CHRM5

Functionⁱ

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

GO - Molecular functionⁱ

G-protein coupled acetylcholine receptor activity Source: GO_Central
phosphatidylinositol phospholipase C activity
Source: ProtInc
Traceable author statementⁱ
- 1905013

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8663391
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 8063729
dopamine transport Source: Ensembl
gastric acid secretion Source: InterPro
G-protein coupled acetylcholine receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 3272174
G-protein coupled receptor signaling pathway Source: Reactome
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway Source: GO_Central
regulation of phosphatidylinositol dephosphorylation Source: Ensembl
synaptic transmission, cholinergic Source: GO_Central
transmission of nerve impulse Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390648 Muscarinic acetylcholine receptors R-HSA-416476 G alpha (q) signalling events

Reactomeⁱ

R-HSA-390648 Muscarinic acetylcholine receptors
R-HSA-416476 G alpha (q) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Muscarinic acetylcholine receptor M5
Gene namesⁱ	Name:CHRM5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000184984.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1954 CHRM5
MIMⁱ	118496 gene
neXtProtⁱ	NX_P08912

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 29	ExtracellularBy similarityAdd BLAST	29
Transmembraneⁱ	30 – 53	Helical; Name=1By similarityAdd BLAST	24
Topological domainⁱ	54 – 66	CytoplasmicBy similarityAdd BLAST	13
Transmembraneⁱ	67 – 87	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	88 – 104	ExtracellularBy similarityAdd BLAST	17
Transmembraneⁱ	105 – 126	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	127 – 146	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	147 – 169	Helical; Name=4By similarityAdd BLAST	23
Topological domainⁱ	170 – 191	ExtracellularBy similarityAdd BLAST	22
Transmembraneⁱ	192 – 214	Helical; Name=5By similarityAdd BLAST	23
Topological domainⁱ	215 – 443	CytoplasmicBy similarityAdd BLAST	229
Transmembraneⁱ	444 – 464	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	465 – 478	ExtracellularBy similarityAdd BLAST	14
Transmembraneⁱ	479 – 498	Helical; Name=7By similarityAdd BLAST	20
Topological domainⁱ	499 – 532	CytoplasmicBy similarityAdd BLAST	34

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1133
Open Targets More...OpenTargetsⁱ	ENSG00000184984
PharmGKBⁱ	PA26486

Chemistry databases

ChEMBLⁱ	CHEMBL2035
Drug and drug target database More...DrugBankⁱ	DB08897 Aclidinium DB05752 ALKS 27 DB00321 Amitriptyline DB00543 Amoxapine DB01238 Aripiprazole DB00572 Atropine DB00767 Benzquinamide DB00835 Brompheniramine DB01239 Chlorprothixene DB00568 Cinnarizine DB00363 Clozapine DB00785 Cryptenamine DB00496 Darifenacin DB01151 Desipramine DB01142 Doxepin DB06702 Fesoterodine DB00725 Homatropine Methylbromide DB00458 Imipramine DB01221 Ketamine DB00408 Loxapine DB00934 Maprotiline DB01403 Methotrimeprazine DB00340 Metixene DB00622 Nicardipine DB00540 Nortriptyline DB00334 Olanzapine DB00715 Paroxetine DB00454 Pethidine DB00420 Promazine DB01069 Promethazine DB00777 Propiomazine DB01224 Quetiapine DB00747 Scopolamine DB01591 Solifenacin DB00342 Terfenadine DB01036 Tolterodine DB00376 Trihexyphenidyl DB00726 Trimipramine DB09076 Umeclidinium DB00246 Ziprasidone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	17

Polymorphism and mutation databases

BioMutaⁱ	CHRM5
DMDMⁱ	543761

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069042	1 – 532	Muscarinic acetylcholine receptor M5Add BLAST		532

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	8	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	103 ↔ 183	PROSITE-ProRule annotation
Modified residueⁱ	501	PhosphothreonineSequence analysis	1
Modified residueⁱ	505	PhosphothreonineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P08912
PeptideAtlas More...PeptideAtlasⁱ	P08912
PRIDEⁱ	P08912
ProteomicsDBⁱ	52175

