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UniProtKB - P08913 (ADA2A_HUMAN)

Entry version 207 (13 Feb 2019)
Sequence version 3 (01 Feb 1996)
Previous versions | rss
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Protein

Alpha-2A adrenergic receptor

Gene

ADRA2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei113Implicated in ligand binding1
Sitei200Implicated in catechol agonist binding and receptor activation1
Sitei204Implicated in catechol agonist binding and receptor activation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390696 Adrenoceptors
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-5683826 Surfactant metabolism

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P08913

SIGNOR Signaling Network Open Resource

More...SIGNORi		P08913

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-2A adrenergic receptor
Alternative name(s):
Alpha-2 adrenergic receptor subtype C10
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADRA2A
Synonyms:ADRA2R, ADRAR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000150594.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:281 ADRA2A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		104210 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08913

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 59Helical; Name=1By similarityAdd BLAST26
Topological domaini60 – 70CytoplasmicBy similarityAdd BLAST11
Transmembranei71 – 96Helical; Name=2By similarityAdd BLAST26
Topological domaini97 – 106ExtracellularBy similarity10
Transmembranei107 – 129Helical; Name=3By similarityAdd BLAST23
Topological domaini130 – 151CytoplasmicBy similarityAdd BLAST22
Transmembranei152 – 172Helical; Name=4By similarityAdd BLAST21
Topological domaini173 – 194ExtracellularBy similarityAdd BLAST22
Transmembranei195 – 217Helical; Name=5By similarityAdd BLAST23
Topological domaini218 – 374CytoplasmicBy similarityAdd BLAST157
Transmembranei375 – 395Helical; Name=6By similarityAdd BLAST21
Topological domaini396 – 409ExtracellularBy similarityAdd BLAST14
Transmembranei410 – 429Helical; Name=7By similarityAdd BLAST20
Topological domaini430 – 450CytoplasmicBy similarityAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi79D → N: No change in binding affinity. eliminates guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi113D → N: No binding to yohimbine. Increase in adenylate cyclase activity. 1 Publication1
Mutagenesisi130D → N: Lower affinity for agonists. Eliminates guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi200S → A: Lower affinity for agonists. No change in guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi204S → A: Lower affinity for agonists. Reduced guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi412F → N: 350-fold reduced affinity for alpha-2 antagonist yohimbine, 3000-fold increase for beta-antagonist alprenolol. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		150

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1867

Drug and drug target database

More...DrugBanki		DB01472 4-Methoxyamphetamine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00182 Amphetamine
DB00714 Apomorphine
DB00964 Apraclonidine
DB01238 Aripiprazole
DB06216 Asenapine
DB00865 Benzphetamine
DB00217 Bethanidine
DB00484 Brimonidine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01136 Carvedilol
DB00477 Chlorpromazine
DB09202 Cirazoline
DB00575 Clonidine
DB00363 Clozapine
DB01151 Desipramine
DB00633 Dexmedetomidine
DB00320 Dihydroergotamine
DB00449 Dipivefrin
DB01142 Doxepin
DB04855 Dronedarone
DB06262 Droxidopa
DB01363 Ephedra
DB05492 Epicept NP-1
DB00751 Epinastine
DB00668 Epinephrine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB06678 Esmirtazapine
DB00800 Fenoldopam
DB06623 Flupirtine
DB00629 Guanabenz
DB01018 Guanfacine
DB06707 Levonordefrin
DB00589 Lisuride
DB04948 Lofexidine
DB00408 Loxapine
DB08815 Lurasidone
DB00934 Maprotiline
DB01365 Mephentermine
DB01577 Methamphetamine
DB01403 Methotrimeprazine
DB00968 Methyldopa
DB06148 Mianserin
DB00370 Mirtazapine
DB06711 Naphazoline
DB01149 Nefazodone
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00935 Oxymetazoline
DB01267 Paliperidone
DB01186 Pergolide
DB00925 Phenoxybenzamine
DB00692 Phentolamine
DB00397 Phenylpropanolamine
DB00413 Pramipexole
DB00457 Prazosin
DB01608 Propericiazine
DB00852 Pseudoephedrine
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB13025 Tiapride
DB00697 Tizanidine
DB00797 Tolazoline
DB00656 Trazodone
DB00726 Trimipramine
DB06694 Xylometazoline
DB01392 Yohimbine
DB00246 Ziprasidone
DB01624 Zuclopenthixol

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		25

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADRA2A

Domain mapping of disease mutations (DMDM)

