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Entry version 146 (13 Feb 2019)
Sequence version 3 (05 Jul 2004)
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Protein

Proto-oncogene tyrosine-protein kinase ROS

Gene

ROS1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor tyrosine kinase (RTK) that may activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1, and PLCG2.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1996ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2095Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1967 – 1975ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein tyrosine kinase activity Source: UniProtKB
  • transmembrane receptor protein tyrosine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proto-oncogene tyrosine-protein kinase ROS (EC:2.7.10.1)
Alternative name(s):
Proto-oncogene c-Ros
Proto-oncogene c-Ros-1
Receptor tyrosine kinase c-ros oncogene 1
c-Ros receptor tyrosine kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ROS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 1873ExtracellularSequence analysisAdd BLAST1849
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1874 – 1898HelicalSequence analysisAdd BLAST25
Topological domaini1899 – 2311CytoplasmicSequence analysisAdd BLAST413

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001672325 – 2311Proto-oncogene tyrosine-protein kinase ROSAdd BLAST2287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi607N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi706N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi714N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi911N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi940N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi962N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi971N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1282N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1509N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1588N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1682N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1696N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1730N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1792N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1795N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1822N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2131Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08941

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08941

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in kidney. Also expressed in gonad, thymus, bursa, brain and kidney.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000036566

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P08941

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P08941

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 202Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini203 – 294Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST92
Domaini571 – 671Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST101
Domaini952 – 1047Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini1051 – 1158Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST108
Domaini1459 – 1569Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST111
Domaini1570 – 1669Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST100
Domaini1671 – 1766Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST96
Domaini1767 – 1868Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST102
Domaini1961 – 2240Protein kinasePROSITE-ProRule annotationAdd BLAST280

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQAA Eukaryota
ENOG410XSTC LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000137937

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058631

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08941

Database of Orthologous Groups

More...
OrthoDBi
203310at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08941