PTM databases

iPTMnetⁱ	P08912
PhosphoSitePlusⁱ	P08912

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000184984
CleanExⁱ	HS_CHRM5
ExpressionAtlasⁱ	P08912 baseline and differential
Genevisibleⁱ	P08912 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA013172

HPAⁱ

HPA013172

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000372750

STRINGⁱ

9606.ENSP00000372750

Chemistry databases

BindingDBⁱ

P08912

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P08912
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4220 Eukaryota ENOG410YCQR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121874
HOGENOMⁱ	HOG000231484
HOVERGENⁱ	HBG105720
InParanoidⁱ	P08912
KEGG Orthology (KO) More...KOⁱ	K04133
OMAⁱ	KLYWQGN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P08912
TreeFamⁱ	TF320495

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000502 Musac_Ach_M5_rcpt IPR000995 Musac_Ach_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00243 MUSCARINICR PR00542 MUSCRINICM5R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P08912-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEGDSYHNAT TVNGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL 
        60         70         80         90        100
VMISFKVNSQ LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS 
       110        120        130        140        150
LACDLWLALD YVASNASVMN LLVISFDRYF SITRPLTYRA KRTPKRAGIM 
       160        170        180        190        200
IGLAWLISFI LWAPAILCWQ YLVGKRTVPL DECQIQFLSE PTITFGTAIA 
       210        220        230        240        250
AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVTKAE KRKPAHRALF 
       260        270        280        290        300
RSCLRCPRPT LAQRERNQAS WSSSRRSTST TGKPSQATGP SANWAKAEQL 
       310        320        330        340        350
TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE ETEETFVKAE 
       360        370        380        390        400
TEKSDYDTPN YLLSPAAAHR PKSQKCVAYK FRLVVKADGN QETNNGCHKV 
       410        420        430        440        450
KIMPCPFPVA KEPSTKGLNP NPSHQMTKRK RVVLVKERKA AQTLSAILLA 
       460        470        480        490        500
FIITWTPYNI MVLVSTFCDK CVPVTLWHLG YWLCYVNSTV NPICYALCNR 
       510        520        530 
TFRKTFKMLL LCRWKKKKVE EKLYWQGNSK LP

Length:532

Mass (Da):60,074

Last modified:June 1, 1994 - v2

Checksum:ⁱEE846186F645DD9B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	526	Q → P (Ref. 5) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M80333 Genomic DNA Translation: AAA51569.1 AF026263 mRNA Translation: AAB95158.1 AB084282 mRNA Translation: BAB91222.1 AF498919 mRNA Translation: AAM18942.1 AF385591 mRNA Translation: AAK68116.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10031.1
PIRⁱ	JT0530
NCBI Reference Sequences More...RefSeqⁱ	NP_001307846.1, NM_001320917.1 NP_036257.1, NM_012125.3
UniGeneⁱ	Hs.584747

Genome annotation databases

Ensemblⁱ	ENST00000383263; ENSP00000372750; ENSG00000184984 ENST00000557872; ENSP00000453745; ENSG00000184984
GeneIDⁱ	1133
KEGGⁱ	hsa:1133
UCSC genome browser More...UCSCⁱ	uc001zhk.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P08912	Muscarinic acetylcholine receptor		HUMAN		532
Muscarinic acetylcholine receptor M5 (Fragment)		HUMAN		22

Protein	Similar proteins		Species	Score	Length
P08912	Muscarinic acetylcholine receptor		HUMAN		532
UPI0004DFD985		URSMA		534
UPI0002BCF932		ORCOR		533
UPI000BB92143		DELLE		533
UPI00053FFCD0		FUKDA		533
+100

Protein	Similar proteins		Species	Score	Length
P08912	Muscarinic acetylcholine receptor		HUMAN		532
UPI0004DFD985		URSMA		534
UPI000441C2F8		LIPVE		533
muscarinic acetylcholine receptor M5		TURTR		533
UPI000BB92143		DELLE		533
+118

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M80333 Genomic DNA Translation: AAA51569.1 AF026263 mRNA Translation: AAB95158.1 AB084282 mRNA Translation: BAB91222.1 AF498919 mRNA Translation: AAM18942.1 AF385591 mRNA Translation: AAK68116.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10031.1
PIRⁱ	JT0530
NCBI Reference Sequences More...RefSeqⁱ	NP_001307846.1, NM_001320917.1 NP_036257.1, NM_012125.3
UniGeneⁱ	Hs.584747

