UniProtKB - P09001 (RM03_HUMAN)
39S ribosomal protein L3, mitochondrial
MRPL3
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- mitochondrial translational elongation Source: Reactome
- mitochondrial translational termination Source: Reactome
- translation Source: ProtInc
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | P09001 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | P09001 |
Names & Taxonomyi
Protein namesi | Recommended name: 39S ribosomal protein L3, mitochondrialShort name: L3mt Short name: MRP-L3 Alternative name(s): Mitochondrial large ribosomal subunit protein uL3m1 Publication |
Gene namesi | Name:MRPL3 Synonyms:MRL3, RPML3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10379, MRPL3 |
MIMi | 607118, gene |
neXtProti | NX_P09001 |
VEuPathDBi | HostDB:ENSG00000114686.8 |
Subcellular locationi
Mitochondrion
- Mitochondrion 3 Publications
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial large ribosomal subunit Source: UniProtKB
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Involvement in diseasei
Combined oxidative phosphorylation deficiency 9 (COXPD9)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066676 | 317 | P → R in COXPD9. 1 PublicationCorresponds to variant dbSNP:rs387906962EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Primary mitochondrial diseaseOrganism-specific databases
DisGeNETi | 11222 |
MalaCardsi | MRPL3 |
MIMi | 614582, phenotype |
OpenTargetsi | ENSG00000114686 |
Orphaneti | 319509, Combined oxidative phosphorylation defect type 9 |
PharmGKBi | PA30960 |
Miscellaneous databases
Pharosi | P09001, Tbio |
Genetic variation databases
BioMutai | MRPL3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 40 | MitochondrionCombined sourcesAdd BLAST | 40 | |
ChainiPRO_0000077253 | 41 – 348 | 39S ribosomal protein L3, mitochondrialAdd BLAST | 308 |
Proteomic databases
EPDi | P09001 |
jPOSTi | P09001 |
MassIVEi | P09001 |
MaxQBi | P09001 |
PaxDbi | P09001 |
PeptideAtlasi | P09001 |
PRIDEi | P09001 |
ProteomicsDBi | 52183 |
PTM databases
iPTMneti | P09001 |
PhosphoSitePlusi | P09001 |
SwissPalmi | P09001 |
Expressioni
Gene expression databases
Bgeei | ENSG00000114686, Expressed in secondary oocyte and 249 other tissues |
ExpressionAtlasi | P09001, baseline and differential |
Genevisiblei | P09001, HS |
Organism-specific databases
HPAi | ENSG00000114686, Low tissue specificity |
Interactioni
Subunit structurei
Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
3 PublicationsProtein-protein interaction databases
BioGRIDi | 116390, 130 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | P09001 |
IntActi | P09001, 55 interactors |
MINTi | P09001 |
STRINGi | 9606.ENSP00000264995 |
Miscellaneous databases
RNActi | P09001, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P09001 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3141, Eukaryota |
GeneTreei | ENSGT00390000011422 |
HOGENOMi | CLU_044142_1_1_1 |
InParanoidi | P09001 |
OrthoDBi | 1269775at2759 |
PhylomeDBi | P09001 |
TreeFami | TF105634 |
Family and domain databases
InterProi | View protein in InterPro IPR000597, Ribosomal_L3 IPR019927, Ribosomal_L3_bac/org-type IPR019926, Ribosomal_L3_CS IPR009000, Transl_B-barrel_sf |
