Alpha-2A adrenergic receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• adrenergic receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• alpha-1B adrenergic receptor binding Source: BHF-UCL
• alpha2-adrenergic receptor activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.12

    "An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling."
    Small K.M., Forbes S.L., Brown K.M., Liggett S.B.
    J. Biol. Chem. 275:38518-38523(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 16-465, VARIANT LYS-266.
• alpha-2C adrenergic receptor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment."
    Small K.M., Schwarb M.R., Glinka C., Theiss C.T., Brown K.M., Seman C.A., Liggett S.B.
    Biochemistry 45:4760-4767(2006) [PubMed] [Europe PMC] [Abstract]
• epinephrine binding Source: BHF-UCLInferred from direct assayⁱ
  • Ref.12

    "An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling."
    Small K.M., Forbes S.L., Brown K.M., Liggett S.B.
    J. Biol. Chem. 275:38518-38523(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 16-465, VARIANT LYS-266.
  • Ref.11

    "Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor."
    Kobilka B.K., Matsui H., Kobilka T.S., Yang-Feng T.L., Francke U., Caron M.G., Lefkowitz R.J., Regan J.W.
    Science 238:650-656(1987) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-465, PARTIAL PROTEIN SEQUENCE.
• heterotrimeric G-protein binding Source: BHF-UCLInferred from direct assayⁱ
  • Ref.12

    "An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling."
    Small K.M., Forbes S.L., Brown K.M., Liggett S.B.
    J. Biol. Chem. 275:38518-38523(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 16-465, VARIANT LYS-266.
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment."
    Small K.M., Schwarb M.R., Glinka C., Theiss C.T., Brown K.M., Seman C.A., Liggett S.B.
    Biochemistry 45:4760-4767(2006) [PubMed] [Europe PMC] [Abstract]
• norepinephrine binding Source: BHF-UCLInferred from direct assayⁱ
  • Ref.11

    "Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor."
    Kobilka B.K., Matsui H., Kobilka T.S., Yang-Feng T.L., Francke U., Caron M.G., Lefkowitz R.J., Regan J.W.
    Science 238:650-656(1987) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-465, PARTIAL PROTEIN SEQUENCE.
• protein heterodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment."
    Small K.M., Schwarb M.R., Glinka C., Theiss C.T., Brown K.M., Seman C.A., Liggett S.B.
    Biochemistry 45:4760-4767(2006) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from direct assayⁱ
  • "Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment."
    Small K.M., Schwarb M.R., Glinka C., Theiss C.T., Brown K.M., Seman C.A., Liggett S.B.
    Biochemistry 45:4760-4767(2006) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2."
    Pao C.S., Benovic J.L.
    J. Biol. Chem. 280:11052-11058(2005) [PubMed] [Europe PMC] [Abstract]
• thioesterase binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation."
    Weber B., Schaper C., Wang Y., Scholz J., Bein B.
    Cell. Signal. 21:1513-1521(2009) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• actin cytoskeleton organization Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes."
    Betuing S., Daviaud D., Pages C., Bonnard E., Valet P., Lafontan M., Saulnier-Blache J.S.
    J. Biol. Chem. 273:15804-15810(1998) [PubMed] [Europe PMC] [Abstract]
• activation of protein kinase activity Source: BHF-UCLInferred from direct assayⁱ
  • "Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2."
    Pao C.S., Benovic J.L.
    J. Biol. Chem. 280:11052-11058(2005) [PubMed] [Europe PMC] [Abstract]
• activation of protein kinase B activity Source: BHF-UCLInferred from direct assayⁱ
  • "Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells."
    Karkoulias G., Flordellis C.
    Cell. Signal. 19:945-957(2007) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-activating adrenergic receptor signaling pathway Source: BHF-UCL
• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Heterodimerization of alpha 2A- and beta 1-adrenergic receptors."
    Xu J., He J., Castleberry A.M., Balasubramanian S., Lau A.G., Hall R.A.
    J. Biol. Chem. 278:10770-10777(2003) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-inhibiting adrenergic receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • Ref.12

    "An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling."
    Small K.M., Forbes S.L., Brown K.M., Liggett S.B.
    J. Biol. Chem. 275:38518-38523(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 16-465, VARIANT LYS-266.
• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents."
    Surprenant A., Horstman D.A., Akbarali H., Limbird L.E.
    Science 257:977-980(1992) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• adrenergic receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • Ref.12

