Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leukocyte tyrosine kinase receptor

Gene

Ltk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei540ATPPROSITE-ProRule annotation1
Active sitei639Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi512 – 520ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte tyrosine kinase receptor (EC:2.7.10.1)
Gene namesi
Name:Ltk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96840 Ltk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 421ExtracellularSequence analysisAdd BLAST405
Transmembranei422 – 446HelicalSequence analysisAdd BLAST25
Topological domaini447 – 888CytoplasmicSequence analysisAdd BLAST442

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001673917 – 888Leukocyte tyrosine kinase receptorAdd BLAST872

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei672Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP08923
PaxDbiP08923
PRIDEiP08923

PTM databases

iPTMnetiP08923
PhosphoSitePlusiP08923

Expressioni

Tissue specificityi

Subsets of lymphoid and neuronal cells.

Gene expression databases

BgeeiENSMUSG00000027297 Expressed in 107 organ(s), highest expression level in prefrontal cortex
CleanExiMM_LTK
ExpressionAtlasiP08923 baseline and differential
GenevisibleiP08923 MM

Interactioni

Subunit structurei

Homodimer when bound to ligand (Probable). Part of a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2 (By similarity). Isoform A binds calnexin.By similarityCurated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028759

Structurei

3D structure databases

ProteinModelPortaliP08923
SMRiP08923
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini506 – 782Protein kinasePROSITE-ProRule annotationAdd BLAST277

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1095 Eukaryota
ENOG410XPVX LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000231766
HOVERGENiHBG052371
InParanoidiP08923
KOiK05118
OrthoDBiEOG091G003T
TreeFamiTF351636

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00219 TyrKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform D (identifier: P08923-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGCSHRLLLW LGAAGTILCS NSEFQTPFLT PSLLPVLVLN SQEQKVTPTP
60 70 80 90 100
SKLEPASLPN PLGTRGPWVF NTCGASGRSG PTQTQCDGAY TGSSVMVTVG
110 120 130 140 150
AAGPLKGVQL WRVPDTGQYL ISAYGAAGGK GAQNHLSRAH GIFLSAVFFL
160 170 180 190 200
RRGEPVYILV GQQGQDACPG GSPESQLVCL GESGEHATTY GTERIPGWRR
210 220 230 240 250
WAGGGGGGGG ATSIFRLRAG EPEPLLVAAG GGGRSYRRRP DRGRTQAVPE
260 270 280 290 300
RLETRAAAPG SGGRGGAAGG GSGWTSRAHS PQAGRSPREG AEGGEGCAEA
310 320 330 340 350
WAALRWAAAG GFGGGGGACA AGGGGGGYRG GDTSESDLLW ADGEDGTSFV
360 370 380 390 400
HPSGELYLQP LAVTEGHGEV EIRKHPNCSH CPFKDCQWQA ELWTAECTCP
410 420 430 440 450
EGTELAVDNV TCMDLPTTAS PLILMGAVVA ALALSLLMMC AVLILVNQKC
460 470 480 490 500
QGLWGTRLPG PELELSKLRS SAIRTAPNPY YCQVGLSPAQ PWPLPPGLTE
510 520 530 540 550
VSPANVTLLR ALGHGAFGEV YEGLVTGLPG DSSPLPVAIK TLPELCSHQD
560 570 580 590 600
ELDFLMEALI ISKFSHQNIV RCVGLSFRSA PRLILLELMS GGDMKSFLRH
610 620 630 640 650
SRPHPGQLAP LTMQDLLQLA QDIAQGCHYL EENHFIHRDI AARNCLLSCS
660 670 680 690 700
GASRVAKIGD FGMARDIYQA SYYRKGGRTL LPVKWMPPEA LLEGLFTSKT
710 720 730 740 750
DSWSFGVLLW EIFSLGYMPY PGHTNQEVLD FIATGNRMDP PRNCPGPVYR
760 770 780 790 800
IMTQCWQHQP ELRPDFGSIL ERIQYCTQDP DVLNSPLPVE PGPILEEEEA
810 820 830 840 850
SRLGNRSLEG LRSPKPLELS SQNLKSWGGG LLGSWLPSGL KTLKPRCLQP
860 870 880
QNIWNPTYGS WTPRGPQGED TGIEHCNGSS SSSIPGIQ
Note: May be produced by alternative promoter usage.
Length:888
Mass (Da):94,471
Last modified:July 27, 2011 - v3
Checksum:i7D204A474DEF0AC6
GO
Isoform A (identifier: P08923-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.
     252-252: L → M
     271-331: Missing.

