	)	PIG		282	UniRef90_P09012
U1 small nuclear ribonucleoprotein A (Fragment)		HUMAN		184
U1 small nuclear ribonucleoprotein A		ALLMI		334
Uncharacterized protein		PROCO		287
Small nuclear ribonucleoprotein polypeptide A		MONDO		287
+60

Protein	Similar proteins		Species	Score	Length	Source
P09012	U1 small nuclear ribonucleoprotein A	)	PIG		282	UniRef50_P09012
U1 small nuclear ribonucleoprotein A (Fragment)		HUMAN		184
U1 small nuclear ribonucleoprotein A		ALLMI		334
Small nuclear ribonucleoprotein polypeptide A		MONDO		287
Uncharacterized protein		PROCO		287
+93

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60784 M60783 Genomic DNA Translation: AAA61245.1 X06347 mRNA Translation: CAA29653.1 BC000405 mRNA Translation: AAH00405.1 BC008290 mRNA Translation: AAH08290.1
CCDSⁱ	CCDS12565.1
PIRⁱ	JQ1528
RefSeqⁱ	NP_004587.1, NM_004596.4
UniGeneⁱ	Hs.466775

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1AUD	NMR	-	A	2-102	[»]
	1DRZ	X-ray	2.30	A	2-98	[»]
	1DZ5	NMR	-	A/B	2-102	[»]
	1FHT	NMR	-	A	2-117	[»]
	1M5K	X-ray	2.40	C/F	1-100	[»]
	1M5O	X-ray	2.20	C/F	1-100	[»]
	1M5P	X-ray	2.60	C/F	1-100	[»]
	1M5V	X-ray	2.40	C/F	1-100	[»]
	1NU4	X-ray	1.80	A/B	2-98	[»]
	1OIA	X-ray	2.40	A/B	1-95	[»]
	1SJ3	X-ray	2.20	P	1-100	[»]
	1SJ4	X-ray	2.70	P	1-100	[»]
	1SJF	X-ray	2.75	A	1-100	[»]
	1U6B	X-ray	3.10	A	1-98	[»]
	1URN	X-ray	1.92	A/B/C	2-98	[»]
	1VBX	X-ray	2.70	A	1-100	[»]
	1VBY	X-ray	2.90	A	1-100	[»]
	1VBZ	X-ray	2.80	A	1-100	[»]
	1VC0	X-ray	2.50	A	1-100	[»]
	1VC5	X-ray	3.40	A	1-100	[»]
	1VC6	X-ray	2.80	A	1-100	[»]
	1ZZN	X-ray	3.37	A	1-98	[»]
	2A3J	NMR	-	A	3-80	[»]
	2NZ4	X-ray	2.50	A/B/C/D	5-98	[»]
	2OIH	X-ray	2.40	A	2-100	[»]
	2OJ3	X-ray	2.90	A	2-100	[»]
	2U1A	NMR	-	A	195-282	[»]
	3BO2	X-ray	3.31	A	4-98	[»]
	3BO3	X-ray	3.40	A	4-98	[»]
	3BO4	X-ray	3.33	A	4-98	[»]
	3CUL	X-ray	2.80	A/B	1-96	[»]
	3CUN	X-ray	3.00	A/B	1-98	[»]
	3EGZ	X-ray	2.20	A	1-98	[»]
	3G8S	X-ray	3.10	A/B/C/D	1-98	[»]
	3G8T	X-ray	3.00	A/B/C/D	1-98	[»]
	3G96	X-ray	3.01	A/B/C/D	1-98	[»]
	3G9C	X-ray	2.90	A/B/C/D	1-98	[»]
	3HHN	X-ray	2.99	B/D	2-98	[»]
	3IIN	X-ray	4.18	A	4-98	[»]
	3IRW	X-ray	2.70	P	1-98	[»]
	3IWN	X-ray	3.20	C/D	6-96	[»]
	3K0J	X-ray	3.10	A/B/C/D	2-97	[»]
	3L3C	X-ray	2.85	A/B/C/D	7-96	[»]
	3MUM	X-ray	2.90	P	1-98	[»]
	3MUR	X-ray	3.00	P	1-98	[»]
	3MUT	X-ray	3.00	P	1-98	[»]
	3MUV	X-ray	3.20	P	1-98	[»]
	3MXH	X-ray	2.30	P	1-98	[»]
	3P49	X-ray	3.55	B	1-98	[»]
	3PGW	X-ray	4.40	A/P	1-282	[»]
	3R1H	X-ray	3.15	A/D	1-98	[»]
	3R1L	X-ray	3.12	A/D	1-98	[»]
	3UCU	X-ray	2.80	P	1-98	[»]
	3UCZ	X-ray	2.80	P	1-98	[»]
	3UD3	X-ray	3.10	P	1-98	[»]
	3UD4	X-ray	2.70	P	1-98	[»]
	3UTR	model	-	B/D	1-98	[»]
	4C4W	X-ray	2.95	A/B/E/F	1-102	[»]
	4PR6	X-ray	2.30	A	4-96	[»]
	4PRF	X-ray	2.40	A	1-100	[»]
	4W90	X-ray	3.12	B	6-96	[»]
	4W92	X-ray	3.21	B	6-96	[»]
	4YB1	X-ray	2.08	P	7-97	[»]
5DDO	X-ray	3.10	C/G	2-98	[»]
5DDP	X-ray	2.30	C/D	2-98	[»]
5DDQ	X-ray	2.40	C/D	2-98	[»]
5DDR	X-ray	2.60	C/D	2-98	[»]
5FJ4	X-ray	2.95	A/B/E/F	1-102	[»]
ProteinModelPortalⁱ	P09012
SMRⁱ	P09012
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112510, 97 interactors
CORUMⁱ	P09012
DIPⁱ	DIP-29407N
IntActⁱ	P09012, 72 interactors
MINTⁱ	P09012
STRINGⁱ	9606.ENSP00000243563

