ADRA2A

Functionⁱ

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	113	Implicated in ligand binding	1
Siteⁱ	200	Implicated in catechol agonist binding and receptor activation	1
Siteⁱ	204	Implicated in catechol agonist binding and receptor activation	1

GO - Molecular functionⁱ

alpha-1B adrenergic receptor binding Source: BHF-UCL
alpha2-adrenergic receptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10948191
alpha-2C adrenergic receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16605244
epinephrine binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10948191
- 2823383
heterotrimeric G-protein binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 10948191
norepinephrine binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 2823383
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16605244
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 16605244
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15653687
thioesterase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19477270

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: ProtInc
Traceable author statementⁱ
- 9624180
activation of protein kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15653687
activation of protein kinase B activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17215105
adenylate cyclase-activating adrenergic receptor signaling pathway Source: BHF-UCL
adenylate cyclase-activating G-protein coupled receptor signaling pathway
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 12529373
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10948191
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 1354394
adrenergic receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10948191
cellular response to hormone stimulus
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 10948198
glucose homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10952463
G-protein coupled receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 17215105
- 17655843
intestinal absorption
Source: BHF-UCL
Traceable author statementⁱ
- 17655843
negative regulation of calcium ion-dependent exocytosis
Source: BHF-UCL
Inferred by curatorⁱ
- 10952463
negative regulation of calcium ion transmembrane transporter activity
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 1354394
negative regulation of calcium ion transport Source: BHF-UCL
negative regulation of epinephrine secretion
Source: BHF-UCL
Non-traceable author statementⁱ
- 16531006
negative regulation of insulin secretion
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 10952463
negative regulation of insulin secretion involved in cellular response to glucose stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19965390
negative regulation of lipid catabolic process
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 10948198
negative regulation of norepinephrine secretion
Source: BHF-UCL
Traceable author statementⁱ
- 19477270
phospholipase C-activating adrenergic receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10948191
platelet activation Source: InterPro
positive regulation of cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17655843
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 10896916
positive regulation of cytokine production
Source: BHF-UCL
Inferred from direct assayⁱ
- 17655843
positive regulation of epidermal growth factor-activated receptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17655843
positive regulation of MAPK cascade
Source: BHF-UCL
Inferred from direct assayⁱ
- 10948191
positive regulation of MAP kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19477270
positive regulation of membrane protein ectodomain proteolysis
Source: BHF-UCL
Inferred from direct assayⁱ
- 17655843
positive regulation of potassium ion transport
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 1354394
positive regulation of wound healing
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17655843
Ras protein signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8226727
receptor transactivation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17215105
- 17655843
regulation of insulin secretion Source: Reactome
regulation of smooth muscle contraction Source: InterPro
regulation of vasoconstriction Source: InterPro
Rho protein signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9624180

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390696 Adrenoceptors R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion R-HSA-418594 G alpha (i) signalling events R-HSA-418597 G alpha (z) signalling events R-HSA-5683826 Surfactant metabolism
SignaLinkⁱ	P08913
SIGNORⁱ	P08913

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-2A adrenergic receptor Alternative name(s): Alpha-2 adrenergic receptor subtype C10 Alpha-2A adrenoreceptor Short name: Alpha-2A adrenoceptor Short name: Alpha-2AAR
Gene namesⁱ	Name:ADRA2A Synonyms:ADRA2R, ADRAR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000150594.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:281 ADRA2A
MIMⁱ	104210 gene
neXtProtⁱ	NX_P08913

