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UniProtKB - P09012 (SNRPA_HUMAN)

Entry version 231 (17 Jun 2020)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

U1 small nuclear ribonucleoprotein A

Gene

SNRPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72163 mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein A
Short name:
U1 snRNP A
Short name:
U1-A
Short name:
U1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNRPA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000077312.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:11151 SNRPA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182285 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P09012

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11T → V: Abolishes RNA binding. 1 Publication1
Mutagenesisi13Y → F: Substantially reduces RNA binding. 1 Publication1
Mutagenesisi15N → V: Abolishes RNA binding. 1 Publication1
Mutagenesisi16N → V: Substantially reduces RNA binding. 1 Publication1
Mutagenesisi52R → Q: Abolishes RNA binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6626

Open Targets

More...OpenTargetsi		ENSG00000077312

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35993

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P09012 Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB02175 Malonic acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SNRPA

Domain mapping of disease mutations (DMDM)

More...DMDMi		134092

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818872 – 282U1 small nuclear ribonucleoprotein AAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei60N6-acetyllysineCombined sources1
Modified residuei131PhosphothreonineCombined sources1
Modified residuei152Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P09012

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P09012

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P09012

MaxQB - The MaxQuant DataBase

More...MaxQBi		P09012

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P09012

PeptideAtlas

More...PeptideAtlasi		P09012

PRoteomics IDEntifications database

More...PRIDEi		P09012

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52184

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P09012

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P09012

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P09012

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P09012

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000077312 Expressed in small intestine Peyer's patch and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P09012 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P09012 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000077312 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C.

Interacts with SFPQ; component of a snRNP-free complex with SFPQ.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P09012
With#Exp.IntAct
CHTOP - isoform 2 [Q9Y3Y2-3]3EBI-607085,EBI-11984237
CIRBP [Q14011]4EBI-607085,EBI-538850
DAZAP1 [Q96EP5]3EBI-607085,EBI-2133162
DDIT4L [Q96D03]3EBI-607085,EBI-742054
DDX39B [Q13838]3EBI-607085,EBI-348622
EEF1AKNMT [Q8N6R0]3EBI-607085,EBI-1053295
ENOX2 - isoform 2 [Q16206-2]3EBI-607085,EBI-10179508
FUBP1 - isoform 2 [Q96AE4-2]3EBI-607085,EBI-12121668
GABPB1 [Q06547]3EBI-607085,EBI-618165
GIGYF1 [O75420]3EBI-607085,EBI-947774
HNRNPK [P61978]4EBI-607085,EBI-304185
HNRNPK - isoform 2 [P61978-2]3EBI-607085,EBI-7060731
LENG8 [Q96PV6]8EBI-607085,EBI-739546
LHX4 [Q969G2]3EBI-607085,EBI-2865388
LNX1 [Q8TBB1]3EBI-607085,EBI-739832
MBNL2 - isoform 2 [Q5VZF2-2]3EBI-607085,EBI-13307411
MRPL15 [Q9P015]3EBI-607085,EBI-2371967
MTUS2 [Q5JR59]3EBI-607085,EBI-742948
NDUFAF3 [Q9BU61]6EBI-607085,EBI-2114801
NDUFAF3 - isoform b [Q9BU61-2]3EBI-607085,EBI-10298649
OTX2 - isoform 2 [P32243-2]3EBI-607085,EBI-9087860
PCBP1 [Q15365]9EBI-607085,EBI-946095
PCBP2 [Q15366]3EBI-607085,EBI-945799
PCBP3 - isoform 2 [P57721-2]5EBI-607085,EBI-11983983
PTBP1 [P26599]7EBI-607085,EBI-350540
PTBP2 - isoform 2 [Q9UKA9-2]3EBI-607085,EBI-12255608
QKI [Q96PU8]3EBI-607085,EBI-945792
RASAL3 [Q86YV0]3EBI-607085,EBI-3437896
RBM11 [P57052]3EBI-607085,EBI-741332
RBM3 [P98179]8EBI-607085,EBI-2949699
RBM4B [Q9BQ04]3EBI-607085,EBI-715531
RBMX [P38159]3EBI-607085,EBI-743526
RBMY1A1 - isoform 2 [P0DJD3-2]4EBI-607085,EBI-11994018
RBMY1J [Q15415]3EBI-607085,EBI-8642021
RBPMS2 [Q6ZRY4]6EBI-607085,EBI-11987469
SDCBP [O00560]3EBI-607085,EBI-727004
SFPQ [P23246]4EBI-607085,EBI-355453
itself8EBI-607085,EBI-607085
SNRPA1 [P09661]9EBI-607085,EBI-876439
TIA1 [P31483]4EBI-607085,EBI-1387216
TIAL1 - isoform 2 [Q01085-2]3EBI-607085,EBI-11064654
TLE5 - isoform 2 [Q08117-2]3EBI-607085,EBI-11741437
TNFAIP8L1 [Q8WVP5]3EBI-607085,EBI-752102
TRIM27 [P14373]6EBI-607085,EBI-719493
TRIR [Q9BQ61]10EBI-607085,EBI-744881
U2AF2 [P26368]5EBI-607085,EBI-742339
U2AF2 - isoform 2 [P26368-2]6EBI-607085,EBI-11097439
ZCCHC13 [Q8WW36]3EBI-607085,EBI-954111

