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Entry version 214 (22 Apr 2020)
Sequence version 4 (11 Dec 2019)
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Protein

Alpha-2A adrenergic receptor

Gene

ADRA2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.1 Publication

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei128Implicated in ligand binding1
Sitei215Implicated in catechol agonist binding and receptor activation1
Sitei219Implicated in catechol agonist binding and receptor activation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390696 Adrenoceptors
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-5683826 Surfactant metabolism

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P08913

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P08913

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-2A adrenergic receptorCurated
Alternative name(s):
Alpha-2 adrenergic receptor subtype C10
Alpha-2A adrenoreceptor
Short name:
Alpha-2A adrenoceptor
Short name:
Alpha-2AAR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADRA2AImported
Synonyms:ADRA2R, ADRAR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:281 ADRA2A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
104210 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08913

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 48ExtracellularBy similarityAdd BLAST48
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 74Helical; Name=1By similarityAdd BLAST26
Topological domaini75 – 85CytoplasmicBy similarityAdd BLAST11
Transmembranei86 – 111Helical; Name=2By similarityAdd BLAST26
Topological domaini112 – 121ExtracellularBy similarity10
Transmembranei122 – 144Helical; Name=3By similarityAdd BLAST23
Topological domaini145 – 166CytoplasmicBy similarityAdd BLAST22
Transmembranei167 – 187Helical; Name=4By similarityAdd BLAST21
Topological domaini188 – 209ExtracellularBy similarityAdd BLAST22
Transmembranei210 – 232Helical; Name=5By similarityAdd BLAST23
Topological domaini233 – 389CytoplasmicBy similarityAdd BLAST157
Transmembranei390 – 410Helical; Name=6By similarityAdd BLAST21
Topological domaini411 – 424ExtracellularBy similarityAdd BLAST14
Transmembranei425 – 444Helical; Name=7By similarityAdd BLAST20
Topological domaini445 – 465CytoplasmicBy similarityAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi94D → N: No change in binding affinity. eliminates guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi128D → N: No binding to yohimbine. Increase in adenylate cyclase activity. 1 Publication1
Mutagenesisi145D → N: Lower affinity for agonists. Eliminates guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi215S → A: Lower affinity for agonists. No change in guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi219S → A: Lower affinity for agonists. Reduced guanine nucleotide-sensitive agonist binding. 1 Publication1
Mutagenesisi427F → N: 350-fold reduced affinity for alpha-2 antagonist yohimbine, 3000-fold increase for beta-antagonist alprenolol. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
150

Open Targets

More...
OpenTargetsi
ENSG00000150594

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P08913 Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1867

Drug and drug target database

More...
DrugBanki
DB01472 4-Methoxyamphetamine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00182 Amphetamine
DB00714 Apomorphine
DB00964 Apraclonidine
DB09229 Aranidipine
DB01238 Aripiprazole
DB14185 Aripiprazole lauroxil
DB06216 Asenapine
DB00865 Benzphetamine
DB00217 Bethanidine
DB00484 Brimonidine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01136 Carvedilol
DB04846 Celiprolol
DB00477 Chlorpromazine
DB09202 Cirazoline
DB00575 Clonidine
DB00363 Clozapine
DB01151 Desipramine
DB00633 Dexmedetomidine
DB11273 Dihydroergocornine
DB13345 Dihydroergocristine
DB00320 Dihydroergotamine
DB00449 Dipivefrin
DB11278 DL-Methylephedrine
DB09167 Dosulepin
DB04855 Dronedarone
DB06262 Droxidopa
DB01363 Ephedra sinica root
DB05492 Epicept NP-1
DB00751 Epinastine
DB00668 Epinephrine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB01175 Escitalopram
DB06678 Esmirtazapine
DB09194 Etoperidone
DB00800 Fenoldopam
DB06623 Flupirtine
DB00629 Guanabenz
DB01018 Guanfacine
DB00502 Haloperidol
DB11577 Indigotindisulfonic acid
DB00555 Lamotrigine
DB06707 Levonordefrin
DB00589 Lisuride
DB04948 Lofexidine
DB09195 Lorpiprazole
DB00408 Loxapine
DB08815 Lurasidone
DB00934 Maprotiline
DB01365 Mephentermine
DB01577 Metamfetamine
DB01403 Methotrimeprazine
DB00968 Methyldopa
DB06148 Mianserin
DB00370 Mirtazapine
DB09205 Moxisylyte
DB09242 Moxonidine
DB06711 Naphazoline
DB01149 Nefazodone
DB00368 Norepinephrine
DB00540 Nortriptyline
DB06229 Ocaperidone
DB00935 Oxymetazoline
DB01267 Paliperidone
DB00715 Paroxetine
DB01186 Pergolide
DB01608 Periciazine
DB00925 Phenoxybenzamine
DB00692 Phentolamine
DB00397 Phenylpropanolamine
DB09286 Pipamperone
DB09244 Pirlindole
DB06153 Pizotifen
DB00413 Pramipexole
DB00457 Prazosin
DB00433 Prochlorperazine
DB00852 Pseudoephedrine
DB01224 Quetiapine
DB11124 Racepinephrine
DB11738 Rilmenidine
DB00734 Risperidone
DB00268 Ropinirole
DB09304 Setiptiline
DB13025 Tiapride
DB00697 Tizanidine
DB00797 Tolazoline
DB00193 Tramadol
DB00656 Trazodone
DB00726 Trimipramine
DB11477 Xylazine
DB06694 Xylometazoline
DB01392 Yohimbine
DB00246 Ziprasidone
DB01624 Zuclopenthixol

