UniProtKB - P08983 (CXB1_XENLA)
Protein
Gap junction beta-1 protein
Gene
gjb1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
GO - Biological processi
- cell communication Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction beta-1 proteinAlternative name(s): Connexin-30 Short name: Cx30 |
Gene namesi | Name:gjb1 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-865435, gjb1.L |
Subcellular locationi
Plasma membrane
Other locations
Plasma Membrane
- connexin complex Source: InterPro
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 22 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 23 – 45 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 46 – 75 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 76 – 98 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 99 – 130 | CytoplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 131 – 153 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 154 – 191 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 192 – 214 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 215 – 264 | CytoplasmicSequence analysisAdd BLAST | 50 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057853 | 1 – 264 | Gap junction beta-1 proteinAdd BLAST | 264 |
Expressioni
Tissue specificityi
Lung, liver, intestines, stomach and kidney.
Interactioni
Subunit structurei
A connexon is composed of a hexamer of connexins.
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002267, Connexin32 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01138, CONNEXINB1 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P08983-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNWAGLYAIL SGVNRHSTSI GRIWLSVVFI FRIMVLVAAA ESVWGDEKSA
60 70 80 90 100
FTCNTQQPGC NSVCYDHFFP ISHIRLWALQ LIIVSTPALL VAMHVAHLQH
110 120 130 140 150
QEKKELRLSR HVKDQELAEV KKHKVKISGT LWWTYISSVF FRIIFEAAFM
160 170 180 190 200
YIFYLIYPGY SMIRLLKCDA YPCPNTVDCF VSRPTEKTIF TVFMLVASGV
210 220 230 240 250
CIVLNVAEVF FLIAQACTRR ARRHRDSGSI SKEHQQNEMN LLITGGSIIK
260
RSAGQEKGDH CSTS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00791 mRNA Translation: CAA68745.1 |
PIRi | A31102 |
RefSeqi | NP_001095219.1, NM_001101749.1 |
Genome annotation databases
GeneIDi | 394373 |
KEGGi | xla:394373 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00791 mRNA Translation: CAA68745.1 |
PIRi | A31102 |
RefSeqi | NP_001095219.1, NM_001101749.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 394373 |
KEGGi | xla:394373 |
Organism-specific databases
CTDi | 394373 |
Xenbasei | XB-GENE-865435, gjb1.L |
Family and domain databases
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002267, Connexin32 IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf |
PANTHERi | PTHR11984, PTHR11984, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01138, CONNEXINB1 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXB1_XENLA | |
Accessioni | P08983Primary (citable) accession number: P08983 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 92 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |