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UniProtKB - P08912 (ACM5_HUMAN)
Protein
Muscarinic acetylcholine receptor M5
Gene
CHRM5
Organism
Homo sapiens (Human)
Status
Functioni
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
GO - Molecular functioni
- G protein-coupled acetylcholine receptor activity Source: GO_Central
- G protein-coupled serotonin receptor activity Source: GO_Central
- neurotransmitter receptor activity Source: GO_Central
- phosphatidylinositol phospholipase C activity Source: ProtInc
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: GO_Central
- chemical synaptic transmission Source: GO_Central
- dopamine transport Source: Ensembl
- gastric acid secretion Source: InterPro
- G protein-coupled acetylcholine receptor signaling pathway Source: ProtInc
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- regulation of phosphatidylinositol dephosphorylation Source: Ensembl
- transmission of nerve impulse Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P08912 |
Reactomei | R-HSA-390648, Muscarinic acetylcholine receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P08912 |
SIGNORi | P08912 |
Names & Taxonomyi
Protein namesi | Recommended name: Muscarinic acetylcholine receptor M5 |
Gene namesi | Name:CHRM5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1954, CHRM5 |
MIMi | 118496, gene |
neXtProti | NX_P08912 |
VEuPathDBi | HostDB:ENSG00000184984 |
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 29 | ExtracellularBy similarityAdd BLAST | 29 | |
Transmembranei | 30 – 53 | Helical; Name=1By similarityAdd BLAST | 24 | |
Topological domaini | 54 – 66 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 67 – 87 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 88 – 104 | ExtracellularBy similarityAdd BLAST | 17 | |
Transmembranei | 105 – 126 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 127 – 146 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 147 – 169 | Helical; Name=4By similarityAdd BLAST | 23 | |
Topological domaini | 170 – 191 | ExtracellularBy similarityAdd BLAST | 22 | |
Transmembranei | 192 – 214 | Helical; Name=5By similarityAdd BLAST | 23 | |
Topological domaini | 215 – 443 | CytoplasmicBy similarityAdd BLAST | 229 | |
Transmembranei | 444 – 464 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 465 – 478 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 479 – 498 | Helical; Name=7By similarityAdd BLAST | 20 | |
Topological domaini | 499 – 532 | CytoplasmicBy similarityAdd BLAST | 34 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 1133 |
OpenTargetsi | ENSG00000184984 |
PharmGKBi | PA26486 |
Miscellaneous databases
Pharosi | P08912, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2035 |
DrugBanki | DB08897, Aclidinium DB05752, ALKS 27 DB00321, Amitriptyline DB00543, Amoxapine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB00572, Atropine DB00767, Benzquinamide DB01019, Bethanechol DB00835, Brompheniramine DB01239, Chlorprothixene DB00568, Cinnarizine DB00363, Clozapine DB00496, Darifenacin DB01151, Desipramine DB09167, Dosulepin DB01142, Doxepin DB00366, Doxylamine DB09194, Etoperidone DB06702, Fesoterodine DB00483, Gallamine triethiodide DB00986, Glycopyrronium DB11181, Homatropine DB00725, Homatropine methylbromide DB00458, Imipramine DB01221, Ketamine DB00408, Loxapine DB00934, Maprotiline DB00454, Meperidine DB06709, Methacholine DB00940, Methantheline DB01403, Methotrimeprazine DB00340, Metixene DB00622, Nicardipine DB00540, Nortriptyline DB00715, Paroxetine DB01069, Promethazine DB00777, Propiomazine DB12278, Propiverine DB01224, Quetiapine DB11855, Revefenacin DB13581, Rociverine DB00747, Scopolamine DB01591, Solifenacin DB00342, Terfenadine DB11235, Thonzylamine DB01409, Tiotropium DB01036, Tolterodine DB00376, Trihexyphenidyl DB00726, Trimipramine DB09076, Umeclidinium DB00246, Ziprasidone |
DrugCentrali | P08912 |
GuidetoPHARMACOLOGYi | 17 |
Genetic variation databases
BioMutai | CHRM5 |
DMDMi | 543761 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069042 | 1 – 532 | Muscarinic acetylcholine receptor M5Add BLAST | 532 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 103 ↔ 183 | PROSITE-ProRule annotation | ||
Modified residuei | 501 | PhosphothreonineSequence analysis | 1 | |
Modified residuei | 505 | PhosphothreonineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P08912 |
PeptideAtlasi | P08912 |
PRIDEi | P08912 |
PTM databases
GlyGeni | P08912, 1 site |
iPTMneti | P08912 |
PhosphoSitePlusi | P08912 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184984, Expressed in C1 segment of cervical spinal cord and 95 other tissues |
ExpressionAtlasi | P08912, baseline and differential |
Genevisiblei | P08912, HS |
Organism-specific databases
HPAi | ENSG00000184984, Tissue enriched (brain) |
Interactioni
Binary interactionsi
P08912
With | #Exp. | IntAct |
---|---|---|
CHRM3 [P20309] | 7 | EBI-6655256,EBI-2687785 |
Protein-protein interaction databases
BioGRIDi | 107555, 36 interactors |
IntActi | P08912, 30 interactors |
MINTi | P08912 |
STRINGi | 9606.ENSP00000372750 |
Chemistry databases
BindingDBi | P08912 |
Miscellaneous databases
RNActi | P08912, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P08912 |
SMRi | P08912 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 262 – 294 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 263 – 294 | Polar residuesSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4220, Eukaryota |
GeneTreei | ENSGT00940000158450 |
HOGENOMi | CLU_009579_11_2_1 |
InParanoidi | P08912 |
OMAi | RHGLWEV |
OrthoDBi | 1245472at2759 |
PhylomeDBi | P08912 |
TreeFami | TF320495 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000502, Musac_Ach_M5_rcpt IPR000995, Musac_Ach_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00243, MUSCARINICR PR00542, MUSCRINICM5R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P08912-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGDSYHNAT TVNGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL
60 70 80 90 100
VMISFKVNSQ LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS
110 120 130 140 150
LACDLWLALD YVASNASVMN LLVISFDRYF SITRPLTYRA KRTPKRAGIM
160 170 180 190 200
IGLAWLISFI LWAPAILCWQ YLVGKRTVPL DECQIQFLSE PTITFGTAIA
210 220 230 240 250
AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVTKAE KRKPAHRALF
260 270 280 290 300
RSCLRCPRPT LAQRERNQAS WSSSRRSTST TGKPSQATGP SANWAKAEQL
310 320 330 340 350
TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE ETEETFVKAE
360 370 380 390 400
TEKSDYDTPN YLLSPAAAHR PKSQKCVAYK FRLVVKADGN QETNNGCHKV
410 420 430 440 450
KIMPCPFPVA KEPSTKGLNP NPSHQMTKRK RVVLVKERKA AQTLSAILLA
460 470 480 490 500
FIITWTPYNI MVLVSTFCDK CVPVTLWHLG YWLCYVNSTV NPICYALCNR
510 520 530
TFRKTFKMLL LCRWKKKKVE EKLYWQGNSK LP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YKC0 | H0YKC0_HUMAN | Muscarinic acetylcholine receptor M... | CHRM5 | 22 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 526 | Q → P (Ref. 5) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80333 Genomic DNA Translation: AAA51569.1 AF026263 mRNA Translation: AAB95158.1 AB084282 mRNA Translation: BAB91222.1 AF498919 mRNA Translation: AAM18942.1 AF385591 mRNA Translation: AAK68116.1 |
CCDSi | CCDS10031.1 |
PIRi | JT0530 |
RefSeqi | NP_001307846.1, NM_001320917.1 NP_036257.1, NM_012125.3 |
Genome annotation databases
Ensembli | ENST00000383263.7; ENSP00000372750.5; ENSG00000184984.10 ENST00000557872.1; ENSP00000453745.1; ENSG00000184984.10 |
GeneIDi | 1133 |
KEGGi | hsa:1133 |
MANE-Selecti | ENST00000383263.7; ENSP00000372750.5; NM_012125.4; NP_036257.1 |
UCSCi | uc001zhk.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80333 Genomic DNA Translation: AAA51569.1 AF026263 mRNA Translation: AAB95158.1 AB084282 mRNA Translation: BAB91222.1 AF498919 mRNA Translation: AAM18942.1 AF385591 mRNA Translation: AAK68116.1 |