DrugCentral

More...
DrugCentrali
P08913

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
25

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADRA2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1351829

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000690801 – 465Alpha-2A adrenergic receptorAdd BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi121 ↔ 203PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei346PhosphoserineBy similarity1
Modified residuei368Omega-N-methylarginineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi457S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P08913

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P08913

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08913

PeptideAtlas

More...
PeptideAtlasi
P08913

PRoteomics IDEntifications database

More...
PRIDEi
P08913

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52176

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08913

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08913

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150594 Expressed in adipose tissue of abdominal region and 176 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08913 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000150594 Tissue enhanced (gallbladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106659, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P08913

Database of interacting proteins

More...
DIPi
DIP-61452N

Protein interaction database and analysis system

More...
IntActi
P08913, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000280155

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P08913

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P08913 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1465
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P08913

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161451

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009579_11_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08913

KEGG Orthology (KO)

More...
KOi
K04138

Database of Orthologous Groups

More...
OrthoDBi
737211at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08913

TreeFam database of animal gene trees

More...
TreeFami
TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002233 ADR_fam
IPR001946 ADRA2A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01103 ADRENERGICR
PR00558 ADRENRGCA2AR
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P08913-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRQEQPLAE GSFAPMGSLQ PDAGNASWNG TEAPGGGARA TPYSLQVTLT
60 70 80 90 100
LVCLAGLLML LTVFGNVLVI IAVFTSRALK APQNLFLVSL ASADILVATL
110 120 130 140 150
VIPFSLANEV MGYWYFGKAW CEIYLALDVL FCTSSIVHLC AISLDRYWSI
160 170 180 190 200
TQAIEYNLKR TPRRIKAIII TVWVISAVIS FPPLISIEKK GGGGGPQPAE
210 220 230 240 250
PRCEINDQKW YVISSCIGSF FAPCLIMILV YVRIYQIAKR RTRVPPSRRG
260 270 280 290 300
PDAVAAPPGG TERRPNGLGP ERSAGPGGAE AEPLPTQLNG APGEPAPAGP
310 320 330 340 350
RDTDALDLEE SSSSDHAERP PGPRRPERGP RGKGKARASQ VKPGDSLPRR
360 370 380 390 400
GPGATGIGTP AAGPGEERVG AAKASRWRGR QNREKRFTFV LAVVIGVFVV
410 420 430 440 450
CWFPFFFTYT LTAVGCSVPR TLFKFFFWFG YCNSSLNPVI YTIFNHDFRR
460
AFKKILCRGD RKRIV
Length:465
Mass (Da):50,647
Last modified:December 11, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i585E576149BDB696
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA51664 differs from that shown. Reason: Frameshift.Curated
The sequence AAA51664 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA51665 differs from that shown. Reason: Frameshift.Curated
