The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P08913 (ADA2A_HUMAN)
Protein
Alpha-2A adrenergic receptor
Gene
ADRA2A
Organism
Homo sapiens (Human)
Status
Functioni
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
1 PublicationCaution
It is uncertain whether Met-1 or Met-16 is the initiator.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 128 | Implicated in ligand binding | 1 | |
Sitei | 215 | Implicated in catechol agonist binding and receptor activation | 1 | |
Sitei | 219 | Implicated in catechol agonist binding and receptor activation | 1 |
GO - Molecular functioni
- alpha-1B adrenergic receptor binding Source: BHF-UCL
- alpha2-adrenergic receptor activity Source: BHF-UCL
- alpha-2C adrenergic receptor binding Source: BHF-UCL
- epinephrine binding Source: BHF-UCL
- G protein-coupled receptor activity Source: GO_Central
- heterotrimeric G-protein binding Source: BHF-UCL
- norepinephrine binding Source: BHF-UCL
- protein heterodimerization activity Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- protein kinase binding Source: BHF-UCL
- thioesterase binding Source: BHF-UCL
GO - Biological processi
- actin cytoskeleton organization Source: ProtInc
- activation of protein kinase activity Source: BHF-UCL
- activation of protein kinase B activity Source: BHF-UCL
- acute inflammatory response Source: Ensembl
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: BHF-UCL
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
- adenylate cyclase-inhibiting adrenergic receptor signaling pathway Source: BHF-UCL
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: BHF-UCL
- adrenergic receptor signaling pathway Source: BHF-UCL
- cellular response to hormone stimulus Source: BHF-UCL
- DNA replication Source: Ensembl
- fear response Source: Ensembl
- female pregnancy Source: Ensembl
- glucose homeostasis Source: BHF-UCL
- G protein-coupled receptor signaling pathway Source: BHF-UCL
- intestinal absorption Source: BHF-UCL
- negative regulation of calcium ion-dependent exocytosis Source: BHF-UCL
- negative regulation of calcium ion transmembrane transporter activity Source: BHF-UCL
- negative regulation of calcium ion transport Source: BHF-UCL
- negative regulation of epinephrine secretion Source: BHF-UCL
- negative regulation of insulin secretion Source: BHF-UCL
- negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: BHF-UCL
- negative regulation of lipid catabolic process Source: BHF-UCL
- negative regulation of norepinephrine secretion Source: BHF-UCL
- negative regulation of uterine smooth muscle contraction Source: Ensembl
- phospholipase C-activating adrenergic receptor signaling pathway Source: BHF-UCL
- platelet activation Source: InterPro
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of cytokine production Source: BHF-UCL
- positive regulation of epidermal growth factor-activated receptor activity Source: BHF-UCL
- positive regulation of MAPK cascade Source: BHF-UCL
- positive regulation of MAP kinase activity Source: BHF-UCL
- positive regulation of membrane protein ectodomain proteolysis Source: BHF-UCL
- positive regulation of potassium ion transport Source: BHF-UCL
- positive regulation of wound healing Source: BHF-UCL
- Ras protein signal transduction Source: ProtInc
- receptor transactivation Source: BHF-UCL
- regulation of synaptic vesicle exocytosis Source: Ensembl
- regulation of vasoconstriction Source: InterPro
- Rho protein signal transduction Source: ProtInc
- thermoception Source: Ensembl
- vasodilation Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P08913 |
Reactomei | R-HSA-390696, Adrenoceptors R-HSA-392023, Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-5683826, Surfactant metabolism |
SignaLinki | P08913 |
SIGNORi | P08913 |
Protein family/group databases
TCDBi | 9.A.14.3.16, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-2A adrenergic receptorCuratedAlternative name(s): Alpha-2 adrenergic receptor subtype C10 Alpha-2A adrenoreceptor Short name: Alpha-2A adrenoceptor Short name: Alpha-2AAR |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:281, ADRA2A |
MIMi | 104210, gene |
neXtProti | NX_P08913 |
VEuPathDBi | HostDB:ENSG00000150594 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- basolateral plasma membrane Source: BHF-UCL
- integral component of plasma membrane Source: BHF-UCL
- integral component of postsynaptic density membrane Source: Ensembl
- integral component of presynaptic active zone membrane Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- axon terminus Source: Ensembl
- cytoplasm Source: BHF-UCL
- dopaminergic synapse Source: Ensembl
- GABA-ergic synapse Source: Ensembl
- glutamatergic synapse Source: Ensembl
- neuronal cell body Source: Ensembl
- receptor complex Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 48 | ExtracellularBy similarityAdd BLAST | 48 | |
Transmembranei | 49 – 74 | Helical; Name=1By similarityAdd BLAST | 26 | |
Topological domaini | 75 – 85 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 86 – 111 | Helical; Name=2By similarityAdd BLAST | 26 | |
Topological domaini | 112 – 121 | ExtracellularBy similarity | 10 | |
Transmembranei | 122 – 144 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 145 – 166 | CytoplasmicBy similarityAdd BLAST | 22 | |
Transmembranei | 167 – 187 | Helical; Name=4By similarityAdd BLAST | 21 | |
Topological domaini | 188 – 209 | ExtracellularBy similarityAdd BLAST | 22 | |
Transmembranei | 210 – 232 | Helical; Name=5By similarityAdd BLAST | 23 | |
Topological domaini | 233 – 389 | CytoplasmicBy similarityAdd BLAST | 157 | |
Transmembranei | 390 – 410 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 411 – 424 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 425 – 444 | Helical; Name=7By similarityAdd BLAST | 20 | |
Topological domaini | 445 – 465 | CytoplasmicBy similarityAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 94 | D → N: No change in binding affinity. eliminates guanine nucleotide-sensitive agonist binding. 1 Publication | 1 | |
Mutagenesisi | 128 | D → N: No binding to yohimbine. Increase in adenylate cyclase activity. 1 Publication | 1 | |
Mutagenesisi | 145 | D → N: Lower affinity for agonists. Eliminates guanine nucleotide-sensitive agonist binding. 1 Publication | 1 | |
Mutagenesisi | 215 | S → A: Lower affinity for agonists. No change in guanine nucleotide-sensitive agonist binding. 1 Publication | 1 | |
Mutagenesisi | 219 | S → A: Lower affinity for agonists. Reduced guanine nucleotide-sensitive agonist binding. 1 Publication | 1 | |
Mutagenesisi | 427 | F → N: 350-fold reduced affinity for alpha-2 antagonist yohimbine, 3000-fold increase for beta-antagonist alprenolol. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 150 |
OpenTargetsi | ENSG00000150594 |
PharmGKBi | PA35 |
Miscellaneous databases
Pharosi | P08913, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1867 |