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 33	ExtracellularBy similarityAdd BLAST	33
Transmembraneⁱ	34 – 59	Helical; Name=1By similarityAdd BLAST	26
Topological domainⁱ	60 – 70	CytoplasmicBy similarityAdd BLAST	11
Transmembraneⁱ	71 – 96	Helical; Name=2By similarityAdd BLAST	26
Topological domainⁱ	97 – 106	ExtracellularBy similarity	10
Transmembraneⁱ	107 – 129	Helical; Name=3By similarityAdd BLAST	23
Topological domainⁱ	130 – 151	CytoplasmicBy similarityAdd BLAST	22
Transmembraneⁱ	152 – 172	Helical; Name=4By similarityAdd BLAST	21
Topological domainⁱ	173 – 194	ExtracellularBy similarityAdd BLAST	22
Transmembraneⁱ	195 – 217	Helical; Name=5By similarityAdd BLAST	23
Topological domainⁱ	218 – 374	CytoplasmicBy similarityAdd BLAST	157
Transmembraneⁱ	375 – 395	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	396 – 409	ExtracellularBy similarityAdd BLAST	14
Transmembraneⁱ	410 – 429	Helical; Name=7By similarityAdd BLAST	20
Topological domainⁱ	430 – 450	CytoplasmicBy similarityAdd BLAST	21

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	79	D → N: No change in binding affinity. eliminates guanine nucleotide-sensitive agonist binding. 1 Publication	1
Mutagenesisⁱ	113	D → N: No binding to yohimbine. Increase in adenylate cyclase activity. 1 Publication	1
Mutagenesisⁱ	130	D → N: Lower affinity for agonists. Eliminates guanine nucleotide-sensitive agonist binding. 1 Publication	1
Mutagenesisⁱ	200	S → A: Lower affinity for agonists. No change in guanine nucleotide-sensitive agonist binding. 1 Publication	1
Mutagenesisⁱ	204	S → A: Lower affinity for agonists. Reduced guanine nucleotide-sensitive agonist binding. 1 Publication	1
Mutagenesisⁱ	412	F → N: 350-fold reduced affinity for alpha-2 antagonist yohimbine, 3000-fold increase for beta-antagonist alprenolol. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	150
PharmGKBⁱ	PA35

Chemistry databases

ChEMBLⁱ	CHEMBL1867
Drug and drug target database More...DrugBankⁱ	DB01472 4-Methoxyamphetamine DB00321 Amitriptyline DB00543 Amoxapine DB00182 Amphetamine DB00714 Apomorphine DB00964 Apraclonidine DB01238 Aripiprazole DB06216 Asenapine DB00865 Benzphetamine DB00217 Bethanidine DB00484 Brimonidine DB01200 Bromocriptine DB00248 Cabergoline DB01136 Carvedilol DB00477 Chlorpromazine DB09202 Cirazoline DB00575 Clonidine DB00363 Clozapine DB01151 Desipramine DB00633 Dexmedetomidine DB00320 Dihydroergotamine DB00449 Dipivefrin DB01142 Doxepin DB04855 Dronedarone DB06262 Droxidopa DB01363 Ephedra DB05492 Epicept NP-1 DB00751 Epinastine DB00668 Epinephrine DB01049 Ergoloid mesylate DB00696 Ergotamine DB06678 Esmirtazapine DB00800 Fenoldopam DB06623 Flupirtine DB00629 Guanabenz DB01018 Guanfacine DB06707 Levonordefrin DB00589 Lisuride DB04948 Lofexidine DB00408 Loxapine DB08815 Lurasidone DB00934 Maprotiline DB01365 Mephentermine DB01577 Methamphetamine DB01403 Methotrimeprazine DB00968 Methyldopa DB06148 Mianserin DB00370 Mirtazapine DB06711 Naphazoline DB01149 Nefazodone DB00368 Norepinephrine DB00540 Nortriptyline DB00334 Olanzapine DB00935 Oxymetazoline DB01267 Paliperidone DB01186 Pergolide DB00925 Phenoxybenzamine DB00692 Phentolamine DB00397 Phenylpropanolamine DB00413 Pramipexole DB00457 Prazosin DB01608 Propericiazine DB00852 Pseudoephedrine DB01224 Quetiapine DB00734 Risperidone DB00268 Ropinirole DB13025 Tiapride DB00697 Tizanidine DB00797 Tolazoline DB00656 Trazodone DB00726 Trimipramine DB06694 Xylometazoline DB01392 Yohimbine DB00246 Ziprasidone DB01624 Zuclopenthixol
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	25

Polymorphism and mutation databases

BioMutaⁱ	ADRA2A
DMDMⁱ	1351829

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069080	1 – 450	Alpha-2A adrenergic receptorAdd BLAST		450