PANTHERi | PTHR11229, PTHR11229, 1 hit |
Pfami | View protein in Pfam PF00297, Ribosomal_L3, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit |
TIGRFAMsi | TIGR03625, L3_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00474, RIBOSOMAL_L3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPGWRLLTQV GAQVLGRLGD GLGAALGPGN RTHIWLFVRG LHGKSGTWWD
60 70 80 90 100
EHLSEENVPF IKQLVSDEDK AQLASKLCPL KDEPWPIHPW EPGSFRVGLI
110 120 130 140 150
ALKLGMMPLW TKDGQKHVVT LLQVQDCHVL KYTSKENCNG KMATLSVGGK
160 170 180 190 200
TVSRFRKATS ILEFYRELGL PPKQTVKIFN ITDNAAIKPG TPLYAAHFRP
210 220 230 240 250
GQYVDVTAKT IGKGFQGVMK RWGFKGQPAT HGQTKTHRRP GAVATGDIGR
260 270 280 290 300
VWPGTKMPGK MGNIYRTEYG LKVWRINTKH NIIYVNGSVP GHKNCLVKVK
310 320 330 340
DSKLPAYKDL GKNLPFPTYF PDGDEEELPE DLYDENVCQP GAPSITFA
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ETU7 | E7ETU7_HUMAN | 39S ribosomal protein L3, mitochond... | MRPL3 | 375 | Annotation score: | ||
H0Y9G6 | H0Y9G6_HUMAN | 39S ribosomal protein L3, mitochond... | MRPL3 | 363 | Annotation score: | ||
D6RC14 | D6RC14_HUMAN | 39S ribosomal protein L3, mitochond... | MRPL3 | 155 | Annotation score: | ||
E9PF06 | E9PF06_HUMAN | 39S ribosomal protein L3, mitochond... | MRPL3 | 176 | Annotation score: | ||
D6RBQ5 | D6RBQ5_HUMAN | 39S ribosomal protein L3, mitochond... | MRPL3 | 28 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020108 | 261 | M → T. Corresponds to variant dbSNP:rs2291381EnsemblClinVar. | 1 | |
Natural variantiVAR_066676 | 317 | P → R in COXPD9. 1 PublicationCorresponds to variant dbSNP:rs387906962EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06323 mRNA Translation: CAA29639.1 CR456720 mRNA Translation: CAG33001.1 CH471052 Genomic DNA Translation: EAW79209.1 BC003375 mRNA Translation: AAH03375.1 |
CCDSi | CCDS3071.1 |
PIRi | A27294, R5HUL3 |
RefSeqi | NP_009139.1, NM_007208.3 |
Genome annotation databases
Ensembli | ENST00000264995; ENSP00000264995; ENSG00000114686 |
GeneIDi | 11222 |
KEGGi | hsa:11222 |
UCSCi | uc003eoh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06323 mRNA Translation: CAA29639.1 CR456720 mRNA Translation: CAG33001.1 CH471052 Genomic DNA Translation: EAW79209.1 BC003375 mRNA Translation: AAH03375.1 |
CCDSi | CCDS3071.1 |
PIRi | A27294, R5HUL3 |
RefSeqi | NP_009139.1, NM_007208.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J7Y | electron microscopy | 3.40 | E | 1-348 | [»] | |
3J9M | electron microscopy | 3.50 | E | 1-348 | [»] | |
5OOL | electron microscopy | 3.06 | E | 1-348 | [»] | |
5OOM | electron microscopy | 3.03 | E | 1-348 | [»] | |
6I9R | electron microscopy | 3.90 | E | 1-348 | [»] | |
6NU2 | electron microscopy | 3.90 | E | 45-348 | [»] | |
6NU3 | electron microscopy | 4.40 | E | 1-348 | [»] | |
6VLZ | electron microscopy | 2.97 | E | 1-348 | [»] | |
6VMI | electron microscopy | 2.96 | E | 1-348 | [»] | |
6ZM5 | electron microscopy | 2.89 | E | 1-348 | [»] | |
6ZM6 | electron microscopy | 2.59 | E | 1-348 | [»] | |
6ZS9 | electron microscopy | 4.00 | XE | 1-348 | [»] | |
6ZSA | electron microscopy | 4.00 | XE | 1-348 | [»] | |
6ZSB | electron microscopy | 4.50 | XE | 1-348 | [»] | |
6ZSC | electron microscopy | 3.50 | XE | 1-348 | [»] | |