More...DMDMi		1351829

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000690801 – 450Alpha-2A adrenergic receptorAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi106 ↔ 188PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei331PhosphoserineBy similarity1
Modified residuei353Omega-N-methylarginineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi442S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P08913

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08913

PeptideAtlas

More...PeptideAtlasi		P08913

PRoteomics IDEntifications database

More...PRIDEi		P08913

ProteomicsDB human proteome resource

More...ProteomicsDBi		52176

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08913

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08913

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000150594 Expressed in 177 organ(s), highest expression level in adipose tissue of abdominal region

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08913 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		106659, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P08913

Database of interacting proteins

More...DIPi		DIP-61452N

Protein interaction database and analysis system

More...IntActi		P08913, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000280155

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P08913

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1450
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLLNMR-A118-149[»]
1HO9NMR-A118-149[»]
1HODNMR-A118-149[»]
1HOFNMR-A118-149[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P08913

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08913

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P08913

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656 Eukaryota
ENOG410XRW9 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000239242

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG106962

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08913

KEGG Orthology (KO)

More...KOi		K04138

Database of Orthologous Groups

More...OrthoDBi		737211at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08913

TreeFam database of animal gene trees

More...TreeFami		TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002233 ADR_fam
IPR001946 ADRA2A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01103 ADRENERGICR
PR00558 ADRENRGCA2AR
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P08913-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSLQPDAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLLTVFG 
        60         70         80         90        100
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY 
       110        120        130        140        150
FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI 
       160        170        180        190        200
KAIIITVWVI SAVISFPPLI SIEKKGGGGG PQPAEPRCEI NDQKWYVISS 
       210        220        230        240        250
CIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDAVA APPGGTERRP 
       260        270        280        290        300
NGLGPERSAG PGGAEAEPLP TQLNGAPGEP APAGPRDTDA LDLEESSSSD 
       310        320        330        340        350
HAERPPGPRR PERGPRGKGK ARASQVKPGD SLPRRGPGAT GIGTPAAGPG 
       360        370        380        390        400
EERVGAAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLTAVG 
       410        420        430        440        450
CSVPRTLFKF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV
Length:450
Mass (Da):48,957
Last modified:February 1, 1996 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA703CF262F04E8AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104A → T in AAA51664 (PubMed:2823383).Curated1
Sequence conflicti124L → P (PubMed:1849485).Curated1
Sequence conflicti157V → C in AAA51664 (PubMed:2823383).Curated1
Sequence conflicti333 – 365PRRGP…RWRGR → RGAGRGRRGSGRRLQGRGRS ASGLPRRRAGAGG in AAA51664 (PubMed:2823383).CuratedAdd BLAST33
Sequence conflicti333 – 365PRRGP…RWRGR → RGAGRGRRGSGRRLQGRGRS ASGLPRRRAGAGG in AAA51665 (PubMed:2568356).CuratedAdd BLAST33
Sequence conflicti368R → L in AAA51664 (PubMed:2823383).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014957251N → K Rare polymorphism; frequency in Caucasians 0.004 and in African-Americans 0.05; 40% increase in agonist-promoted Gi coupling. 3 PublicationsCorresponds to variant dbSNP:rs1800035Ensembl.1
Natural variantiVAR_055908401C → S. Corresponds to variant dbSNP:rs35658213Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M18415 Genomic DNA Translation: AAA51664.1
M23533 Genomic DNA Translation: AAA51665.1
AF281308 Genomic DNA Translation: AAF91441.1
AF316894 Genomic DNA Translation: AAK01634.1
DQ149926 Genomic DNA Translation: AAZ73101.1
AF284095 mRNA Translation: AAK26743.1
AF262016 Genomic DNA Translation: AAG00447.2
AY032736 Genomic DNA Translation: AAK51162.1
DQ285607 Genomic DNA Translation: ABB72683.1
EU332846 Genomic DNA Translation: ABY87535.1
AL158163 Genomic DNA No translation available.
BC035047 mRNA Translation: AAH35047.1
BC050414 mRNA Translation: AAH50414.4

Protein sequence database of the Protein Information Resource

More...PIRi		A34169

NCBI Reference Sequences

More...RefSeqi		NP_000672.3, NM_000681.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.249159

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000280155; ENSP00000280155; ENSG00000150594