    "An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling."
    Small K.M., Forbes S.L., Brown K.M., Liggett S.B.
    J. Biol. Chem. 275:38518-38523(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 16-465, VARIANT LYS-266.
• cell-cell signaling Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to hormone stimulus Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity."
    Valet P., Grujic D., Wade J., Ito M., Zingaretti M.C., Soloveva V., Ross S.R., Graves R.A., Cinti S., Lafontan M., Lowell B.B.
    J. Biol. Chem. 275:34797-34802(2000) [PubMed] [Europe PMC] [Abstract]
• glucose homeostasis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis."
    Devedjian J.C., Pujol A., Cayla C., George M., Casellas A., Paris H., Bosch F.
    Diabetologia 43:899-906(2000) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells."
    Karkoulias G., Flordellis C.
    Cell. Signal. 19:945-957(2007) [PubMed] [Europe PMC] [Abstract]
  • "EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing."
    Buffin-Meyer B., Crassous P.A., Delage C., Denis C., Schaak S., Paris H.
    Eur. J. Pharmacol. 574:85-93(2007) [PubMed] [Europe PMC] [Abstract]
• intestinal absorption Source: BHF-UCLTraceable author statementⁱ
  • "EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing."
    Buffin-Meyer B., Crassous P.A., Delage C., Denis C., Schaak S., Paris H.
    Eur. J. Pharmacol. 574:85-93(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of calcium ion-dependent exocytosis Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis."
    Devedjian J.C., Pujol A., Cayla C., George M., Casellas A., Paris H., Bosch F.
    Diabetologia 43:899-906(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of calcium ion transmembrane transporter activity Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents."
    Surprenant A., Horstman D.A., Akbarali H., Limbird L.E.
    Science 257:977-980(1992) [PubMed] [Europe PMC] [Abstract]
• negative regulation of calcium ion transport Source: BHF-UCL
• negative regulation of epinephrine secretion Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase."
    Weber B., Schaper C., Scholz J., Bein B., Rodde C., H Tonner P.
    Cell. Signal. 18:1748-1757(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of insulin secretion Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis."
    Devedjian J.C., Pujol A., Cayla C., George M., Casellas A., Paris H., Bosch F.
    Diabetologia 43:899-906(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes."
    Rosengren A.H., Jokubka R., Tojjar D., Granhall C., Hansson O., Li D.Q., Nagaraj V., Reinbothe T.M., Tuncel J., Eliasson L., Groop L., Rorsman P., Salehi A., Lyssenko V., Luthman H., Renstrom E.
    Science 327:217-220(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of lipid catabolic process Source: BHF-UCLInferred from genetic interactionⁱ
  • "Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity."
    Valet P., Grujic D., Wade J., Ito M., Zingaretti M.C., Soloveva V., Ross S.R., Graves R.A., Cinti S., Lafontan M., Lowell B.B.
    J. Biol. Chem. 275:34797-34802(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of norepinephrine secretion Source: BHF-UCLTraceable author statementⁱ
  • "Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation."
    Weber B., Schaper C., Wang Y., Scholz J., Bein B.
    Cell. Signal. 21:1513-1521(2009) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating adrenergic receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • Ref.12

    "An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling."
    Small K.M., Forbes S.L., Brown K.M., Liggett S.B.
    J. Biol. Chem. 275:38518-38523(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 16-465, VARIANT LYS-266.
• platelet activation Source: InterPro
• positive regulation of cell migration Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing."
    Buffin-Meyer B., Crassous P.A., Delage C., Denis C., Schaak S., Paris H.
    Eur. J. Pharmacol. 574:85-93(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: ProtIncTraceable author statementⁱ
  • "Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells."
    Schaak S., Cussac D., Cayla C., Devedjian J.C., Guyot R., Paris H., Denis C.
    Gut 47:242-250(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytokine production Source: BHF-UCLInferred from direct assayⁱ
  • "EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing."
    Buffin-Meyer B., Crassous P.A., Delage C., Denis C., Schaak S., Paris H.
    Eur. J. Pharmacol. 574:85-93(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epidermal growth factor-activated receptor activity Source: BHF-UCLInferred from direct assayⁱ
  • "EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing."
    Buffin-Meyer B., Crassous P.A., Delage C., Denis C., Schaak S., Paris H.
    Eur. J. Pharmacol. 574:85-93(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of MAPK cascade Source: BHF-UCLInferred from direct assayⁱ
  • Ref.12

