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Protein

Monoacylglycerol lipase ABHD2

Gene

ABHD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).By similarity1 Publication

Caution

Was originally thought to be a G-coupled receptor.1 Publication

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.1 Publication

Activity regulationi

Acylglycerol lipase activity is activated upon binding to progesterone.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei207NucleophileBy similarity1
Active sitei345Charge relay systemBy similarity1
Active sitei376Charge relay systemBy similarity1

GO - Molecular functioni

  • acylglycerol lipase activity Source: UniProtKB
  • hormone binding Source: UniProtKB
  • lipase activity Source: GO_Central
  • short-chain carboxylesterase activity Source: GO_Central
  • steroid hormone receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase
Biological processLipid degradation, Lipid metabolism

Protein family/group databases

ESTHERihuman-ABHD2 abh_upf0017

Chemistry databases

SwissLipidsiSLP:000001546

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase ABHD2Curated (EC:3.1.1.231 Publication)
Alternative name(s):
2-arachidonoylglycerol hydrolaseCurated
Abhydrolase domain-containing protein 2Curated
Lung alpha/beta hydrolase 2By similarity
Protein PHPS1-21 Publication
Gene namesi
Name:ABHD2Imported
Synonyms:LABH2By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140526.16
HGNCiHGNC:18717 ABHD2
MIMi612196 gene
neXtProtiNX_P08910

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicCurated9
Transmembranei10 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini31 – 425ExtracellularCuratedAdd BLAST395

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11057
OpenTargetsiENSG00000140526
PharmGKBiPA38658

Polymorphism and mutation databases

BioMutaiABHD2
DMDMi123504

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124571 – 425Monoacylglycerol lipase ABHD2Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi136N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP08910
PaxDbiP08910
PeptideAtlasiP08910
PRIDEiP08910
ProteomicsDBi52174

PTM databases

iPTMnetiP08910
PhosphoSitePlusiP08910
SwissPalmiP08910

Expressioni

Tissue specificityi

Present in sperm (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000140526 Expressed in 225 organ(s), highest expression level in caput epididymis
CleanExiHS_ABHD2
ExpressionAtlasiP08910 baseline and differential
GenevisibleiP08910 HS

Organism-specific databases

HPAiHPA005999

Interactioni

Protein-protein interaction databases

BioGridi116242, 1 interactor
STRINGi9606.ENSP00000268129

Structurei

3D structure databases

ProteinModelPortaliP08910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 382AB hydrolase-1Sequence analysisAdd BLAST255

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1838 Eukaryota
COG0429 LUCA
GeneTreeiENSGT00530000062981
HOGENOMiHOG000230852
HOVERGENiHBG080812
InParanoidiP08910
KOiK13697
OMAiCPWPIGE
OrthoDBiEOG091G08XK
PhylomeDBiP08910
TreeFamiTF313195

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000952 AB_hydrolase_4_CS
IPR012020 ABHD4
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF005211 Ab_hydro_YheT, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS01133 UPF0017, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P08910-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG
60 70 80 90 100
LSRFLLKSCP LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF
110 120 130 140 150
ITMSDGATST FDLFEPLAEH CVGDDITMVI CPGIANHSEK QYIRTFVDYA
160 170 180 190 200
QKNGYRCAVL NHLGALPNIE LTSPRMFTYG CTWEFGAMVN YIKKTYPLTQ
210 220 230 240 250
LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL RAQETFMQWD
260 270 280 290 300
QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL
310 320 330 340 350
MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE
360 370 380 390 400
SLLTIPKSLS EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY
410 420
ANAICQWERN KLQCSDTEQV EADLE
Length:425
Mass (Da):48,315
Last modified:November 1, 1988 - v1
Checksum:i747C6AB2C99B3CC2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUZ6H3BUZ6_HUMAN
Monoacylglycerol lipase ABHD2
ABHD2
131Annotation score:
H3BMT2H3BMT2_HUMAN
Monoacylglycerol lipase ABHD2
ABHD2
123Annotation score:
H3BN19H3BN19_HUMAN
Monoacylglycerol lipase ABHD2
ABHD2
55Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27Y → C in BAD96803 (Ref. 3) Curated1
Sequence conflicti388E → G in BAD96561 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031203253R → Q1 PublicationCorresponds to variant dbSNP:rs17851730Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12433 mRNA Translation: CAA30976.1
AF546700 mRNA Translation: AAQ12021.1
AK222841 mRNA Translation: BAD96561.1
AK223083 mRNA Translation: BAD96803.1
BC019248 mRNA Translation: AAH19248.1
BC090052 mRNA Translation: AAH90052.1
CCDSiCCDS10348.1
PIRiA31026
RefSeqiNP_008942.3, NM_007011.7
NP_690888.1, NM_152924.4
XP_005254889.1, XM_005254832.1
XP_005254890.1, XM_005254833.1
XP_011519467.1, XM_011521165.1
UniGeneiHs.122337