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	10	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	14	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	106 ↔ 188	PROSITE-ProRule annotation
Modified residueⁱ	331	PhosphoserineBy similarity	1
Modified residueⁱ	353	Omega-N-methylarginineBy similarity	1
Lipidationⁱ	442	S-palmitoyl cysteineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

PaxDbⁱ	P08913
PeptideAtlas More...PeptideAtlasⁱ	P08913
PRIDEⁱ	P08913
ProteomicsDBⁱ	52176

PTM databases

iPTMnetⁱ	P08913
PhosphoSitePlusⁱ	P08913

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000150594 Expressed in 177 organ(s), highest expression level in adipose tissue of abdominal region
CleanExⁱ	HS_ADRA2A
Genevisibleⁱ	P08913 HS

Interactionⁱ

GO - Molecular functionⁱ

alpha-1B adrenergic receptor binding Source: BHF-UCL
alpha-2C adrenergic receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16605244
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16605244
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 16605244
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15653687
thioesterase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19477270

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106659, 8 interactors
CORUMⁱ	P08913
Database of interacting proteins More...DIPⁱ	DIP-61452N
IntActⁱ	P08913, 6 interactors
STRINGⁱ	9606.ENSP00000280155

Chemistry databases

BindingDBⁱ

P08913

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	119 – 128	Combined sources	10
Helixⁱ	130 – 139	Combined sources	10
Helixⁱ	140 – 142	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P08913
SMRⁱ	P08913
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P08913

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P08913
KEGG Orthology (KO) More...KOⁱ	K04138
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P08913
TreeFamⁱ	TF316350

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR001946 ADRA2A_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00558 ADRENRGCA2AR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P08913-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSLQPDAGN ASWNGTEAPG GGARATPYSL QVTLTLVCLA GLLMLLTVFG 
        60         70         80         90        100
NVLVIIAVFT SRALKAPQNL FLVSLASADI LVATLVIPFS LANEVMGYWY 
       110        120        130        140        150
FGKAWCEIYL ALDVLFCTSS IVHLCAISLD RYWSITQAIE YNLKRTPRRI 
       160        170        180        190        200
KAIIITVWVI SAVISFPPLI SIEKKGGGGG PQPAEPRCEI NDQKWYVISS 
       210        220        230        240        250
CIGSFFAPCL IMILVYVRIY QIAKRRTRVP PSRRGPDAVA APPGGTERRP 
       260        270        280        290        300
NGLGPERSAG PGGAEAEPLP TQLNGAPGEP APAGPRDTDA LDLEESSSSD 
       310        320        330        340        350
HAERPPGPRR PERGPRGKGK ARASQVKPGD SLPRRGPGAT GIGTPAAGPG 
       360        370        380        390        400
EERVGAAKAS RWRGRQNREK RFTFVLAVVI GVFVVCWFPF FFTYTLTAVG 
       410        420        430        440        450
CSVPRTLFKF FFWFGYCNSS LNPVIYTIFN HDFRRAFKKI LCRGDRKRIV