Note: May be produced by alternative promoter usage. Starts at a CUG codon.
Show »
Length:576
Mass (Da):62,749
Checksum:i3598526F13E50B4E
GO
Isoform B (identifier: P08923-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.
     252-252: L → M

Note: May be produced by alternative promoter usage. Starts at a CUG codon.
Show »
Length:637
Mass (Da):68,323
Checksum:i72225A1464E47365
GO
Isoform C (identifier: P08923-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-331: Missing.

Show »
Length:827
Mass (Da):88,897
Checksum:i906AFE379E266FD6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6V2R5F6V2R5_MOUSE
Tyrosine-protein kinase receptor
Ltk
476Annotation score:

Sequence cautioni

The sequence CAA30793 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26T → A in AAA39451 (PubMed:8380920).Curated1
Sequence conflicti113V → A in AAA39451 (PubMed:8380920).Curated1
Sequence conflicti789V → M in CAA36848 (PubMed:1662793).Curated1
Sequence conflicti789V → M in AAA39451 (PubMed:8380920).Curated1
Sequence conflicti875H → Q in CAA36848 (PubMed:1662793).Curated1
Sequence conflicti875H → Q in AAA39451 (PubMed:8380920).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti746G → E1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0029501 – 251Missing in isoform A and isoform B. 4 PublicationsAdd BLAST251
Alternative sequenceiVSP_002951252L → M in isoform A and isoform B. 4 Publications1
Alternative sequenceiVSP_002952271 – 331Missing in isoform A and isoform C. 4 PublicationsAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52621 mRNA Translation: CAA36848.1
M90470 mRNA Translation: AAA39451.1
AL844536 Genomic DNA No translation available.
X07984 mRNA Translation: CAA30793.1 Different initiation.
CCDSiCCDS16608.1 [P08923-1]
CCDS16609.1 [P08923-4]
CCDS50674.1 [P08923-2]
PIRiI58378
S12792
RefSeqiNP_976220.2, NM_203345.2 [P08923-1]
NP_996824.1, NM_206941.1 [P08923-3]
NP_996825.2, NM_206942.2 [P08923-4]
UniGeneiMm.1740

Genome annotation databases

EnsembliENSMUST00000028759; ENSMUSP00000028759; ENSMUSG00000027297 [P08923-1]
ENSMUST00000082130; ENSMUSP00000080774; ENSMUSG00000027297 [P08923-4]
ENSMUST00000182203; ENSMUSP00000138201; ENSMUSG00000027297 [P08923-2]
GeneIDi17005
KEGGimmu:17005
UCSCiuc008lug.1 mouse [P08923-3]
uc008lui.1 mouse [P08923-1]
uc008luj.1 mouse [P08923-4]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52621 mRNA Translation: CAA36848.1
M90470 mRNA Translation: AAA39451.1
AL844536 Genomic DNA No translation available.
X07984 mRNA Translation: CAA30793.1 Different initiation.
CCDSiCCDS16608.1 [P08923-1]
CCDS16609.1 [P08923-4]
CCDS50674.1 [P08923-2]
PIRiI58378
S12792
RefSeqiNP_976220.2, NM_203345.2 [P08923-1]
NP_996824.1, NM_206941.1 [P08923-3]
NP_996825.2, NM_206942.2 [P08923-4]
UniGeneiMm.1740

3D structure databases

ProteinModelPortaliP08923
SMRiP08923
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028759

PTM databases

iPTMnetiP08923
PhosphoSitePlusiP08923

Proteomic databases

MaxQBiP08923
PaxDbiP08923
PRIDEiP08923

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028759; ENSMUSP00000028759; ENSMUSG00000027297 [P08923-1]
ENSMUST00000082130; ENSMUSP00000080774; ENSMUSG00000027297 [P08923-4]
ENSMUST00000182203; ENSMUSP00000138201; ENSMUSG00000027297 [P08923-2]
GeneIDi17005
KEGGimmu:17005
UCSCiuc008lug.1 mouse [P08923-3]
uc008lui.1 mouse [P08923-1]
uc008luj.1 mouse [P08923-4]

Organism-specific databases

CTDi4058
MGIiMGI:96840 Ltk

Phylogenomic databases

eggNOGiKOG1095 Eukaryota
ENOG410XPVX LUCA
GeneTreeiENSGT00760000118818
HOGENOMiHOG000231766
HOVERGENiHBG052371
InParanoidiP08923
KOiK05118
OrthoDBiEOG091G003T
TreeFamiTF351636

Enzyme and pathway databases

BRENDAi2.7.10.1 3474

Miscellaneous databases

PROiPR:P08923
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027297 Expressed in 107 organ(s), highest expression level in prefrontal cortex
CleanExiMM_LTK
ExpressionAtlasiP08923 baseline and differential
GenevisibleiP08923 MM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00219 TyrKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTK_MOUSE
AccessioniPrimary (citable) accession number: P08923
Secondary accession number(s): A2AQ22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again