6ZSD | electron microscopy | 3.70 | XE | 1-348 | [»] | |
6ZSE | electron microscopy | 5.00 | XE | 1-348 | [»] | |
6ZSG | electron microscopy | 4.00 | XE | 1-348 | [»] | |
7A5F | electron microscopy | 4.40 | E3 | 1-348 | [»] | |
7A5G | electron microscopy | 4.33 | E3 | 1-348 | [»] | |
7A5H | electron microscopy | 3.30 | E | 1-348 | [»] | |
7A5I | electron microscopy | 3.70 | E3 | 1-348 | [»] | |
7A5J | electron microscopy | 3.10 | E | 1-348 | [»] | |
7A5K | electron microscopy | 3.70 | E3 | 1-348 | [»] | |
SMRi | P09001 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116390, 130 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | P09001 |
IntActi | P09001, 55 interactors |
MINTi | P09001 |
STRINGi | 9606.ENSP00000264995 |
PTM databases
iPTMneti | P09001 |
PhosphoSitePlusi | P09001 |
SwissPalmi | P09001 |
Genetic variation databases
BioMutai | MRPL3 |
Proteomic databases
EPDi | P09001 |
jPOSTi | P09001 |
MassIVEi | P09001 |
MaxQBi | P09001 |
PaxDbi | P09001 |
PeptideAtlasi | P09001 |
PRIDEi | P09001 |
ProteomicsDBi | 52183 |
Protocols and materials databases
Antibodypediai | 33349, 189 antibodies |
DNASUi | 11222 |
Genome annotation databases
Ensembli | ENST00000264995; ENSP00000264995; ENSG00000114686 |
GeneIDi | 11222 |
KEGGi | hsa:11222 |
UCSCi | uc003eoh.4, human |
Organism-specific databases
CTDi | 11222 |
DisGeNETi | 11222 |
GeneCardsi | MRPL3 |
HGNCi | HGNC:10379, MRPL3 |
HPAi | ENSG00000114686, Low tissue specificity |
MalaCardsi | MRPL3 |
MIMi | 607118, gene 614582, phenotype |
neXtProti | NX_P09001 |
OpenTargetsi | ENSG00000114686 |
Orphaneti | 319509, Combined oxidative phosphorylation defect type 9 |
PharmGKBi | PA30960 |
VEuPathDBi | HostDB:ENSG00000114686.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3141, Eukaryota |
GeneTreei | ENSGT00390000011422 |
HOGENOMi | CLU_044142_1_1_1 |
InParanoidi | P09001 |
OrthoDBi | 1269775at2759 |
PhylomeDBi | P09001 |
TreeFami | TF105634 |
Enzyme and pathway databases
PathwayCommonsi | P09001 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | P09001 |
Miscellaneous databases
BioGRID-ORCSi | 11222, 278 hits in 1000 CRISPR screens |
ChiTaRSi | MRPL3, human |
GeneWikii | MRPL3 |
GenomeRNAii | 11222 |
Pharosi | P09001, Tbio |
PROi | PR:P09001 |
RNActi | P09001, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114686, Expressed in secondary oocyte and 249 other tissues |
ExpressionAtlasi | P09001, baseline and differential |
Genevisiblei | P09001, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000597, Ribosomal_L3 IPR019927, Ribosomal_L3_bac/org-type IPR019926, Ribosomal_L3_CS IPR009000, Transl_B-barrel_sf |
PANTHERi | PTHR11229, PTHR11229, 1 hit |
Pfami | View protein in Pfam PF00297, Ribosomal_L3, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit |
TIGRFAMsi | TIGR03625, L3_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00474, RIBOSOMAL_L3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RM03_HUMAN | |
Accessioni | P09001Primary (citable) accession number: P09001 Secondary accession number(s): Q6IBT2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | April 7, 2021 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families