UniProtKB - P08910 (ABHD2_HUMAN)
Protein
Monoacylglycerol lipase ABHD2
Gene
ABHD2
Organism
Homo sapiens (Human)
Status
Functioni
Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).By similarity1 Publication
Caution
Was originally thought to be a G-coupled receptor.1 Publication
Catalytic activityi
- Hydrolyzes glycerol monoesters of long-chain fatty acids.1 Publication EC:3.1.1.23
Activity regulationi
Acylglycerol lipase activity is activated upon binding to progesterone.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 207 | NucleophileBy similarity | 1 | |
Active sitei | 345 | Charge relay systemBy similarity | 1 | |
Active sitei | 376 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- acylglycerol lipase activity Source: UniProtKB
- hormone binding Source: UniProtKB
- lipase activity Source: GO_Central
- short-chain carboxylesterase activity Source: GO_Central
- steroid hormone receptor activity Source: UniProtKB
GO - Biological processi
- acrosome reaction Source: Ensembl
- acylglycerol catabolic process Source: UniProtKB
- cellular lipid metabolic process Source: GO_Central
- medium-chain fatty acid biosynthetic process Source: GO_Central
- medium-chain fatty acid catabolic process Source: GO_Central
- negative regulation of cell migration Source: Ensembl
- response to progesterone Source: UniProtKB
- response to wounding Source: Ensembl
- sperm capacitation Source: UniProtKB
- steroid hormone mediated signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Serine esterase |
Biological process | Lipid degradation, Lipid metabolism |
Protein family/group databases
ESTHERi | human-ABHD2 abh_upf0017 |
Chemistry databases
SwissLipidsi | SLP:000001546 |
Names & Taxonomyi
Protein namesi | Recommended name: Monoacylglycerol lipase ABHD2Curated (EC:3.1.1.231 Publication)Alternative name(s): 2-arachidonoylglycerol hydrolaseCurated Abhydrolase domain-containing protein 2Curated Lung alpha/beta hydrolase 2By similarity Protein PHPS1-21 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000140526.16 |
HGNCi | HGNC:18717 ABHD2 |
MIMi | 612196 gene |
neXtProti | NX_P08910 |
Subcellular locationi
Plasma membrane
- flagellum membrane 1 Publication; Single-pass type II membrane protein Curated
- Cell membrane Curated; Single-pass type II membrane protein Curated
Plasma Membrane
- sperm plasma membrane Source: UniProtKB
Other locations
- acrosomal vesicle Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- sperm flagellum Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | CytoplasmicCurated | 9 | |
Transmembranei | 10 – 30 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 31 – 425 | ExtracellularCuratedAdd BLAST | 395 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Cilium, Flagellum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 11057 |
OpenTargetsi | ENSG00000140526 |
PharmGKBi | PA38658 |
Polymorphism and mutation databases
BioMutai | ABHD2 |
DMDMi | 123504 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212457 | 1 – 425 | Monoacylglycerol lipase ABHD2Add BLAST | 425 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 136 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | P08910 |
PaxDbi | P08910 |
PeptideAtlasi | P08910 |
PRIDEi | P08910 |
ProteomicsDBi | 52174 |
PTM databases
iPTMneti | P08910 |
PhosphoSitePlusi | P08910 |
SwissPalmi | P08910 |
Expressioni
Tissue specificityi
Present in sperm (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000140526 Expressed in 225 organ(s), highest expression level in caput epididymis |
ExpressionAtlasi | P08910 baseline and differential |
Genevisiblei | P08910 HS |
Organism-specific databases
HPAi | HPA005999 |
Interactioni
Protein-protein interaction databases
BioGridi | 116242, 1 interactor |
STRINGi | 9606.ENSP00000268129 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 128 – 382 | AB hydrolase-1Sequence analysisAdd BLAST | 255 |
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1838 Eukaryota COG0429 LUCA |
GeneTreei | ENSGT00940000153712 |
HOGENOMi | HOG000230852 |
HOVERGENi | HBG080812 |
InParanoidi | P08910 |
KOi | K13697 |
OMAi | CPWPIGE |
OrthoDBi | 1033151at2759 |
PhylomeDBi | P08910 |
TreeFami | TF313195 |
Family and domain databases
InterProi | View protein in InterPro IPR029058 AB_hydrolase IPR000073 AB_hydrolase_1 IPR000952 AB_hydrolase_4_CS IPR012020 ABHD4 |
Pfami | View protein in Pfam PF00561 Abhydrolase_1, 1 hit |
PIRSFi | PIRSF005211 Ab_hydro_YheT, 1 hit |
SUPFAMi | SSF53474 SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS01133 UPF0017, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P08910-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNAMLETPEL PAVFDGVKLA AVAAVLYVIV RCLNLKSPTA PPDLYFQDSG