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112510, 117 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P09012

Database of interacting proteins

More...DIPi		DIP-29407N

Protein interaction database and analysis system

More...IntActi		P09012, 94 interactors

Molecular INTeraction database

More...MINTi		P09012

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000243563

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P09012 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P09012

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P09012

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 89RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini208 – 282RRM 2PROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi140 – 206Pro-richAdd BLAST67

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM U1 A/B'' family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4206 Eukaryota
ENOG410XPZI LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007046

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_041869_1_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P09012

KEGG Orthology (KO)

More...KOi		K11091

Identification of Orthologs from Complete Genome Data

More...OMAi		QYPNLHE

Database of Orthologous Groups

More...OrthoDBi		1608132at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P09012

TreeFam database of animal gene trees

More...TreeFami		TF313834

Family and domain databases

Conserved Domains Database

More...CDDi		cd12477 RRM1_U1A, 1 hit
cd12480 RRM2_U1A, 1 hit

Database of protein disorder

More...DisProti		DP01857

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 2 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00018

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034407 U1A_RRM1
IPR034409 U1A_RRM2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076 RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360 RRM, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102 RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P09012-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVPETRPNH TIYINNLNEK IKKDELKKSL YAIFSQFGQI LDILVSRSLK 
        60         70         80         90        100
MRGQAFVIFK EVSSATNALR SMQGFPFYDK PMRIQYAKTD SDIIAKMKGT 
       110        120        130        140        150
FVERDRKREK RKPKSQETPA TKKAVQGGGA TPVVGAVQGP VPGMPPMTQA 
       160        170        180        190        200
PRIMHHMPGQ PPYMPPPGMI PPPGLAPGQI PPGAMPPQQL MPGQMPPAQP 
       210        220        230        240        250
LSENPPNHIL FLTNLPEETN ELMLSMLFNQ FPGFKEVRLV PGRHDIAFVE 
       260        270        280 
FDNEVQAGAA RDALQGFKIT QNNAMKISFA KK
Length:282
Mass (Da):31,280
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9426E83EE5A22894
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R268M0R268_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZG7M0QZG7_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R221M0R221_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2B8M0R2B8_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXK2M0QXK2_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0G9M0R0G9_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRPA
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M60784 M60783 Genomic DNA Translation: AAA61245.1
X06347 mRNA Translation: CAA29653.1
BC000405 mRNA Translation: AAH00405.1
BC008290 mRNA Translation: AAH08290.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12565.1

Protein sequence database of the Protein Information Resource

More...PIRi		JQ1528

NCBI Reference Sequences

More...RefSeqi		NP_004587.1, NM_004596.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000243563; ENSP00000243563; ENSG00000077312