The sequence AAA51665 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAG00447 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH35047 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH50414 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAK26743 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAK51162 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAZ73101 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence ABB72683 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence ABY87535 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119A → T in AAA51664 (PubMed:2823383).Curated1
Sequence conflicti139L → P (PubMed:1849485).Curated1
Sequence conflicti172V → C in AAA51664 (PubMed:2823383).Curated1
Sequence conflicti383R → L in AAA51664 (PubMed:2823383).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014957266N → K Rare polymorphism; frequency in Caucasians 0.004 and in African-Americans 0.05; 40% increase in agonist-promoted Gi coupling. 2 PublicationsCorresponds to variant dbSNP:rs1800035Ensembl.1
Natural variantiVAR_055908416C → S. Corresponds to variant dbSNP:rs35658213Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M23533 Genomic DNA Translation: AAA51665.1 Sequence problems.
DQ149926 Genomic DNA Translation: AAZ73101.1 Different initiation.
AF284095 mRNA Translation: AAK26743.1 Different initiation.
AF262016 Genomic DNA Translation: AAG00447.2 Different initiation.
AY032736 Genomic DNA Translation: AAK51162.1 Different initiation.
DQ285607 Genomic DNA Translation: ABB72683.1 Different initiation.
EU332846 Genomic DNA Translation: ABY87535.1 Different initiation.
AL158163 Genomic DNA No translation available.
BC035047 mRNA Translation: AAH35047.1 Different initiation.
BC050414 mRNA Translation: AAH50414.4 Different initiation.
M18415 Genomic DNA Translation: AAA51664.1 Sequence problems.
AF281308 Genomic DNA Translation: AAF91441.1
AF316894 Genomic DNA Translation: AAK01634.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7569.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A34169

NCBI Reference Sequences

More...
RefSeqi
NP_000672.3, NM_000681.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000280155; ENSP00000280155; ENSG00000150594

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
150

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:150

UCSC genome browser

More...
UCSCi
uc001kzo.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23533 Genomic DNA Translation: AAA51665.1 Sequence problems.
DQ149926 Genomic DNA Translation: AAZ73101.1 Different initiation.
AF284095 mRNA Translation: AAK26743.1 Different initiation.
AF262016 Genomic DNA Translation: AAG00447.2 Different initiation.
AY032736 Genomic DNA Translation: AAK51162.1 Different initiation.
DQ285607 Genomic DNA Translation: ABB72683.1 Different initiation.
EU332846 Genomic DNA Translation: ABY87535.1 Different initiation.
AL158163 Genomic DNA No translation available.
BC035047 mRNA Translation: AAH35047.1 Different initiation.
BC050414 mRNA Translation: AAH50414.4 Different initiation.
M18415 Genomic DNA Translation: AAA51664.1 Sequence problems.
AF281308 Genomic DNA Translation: AAF91441.1
AF316894 Genomic DNA Translation: AAK01634.1
CCDSiCCDS7569.2
PIRiA34169
RefSeqiNP_000672.3, NM_000681.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLLNMR-A133-164[»]
1HO9NMR-A133-164[»]
1HODNMR-A133-164[»]
1HOFNMR-A133-164[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi106659, 9 interactors
CORUMiP08913
DIPiDIP-61452N
IntActiP08913, 7 interactors
STRINGi9606.ENSP00000280155