3D structure databases

ProteinModelPortalⁱ	P08912
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000372750

STRINGⁱ

9606.ENSP00000372750

Chemistry databases

BindingDBⁱ	P08912
ChEMBLⁱ	CHEMBL2035
Drug and drug target database More...DrugBankⁱ	DB08897 Aclidinium DB05752 ALKS 27 DB00321 Amitriptyline DB00543 Amoxapine DB01238 Aripiprazole DB00572 Atropine DB00767 Benzquinamide DB00835 Brompheniramine DB01239 Chlorprothixene DB00568 Cinnarizine DB00363 Clozapine DB00785 Cryptenamine DB00496 Darifenacin DB01151 Desipramine DB01142 Doxepin DB06702 Fesoterodine DB00725 Homatropine Methylbromide DB00458 Imipramine DB01221 Ketamine DB00408 Loxapine DB00934 Maprotiline DB01403 Methotrimeprazine DB00340 Metixene DB00622 Nicardipine DB00540 Nortriptyline DB00334 Olanzapine DB00715 Paroxetine DB00454 Pethidine DB00420 Promazine DB01069 Promethazine DB00777 Propiomazine DB01224 Quetiapine DB00747 Scopolamine DB01591 Solifenacin DB00342 Terfenadine DB01036 Tolterodine DB00376 Trihexyphenidyl DB00726 Trimipramine DB09076 Umeclidinium DB00246 Ziprasidone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	17

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P08912
PhosphoSitePlusⁱ	P08912

Polymorphism and mutation databases

BioMutaⁱ	CHRM5
DMDMⁱ	543761

Proteomic databases

PaxDbⁱ	P08912
PeptideAtlas More...PeptideAtlasⁱ	P08912
PRIDEⁱ	P08912
ProteomicsDBⁱ	52175

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1133
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000383263; ENSP00000372750; ENSG00000184984 ENST00000557872; ENSP00000453745; ENSG00000184984
GeneIDⁱ	1133
KEGGⁱ	hsa:1133
UCSC genome browser More...UCSCⁱ	uc001zhk.2 human

Organism-specific databases

CTDⁱ	1133
DisGeNET More...DisGeNETⁱ	1133
EuPathDBⁱ	HostDB:ENSG00000184984.9
GeneCardsⁱ	CHRM5
H-InvDBⁱ	HIX0012084
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1954 CHRM5
Human Protein Atlas More...HPAⁱ	HPA013172
MIMⁱ	118496 gene
neXtProtⁱ	NX_P08912
Open Targets More...OpenTargetsⁱ	ENSG00000184984
PharmGKBⁱ	PA26486
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4220 Eukaryota ENOG410YCQR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00780000121874
HOGENOMⁱ	HOG000231484
HOVERGENⁱ	HBG105720
InParanoidⁱ	P08912
KEGG Orthology (KO) More...KOⁱ	K04133
OMAⁱ	KLYWQGN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P08912
TreeFamⁱ	TF320495

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390648 Muscarinic acetylcholine receptors R-HSA-416476 G alpha (q) signalling events

Reactomeⁱ

R-HSA-390648 Muscarinic acetylcholine receptors
R-HSA-416476 G alpha (q) signalling events

Miscellaneous databases

GeneWikiⁱ	Muscarinic_acetylcholine_receptor_M5
GenomeRNAiⁱ	1133
Protein Ontology More...PROⁱ	PR:P08912
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000184984
CleanExⁱ	HS_CHRM5
ExpressionAtlasⁱ	P08912 baseline and differential
Genevisibleⁱ	P08912 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000502 Musac_Ach_M5_rcpt IPR000995 Musac_Ach_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00243 MUSCARINICR PR00542 MUSCRINICM5R
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACM5_HUMAN
Accessionⁱ	P08912Primary (citable) accession number: P08912 Secondary accession number(s): Q96RG7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
	Last sequence update:	June 1, 1994
	Last modified:	June 20, 2018
	This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - P08912 (ACM5_HUMAN)

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Muscarinic acetylcholine receptor M5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