    "An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling."
    Small K.M., Forbes S.L., Brown K.M., Liggett S.B.
    J. Biol. Chem. 275:38518-38523(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 16-465, VARIANT LYS-266.
• positive regulation of MAP kinase activity Source: BHF-UCLInferred from direct assayⁱ
  • "Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation."
    Weber B., Schaper C., Wang Y., Scholz J., Bein B.
    Cell. Signal. 21:1513-1521(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of membrane protein ectodomain proteolysis Source: BHF-UCLInferred from direct assayⁱ
  • "EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing."
    Buffin-Meyer B., Crassous P.A., Delage C., Denis C., Schaak S., Paris H.
    Eur. J. Pharmacol. 574:85-93(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of potassium ion transport Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents."
    Surprenant A., Horstman D.A., Akbarali H., Limbird L.E.
    Science 257:977-980(1992) [PubMed] [Europe PMC] [Abstract]
• positive regulation of wound healing Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing."
    Buffin-Meyer B., Crassous P.A., Delage C., Denis C., Schaak S., Paris H.
    Eur. J. Pharmacol. 574:85-93(2007) [PubMed] [Europe PMC] [Abstract]
• Ras protein signal transduction Source: ProtIncTraceable author statementⁱ
  • "Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts."
    Alblas J., van Corven E.J., Hordijk P.L., Milligan G., Moolenaar W.H.
    J. Biol. Chem. 268:22235-22238(1993) [PubMed] [Europe PMC] [Abstract]
• receptor transactivation Source: BHF-UCLInferred from direct assayⁱ
  • "Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells."
    Karkoulias G., Flordellis C.
    Cell. Signal. 19:945-957(2007) [PubMed] [Europe PMC] [Abstract]
  • "EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing."
    Buffin-Meyer B., Crassous P.A., Delage C., Denis C., Schaak S., Paris H.
    Eur. J. Pharmacol. 574:85-93(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of insulin secretion Source: Reactome
• regulation of smooth muscle contraction Source: InterPro
• regulation of vasoconstriction Source: InterPro
• Rho protein signal transduction Source: ProtIncTraceable author statementⁱ
  • "Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes."
    Betuing S., Daviaud D., Pages C., Bonnard E., Valet P., Lafontan M., Saulnier-Blache J.S.
    J. Biol. Chem. 273:15804-15810(1998) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• alpha-1B adrenergic receptor binding Source: BHF-UCL
• alpha-2C adrenergic receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment."
    Small K.M., Schwarb M.R., Glinka C., Theiss C.T., Brown K.M., Seman C.A., Liggett S.B.
    Biochemistry 45:4760-4767(2006) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment."
    Small K.M., Schwarb M.R., Glinka C., Theiss C.T., Brown K.M., Seman C.A., Liggett S.B.
    Biochemistry 45:4760-4767(2006) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment."
    Small K.M., Schwarb M.R., Glinka C., Theiss C.T., Brown K.M., Seman C.A., Liggett S.B.
    Biochemistry 45:4760-4767(2006) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from direct assayⁱ
  • "Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment."
    Small K.M., Schwarb M.R., Glinka C., Theiss C.T., Brown K.M., Seman C.A., Liggett S.B.
    Biochemistry 45:4760-4767(2006) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2."
    Pao C.S., Benovic J.L.
    J. Biol. Chem. 280:11052-11058(2005) [PubMed] [Europe PMC] [Abstract]
• thioesterase binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation."
    Weber B., Schaper C., Wang Y., Scholz J., Bein B.
    Cell. Signal. 21:1513-1521(2009) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MFRQEQPLAE GSFAPMGSLQ PDAGNASWNG TEAPGGGARA TPYSLQVTLT 
        60         70         80         90        100
LVCLAGLLML LTVFGNVLVI IAVFTSRALK APQNLFLVSL ASADILVATL 
       110        120        130        140        150
VIPFSLANEV MGYWYFGKAW CEIYLALDVL FCTSSIVHLC AISLDRYWSI 
       160        170        180        190        200
TQAIEYNLKR TPRRIKAIII TVWVISAVIS FPPLISIEKK GGGGGPQPAE 
       210        220        230        240        250
PRCEINDQKW YVISSCIGSF FAPCLIMILV YVRIYQIAKR RTRVPPSRRG 
       260        270        280        290        300
PDAVAAPPGG TERRPNGLGP ERSAGPGGAE AEPLPTQLNG APGEPAPAGP 
       310        320        330        340        350
RDTDALDLEE SSSSDHAERP PGPRRPERGP RGKGKARASQ VKPGDSLPRR 
       360        370        380        390        400
GPGATGIGTP AAGPGEERVG AAKASRWRGR QNREKRFTFV LAVVIGVFVV 
       410        420        430        440        450
CWFPFFFTYT LTAVGCSVPR TLFKFFFWFG YCNSSLNPVI YTIFNHDFRR 
       460 
AFKKILCRGD RKRIV                                       

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. SIMILARITY comments
   Index of protein domains and families
3. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
4. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
5. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
6. Human chromosome 10
   Human chromosome 10: entries, gene names and cross-references to MIM
7. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references