HTR1A

Functionⁱ

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca²⁺ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.4 Publications

GO - Molecular functionⁱ

G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled serotonin receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8393041
neurotransmitter receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
receptor-receptor interaction
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 24157794
serotonin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting serotonin receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 8393041
behavioral fear response Source: UniProtKB
cell proliferation Source: InterPro
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
exploration behavior Source: UniProtKB
G protein-coupled receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22957663
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 1330092
regulation of behavior Source: InterPro
regulation of dopamine metabolic process Source: UniProtKB
regulation of hormone secretion Source: InterPro
regulation of serotonin secretion Source: UniProtKB
serotonin metabolic process Source: UniProtKB
serotonin receptor signaling pathway Source: UniProtKB
vasoconstriction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Behavior

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P08908

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 1A Short name: 5-HT-1A Short name: 5-HT1A Alternative name(s): G-21 Serotonin receptor 1A
Gene namesⁱ	Name:HTR1A Synonyms:ADRB2RL1, ADRBRL1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000178394.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5286 HTR1A
MIMⁱ	109760 gene
neXtProtⁱ	NX_P08908

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 36	ExtracellularBy similarityAdd BLAST	36
Transmembraneⁱ	37 – 62	Helical; Name=1By similarityAdd BLAST	26
Topological domainⁱ	63 – 73	CytoplasmicBy similarityAdd BLAST	11
Transmembraneⁱ	74 – 98	Helical; Name=2By similarityAdd BLAST	25
Topological domainⁱ	99 – 110	ExtracellularBy similarityAdd BLAST	12
Transmembraneⁱ	111 – 132	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	133 – 152	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	153 – 178	Helical; Name=4By similarityAdd BLAST	26
Topological domainⁱ	179 – 191	ExtracellularBy similarityAdd BLAST	13
Transmembraneⁱ	192 – 217	Helical; Name=5By similarityAdd BLAST	26
Topological domainⁱ	218 – 345	CytoplasmicBy similarityAdd BLAST	128
Transmembraneⁱ	346 – 367	Helical; Name=6By similarityAdd BLAST	22
Topological domainⁱ	368 – 378	ExtracellularBy similarityAdd BLAST	11
Transmembraneⁱ	379 – 403	Helical; Name=7By similarityAdd BLAST	25
Topological domainⁱ	404 – 422	CytoplasmicBy similarityAdd BLAST	19

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Periodic fever, menstrual cycle-dependent (PFMC)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3350
MalaCards human disease database More...MalaCardsⁱ	HTR1A
MIMⁱ	614674 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000178394
Orphanetⁱ	498251 Menstrual cycle-dependent periodic fever
PharmGKBⁱ	PA192

Chemistry databases

ChEMBLⁱ	CHEMBL214
Drug and drug target database More...DrugBankⁱ	DB01614 Acepromazine DB00866 Alprenolol DB01616 Alverine DB00321 Amitriptyline DB00543 Amoxapine DB00714 Apomorphine DB01238 Aripiprazole DB06216 Asenapine DB04888 Bifeprunox DB08807 Bopindolol DB09128 Brexpiprazole DB01200 Bromocriptine DB00490 Buspirone DB00248 Cabergoline DB06016 Cariprazine DB00477 Chlorpromazine DB08810 Cinitapride DB00363 Clozapine DB04884 Dapoxetine DB01151 Desipramine DB00988 Dopamine DB01142 Doxepin DB00216 Eletriptan DB01049 Ergoloid mesylate DB00696 Ergotamine DB04908 Flibanserin DB04946 Iloperidone DB00458 Imipramine DB01221 Ketamine DB04970 Lesopitron DB05509 LI-301 DB00589 Lisuride DB00408 Loxapine DB08815 Lurasidone DB04829 Lysergic Acid Diethylamide DB00247 Methysergide DB06148 Mianserin DB05339 MN-305 DB01618 Molindone DB00952 Naratriptan DB01149 Nefazodone DB00540 Nortriptyline DB00334 Olanzapine DB00904 Ondansetron DB01267 Paliperidone DB01359 Penbutolol DB01186 Pergolide DB00960 Pindolol DB01621 Pipotiazine DB00413 Pramipexole DB00571 Propranolol DB01224 Quetiapine DB00734 Risperidone DB00268 Ropinirole DB05271 Rotigotine DB05280 SLV 308 DB00669 Sumatriptan DB01622 Thioproperazine DB13025 Tiapride DB00656 Trazodone DB00726 Trimipramine DB06684 Vilazodone DB09068 Vortioxetine DB01392 Yohimbine DB00246 Ziprasidone DB00315 Zolmitriptan
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1

Polymorphism and mutation databases

BioMutaⁱ	HTR1A
DMDMⁱ	231454

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068903	1 – 422	5-hydroxytryptamine receptor 1AAdd BLAST		422

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	10	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	11	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	24	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	109 ↔ 187	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P08908
PeptideAtlas More...PeptideAtlasⁱ	P08908
PRIDEⁱ	P08908
ProteomicsDBⁱ	52173

PTM databases

iPTMnetⁱ	P08908
PhosphoSitePlusⁱ	P08908

Expressionⁱ

Tissue specificityⁱ

Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000178394 Expressed in 23 organ(s), highest expression level in temporal lobe
CleanExⁱ	HS_HTR1A
ExpressionAtlasⁱ	P08908 baseline and differential
Genevisibleⁱ	P08908 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018073

HPAⁱ

HPA018073

Interactionⁱ

Subunit structureⁱ

Heterodimer; heterodimerizes with GPER1.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FGFR1	P11362	6	EBI-6570214,EBI-1028277

With

Entry

#Exp.