Chemistry databases

BindingDBiP08913
ChEMBLiCHEMBL1867
DrugBankiDB01472 4-Methoxyamphetamine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00182 Amphetamine
DB00714 Apomorphine
DB00964 Apraclonidine
DB09229 Aranidipine
DB01238 Aripiprazole
DB14185 Aripiprazole lauroxil
DB06216 Asenapine
DB00865 Benzphetamine
DB00217 Bethanidine
DB00484 Brimonidine
DB01200 Bromocriptine
DB00248 Cabergoline
DB01136 Carvedilol
DB04846 Celiprolol
DB00477 Chlorpromazine
DB09202 Cirazoline
DB00575 Clonidine
DB00363 Clozapine
DB01151 Desipramine
DB00633 Dexmedetomidine
DB11273 Dihydroergocornine
DB13345 Dihydroergocristine
DB00320 Dihydroergotamine
DB00449 Dipivefrin
DB11278 DL-Methylephedrine
DB09167 Dosulepin
DB04855 Dronedarone
DB06262 Droxidopa
DB01363 Ephedra sinica root
DB05492 Epicept NP-1
DB00751 Epinastine
DB00668 Epinephrine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB01175 Escitalopram
DB06678 Esmirtazapine
DB09194 Etoperidone
DB00800 Fenoldopam
DB06623 Flupirtine
DB00629 Guanabenz
DB01018 Guanfacine
DB00502 Haloperidol
DB11577 Indigotindisulfonic acid
DB00555 Lamotrigine
DB06707 Levonordefrin
DB00589 Lisuride
DB04948 Lofexidine
DB09195 Lorpiprazole
DB00408 Loxapine
DB08815 Lurasidone
DB00934 Maprotiline
DB01365 Mephentermine
DB01577 Metamfetamine
DB01403 Methotrimeprazine
DB00968 Methyldopa
DB06148 Mianserin
DB00370 Mirtazapine
DB09205 Moxisylyte
DB09242 Moxonidine
DB06711 Naphazoline
DB01149 Nefazodone
DB00368 Norepinephrine
DB00540 Nortriptyline
DB06229 Ocaperidone
DB00935 Oxymetazoline
DB01267 Paliperidone
DB00715 Paroxetine
DB01186 Pergolide
DB01608 Periciazine
DB00925 Phenoxybenzamine
DB00692 Phentolamine
DB00397 Phenylpropanolamine
DB09286 Pipamperone
DB09244 Pirlindole
DB06153 Pizotifen
DB00413 Pramipexole
DB00457 Prazosin
DB00433 Prochlorperazine
DB00852 Pseudoephedrine
DB01224 Quetiapine
DB11124 Racepinephrine
DB11738 Rilmenidine
DB00734 Risperidone
DB00268 Ropinirole
DB09304 Setiptiline
DB13025 Tiapride
DB00697 Tizanidine
DB00797 Tolazoline
DB00193 Tramadol
DB00656 Trazodone
DB00726 Trimipramine
DB11477 Xylazine
DB06694 Xylometazoline
DB01392 Yohimbine
DB00246 Ziprasidone
DB01624 Zuclopenthixol
DrugCentraliP08913
GuidetoPHARMACOLOGYi25

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP08913
PhosphoSitePlusiP08913

Polymorphism and mutation databases

BioMutaiADRA2A
DMDMi1351829

Proteomic databases

jPOSTiP08913
MassIVEiP08913
PaxDbiP08913
PeptideAtlasiP08913
PRIDEiP08913
ProteomicsDBi52176

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31769 319 antibodies

The DNASU plasmid repository

More...
DNASUi
150

Genome annotation databases

EnsembliENST00000280155; ENSP00000280155; ENSG00000150594
GeneIDi150
KEGGihsa:150
UCSCiuc001kzo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
150
DisGeNETi150

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADRA2A
HGNCiHGNC:281 ADRA2A
HPAiENSG00000150594 Tissue enhanced (gallbladder)
MIMi104210 gene
neXtProtiNX_P08913
OpenTargetsiENSG00000150594
PharmGKBiPA35

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000161451
HOGENOMiCLU_009579_11_1_1
InParanoidiP08913
KOiK04138
OrthoDBi737211at2759
PhylomeDBiP08913
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-5683826 Surfactant metabolism
SignaLinkiP08913
SIGNORiP08913

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADRA2A human
EvolutionaryTraceiP08913

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Alpha-2A_adrenergic_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
150
PharosiP08913 Tclin

Protein Ontology

More...
PROi
PR:P08913
RNActiP08913 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000150594 Expressed in adipose tissue of abdominal region and 176 other tissues
GenevisibleiP08913 HS

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001946 ADRA2A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00558 ADRENRGCA2AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADA2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08913
Secondary accession number(s): B0LPF6
, Q2I8G2, Q2XN99, Q86TH8, Q9BZK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: December 11, 2019
Last modified: April 22, 2020
This is version 214 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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