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6626

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6626

UCSC genome browser

More...UCSCi		uc002ooz.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60784 M60783 Genomic DNA Translation: AAA61245.1
X06347 mRNA Translation: CAA29653.1
BC000405 mRNA Translation: AAH00405.1
BC008290 mRNA Translation: AAH08290.1
CCDSiCCDS12565.1
PIRiJQ1528
RefSeqiNP_004587.1, NM_004596.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AUDNMR-A2-102[»]
1DRZX-ray2.30A2-98[»]
1DZ5NMR-A/B2-102[»]
1FHTNMR-A2-117[»]
1M5KX-ray2.40C/F1-100[»]
1M5OX-ray2.20C/F1-100[»]
1M5PX-ray2.60C/F1-100[»]
1M5VX-ray2.40C/F1-100[»]
1NU4X-ray1.80A/B2-98[»]
1OIAX-ray2.40A/B1-95[»]
1SJ3X-ray2.20P1-100[»]
1SJ4X-ray2.70P1-100[»]
1SJFX-ray2.75A1-100[»]
1U6BX-ray3.10A1-98[»]
1URNX-ray1.92A/B/C2-98[»]
1VBXX-ray2.70A1-100[»]
1VBYX-ray2.90A1-100[»]
1VBZX-ray2.80A1-100[»]
1VC0X-ray2.50A1-100[»]
1VC5X-ray3.40A1-100[»]
1VC6X-ray2.80A1-100[»]
1ZZNX-ray3.37A1-98[»]
2A3JNMR-A3-80[»]
2NZ4X-ray2.50A/B/C/D5-98[»]
2OIHX-ray2.40A2-100[»]
2OJ3X-ray2.90A2-100[»]
2U1ANMR-A195-282[»]
3BO2X-ray3.31A4-98[»]
3BO3X-ray3.40A4-98[»]
3BO4X-ray3.33A4-98[»]
3CULX-ray2.80A/B1-96[»]
3CUNX-ray3.00A/B1-98[»]
3EGZX-ray2.20A1-98[»]
3G8SX-ray3.10A/B/C/D1-98[»]
3G8TX-ray3.00A/B/C/D1-98[»]
3G96X-ray3.01A/B/C/D1-98[»]
3G9CX-ray2.90A/B/C/D1-98[»]
3HHNX-ray2.99B/D2-98[»]
3IINX-ray4.18A4-98[»]
3IRWX-ray2.70P1-98[»]
3IWNX-ray3.20C/D6-96[»]
3K0JX-ray3.10A/B/C/D2-97[»]
3L3CX-ray2.85A/B/C/D7-96[»]
3MUMX-ray2.90P1-98[»]
3MURX-ray3.00P1-98[»]
3MUTX-ray3.00P1-98[»]
3MUVX-ray3.20P1-98[»]
3MXHX-ray2.30P1-98[»]
3P49X-ray3.55B1-98[»]
3PGWX-ray4.40A/P1-282[»]
3R1HX-ray3.15A/D1-98[»]
3R1LX-ray3.12A/D1-98[»]
3UCUX-ray2.80P1-98[»]
3UCZX-ray2.80P1-98[»]
3UD3X-ray3.10P1-98[»]
3UD4X-ray2.70P1-98[»]
3UTRmodel-B/D1-98[»]
4C4WX-ray2.95A/B/E/F1-102[»]
4PR6X-ray2.30A4-96[»]
4PRFX-ray2.40A1-100[»]
4W90X-ray3.12B6-96[»]
4W92X-ray3.21B6-96[»]
4YB1X-ray2.08P7-97[»]
5DDOX-ray3.10C/G2-98[»]
5DDPX-ray2.30C/D2-98[»]
5DDQX-ray2.40C/D2-98[»]
5DDRX-ray2.60C/D2-98[»]
5FJ4X-ray2.95A/B/E/F1-102[»]
6LASX-ray2.71C/D/E6-96[»]
6LAUX-ray3.11C/D/E6-96[»]
6LAXX-ray2.70C/D/E6-96[»]
6LAZX-ray2.76C/D/E6-96[»]
6QX9electron microscopy3.281A1-282[»]
SMRiP09012
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112510, 117 interactors
CORUMiP09012
DIPiDIP-29407N
IntActiP09012, 94 interactors
MINTiP09012
STRINGi9606.ENSP00000243563

Chemistry databases

DrugBankiDB02175 Malonic acid

PTM databases

iPTMnetiP09012
MetOSiteiP09012
PhosphoSitePlusiP09012

Polymorphism and mutation databases

BioMutaiSNRPA
DMDMi134092

Proteomic databases

EPDiP09012
jPOSTiP09012
MassIVEiP09012
MaxQBiP09012
PaxDbiP09012
PeptideAtlasiP09012
PRIDEiP09012
ProteomicsDBi52184
TopDownProteomicsiP09012

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3308 310 antibodies

Genome annotation databases

EnsembliENST00000243563; ENSP00000243563; ENSG00000077312
GeneIDi6626
KEGGihsa:6626
UCSCiuc002ooz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6626
DisGeNETi6626
EuPathDBiHostDB:ENSG00000077312.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		SNRPA
HGNCiHGNC:11151 SNRPA
HPAiENSG00000077312 Low tissue specificity
MIMi182285 gene
neXtProtiNX_P09012
OpenTargetsiENSG00000077312
PharmGKBiPA35993

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4206 Eukaryota
ENOG410XPZI LUCA
GeneTreeiENSGT00390000007046
HOGENOMiCLU_041869_1_3_1
InParanoidiP09012
KOiK11091
OMAiQYPNLHE
OrthoDBi1608132at2759
PhylomeDBiP09012
TreeFamiTF313834

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6626 210 hits in 798 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SNRPA human
EvolutionaryTraceiP09012

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Small_nuclear_ribonucleoprotein_polypeptide_A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6626
PharosiP09012 Tbio

Protein Ontology

More...PROi		PR:P09012
RNActiP09012 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000077312 Expressed in small intestine Peyer's patch and 224 other tissues
ExpressionAtlasiP09012 baseline and differential
GenevisibleiP09012 HS

Family and domain databases

CDDicd12477 RRM1_U1A, 1 hit
cd12480 RRM2_U1A, 1 hit
DisProtiDP01857
Gene3Di3.30.70.330, 2 hits
IDEALiIID00018
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034407 U1A_RRM1
IPR034409 U1A_RRM2
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNRPA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09012
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: June 17, 2020
This is version 231 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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