Genome annotation databases

EnsembliENST00000352732; ENSP00000268129; ENSG00000140526
ENST00000565973; ENSP00000455639; ENSG00000140526
GeneIDi11057
KEGGihsa:11057
UCSCiuc002bnk.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12433 mRNA Translation: CAA30976.1
AF546700 mRNA Translation: AAQ12021.1
AK222841 mRNA Translation: BAD96561.1
AK223083 mRNA Translation: BAD96803.1
BC019248 mRNA Translation: AAH19248.1
BC090052 mRNA Translation: AAH90052.1
CCDSiCCDS10348.1
PIRiA31026
RefSeqiNP_008942.3, NM_007011.7
NP_690888.1, NM_152924.4
XP_005254889.1, XM_005254832.1
XP_005254890.1, XM_005254833.1
XP_011519467.1, XM_011521165.1
UniGeneiHs.122337

3D structure databases

ProteinModelPortaliP08910
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116242, 1 interactor
STRINGi9606.ENSP00000268129

Chemistry databases

SwissLipidsiSLP:000001546

Protein family/group databases

ESTHERihuman-ABHD2 abh_upf0017

PTM databases

iPTMnetiP08910
PhosphoSitePlusiP08910
SwissPalmiP08910

Polymorphism and mutation databases

BioMutaiABHD2
DMDMi123504

Proteomic databases

MaxQBiP08910
PaxDbiP08910
PeptideAtlasiP08910
PRIDEiP08910
ProteomicsDBi52174

Protocols and materials databases

DNASUi11057
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352732; ENSP00000268129; ENSG00000140526
ENST00000565973; ENSP00000455639; ENSG00000140526
GeneIDi11057
KEGGihsa:11057
UCSCiuc002bnk.2 human

Organism-specific databases

CTDi11057
DisGeNETi11057
EuPathDBiHostDB:ENSG00000140526.16
GeneCardsiABHD2
HGNCiHGNC:18717 ABHD2
HPAiHPA005999
MIMi612196 gene
neXtProtiNX_P08910
OpenTargetsiENSG00000140526
PharmGKBiPA38658
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1838 Eukaryota
COG0429 LUCA
GeneTreeiENSGT00530000062981
HOGENOMiHOG000230852
HOVERGENiHBG080812
InParanoidiP08910
KOiK13697
OMAiCPWPIGE
OrthoDBiEOG091G08XK
PhylomeDBiP08910
TreeFamiTF313195

Miscellaneous databases

ChiTaRSiABHD2 human
GeneWikiiABHD2
GenomeRNAii11057
PROiPR:P08910
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140526 Expressed in 225 organ(s), highest expression level in caput epididymis
CleanExiHS_ABHD2
ExpressionAtlasiP08910 baseline and differential
GenevisibleiP08910 HS

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000952 AB_hydrolase_4_CS
IPR012020 ABHD4
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF005211 Ab_hydro_YheT, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS01133 UPF0017, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABHD2_HUMAN
AccessioniPrimary (citable) accession number: P08910
Secondary accession number(s): Q53G48
, Q53GU0, Q5FVD9, Q8TC79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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