CCDSi | CCDS10031.1 |
PIRi | JT0530 |
RefSeqi | NP_001307846.1, NM_001320917.1 NP_036257.1, NM_012125.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6OL9 | X-ray | 2.54 | A | 21-224 | [»] | |
A | 431-532 | [»] | ||||
AlphaFoldDBi | P08912 | |||||
SMRi | P08912 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107555, 36 interactors |
IntActi | P08912, 30 interactors |
MINTi | P08912 |
STRINGi | 9606.ENSP00000372750 |
Chemistry databases
BindingDBi | P08912 |
ChEMBLi | CHEMBL2035 |
DrugBanki | DB08897, Aclidinium DB05752, ALKS 27 DB00321, Amitriptyline DB00543, Amoxapine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB00572, Atropine DB00767, Benzquinamide DB01019, Bethanechol DB00835, Brompheniramine DB01239, Chlorprothixene DB00568, Cinnarizine DB00363, Clozapine DB00496, Darifenacin DB01151, Desipramine DB09167, Dosulepin DB01142, Doxepin DB00366, Doxylamine DB09194, Etoperidone DB06702, Fesoterodine DB00483, Gallamine triethiodide DB00986, Glycopyrronium DB11181, Homatropine DB00725, Homatropine methylbromide DB00458, Imipramine DB01221, Ketamine DB00408, Loxapine DB00934, Maprotiline DB00454, Meperidine DB06709, Methacholine DB00940, Methantheline DB01403, Methotrimeprazine DB00340, Metixene DB00622, Nicardipine DB00540, Nortriptyline DB00715, Paroxetine DB01069, Promethazine DB00777, Propiomazine DB12278, Propiverine DB01224, Quetiapine DB11855, Revefenacin DB13581, Rociverine DB00747, Scopolamine DB01591, Solifenacin DB00342, Terfenadine DB11235, Thonzylamine DB01409, Tiotropium DB01036, Tolterodine DB00376, Trihexyphenidyl DB00726, Trimipramine DB09076, Umeclidinium DB00246, Ziprasidone |
DrugCentrali | P08912 |
GuidetoPHARMACOLOGYi | 17 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P08912, 1 site |
iPTMneti | P08912 |
PhosphoSitePlusi | P08912 |
Genetic variation databases
BioMutai | CHRM5 |
DMDMi | 543761 |
Proteomic databases
PaxDbi | P08912 |
PeptideAtlasi | P08912 |
PRIDEi | P08912 |
Protocols and materials databases
Antibodypediai | 2963, 251 antibodies from 27 providers |
DNASUi | 1133 |
Genome annotation databases
Ensembli | ENST00000383263.7; ENSP00000372750.5; ENSG00000184984.10 ENST00000557872.1; ENSP00000453745.1; ENSG00000184984.10 |
GeneIDi | 1133 |
KEGGi | hsa:1133 |
MANE-Selecti | ENST00000383263.7; ENSP00000372750.5; NM_012125.4; NP_036257.1 |
UCSCi | uc001zhk.2, human |
Organism-specific databases
CTDi | 1133 |
DisGeNETi | 1133 |
GeneCardsi | CHRM5 |
HGNCi | HGNC:1954, CHRM5 |
HPAi | ENSG00000184984, Tissue enriched (brain) |
MIMi | 118496, gene |
neXtProti | NX_P08912 |
OpenTargetsi | ENSG00000184984 |
PharmGKBi | PA26486 |
VEuPathDBi | HostDB:ENSG00000184984 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4220, Eukaryota |
GeneTreei | ENSGT00940000158450 |
HOGENOMi | CLU_009579_11_2_1 |
InParanoidi | P08912 |
OMAi | RHGLWEV |
OrthoDBi | 1245472at2759 |
PhylomeDBi | P08912 |
TreeFami | TF320495 |
Enzyme and pathway databases
PathwayCommonsi | P08912 |
Reactomei | R-HSA-390648, Muscarinic acetylcholine receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P08912 |
SIGNORi | P08912 |
Miscellaneous databases
BioGRID-ORCSi | 1133, 12 hits in 1073 CRISPR screens |
GeneWikii | Muscarinic_acetylcholine_receptor_M5 |
GenomeRNAii | 1133 |
Pharosi | P08912, Tclin |
PROi | PR:P08912 |
RNActi | P08912, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184984, Expressed in C1 segment of cervical spinal cord and 95 other tissues |
ExpressionAtlasi | P08912, baseline and differential |
Genevisiblei | P08912, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000502, Musac_Ach_M5_rcpt IPR000995, Musac_Ach_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00243, MUSCARINICR PR00542, MUSCRINICM5R |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACM5_HUMAN | |
Accessioni | P08912Primary (citable) accession number: P08912 Secondary accession number(s): Q96RG7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families