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Protein

Muscarinic acetylcholine receptor M5

Gene

Chrm5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109AntagonistBy similarity1

GO - Molecular functioni

  • G-protein coupled acetylcholine receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390648 Muscarinic acetylcholine receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M5
Gene namesi
Name:Chrm5
Synonyms:Chrm-5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620027 Chrm5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularBy similarityAdd BLAST28
Transmembranei29 – 52Helical; Name=1By similarityAdd BLAST24
Topological domaini53 – 65CytoplasmicBy similarityAdd BLAST13
Transmembranei66 – 86Helical; Name=2By similarityAdd BLAST21
Topological domaini87 – 103ExtracellularBy similarityAdd BLAST17
Transmembranei104 – 125Helical; Name=3By similarityAdd BLAST22
Topological domaini126 – 145CytoplasmicBy similarityAdd BLAST20
Transmembranei146 – 168Helical; Name=4By similarityAdd BLAST23
Topological domaini169 – 190ExtracellularBy similarityAdd BLAST22
Transmembranei191 – 213Helical; Name=5By similarityAdd BLAST23
Topological domaini214 – 442CytoplasmicBy similarityAdd BLAST229
Transmembranei443 – 463Helical; Name=6By similarityAdd BLAST21
Topological domaini464 – 477ExtracellularBy similarityAdd BLAST14
Transmembranei478 – 497Helical; Name=7By similarityAdd BLAST20
Topological domaini498 – 531CytoplasmicBy similarityAdd BLAST34

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL277
GuidetoPHARMACOLOGYi17

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690461 – 531Muscarinic acetylcholine receptor M5Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi102 ↔ 182PROSITE-ProRule annotation
Modified residuei500PhosphothreonineSequence analysis1
Modified residuei504PhosphothreonineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP08911
PRIDEiP08911

PTM databases

iPTMnetiP08911
PhosphoSitePlusiP08911

Expressioni

Gene expression databases

BgeeiENSRNOG00000006397 Expressed in 2 organ(s), highest expression level in Ammon's horn
GenevisibleiP08911 RN

Interactioni

Protein-protein interaction databases

IntActiP08911, 3 interactors
MINTiP08911
STRINGi10116.ENSRNOP00000008387

Chemistry databases

BindingDBiP08911

Structurei

3D structure databases

ProteinModelPortaliP08911
SMRiP08911
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00780000121874
HOGENOMiHOG000231484
HOVERGENiHBG105720
InParanoidiP08911
KOiK04133
OMAiKLYWQGN
OrthoDBiEOG091G06VI
PhylomeDBiP08911
TreeFamiTF320495

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000502 Musac_Ach_M5_rcpt
IPR000995 Musac_Ach_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00243 MUSCARINICR
PR00542 MUSCRINICM5R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P08911-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGESYNEST VNGTPVNHQA LERHGLWEVI TIAVVTAVVS LMTIVGNVLV
60 70 80 90 100
MISFKVNSQL KTVNNYYLLS LACADLIIGI FSMNLYTTYI LMGRWVLGSL
110 120 130 140 150
ACDLWLALDY VASNASVMNL LVISFDRYFS ITRPLTYRAK RTPKRAGIMI
160 170 180 190 200
GLAWLVSFIL WAPAILCWQY LVGKRTVPPD ECQIQFLSEP TITFGTAIAA
210 220 230 240 250
FYIPVSVMTI LYCRIYRETE KRTKDLADLQ GSDSVAEAKK REPAQRTLLR
260 270 280 290 300
SFFSCPRPSL AQRERNQASW SSSRRSTSTT GKTTQATDLS ADWEKAEQVT
310 320 330 340 350
TCSSYPSSED EAKPTTDPVF QMVYKSEAKE SPGKESNTQE TKETVVNTRT
360 370 380 390 400
ENSDYDTPKY FLSPAAAHRL KSQKCVAYKF RLVVKADGTQ ETNNGCRKVK
410 420 430 440 450
IMPCSFPVSK DPSTKGPDPN LSHQMTKRKR MVLVKERKAA QTLSAILLAF
460 470 480 490 500
IITWTPYNIM VLVSTFCDKC VPVTLWHLGY WLCYVNSTIN PICYALCNRT
510 520 530
FRKTFKLLLL CRWKKKKVEE KLYWQGNSKL P
Length:531
Mass (Da):60,137
Last modified:November 1, 1988 - v1
Checksum:i647CE0D5D75A2BB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22926 mRNA Translation: AAA40658.1
M22925 Genomic DNA Translation: AAA41572.1
PIRiJT0531
RefSeqiNP_059058.1, NM_017362.4
UniGeneiRn.44293

Genome annotation databases

EnsembliENSRNOT00000008387; ENSRNOP00000008387; ENSRNOG00000006397
GeneIDi53949
KEGGirno:53949
UCSCiRGD:620027 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22926 mRNA Translation: AAA40658.1
M22925 Genomic DNA Translation: AAA41572.1
PIRiJT0531
RefSeqiNP_059058.1, NM_017362.4
UniGeneiRn.44293

3D structure databases

ProteinModelPortaliP08911
SMRiP08911
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08911, 3 interactors
MINTiP08911
STRINGi10116.ENSRNOP00000008387

Chemistry databases

BindingDBiP08911
ChEMBLiCHEMBL277
GuidetoPHARMACOLOGYi17

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP08911
PhosphoSitePlusiP08911

Proteomic databases

PaxDbiP08911
PRIDEiP08911

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008387; ENSRNOP00000008387; ENSRNOG00000006397
GeneIDi53949
KEGGirno:53949
UCSCiRGD:620027 rat

Organism-specific databases

CTDi1133
RGDi620027 Chrm5

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00780000121874
HOGENOMiHOG000231484
HOVERGENiHBG105720
InParanoidiP08911
KOiK04133
OMAiKLYWQGN
OrthoDBiEOG091G06VI
PhylomeDBiP08911
TreeFamiTF320495

Enzyme and pathway databases

ReactomeiR-RNO-390648 Muscarinic acetylcholine receptors
R-RNO-416476 G alpha (q) signalling events

Miscellaneous databases

PROiPR:P08911

Gene expression databases

BgeeiENSRNOG00000006397 Expressed in 2 organ(s), highest expression level in Ammon's horn
GenevisibleiP08911 RN

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000502 Musac_Ach_M5_rcpt
IPR000995 Musac_Ach_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00243 MUSCARINICR
PR00542 MUSCRINICM5R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACM5_RAT
AccessioniPrimary (citable) accession number: P08911
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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