DrugBanki | DB01472, 4-Methoxyamphetamine DB00321, Amitriptyline DB00543, Amoxapine DB00182, Amphetamine DB00714, Apomorphine DB00964, Apraclonidine DB09229, Aranidipine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB00865, Benzphetamine DB00217, Bethanidine DB00484, Brimonidine DB01200, Bromocriptine DB00248, Cabergoline DB01136, Carvedilol DB04846, Celiprolol DB00477, Chlorpromazine DB09202, Cirazoline DB00575, Clonidine DB00363, Clozapine DB01151, Desipramine DB00633, Dexmedetomidine DB01576, Dextroamphetamine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB00320, Dihydroergotamine DB00449, Dipivefrin DB11278, DL-Methylephedrine DB09167, Dosulepin DB04855, Dronedarone DB06262, Droxidopa DB01363, Ephedra sinica root DB05492, Epicept NP-1 DB00751, Epinastine DB00668, Epinephrine DB01049, Ergoloid mesylate DB00696, Ergotamine DB01175, Escitalopram DB06678, Esmirtazapine DB09194, Etoperidone DB00800, Fenoldopam DB06623, Flupirtine DB00629, Guanabenz DB01018, Guanfacine DB00502, Haloperidol DB11577, Indigotindisulfonic acid DB00555, Lamotrigine DB06707, Levonordefrin DB00589, Lisuride DB04948, Lofexidine DB09195, Lorpiprazole DB00408, Loxapine DB08815, Lurasidone DB00934, Maprotiline DB01365, Mephentermine DB01577, Metamfetamine DB01403, Methotrimeprazine DB00968, Methyldopa DB06148, Mianserin DB00370, Mirtazapine DB09205, Moxisylyte DB09242, Moxonidine DB06711, Naphazoline DB01149, Nefazodone DB00368, Norepinephrine DB00540, Nortriptyline DB06229, Ocaperidone DB00935, Oxymetazoline DB01267, Paliperidone DB00715, Paroxetine DB01186, Pergolide DB01608, Periciazine DB00925, Phenoxybenzamine DB00692, Phentolamine DB00397, Phenylpropanolamine DB09286, Pipamperone DB09244, Pirlindole DB06153, Pizotifen DB00413, Pramipexole DB00457, Prazosin DB00433, Prochlorperazine DB01069, Promethazine DB00852, Pseudoephedrine DB01224, Quetiapine DB11124, Racepinephrine DB11738, Rilmenidine DB00268, Ropinirole DB09304, Setiptiline DB06764, Tetryzoline DB13025, Tiapride DB00697, Tizanidine DB00797, Tolazoline DB00193, Tramadol DB00656, Trazodone DB00726, Trimipramine DB11477, Xylazine DB06694, Xylometazoline DB01392, Yohimbine DB00246, Ziprasidone DB01624, Zuclopenthixol |
DrugCentrali | P08913 |
GuidetoPHARMACOLOGYi | 25 |
Genetic variation databases
BioMutai | ADRA2A |
DMDMi | 1351829 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069080 | 1 – 465 | Alpha-2A adrenergic receptorAdd BLAST | 465 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 121 ↔ 203 | PROSITE-ProRule annotation | ||
Modified residuei | 346 | PhosphoserineBy similarity | 1 | |
Modified residuei | 368 | Omega-N-methylarginineBy similarity | 1 | |
Lipidationi | 457 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, PhosphoproteinProteomic databases
jPOSTi | P08913 |
MassIVEi | P08913 |
PaxDbi | P08913 |
PeptideAtlasi | P08913 |
PRIDEi | P08913 |
ProteomicsDBi | 52176 |
PTM databases
GlyGeni | P08913, 2 sites |
iPTMneti | P08913 |
PhosphoSitePlusi | P08913 |
Expressioni
Gene expression databases
Bgeei | ENSG00000150594, Expressed in adipose tissue of abdominal region and 193 other tissues |
Genevisiblei | P08913, HS |
Organism-specific databases
HPAi | ENSG00000150594, Tissue enhanced (adipose tissue, cervix) |
Interactioni
GO - Molecular functioni
- alpha-1B adrenergic receptor binding Source: BHF-UCL
- alpha-2C adrenergic receptor binding Source: BHF-UCL
- protein heterodimerization activity Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- protein kinase binding Source: BHF-UCL
- thioesterase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 106659, 9 interactors |
CORUMi | P08913 |
DIPi | DIP-61452N |
IntActi | P08913, 7 interactors |
STRINGi | 9606.ENSP00000280155 |
Chemistry databases
BindingDBi | P08913 |
Miscellaneous databases
RNActi | P08913, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P08913 |
BMRBi | P08913 |
SMRi | P08913 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08913 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 242 – 368 | DisorderedSequence analysisAdd BLAST | 127 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 303 – 334 | Basic and acidic residuesSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161451 |
HOGENOMi | CLU_009579_11_1_1 |
InParanoidi | P08913 |
OMAi | KILCRVD |
OrthoDBi | 737211at2759 |
PhylomeDBi | P08913 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR001946, ADRA2A_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00558, ADRENRGCA2AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P08913-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFRQEQPLAE GSFAPMGSLQ PDAGNASWNG TEAPGGGARA TPYSLQVTLT
60 70 80 90 100
LVCLAGLLML LTVFGNVLVI IAVFTSRALK APQNLFLVSL ASADILVATL
110 120 130 140 150
VIPFSLANEV MGYWYFGKAW CEIYLALDVL FCTSSIVHLC AISLDRYWSI
160 170 180 190 200
TQAIEYNLKR TPRRIKAIII TVWVISAVIS FPPLISIEKK GGGGGPQPAE
210 220 230 240 250
PRCEINDQKW YVISSCIGSF FAPCLIMILV YVRIYQIAKR RTRVPPSRRG
260 270 280 290 300
PDAVAAPPGG TERRPNGLGP ERSAGPGGAE AEPLPTQLNG APGEPAPAGP
310 320 330 340 350
RDTDALDLEE SSSSDHAERP PGPRRPERGP RGKGKARASQ VKPGDSLPRR
360 370 380 390 400
GPGATGIGTP AAGPGEERVG AAKASRWRGR QNREKRFTFV LAVVIGVFVV
410 420 430 440 450
CWFPFFFTYT LTAVGCSVPR TLFKFFFWFG YCNSSLNPVI YTIFNHDFRR
460
AFKKILCRGD RKRIV
Sequence cautioni
The sequence AAA51664 differs from that shown. Reason: Frameshift.Curated
The sequence AAA51664 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA51665 differs from that shown. Reason: Frameshift.Curated
The sequence AAA51665 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAG00447 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH35047 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH50414 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAK26743 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAK51162 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAZ73101 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence ABB72683 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence ABY87535 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 119 | A → T in AAA51664 (PubMed:2823383).Curated | 1 | |
Sequence conflicti | 139 | L → P (PubMed:1849485).Curated | 1 | |
Sequence conflicti | 172 | V → C in AAA51664 (PubMed:2823383).Curated | 1 | |
Sequence conflicti | 383 | R → L in AAA51664 (PubMed:2823383).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014957 | 266 | N → K Frequency in Caucasians 0.004 and in African-Americans 0.05; 40% increase in agonist-promoted Gi coupling. 2 PublicationsCorresponds to variant dbSNP:rs1800035Ensembl. | 1 | |
Natural variantiVAR_055908 | 416 | C → S. Corresponds to variant dbSNP:rs35658213Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23533 Genomic DNA Translation: AAA51665.1 Sequence problems. DQ149926 Genomic DNA Translation: AAZ73101.1 Different initiation. AF284095 mRNA Translation: AAK26743.1 Different initiation. AF262016 Genomic DNA Translation: AAG00447.2 Different initiation. AY032736 Genomic DNA Translation: AAK51162.1 Different initiation. DQ285607 Genomic DNA Translation: ABB72683.1 Different initiation. EU332846 Genomic DNA Translation: ABY87535.1 Different initiation. AL158163 Genomic DNA No translation available. BC035047 mRNA Translation: AAH35047.1 Different initiation. BC050414 mRNA Translation: AAH50414.4 Different initiation. M18415 Genomic DNA Translation: AAA51664.1 Sequence problems. AF281308 Genomic DNA Translation: AAF91441.1 AF316894 Genomic DNA Translation: AAK01634.1 |
CCDSi | CCDS7569.2 |
PIRi | A34169 |
RefSeqi | NP_000672.3, NM_000681.3 |
Genome annotation databases
Ensembli | ENST00000280155.4; ENSP00000280155.2; ENSG00000150594.7 |
GeneIDi | 150 |
KEGGi | hsa:150 |
MANE-Selecti | ENST00000280155.4; ENSP00000280155.2; NM_000681.4; NP_000672.3 |
UCSCi | uc001kzo.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23533 Genomic DNA Translation: AAA51665.1 Sequence problems. DQ149926 Genomic DNA Translation: AAZ73101.1 Different initiation. AF284095 mRNA Translation: AAK26743.1 Different initiation. AF262016 Genomic DNA Translation: AAG00447.2 Different initiation. AY032736 Genomic DNA Translation: AAK51162.1 Different initiation. DQ285607 Genomic DNA Translation: ABB72683.1 Different initiation. EU332846 Genomic DNA Translation: ABY87535.1 Different initiation. AL158163 Genomic DNA No translation available. BC035047 mRNA Translation: AAH35047.1 Different initiation. BC050414 mRNA Translation: AAH50414.4 Different initiation. M18415 Genomic DNA Translation: AAA51664.1 Sequence problems. AF281308 Genomic DNA Translation: AAF91441.1 AF316894 Genomic DNA Translation: AAK01634.1 |
CCDSi | CCDS7569.2 |
PIRi | A34169 |
RefSeqi | NP_000672.3, NM_000681.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HLL | NMR | - | A | 133-164 | [»] | |
1HO9 | NMR | - | A | 133-164 | [»] | |
1HOD | NMR | - | A | 133-164 | [»] | |
1HOF | NMR | - | A | 133-164 | [»] | |
6K42 | electron microscopy | 4.10 | R | 37-44 | [»] | |
6KUX | X-ray | 2.70 | A | 35-460 | [»] | |
6KUY | X-ray | 3.20 | A | 35-460 | [»] | |
AlphaFoldDBi | P08913 | |||||
BMRBi | P08913 | |||||
SMRi | P08913 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106659, 9 interactors |
CORUMi | P08913 |
DIPi | DIP-61452N |
IntActi | P08913, 7 interactors |
STRINGi | 9606.ENSP00000280155 |
Chemistry databases
BindingDBi | P08913 |
ChEMBLi | CHEMBL1867 |
DrugBanki | DB01472, 4-Methoxyamphetamine DB00321, Amitriptyline DB00543, Amoxapine DB00182, Amphetamine DB00714, Apomorphine DB00964, Apraclonidine DB09229, Aranidipine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB00865, Benzphetamine DB00217, Bethanidine DB00484, Brimonidine DB01200, Bromocriptine DB00248, Cabergoline DB01136, Carvedilol DB04846, Celiprolol DB00477, Chlorpromazine DB09202, Cirazoline DB00575, Clonidine DB00363, Clozapine DB01151, Desipramine DB00633, Dexmedetomidine DB01576, Dextroamphetamine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB00320, Dihydroergotamine DB00449, Dipivefrin DB11278, DL-Methylephedrine DB09167, Dosulepin DB04855, Dronedarone DB06262, Droxidopa DB01363, Ephedra sinica root DB05492, Epicept NP-1 DB00751, Epinastine DB00668, Epinephrine DB01049, Ergoloid mesylate DB00696, Ergotamine DB01175, Escitalopram DB06678, Esmirtazapine DB09194, Etoperidone DB00800, Fenoldopam DB06623, Flupirtine DB00629, Guanabenz DB01018, Guanfacine DB00502, Haloperidol DB11577, Indigotindisulfonic acid DB00555, Lamotrigine DB06707, Levonordefrin DB00589, Lisuride DB04948, Lofexidine DB09195, Lorpiprazole DB00408, Loxapine DB08815, Lurasidone DB00934, Maprotiline DB01365, Mephentermine DB01577, Metamfetamine DB01403, Methotrimeprazine DB00968, Methyldopa DB06148, Mianserin DB00370, Mirtazapine DB09205, Moxisylyte DB09242, Moxonidine DB06711, Naphazoline DB01149, Nefazodone DB00368, Norepinephrine DB00540, Nortriptyline DB06229, Ocaperidone DB00935, Oxymetazoline DB01267, Paliperidone DB00715, Paroxetine DB01186, Pergolide DB01608, Periciazine DB00925, Phenoxybenzamine DB00692, Phentolamine DB00397, Phenylpropanolamine DB09286, Pipamperone DB09244, Pirlindole DB06153, Pizotifen DB00413, Pramipexole DB00457, Prazosin DB00433, Prochlorperazine DB01069, Promethazine DB00852, Pseudoephedrine DB01224, Quetiapine DB11124, Racepinephrine DB11738, Rilmenidine DB00268, Ropinirole DB09304, Setiptiline DB06764, Tetryzoline DB13025, Tiapride DB00697, Tizanidine DB00797, Tolazoline DB00193, Tramadol DB00656, Trazodone DB00726, Trimipramine DB11477, Xylazine DB06694, Xylometazoline DB01392, Yohimbine DB00246, Ziprasidone DB01624, Zuclopenthixol |
DrugCentrali | P08913 |
GuidetoPHARMACOLOGYi | 25 |
Protein family/group databases
TCDBi | 9.A.14.3.16, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P08913, 2 sites |
iPTMneti | P08913 |
PhosphoSitePlusi | P08913 |
Genetic variation databases
BioMutai | ADRA2A |
DMDMi | 1351829 |
Proteomic databases
jPOSTi | P08913 |
MassIVEi | P08913 |
PaxDbi | P08913 |
PeptideAtlasi | P08913 |
PRIDEi | P08913 |
ProteomicsDBi | 52176 |
Protocols and materials databases
Antibodypediai | 31769, 344 antibodies from 37 providers |
DNASUi | 150 |
Genome annotation databases
Ensembli | ENST00000280155.4; ENSP00000280155.2; ENSG00000150594.7 |
GeneIDi | 150 |
KEGGi | hsa:150 |
MANE-Selecti | ENST00000280155.4; ENSP00000280155.2; NM_000681.4; NP_000672.3 |
UCSCi | uc001kzo.4, human |
Organism-specific databases
CTDi | 150 |
DisGeNETi | 150 |
GeneCardsi | ADRA2A |
HGNCi | HGNC:281, ADRA2A |
HPAi | ENSG00000150594, Tissue enhanced (adipose tissue, cervix) |
MIMi | 104210, gene |
neXtProti | NX_P08913 |
OpenTargetsi | ENSG00000150594 |
PharmGKBi | PA35 |
VEuPathDBi | HostDB:ENSG00000150594 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161451 |
HOGENOMi | CLU_009579_11_1_1 |
InParanoidi | P08913 |
OMAi | KILCRVD |
OrthoDBi | 737211at2759 |
PhylomeDBi | P08913 |
TreeFami | TF316350 |
Enzyme and pathway databases
PathwayCommonsi | P08913 |
Reactomei | R-HSA-390696, Adrenoceptors R-HSA-392023, Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-5683826, Surfactant metabolism |
SignaLinki | P08913 |
SIGNORi | P08913 |
Miscellaneous databases
BioGRID-ORCSi | 150, 9 hits in 1068 CRISPR screens |
ChiTaRSi | ADRA2A, human |
EvolutionaryTracei | P08913 |
GeneWikii | Alpha-2A_adrenergic_receptor |
GenomeRNAii | 150 |
Pharosi | P08913, Tclin |
PROi | PR:P08913 |
RNActi | P08913, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000150594, Expressed in adipose tissue of abdominal region and 193 other tissues |
Genevisiblei | P08913, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR001946, ADRA2A_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00558, ADRENRGCA2AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADA2A_HUMAN | |
Accessioni | P08913Primary (citable) accession number: P08913 Secondary accession number(s): B0LPF6 Q9BZK1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | December 11, 2019 | |
Last modified: | May 25, 2022 | |
This is version 224 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families