Database of genes from NCBI RefSeq genomes

More...GeneIDi		150

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:150

UCSC genome browser

More...UCSCi		uc001kzo.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18415 Genomic DNA Translation: AAA51664.1
M23533 Genomic DNA Translation: AAA51665.1
AF281308 Genomic DNA Translation: AAF91441.1
AF316894 Genomic DNA Translation: AAK01634.1
DQ149926 Genomic DNA Translation: AAZ73101.1
AF284095 mRNA Translation: AAK26743.1
AF262016 Genomic DNA Translation: AAG00447.2
AY032736 Genomic DNA Translation: AAK51162.1
DQ285607 Genomic DNA Translation: ABB72683.1
EU332846 Genomic DNA Translation: ABY87535.1
AL158163 Genomic DNA No translation available.
BC035047 mRNA Translation: AAH35047.1
BC050414 mRNA Translation: AAH50414.4
PIRiA34169
RefSeqiNP_000672.3, NM_000681.3
UniGeneiHs.249159

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLLNMR-A118-149[»]
1HO9NMR-A118-149[»]
1HODNMR-A118-149[»]
1HOFNMR-A118-149[»]
ProteinModelPortaliP08913
SMRiP08913
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106659, 9 interactors
CORUMiP08913
DIPiDIP-61452N
IntActiP08913, 6 interactors
STRINGi9606.ENSP00000280155

Chemistry databases

BindingDBiP08913
ChEMBLiCHEMBL1867
DrugBankiDB01472 4-Methoxyamphetamine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00182 Amphetamine
DB00714 Apomorphine
DB00964 Apraclonidine
DB01238 Aripiprazole
DB06216 Asenapine
DB00865 Benzphetamine
DB00217 Bethanidine
DB00484 Brimonidine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01136 Carvedilol
DB00477 Chlorpromazine
DB09202 Cirazoline
DB00575 Clonidine
DB00363 Clozapine
DB01151 Desipramine
DB00633 Dexmedetomidine
DB00320 Dihydroergotamine
DB00449 Dipivefrin
DB01142 Doxepin
DB04855 Dronedarone
DB06262 Droxidopa
DB01363 Ephedra
DB05492 Epicept NP-1
DB00751 Epinastine
DB00668 Epinephrine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB06678 Esmirtazapine
DB00800 Fenoldopam
DB06623 Flupirtine
DB00629 Guanabenz
DB01018 Guanfacine
DB06707 Levonordefrin
DB00589 Lisuride
DB04948 Lofexidine
DB00408 Loxapine
DB08815 Lurasidone
DB00934 Maprotiline
DB01365 Mephentermine
DB01577 Methamphetamine
DB01403 Methotrimeprazine
DB00968 Methyldopa
DB06148 Mianserin
DB00370 Mirtazapine
DB06711 Naphazoline
DB01149 Nefazodone
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00935 Oxymetazoline
DB01267 Paliperidone
DB01186 Pergolide
DB00925 Phenoxybenzamine
DB00692 Phentolamine
DB00397 Phenylpropanolamine
DB00413 Pramipexole
DB00457 Prazosin
DB01608 Propericiazine
DB00852 Pseudoephedrine
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB13025 Tiapride
DB00697 Tizanidine
DB00797 Tolazoline
DB00656 Trazodone
DB00726 Trimipramine
DB06694 Xylometazoline
DB01392 Yohimbine
DB00246 Ziprasidone
DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYi25

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiP08913
PhosphoSitePlusiP08913

Polymorphism and mutation databases

BioMutaiADRA2A
DMDMi1351829

Proteomic databases

jPOSTiP08913
PaxDbiP08913
PeptideAtlasiP08913
PRIDEiP08913
ProteomicsDBi52176

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		150
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280155; ENSP00000280155; ENSG00000150594
GeneIDi150
KEGGihsa:150
UCSCiuc001kzo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		150
DisGeNETi150
EuPathDBiHostDB:ENSG00000150594.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADRA2A

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0190540
HGNCiHGNC:281 ADRA2A
MIMi104210 gene
neXtProtiNX_P08913
PharmGKBiPA35

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP08913
KOiK04138
OrthoDBi737211at2759
PhylomeDBiP08913
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-5683826 Surfactant metabolism
SignaLinkiP08913
SIGNORiP08913

Miscellaneous databases

EvolutionaryTraceiP08913

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Alpha-2A_adrenergic_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		150

Protein Ontology

More...PROi		PR:P08913

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000150594 Expressed in 177 organ(s), highest expression level in adipose tissue of abdominal region
GenevisibleiP08913 HS

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001946 ADRA2A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00558 ADRENRGCA2AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADA2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08913
Secondary accession number(s): B0LPF6
, Q2I8G2, Q2XN99, Q86TH8, Q9BZK1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1996
Last modified: February 13, 2019
This is version 207 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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