60 70 80 90 100
LSRFLLKSCP LLTKEYIPPL IWGKSGHIQT ALYGKMGRVR SPHPYGHRKF
110 120 130 140 150
ITMSDGATST FDLFEPLAEH CVGDDITMVI CPGIANHSEK QYIRTFVDYA
160 170 180 190 200
QKNGYRCAVL NHLGALPNIE LTSPRMFTYG CTWEFGAMVN YIKKTYPLTQ
210 220 230 240 250
LVVVGFSLGG NIVCKYLGET QANQEKVLCC VSVCQGYSAL RAQETFMQWD
260 270 280 290 300
QCRRFYNFLM ADNMKKIILS HRQALFGDHV KKPQSLEDTD LSRLYTATSL
310 320 330 340 350
MQIDDNVMRK FHGYNSLKEY YEEESCMRYL HRIYVPLMLV NAADDPLVHE
360 370 380 390 400
SLLTIPKSLS EKRENVMFVL PLHGGHLGFF EGSVLFPEPL TWMDKLVVEY
410 420
ANAICQWERN KLQCSDTEQV EADLE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BN19 | H3BN19_HUMAN | Monoacylglycerol lipase ABHD2 | ABHD2 | 55 | Annotation score: | ||
H3BMT2 | H3BMT2_HUMAN | Monoacylglycerol lipase ABHD2 | ABHD2 | 123 | Annotation score: | ||
H3BUZ6 | H3BUZ6_HUMAN | Monoacylglycerol lipase ABHD2 | ABHD2 | 131 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | Y → C in BAD96803 (Ref. 3) Curated | 1 | |
Sequence conflicti | 388 | E → G in BAD96561 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031203 | 253 | R → Q1 PublicationCorresponds to variant dbSNP:rs17851730Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12433 mRNA Translation: CAA30976.1 AF546700 mRNA Translation: AAQ12021.1 AK222841 mRNA Translation: BAD96561.1 AK223083 mRNA Translation: BAD96803.1 BC019248 mRNA Translation: AAH19248.1 BC090052 mRNA Translation: AAH90052.1 |
CCDSi | CCDS10348.1 |
PIRi | A31026 |
RefSeqi | NP_008942.3, NM_007011.7 NP_690888.1, NM_152924.4 XP_005254889.1, XM_005254832.1 XP_005254890.1, XM_005254833.1 XP_011519467.1, XM_011521165.1 |
UniGenei | Hs.122337 |
Genome annotation databases
Ensembli | ENST00000352732; ENSP00000268129; ENSG00000140526 ENST00000565973; ENSP00000455639; ENSG00000140526 |
GeneIDi | 11057 |
KEGGi | hsa:11057 |
UCSCi | uc002bnk.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12433 mRNA Translation: CAA30976.1 AF546700 mRNA Translation: AAQ12021.1 AK222841 mRNA Translation: BAD96561.1 AK223083 mRNA Translation: BAD96803.1 BC019248 mRNA Translation: AAH19248.1 BC090052 mRNA Translation: AAH90052.1 |
CCDSi | CCDS10348.1 |
PIRi | A31026 |
RefSeqi | NP_008942.3, NM_007011.7 NP_690888.1, NM_152924.4 XP_005254889.1, XM_005254832.1 XP_005254890.1, XM_005254833.1 XP_011519467.1, XM_011521165.1 |
UniGenei | Hs.122337 |
3D structure databases
ProteinModelPortali | P08910 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 116242, 1 interactor |
STRINGi | 9606.ENSP00000268129 |
Chemistry databases
SwissLipidsi | SLP:000001546 |
Protein family/group databases
ESTHERi | human-ABHD2 abh_upf0017 |
PTM databases
iPTMneti | P08910 |
PhosphoSitePlusi | P08910 |
SwissPalmi | P08910 |
Polymorphism and mutation databases
BioMutai | ABHD2 |
DMDMi | 123504 |
Proteomic databases
MaxQBi | P08910 |
PaxDbi | P08910 |
PeptideAtlasi | P08910 |
PRIDEi | P08910 |
ProteomicsDBi | 52174 |
Protocols and materials databases
DNASUi | 11057 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000352732; ENSP00000268129; ENSG00000140526 ENST00000565973; ENSP00000455639; ENSG00000140526 |
GeneIDi | 11057 |
KEGGi | hsa:11057 |
UCSCi | uc002bnk.2 human |
Organism-specific databases
CTDi | 11057 |
DisGeNETi | 11057 |
EuPathDBi | HostDB:ENSG00000140526.16 |
GeneCardsi | ABHD2 |
HGNCi | HGNC:18717 ABHD2 |
HPAi | HPA005999 |
MIMi | 612196 gene |
neXtProti | NX_P08910 |
OpenTargetsi | ENSG00000140526 |
PharmGKBi | PA38658 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1838 Eukaryota COG0429 LUCA |
GeneTreei | ENSGT00940000153712 |
HOGENOMi | HOG000230852 |
HOVERGENi | HBG080812 |
InParanoidi | P08910 |
KOi | K13697 |
OMAi | CPWPIGE |
OrthoDBi | 1033151at2759 |
PhylomeDBi | P08910 |
TreeFami | TF313195 |
Miscellaneous databases
ChiTaRSi | ABHD2 human |
GeneWikii | ABHD2 |
GenomeRNAii | 11057 |
PROi | PR:P08910 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140526 Expressed in 225 organ(s), highest expression level in caput epididymis |
ExpressionAtlasi | P08910 baseline and differential |
Genevisiblei | P08910 HS |
Family and domain databases
InterProi | View protein in InterPro IPR029058 AB_hydrolase IPR000073 AB_hydrolase_1 IPR000952 AB_hydrolase_4_CS IPR012020 ABHD4 |
Pfami | View protein in Pfam PF00561 Abhydrolase_1, 1 hit |
PIRSFi | PIRSF005211 Ab_hydro_YheT, 1 hit |
SUPFAMi | SSF53474 SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS01133 UPF0017, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | ABHD2_HUMAN | |
Accessioni | P08910Primary (citable) accession number: P08910 Secondary accession number(s): Q53G48 Q8TC79 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | February 13, 2019 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations