Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - P08912 (ACM5_HUMAN)

Entry version 201 (25 May 2022)
Sequence version 2 (01 Jun 1994)
Previous versions | rss
Add a publicationFeedback
Protein

Muscarinic acetylcholine receptor M5

Gene

CHRM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08912

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390648, Muscarinic acetylcholine receptors
R-HSA-416476, G alpha (q) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P08912

SIGNOR Signaling Network Open Resource

More...SIGNORi		P08912

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHRM5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1954, CHRM5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		118496, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08912

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000184984

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 53Helical; Name=1By similarityAdd BLAST24
Topological domaini54 – 66CytoplasmicBy similarityAdd BLAST13
Transmembranei67 – 87Helical; Name=2By similarityAdd BLAST21
Topological domaini88 – 104ExtracellularBy similarityAdd BLAST17
Transmembranei105 – 126Helical; Name=3By similarityAdd BLAST22
Topological domaini127 – 146CytoplasmicBy similarityAdd BLAST20
Transmembranei147 – 169Helical; Name=4By similarityAdd BLAST23
Topological domaini170 – 191ExtracellularBy similarityAdd BLAST22
Transmembranei192 – 214Helical; Name=5By similarityAdd BLAST23
Topological domaini215 – 443CytoplasmicBy similarityAdd BLAST229
Transmembranei444 – 464Helical; Name=6By similarityAdd BLAST21
Topological domaini465 – 478ExtracellularBy similarityAdd BLAST14
Transmembranei479 – 498Helical; Name=7By similarityAdd BLAST20
Topological domaini499 – 532CytoplasmicBy similarityAdd BLAST34

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1133

Open Targets

More...OpenTargetsi		ENSG00000184984

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26486

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08912, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2035

Drug and drug target database

More...DrugBanki		DB08897, Aclidinium
DB05752, ALKS 27
DB00321, Amitriptyline
DB00543, Amoxapine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB00572, Atropine
DB00767, Benzquinamide
DB01019, Bethanechol
DB00835, Brompheniramine
DB01239, Chlorprothixene
DB00568, Cinnarizine
DB00363, Clozapine
DB00496, Darifenacin
DB01151, Desipramine
DB09167, Dosulepin
DB01142, Doxepin
DB00366, Doxylamine
DB09194, Etoperidone
DB06702, Fesoterodine
DB00483, Gallamine triethiodide
DB00986, Glycopyrronium
DB11181, Homatropine
DB00725, Homatropine methylbromide
DB00458, Imipramine
DB01221, Ketamine
DB00408, Loxapine
DB00934, Maprotiline
DB00454, Meperidine
DB06709, Methacholine
DB00940, Methantheline
DB01403, Methotrimeprazine
DB00340, Metixene
DB00622, Nicardipine
DB00540, Nortriptyline
DB00715, Paroxetine
DB01069, Promethazine
DB00777, Propiomazine
DB12278, Propiverine
DB01224, Quetiapine
DB11855, Revefenacin
DB13581, Rociverine
DB00747, Scopolamine
DB01591, Solifenacin
DB00342, Terfenadine
DB11235, Thonzylamine
DB01409, Tiotropium
DB01036, Tolterodine
DB00376, Trihexyphenidyl
DB00726, Trimipramine
DB09076, Umeclidinium
DB00246, Ziprasidone

DrugCentral

More...DrugCentrali		P08912

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		17

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CHRM5

Domain mapping of disease mutations (DMDM)

More...DMDMi		543761

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000690421 – 532Muscarinic acetylcholine receptor M5Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi103 ↔ 183PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei501PhosphothreonineSequence analysis1
Modified residuei505PhosphothreonineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08912

PeptideAtlas

More...PeptideAtlasi		P08912

PRoteomics IDEntifications database

More...PRIDEi		P08912

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P08912, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08912

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08912

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000184984, Expressed in C1 segment of cervical spinal cord and 95 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P08912, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08912, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000184984, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107555, 36 interactors

Protein interaction database and analysis system

More...IntActi		P08912, 30 interactors

Molecular INTeraction database

More...MINTi		P08912

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000372750

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P08912

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08912, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1532
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P08912

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08912

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni262 – 294DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi263 – 294Polar residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4220, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158450

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08912

Identification of Orthologs from Complete Genome Data

More...OMAi		RHGLWEV

Database of Orthologous Groups

More...OrthoDBi		1245472at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08912

TreeFam database of animal gene trees

More...TreeFami		TF320495

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR000502, Musac_Ach_M5_rcpt
IPR000995, Musac_Ach_rcpt

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00237, GPCRRHODOPSN
PR00243, MUSCARINICR
PR00542, MUSCRINICM5R

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P08912-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGDSYHNAT TVNGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL 
        60         70         80         90        100
VMISFKVNSQ LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS 
       110        120        130        140        150
LACDLWLALD YVASNASVMN LLVISFDRYF SITRPLTYRA KRTPKRAGIM 
       160        170        180        190        200
IGLAWLISFI LWAPAILCWQ YLVGKRTVPL DECQIQFLSE PTITFGTAIA 
       210        220        230        240        250
AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVTKAE KRKPAHRALF 
       260        270        280        290        300
RSCLRCPRPT LAQRERNQAS WSSSRRSTST TGKPSQATGP SANWAKAEQL 
       310        320        330        340        350
TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE ETEETFVKAE 
       360        370        380        390        400
TEKSDYDTPN YLLSPAAAHR PKSQKCVAYK FRLVVKADGN QETNNGCHKV 
       410        420        430        440        450
KIMPCPFPVA KEPSTKGLNP NPSHQMTKRK RVVLVKERKA AQTLSAILLA 
       460        470        480        490        500
FIITWTPYNI MVLVSTFCDK CVPVTLWHLG YWLCYVNSTV NPICYALCNR 
       510        520        530 
TFRKTFKMLL LCRWKKKKVE EKLYWQGNSK LP
Length:532
Mass (Da):60,074
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE846186F645DD9B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKC0H0YKC0_HUMAN
Muscarinic acetylcholine receptor M...
CHRM5
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti526Q → P (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M80333 Genomic DNA Translation: AAA51569.1
AF026263 mRNA Translation: AAB95158.1
AB084282 mRNA Translation: BAB91222.1
AF498919 mRNA Translation: AAM18942.1
AF385591 mRNA Translation: AAK68116.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10031.1

Protein sequence database of the Protein Information Resource

More...PIRi		JT0530

NCBI Reference Sequences

More...RefSeqi		NP_001307846.1, NM_001320917.1
NP_036257.1, NM_012125.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000383263.7; ENSP00000372750.5; ENSG00000184984.10
ENST00000557872.1; ENSP00000453745.1; ENSG00000184984.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1133

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000383263.7; ENSP00000372750.5; NM_012125.4; NP_036257.1

UCSC genome browser

More...UCSCi		uc001zhk.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80333 Genomic DNA Translation: AAA51569.1
AF026263 mRNA Translation: AAB95158.1
AB084282 mRNA Translation: BAB91222.1
AF498919 mRNA Translation: AAM18942.1
AF385591 mRNA Translation: AAK68116.1
CCDSiCCDS10031.1
PIRiJT0530
RefSeqiNP_001307846.1, NM_001320917.1
NP_036257.1, NM_012125.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6OL9X-ray2.54A21-224[»]
A431-532[»]
AlphaFoldDBiP08912
SMRiP08912
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107555, 36 interactors
IntActiP08912, 30 interactors
MINTiP08912
STRINGi9606.ENSP00000372750

Chemistry databases

BindingDBiP08912
ChEMBLiCHEMBL2035
DrugBankiDB08897, Aclidinium
DB05752, ALKS 27
DB00321, Amitriptyline
DB00543, Amoxapine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB00572, Atropine
DB00767, Benzquinamide
DB01019, Bethanechol
DB00835, Brompheniramine
DB01239, Chlorprothixene
DB00568, Cinnarizine
DB00363, Clozapine
DB00496, Darifenacin
DB01151, Desipramine
DB09167, Dosulepin
DB01142, Doxepin
DB00366, Doxylamine
DB09194, Etoperidone
DB06702, Fesoterodine
DB00483, Gallamine triethiodide
DB00986, Glycopyrronium
DB11181, Homatropine
DB00725, Homatropine methylbromide
DB00458, Imipramine
DB01221, Ketamine
DB00408, Loxapine
DB00934, Maprotiline
DB00454, Meperidine
DB06709, Methacholine
DB00940, Methantheline
DB01403, Methotrimeprazine
DB00340, Metixene
DB00622, Nicardipine
DB00540, Nortriptyline
DB00715, Paroxetine
DB01069, Promethazine
DB00777, Propiomazine
DB12278, Propiverine
DB01224, Quetiapine
DB11855, Revefenacin
DB13581, Rociverine
DB00747, Scopolamine
DB01591, Solifenacin
DB00342, Terfenadine
DB11235, Thonzylamine
DB01409, Tiotropium
DB01036, Tolterodine
DB00376, Trihexyphenidyl
DB00726, Trimipramine
DB09076, Umeclidinium
DB00246, Ziprasidone
DrugCentraliP08912
GuidetoPHARMACOLOGYi17

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP08912, 1 site
iPTMnetiP08912
PhosphoSitePlusiP08912

Genetic variation databases

BioMutaiCHRM5
DMDMi543761

Proteomic databases

PaxDbiP08912
PeptideAtlasiP08912
PRIDEiP08912

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2963, 251 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		1133

Genome annotation databases

EnsembliENST00000383263.7; ENSP00000372750.5; ENSG00000184984.10
ENST00000557872.1; ENSP00000453745.1; ENSG00000184984.10
GeneIDi1133
KEGGihsa:1133
MANE-SelectiENST00000383263.7; ENSP00000372750.5; NM_012125.4; NP_036257.1
UCSCiuc001zhk.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1133
DisGeNETi1133

GeneCards: human genes, protein and diseases

More...GeneCardsi		CHRM5
HGNCiHGNC:1954, CHRM5
HPAiENSG00000184984, Tissue enriched (brain)
MIMi118496, gene
neXtProtiNX_P08912
OpenTargetsiENSG00000184984
PharmGKBiPA26486
VEuPathDBiHostDB:ENSG00000184984

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4220, Eukaryota
GeneTreeiENSGT00940000158450
HOGENOMiCLU_009579_11_2_1
InParanoidiP08912
OMAiRHGLWEV
OrthoDBi1245472at2759
PhylomeDBiP08912
TreeFamiTF320495

Enzyme and pathway databases

PathwayCommonsiP08912
ReactomeiR-HSA-390648, Muscarinic acetylcholine receptors
R-HSA-416476, G alpha (q) signalling events
SignaLinkiP08912
SIGNORiP08912

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1133, 12 hits in 1073 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Muscarinic_acetylcholine_receptor_M5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1133
PharosiP08912, Tclin

Protein Ontology

More...PROi		PR:P08912
RNActiP08912, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000184984, Expressed in C1 segment of cervical spinal cord and 95 other tissues
ExpressionAtlasiP08912, baseline and differential
GenevisibleiP08912, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR000502, Musac_Ach_M5_rcpt
IPR000995, Musac_Ach_rcpt
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PR00243, MUSCARINICR
PR00542, MUSCRINICM5R
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACM5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08912
Secondary accession number(s): Q96RG7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 1, 1994
Last modified: May 25, 2022
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again