Chemistry databases

DrugBankⁱ	DB02175 Malonic acid

DrugBankⁱ

DB02175 Malonic acid

PTM databases

iPTMnetⁱ	P09012
PhosphoSitePlusⁱ	P09012

Polymorphism and mutation databases

BioMutaⁱ	SNRPA
DMDMⁱ	134092

Proteomic databases

EPDⁱ	P09012
MaxQBⁱ	P09012
PaxDbⁱ	P09012
PeptideAtlasⁱ	P09012
PRIDEⁱ	P09012
ProteomicsDBⁱ	52184
TopDownProteomicsⁱ	P09012

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000243563; ENSP00000243563; ENSG00000077312
GeneIDⁱ	6626
KEGGⁱ	hsa:6626
UCSCⁱ	uc002ooz.4 human

Organism-specific databases

CTDⁱ	6626
DisGeNETⁱ	6626
EuPathDBⁱ	HostDB:ENSG00000077312.8
GeneCardsⁱ	SNRPA
HGNCⁱ	HGNC:11151 SNRPA
HPAⁱ	CAB004652 HPA046440 HPA054834
MIMⁱ	182285 gene
neXtProtⁱ	NX_P09012
OpenTargetsⁱ	ENSG00000077312
PharmGKBⁱ	PA35993
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4206 Eukaryota ENOG410XPZI LUCA
GeneTreeⁱ	ENSGT00390000007046
HOGENOMⁱ	HOG000217519
HOVERGENⁱ	HBG000895
InParanoidⁱ	P09012
KOⁱ	K11091
OMAⁱ	ALHNYKL
OrthoDBⁱ	EOG091G0NFU
PhylomeDBⁱ	P09012
TreeFamⁱ	TF313834

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSⁱ	SNRPA human
EvolutionaryTraceⁱ	P09012
GeneWikiⁱ	Small_nuclear_ribonucleoprotein_polypeptide_A
GenomeRNAiⁱ	6626
Protein Ontology More...PROⁱ	PR:P09012
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000077312 Expressed in 225 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_SNRPA
ExpressionAtlasⁱ	P09012 baseline and differential
Genevisibleⁱ	P09012 HS

Family and domain databases

CDDⁱ	cd12477 RRM1_U1A, 1 hit cd12480 RRM2_U1A, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR034407 U1A_RRM1 IPR034409 U1A_RRM2
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNRPA_HUMAN
Accessionⁱ	P09012Primary (citable) accession number: P09012
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 217 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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Supporting data

UniProtKB - P09012 (SNRPA_HUMAN)

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U1 small nuclear ribonucleoprotein A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