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 3 hits
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000033 LDLR_classB_rpt
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 3 hits
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 9 hits
SM00135 LY, 3 hits
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 5 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P08941-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRNACLLLNR LGAFYFIWIS AAYCSFSKNC QDLCTSNLEG ELGIANLCNV
60 70 80 90 100
SDINVACTQG CQFWNATEQV NCPLKCNKTY TRECETVSCK FGCSRAEDAY
110 120 130 140 150
GVEAQNCLNK PGAPFASSIG SHNITLGWKP ANISEVKYII QWKFHQLPGD
160 170 180 190 200
WRYTEVVSET SYTVKDLQAF TEYEFRVVWI ITSQLQLHSP PSPSYRTHAS
210 220 230 240 250
GVPTTAPIIK DIQSSSPNTV EVSWFPPLFP NGLIVGYNLV LTSENHELLR
260 270 280 290 300
ASRGHSFQFY STFPNSTYRF SIVAVNEAGA GPPAEANITT PESKVKEKAK
310 320 330 340 350
WLFLSRNQSL RKRYMEHFLE AAHCLQNGII HHNITGISVN VYQQVVYFSE
360 370 380 390 400
GNSIWVKGVV DMSDVSDLTL FYTGWGNITS ISVDWLYQRM YFVMNEKIHV
410 420 430 440 450
CQLENCTAAE DITPPYETSP RKIVADPYNG YIFCLLEDGI YRANLPLFPD
460 470 480 490 500
TASAASLVVK SHTLRDFMIN FQSKRLIFFN KTEQAFVSGF LDGSEFHTLR
510 520 530 540 550
AHVPLDDMES FVYEDNIFTV TDGRAVFHEE ISQVGSSSFN EYVVDCSLEY
560 570 580 590 600
PEYFGFGNLL FYAASTQPYP LPTLPRLVTV LFGSDQAVIS WSPPEYTIGT
610 620 630 640 650
SRSAWQNWTY DVKVSSQSTF EEEWVVSNIT DTRFAVKNLV SFTEYEMSVR
660 670 680 690 700
AVSPAGEGPW SEPFRGMTFE EAEEEPYILA VGAEGLWKQR LDSYGPGEFL
710 720 730 740 750
YPHIRNISDL DWYNDTLYWS NSMGKVQTWS MNKKEGTTEN SYVPDIKNAR
760 770 780 790 800
MLAFDWLGQC LYWAGKANTI YRKSLLGDHM DVVAHVVYVV KDLAVDSVNG
810 820 830 840 850
YLYWATTYTV ESARLNGEEY LILQEHLQFS GKQVVGLALD LTSGFLYWLV
860 870 880 890 900
QDGLCLNLYR ISICKESCGN IMVTEISAWS VSEVSQNALQ YYSGRLFWIN
910 920 930 940 950
RLKFITTQEL NQSISIPFSE PAEFAAFTLV HTSLKPLPGN FSFTPKVIPS
960 970 980 990 1000
SVPESSFKIK GNSSSFHIIW NASTDVQWGT VFYCVGSNAL QMRTLESERC
1010 1020 1030 1040 1050
LHPHDLTVPS YKVDWLEPFT LFDFSVTPYT YWGKAPTTSV YLRAPEGVPS
1060 1070 1080 1090 1100
APANPRIYVL HSNTHEGEEK VLVELRWDKP ERDNGVLTQF RVYYQLLYES
1110 1120 1130 1140 1150
GAADTLMEWN VSDVKPTALL FSIRDEHPRL TVRFQVQAFT SVGPGPMSDV
1160 1170 1180 1190 1200
AQRNSSDIFP VPTLITFSSN KLFLTDIDSN HTIWEVLTNR NIKDICYTAD
1210 1220 1230 1240 1250
DDKVYYILED SLFLLNVQST SESQLFEDVF LRNVTAITVD WIARHLFVAM
1260 1270 1280 1290 1300
KTSWNETQVF FIDLELKTKS LKALNIQLGK RNSTISSLLS YPFLSRLYWI
1310 1320 1330 1340 1350
EELDYGSRMF YYDILNNTMY HILGYESVEE KMRNYCNCNV AEAELGRPIS
1360 1370 1380 1390 1400
IDVTDIKKPQ LLFIRGRDEI WASDVDACHC WRITKIPSFQ GTKIGSLTVD
1410 1420 1430 1440 1450
KQFIYWTIEK KEYTEICLAD KESTRHSLQR KANHELKILA YSSAMQSYPD
1460 1470 1480 1490 1500
KKCLTPLLDT EKPTILDTTN TSFTLSLPSV TTQQLCPSIS QPTPTYLVFF
1510 1520 1530 1540 1550
REITSNHENS TYHFSTLLQK TLEIQEPIAV INNLKPFSTY AIQVAVKNYY
1560 1570 1580 1590 1600
SNQNQLAVGR EAISTTLYGV PEGVDSIKTV VLSDTTINIS WSEPLEPNGP
1610 1620 1630 1640 1650
LESIRYQISV NLLSLFPEAP LRKSEFPNGT LSWSVSDLQS GTNNLFKVLA
1660 1670 1680 1690 1700
FHPNENWFSE SVPVIAKTFE TPLSPSNIIP RNTSFQLEWR APLHINGTSF
1710 1720 1730 1740 1750
WFELSKWQTR SDWFSPASTT CTVGPVYTCN LTGTLPSANY LVRATVVYVT
1760 1770 1780 1790 1800
GMKSTSSPTS FKTTAGVPSK PGTPKRAEDS KNSVQWEKAE DNGSNLTYYI
1810 1820 1830 1840 1850
LESRKQSGNT NKVKSLWVVV YNGSCDNICT WKAENLEGTF QFRAAAANML
1860 1870 1880 1890 1900
GLGEYSDTSK DIVLAKDTVT SPDITAIVAV IGAVVLGLTI IILFGFVWHQ
1910 1920 1930 1940 1950
RWKSRKPAST GQIVLVKEDK ELAQLRGMAE TVGLANACYA VSTLPSQAEI
1960 1970 1980 1990 2000
ESLPAFPRDK LNLHKLLGSG AFGEVYEGTA LDILADGSGE SRVAVKTLKR
2010 2020 2030 2040 2050
GATDQEKSEF LKEAHLMSKF DHPHILKLLG VCLLNEPQYL ILELMEGGDL
2060 2070 2080 2090 2100
LSYLRGARKQ KFQSPLLTLT DLLDICLDIC KGCVYLEKMR FIHRDLAARN
2110 2120 2130 2140 2150
CLVSEKQYGS CSRVVKIGDF GLARDIYKND YYRKRGEGLI NVRWMAPESL
2160 2170 2180 2190 2200
IDGVFTNHSD VWAFGVLVWE TLTLGQQPYP GLSNIEVLHH VRSGGRLESP
2210 2220 2230 2240 2250
NNCPDDIRDL MTRCWAQDPH NRPTFFYIQH KLQEIRHSPL CFSYFLGDKE
2260 2270 2280 2290 2300
SVAGFINQAF EDIDVPPADS DSILSTTLME ARDQEGLNYL VVVKESNQDQ
2310
GSISSAELTS V
Length:2,311
Mass (Da):260,961
Last modified:July 5, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF9680E5B0491417
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1827N → S (PubMed:3023956).Curated1
Sequence conflicti2140 – 2141IN → LP (PubMed:3023892).Curated2
Sequence conflicti2140 – 2141IN → LP (PubMed:3325887).Curated2
Sequence conflicti2255 – 2292FINQA…NYLVV → SSTKLLRVSLGSAVPTAFAQ TCNSVNVESQNGLGWKGP in AAA49058 (PubMed:3023892).CuratedAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M13013 Genomic DNA Translation: AAA49058.1
X06770 mRNA Translation: CAA29938.1

Protein sequence database of the Protein Information Resource

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PIRi
A60197 TVCHSR

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Gga.702

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13013 Genomic DNA Translation: AAA49058.1
X06770 mRNA Translation: CAA29938.1
PIRiA60197 TVCHSR
UniGeneiGga.702

3D structure databases

ProteinModelPortaliP08941
SMRiP08941
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036566

PTM databases

iPTMnetiP08941

Proteomic databases

PaxDbiP08941

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IQAA Eukaryota
ENOG410XSTC LUCA
HOGENOMiHOG000137937
HOVERGENiHBG058631
InParanoidiP08941
OrthoDBi203310at2759
PhylomeDBiP08941

Family and domain databases

CDDicd00063 FN3, 7 hits
Gene3Di2.120.10.30, 3 hits
2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000033 LDLR_classB_rpt
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SM00135 LY, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF49265 SSF49265, 5 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROS1_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08941
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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