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Protein

T-cell surface antigen CD2

Gene

Cd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface antigen CD2
Alternative name(s):
LFA-2
LFA-3 receptor
Lymphocyte antigen 37
Short name:
Ly-37
T-cell surface antigen T11/Leu-5
CD_antigen: CD2
Gene namesi
Name:Cd2
Synonyms:Ly-37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88320 Cd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 203ExtracellularSequence analysisAdd BLAST181
Transmembranei204 – 229HelicalSequence analysisAdd BLAST26
Topological domaini230 – 344CytoplasmicSequence analysisAdd BLAST115

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000001460223 – 344T-cell surface antigen CD2Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 197By similarity
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 180By similarity
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP08920
PaxDbiP08920
PRIDEiP08920

PTM databases

PhosphoSitePlusiP08920

Expressioni

Tissue specificityi

Detected in thymus and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000027863 Expressed in 68 organ(s), highest expression level in blood
CleanExiMM_CD2
ExpressionAtlasiP08920 baseline and differential
GenevisibleiP08920 MM

Interactioni

Subunit structurei

Interacts with CD48 (By similarity). Interacts with CD58 (LFA-3) (By similarity). Interacts with CD2AP (PubMed:9741631). Interacts with PSTPIP1 (PubMed:12530983).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP08920, 1 interactor
MINTiP08920
STRINGi10090.ENSMUSP00000029456

Structurei

3D structure databases

ProteinModelPortaliP08920
SMRiP08920
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 121Ig-like V-typeAdd BLAST99
Domaini122 – 202Ig-like C2-typeAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 68CD58 binding region 1By similarityAdd BLAST13
Regioni100 – 114CD58 binding region 2By similarityAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 343Pro-richAdd BLAST68

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW98 Eukaryota
ENOG410Y7BE LUCA
GeneTreeiENSGT00390000009232
HOGENOMiHOG000276890
HOVERGENiHBG000262
InParanoidiP08920
KOiK06449
OMAiFEEKDAY
OrthoDBiEOG091G0M7A
PhylomeDBiP08920
TreeFamiTF335971

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015632 CD2
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR008424 Ig_C2-set
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF05790 C2-set, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01870 CD2ANTIGEN
SUPFAMiSSF48726 SSF48726, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08920-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKCKFLGSFF LLFSLSGKGA DCRDNETIWG VLGHGITLNI PNFQMTDDID
60 70 80 90 100
EVRWVRRGTL VAEFKRKKPP FLISETYEVL ANGSLKIKKP MMRNDSGTYN
110 120 130 140 150
VMVYGTNGMT RLEKDLDVRI LERVSKPMIH WECPNTTLTC AVLQGTDFEL
160 170 180 190 200
KLYQGETLLN SLPQKNMSYQ WTNLNAPFKC EAINPVSKES KMEVVNCPEK
210 220 230 240 250
GLSFYVTVGV GAGGLLLVLL VALFIFCICK RRKRNRRRKD EELEIKASRT
260 270 280 290 300
STVERGPKPH STPAAAAQNS VALQAPPPPG HHLQTPGHRP LPPGHRTREH
310 320 330 340
QQKKRPPPSG TQIHQQKGPP LPRPRVQPKP PCGSGDGVSL PPPN
Length:344
Mass (Da):38,415
Last modified:November 1, 1988 - v1
Checksum:iCFD12FCBD1444450
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99Y → T (PubMed:2894031).Curated1
Sequence conflicti128M → V (PubMed:2894031).Curated1
Sequence conflicti128M → V (PubMed:3257775).Curated1
Sequence conflicti139T → I in AAA37397 (PubMed:3257775).Curated1
Sequence conflicti175N → A (PubMed:2894031).Curated1
Sequence conflicti175N → S in AAA37393 (PubMed:3257775).Curated1
Sequence conflicti175N → S in AAA37397 (PubMed:3257775).Curated1
Sequence conflicti191K → N in CAA29500 (PubMed:2820751).Curated1
Sequence conflicti192M → T (PubMed:2894031).Curated1
Sequence conflicti192M → T (PubMed:3257775).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00023 mRNA Translation: CAA68258.1
X06143 mRNA Translation: CAA29500.1
M19807
, M19799, M19801, M19803, M19805 Genomic DNA Translation: AAA37393.1
M18934 mRNA Translation: AAA37397.1
BC053731 mRNA Translation: AAH53731.1
CCDSiCCDS17681.1
PIRiI49585
RefSeqiNP_038514.1, NM_013486.2
UniGeneiMm.22842

Genome annotation databases

EnsembliENSMUST00000029456; ENSMUSP00000029456; ENSMUSG00000027863
GeneIDi12481
KEGGimmu:12481
UCSCiuc008qrf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00023 mRNA Translation: CAA68258.1
X06143 mRNA Translation: CAA29500.1
M19807
, M19799, M19801, M19803, M19805 Genomic DNA Translation: AAA37393.1
M18934 mRNA Translation: AAA37397.1
BC053731 mRNA Translation: AAH53731.1
CCDSiCCDS17681.1
PIRiI49585
RefSeqiNP_038514.1, NM_013486.2
UniGeneiMm.22842

3D structure databases

ProteinModelPortaliP08920
SMRiP08920
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08920, 1 interactor
MINTiP08920
STRINGi10090.ENSMUSP00000029456

PTM databases

PhosphoSitePlusiP08920

Proteomic databases

EPDiP08920
PaxDbiP08920
PRIDEiP08920

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029456; ENSMUSP00000029456; ENSMUSG00000027863
GeneIDi12481
KEGGimmu:12481
UCSCiuc008qrf.1 mouse

Organism-specific databases

CTDi914
MGIiMGI:88320 Cd2

Phylogenomic databases

eggNOGiENOG410IW98 Eukaryota
ENOG410Y7BE LUCA
GeneTreeiENSGT00390000009232
HOGENOMiHOG000276890
HOVERGENiHBG000262
InParanoidiP08920
KOiK06449
OMAiFEEKDAY
OrthoDBiEOG091G0M7A
PhylomeDBiP08920
TreeFamiTF335971

Miscellaneous databases

ChiTaRSiCcnd2 mouse
PROiPR:P08920
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027863 Expressed in 68 organ(s), highest expression level in blood
CleanExiMM_CD2
ExpressionAtlasiP08920 baseline and differential
GenevisibleiP08920 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015632 CD2
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR008424 Ig_C2-set
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF05790 C2-set, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01870 CD2ANTIGEN
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCD2_MOUSE
AccessioniPrimary (citable) accession number: P08920
Secondary accession number(s): Q61394
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: November 7, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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