Length:450

Mass (Da):48,957

Last modified:February 1, 1996 - v3

Checksum:ⁱA703CF262F04E8AC

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	104	A → T in AAA51664 (PubMed:2823383).Curated	1
Sequence conflictⁱ	124	L → P (PubMed:1849485).Curated	1
Sequence conflictⁱ	157	V → C in AAA51664 (PubMed:2823383).Curated	1
Sequence conflictⁱ	333 – 365	PRRGP…RWRGR → RGAGRGRRGSGRRLQGRGRS ASGLPRRRAGAGG in AAA51664 (PubMed:2823383).CuratedAdd BLAST	33
Sequence conflictⁱ	333 – 365	PRRGP…RWRGR → RGAGRGRRGSGRRLQGRGRS ASGLPRRRAGAGG in AAA51665 (PubMed:2568356).CuratedAdd BLAST	33
Sequence conflictⁱ	368	R → L in AAA51664 (PubMed:2823383).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_014957	251	N → K Rare polymorphism; frequency in Caucasians 0.004 and in African-Americans 0.05; 40% increase in agonist-promoted Gi coupling. 3 PublicationsCorresponds to variant dbSNP:rs1800035Ensembl.		1
Natural variantⁱVAR_055908	401	C → S. Corresponds to variant dbSNP:rs35658213Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M18415 Genomic DNA Translation: AAA51664.1 M23533 Genomic DNA Translation: AAA51665.1 AF281308 Genomic DNA Translation: AAF91441.1 AF316894 Genomic DNA Translation: AAK01634.1 DQ149926 Genomic DNA Translation: AAZ73101.1 AF284095 mRNA Translation: AAK26743.1 AF262016 Genomic DNA Translation: AAG00447.2 AY032736 Genomic DNA Translation: AAK51162.1 DQ285607 Genomic DNA Translation: ABB72683.1 EU332846 Genomic DNA Translation: ABY87535.1 AL158163 Genomic DNA No translation available. BC035047 mRNA Translation: AAH35047.1 BC050414 mRNA Translation: AAH50414.4
PIRⁱ	A34169
NCBI Reference Sequences More...RefSeqⁱ	NP_000672.3, NM_000681.3
UniGeneⁱ	Hs.249159

Genome annotation databases

Ensemblⁱ	ENST00000280155; ENSP00000280155; ENSG00000150594
GeneIDⁱ	150
KEGGⁱ	hsa:150
UCSC genome browser More...UCSCⁱ	uc001kzo.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08913	Alpha-2A adrenergic receptor		PIG		450	UniRef90_P08913
Alpha-2A adrenergic receptor		MOUSE		450
Adrenoceptor alpha 2A		MACMU		465
alpha-2A adrenergic receptor		DELLE		465
ADRA2A isoform 1		PONAB		465
+34

Protein	Similar proteins		Species	Score	Length	Source
P08913	Alpha-2A adrenergic receptor		MOUSE		450	UniRef50_P08913
Alpha-2A adrenergic receptor		PIG		450
Alpha-2A adrenergic receptor		RAT		450
ADRA2A isoform 1		PONAB		465
alpha-2A adrenergic receptor		PHYCD		465
+74

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M18415 Genomic DNA Translation: AAA51664.1 M23533 Genomic DNA Translation: AAA51665.1 AF281308 Genomic DNA Translation: AAF91441.1 AF316894 Genomic DNA Translation: AAK01634.1 DQ149926 Genomic DNA Translation: AAZ73101.1 AF284095 mRNA Translation: AAK26743.1 AF262016 Genomic DNA Translation: AAG00447.2 AY032736 Genomic DNA Translation: AAK51162.1 DQ285607 Genomic DNA Translation: ABB72683.1 EU332846 Genomic DNA Translation: ABY87535.1 AL158163 Genomic DNA No translation available. BC035047 mRNA Translation: AAH35047.1 BC050414 mRNA Translation: AAH50414.4
PIRⁱ	A34169
RefSeqⁱ	NP_000672.3, NM_000681.3
UniGeneⁱ	Hs.249159

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HLL	NMR	-	A	118-149	[»]
	1HO9	NMR	-	A	118-149	[»]
	1HOD	NMR	-	A	118-149	[»]
	1HOF	NMR	-	A	118-149	[»]
ProteinModelPortalⁱ	P08913
SMRⁱ	P08913
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106659, 8 interactors
CORUMⁱ	P08913
DIPⁱ	DIP-61452N
IntActⁱ	P08913, 6 interactors
STRINGⁱ	9606.ENSP00000280155

