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Protein

Muscarinic acetylcholine receptor M5

Gene

CHRM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390648 Muscarinic acetylcholine receptors
R-HSA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M5
Gene namesi
Name:CHRM5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000184984.9
HGNCiHGNC:1954 CHRM5
MIMi118496 gene
neXtProtiNX_P08912

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
Transmembranei30 – 53Helical; Name=1By similarityAdd BLAST24
Topological domaini54 – 66CytoplasmicBy similarityAdd BLAST13
Transmembranei67 – 87Helical; Name=2By similarityAdd BLAST21
Topological domaini88 – 104ExtracellularBy similarityAdd BLAST17
Transmembranei105 – 126Helical; Name=3By similarityAdd BLAST22
Topological domaini127 – 146CytoplasmicBy similarityAdd BLAST20
Transmembranei147 – 169Helical; Name=4By similarityAdd BLAST23
Topological domaini170 – 191ExtracellularBy similarityAdd BLAST22
Transmembranei192 – 214Helical; Name=5By similarityAdd BLAST23
Topological domaini215 – 443CytoplasmicBy similarityAdd BLAST229
Transmembranei444 – 464Helical; Name=6By similarityAdd BLAST21
Topological domaini465 – 478ExtracellularBy similarityAdd BLAST14
Transmembranei479 – 498Helical; Name=7By similarityAdd BLAST20
Topological domaini499 – 532CytoplasmicBy similarityAdd BLAST34

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi1133
OpenTargetsiENSG00000184984
PharmGKBiPA26486

Chemistry databases

ChEMBLiCHEMBL2035
DrugBankiDB08897 Aclidinium
DB05752 ALKS 27
DB00321 Amitriptyline
DB00543 Amoxapine
DB01238 Aripiprazole
DB00572 Atropine
DB00767 Benzquinamide
DB00835 Brompheniramine
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00363 Clozapine
DB00785 Cryptenamine
DB00496 Darifenacin
DB01151 Desipramine
DB01142 Doxepin
DB06702 Fesoterodine
DB00725 Homatropine Methylbromide
DB00458 Imipramine
DB01221 Ketamine
DB00408 Loxapine
DB00934 Maprotiline
DB01403 Methotrimeprazine
DB00340 Metixene
DB00622 Nicardipine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00715 Paroxetine
DB00454 Pethidine
DB00420 Promazine
DB01069 Promethazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00747 Scopolamine
DB01591 Solifenacin
DB00342 Terfenadine
DB01036 Tolterodine
DB00376 Trihexyphenidyl
DB00726 Trimipramine
DB09076 Umeclidinium
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi17

Polymorphism and mutation databases

BioMutaiCHRM5
DMDMi543761

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690421 – 532Muscarinic acetylcholine receptor M5Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 183PROSITE-ProRule annotation
Modified residuei501PhosphothreonineSequence analysis1
Modified residuei505PhosphothreonineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP08912
PeptideAtlasiP08912
PRIDEiP08912
ProteomicsDBi52175

PTM databases

iPTMnetiP08912
PhosphoSitePlusiP08912

Expressioni

Gene expression databases

BgeeiENSG00000184984
CleanExiHS_CHRM5
ExpressionAtlasiP08912 baseline and differential
GenevisibleiP08912 HS

Organism-specific databases

HPAiHPA013172

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000372750

Chemistry databases

BindingDBiP08912

Structurei

3D structure databases

ProteinModelPortaliP08912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00780000121874
HOGENOMiHOG000231484
HOVERGENiHBG105720
InParanoidiP08912
KOiK04133
OMAiKLYWQGN
OrthoDBiEOG091G06VI
PhylomeDBiP08912
TreeFamiTF320495

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000502 Musac_Ach_M5_rcpt
IPR000995 Musac_Ach_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00243 MUSCARINICR
PR00542 MUSCRINICM5R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P08912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGDSYHNAT TVNGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL
60 70 80 90 100
VMISFKVNSQ LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS
110 120 130 140 150
LACDLWLALD YVASNASVMN LLVISFDRYF SITRPLTYRA KRTPKRAGIM
160 170 180 190 200
IGLAWLISFI LWAPAILCWQ YLVGKRTVPL DECQIQFLSE PTITFGTAIA
210 220 230 240 250
AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVTKAE KRKPAHRALF
260 270 280 290 300
RSCLRCPRPT LAQRERNQAS WSSSRRSTST TGKPSQATGP SANWAKAEQL
310 320 330 340 350
TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE ETEETFVKAE
360 370 380 390 400
TEKSDYDTPN YLLSPAAAHR PKSQKCVAYK FRLVVKADGN QETNNGCHKV
410 420 430 440 450
KIMPCPFPVA KEPSTKGLNP NPSHQMTKRK RVVLVKERKA AQTLSAILLA
460 470 480 490 500
FIITWTPYNI MVLVSTFCDK CVPVTLWHLG YWLCYVNSTV NPICYALCNR
510 520 530
TFRKTFKMLL LCRWKKKKVE EKLYWQGNSK LP
Length:532
Mass (Da):60,074
Last modified:June 1, 1994 - v2
Checksum:iEE846186F645DD9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti526Q → P (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80333 Genomic DNA Translation: AAA51569.1
AF026263 mRNA Translation: AAB95158.1
AB084282 mRNA Translation: BAB91222.1
AF498919 mRNA Translation: AAM18942.1
AF385591 mRNA Translation: AAK68116.1
CCDSiCCDS10031.1
PIRiJT0530
RefSeqiNP_001307846.1, NM_001320917.1
NP_036257.1, NM_012125.3
UniGeneiHs.584747

Genome annotation databases

EnsembliENST00000383263; ENSP00000372750; ENSG00000184984
ENST00000557872; ENSP00000453745; ENSG00000184984
GeneIDi1133
KEGGihsa:1133
UCSCiuc001zhk.2 human

Similar proteinsi

Entry informationi

Entry nameiACM5_HUMAN
AccessioniPrimary (citable) accession number: P08912
Secondary accession number(s): Q96RG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 1, 1994
Last modified: June 20, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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