Chemistry databases

BindingDBⁱ	P08913
ChEMBLⁱ	CHEMBL1867
DrugBankⁱ	DB01472 4-Methoxyamphetamine DB00321 Amitriptyline DB00543 Amoxapine DB00182 Amphetamine DB00714 Apomorphine DB00964 Apraclonidine DB01238 Aripiprazole DB06216 Asenapine DB00865 Benzphetamine DB00217 Bethanidine DB00484 Brimonidine DB01200 Bromocriptine DB00248 Cabergoline DB01136 Carvedilol DB00477 Chlorpromazine DB09202 Cirazoline DB00575 Clonidine DB00363 Clozapine DB01151 Desipramine DB00633 Dexmedetomidine DB00320 Dihydroergotamine DB00449 Dipivefrin DB01142 Doxepin DB04855 Dronedarone DB06262 Droxidopa DB01363 Ephedra DB05492 Epicept NP-1 DB00751 Epinastine DB00668 Epinephrine DB01049 Ergoloid mesylate DB00696 Ergotamine DB06678 Esmirtazapine DB00800 Fenoldopam DB06623 Flupirtine DB00629 Guanabenz DB01018 Guanfacine DB06707 Levonordefrin DB00589 Lisuride DB04948 Lofexidine DB00408 Loxapine DB08815 Lurasidone DB00934 Maprotiline DB01365 Mephentermine DB01577 Methamphetamine DB01403 Methotrimeprazine DB00968 Methyldopa DB06148 Mianserin DB00370 Mirtazapine DB06711 Naphazoline DB01149 Nefazodone DB00368 Norepinephrine DB00540 Nortriptyline DB00334 Olanzapine DB00935 Oxymetazoline DB01267 Paliperidone DB01186 Pergolide DB00925 Phenoxybenzamine DB00692 Phentolamine DB00397 Phenylpropanolamine DB00413 Pramipexole DB00457 Prazosin DB01608 Propericiazine DB00852 Pseudoephedrine DB01224 Quetiapine DB00734 Risperidone DB00268 Ropinirole DB13025 Tiapride DB00697 Tizanidine DB00797 Tolazoline DB00656 Trazodone DB00726 Trimipramine DB06694 Xylometazoline DB01392 Yohimbine DB00246 Ziprasidone DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYⁱ	25

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P08913
PhosphoSitePlusⁱ	P08913

Polymorphism and mutation databases

BioMutaⁱ	ADRA2A
DMDMⁱ	1351829

Proteomic databases

PaxDbⁱ	P08913
PeptideAtlasⁱ	P08913
PRIDEⁱ	P08913
ProteomicsDBⁱ	52176

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	150
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000280155; ENSP00000280155; ENSG00000150594
GeneIDⁱ	150
KEGGⁱ	hsa:150
UCSCⁱ	uc001kzo.4 human

Organism-specific databases

CTDⁱ	150
DisGeNETⁱ	150
EuPathDBⁱ	HostDB:ENSG00000150594.6
GeneCardsⁱ	ADRA2A
H-InvDBⁱ	HIX0190540
HGNCⁱ	HGNC:281 ADRA2A
MIMⁱ	104210 gene
neXtProtⁱ	NX_P08913
PharmGKBⁱ	PA35
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P08913
KOⁱ	K04138
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P08913
TreeFamⁱ	TF316350

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390696 Adrenoceptors R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion R-HSA-418594 G alpha (i) signalling events R-HSA-418597 G alpha (z) signalling events R-HSA-5683826 Surfactant metabolism
SignaLinkⁱ	P08913
SIGNORⁱ	P08913

Miscellaneous databases

EvolutionaryTraceⁱ	P08913
GeneWikiⁱ	Alpha-2A_adrenergic_receptor
GenomeRNAiⁱ	150
Protein Ontology More...PROⁱ	PR:P08913
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000150594 Expressed in 177 organ(s), highest expression level in adipose tissue of abdominal region
CleanExⁱ	HS_ADRA2A
Genevisibleⁱ	P08913 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR001946 ADRA2A_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00558 ADRENRGCA2AR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADA2A_HUMAN
Accessionⁱ	P08913Primary (citable) accession number: P08913 Secondary accession number(s): B0LPF6 , Q2I8G2, Q2XN99, Q86TH8, Q9BZK1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
	Last sequence update:	February 1, 1996
	Last modified:	September 12, 2018
	This is version 203 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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UniProtKB - P08913 (ADA2A_HUMAN)

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Alpha-2A adrenergic receptor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

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Plasma Membrane

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Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

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Gene expression databases

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GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

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Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

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Experimental Info

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Sequence databases

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Keywords - Coding sequence diversityi

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Sequence databases

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Protein-protein interaction databases

Chemistry databases

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PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

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Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