IntAct

Notes

FGFR1

P11362

6

EBI-6570214,EBI-1028277

GO - Molecular functionⁱ

receptor-receptor interaction
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 24157794

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109582, 6 interactors
CORUMⁱ	P08908
IntActⁱ	P08908, 2 interactors
STRINGⁱ	9606.ENSP00000316244

Chemistry databases

BindingDBⁱ

P08908

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P08908
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	112 – 121	Agonist bindingBy similarity		10
Regionⁱ	358 – 362	Agonist bindingBy similarity		5

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	133 – 135	DRY motif; important for ligand-induced conformation changesBy similarity		3
Motifⁱ	396 – 400	NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity		5

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P08908
KEGG Orthology (KO) More...KOⁱ	K04153
OMAⁱ	YQVLNKW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P08908
TreeFamⁱ	TF316350

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15330 7tmA_5-HT1A_vertebrates, 1 hit
InterProⁱ	View protein in InterPro IPR000610 5HT1A_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF20 PTHR24247:SF20, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00512 5HT1ARECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P08908-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA 
        60         70         80         90        100
VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN 
       110        120        130        140        150
KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP 
       160        170        180        190        200
RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST 
       210        220        230        240        250
FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP 
       260        270        280        290        300
KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN 
       310        320        330        340        350
SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII 
       360        370        380        390        400
MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY 
       410        420 
AYFNKDFQNA FKKIIKCKFC RQ

Length:422

Mass (Da):46,107

Last modified:April 1, 1993 - v3

Checksum:ⁱ762664FCF62CFD8F

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RA34	D6RA34_HUMAN		5-hydroxytryptamine receptor 1A 5-hydroxytryptamine receptor 1A	HTR1A	41	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	152 – 154	RAA → PR in AAA36440 (PubMed:3041227).Curated	3
Sequence conflictⁱ	152 – 154	RAA → PR in CAA31908 (PubMed:3041227).Curated	3
Sequence conflictⁱ	172	M → I in AAA36440 (PubMed:3041227).Curated	1
Sequence conflictⁱ	172	M → I in CAA31908 (PubMed:3041227).Curated	1
Sequence conflictⁱ	200 – 202	TFG → RPR no nucleotide entry (PubMed:8393041).Curated	3
Sequence conflictⁱ	228	K → R no nucleotide entry (PubMed:8393041).Curated	1
Sequence conflictⁱ	244	A → AA no nucleotide entry (PubMed:8393041).Curated	1
Sequence conflictⁱ	355	I → T no nucleotide entry (PubMed:8393041).Curated	1
Sequence conflictⁱ	363 – 365	IVA → MRP no nucleotide entry (PubMed:8393041).Curated	3
Sequence conflictⁱ	418	K → N in AAA36440 (PubMed:3041227).Curated	1
Sequence conflictⁱ	418	K → N in CAA31908 (PubMed:3041227).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_003446	16	P → L1 PublicationCorresponds to variant dbSNP:rs1800041Ensembl.	1
Natural variantⁱVAR_011826	22	G → S1 PublicationCorresponds to variant dbSNP:rs1799920Ensembl.	1
Natural variantⁱVAR_011827	28	I → V1 PublicationCorresponds to variant dbSNP:rs1799921Ensembl.	1
Natural variantⁱVAR_011828	184	P → L. Corresponds to variant dbSNP:rs1800043Ensembl.	1
Natural variantⁱVAR_011829	220	R → L. Corresponds to variant dbSNP:rs1800044Ensembl.	1
Natural variantⁱVAR_011830	273	G → D1 PublicationCorresponds to variant dbSNP:rs1800042Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M28269 Genomic DNA Translation: AAA36440.1 X13556 Genomic DNA Translation: CAA31908.1 X57829 Genomic DNA Translation: CAA40962.1 M83181 Genomic DNA Translation: AAA66493.1 AB041403 Genomic DNA Translation: BAA94488.1 AF498978 mRNA Translation: AAM21125.1 BC069159 mRNA Translation: AAH69159.1 Z11168 Genomic DNA Translation: CAA77560.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34168.1
PIRⁱ	I38209
NCBI Reference Sequences More...RefSeqⁱ	NP_000515.2, NM_000524.3
UniGeneⁱ	Hs.247940

Genome annotation databases

Ensemblⁱ	ENST00000323865; ENSP00000316244; ENSG00000178394
GeneIDⁱ	3350
KEGGⁱ	hsa:3350

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08908	5-hydroxytryptamine (Serotonin) receptor 1A		HUMAN		422	UniRef100_P08908
5-hydroxytryptamine receptor 1A (Fragment)		HUMAN		41

Protein	Similar proteins		Species	Score	Length	Source
P08908	5-hydroxytryptamine receptor 1A		CANLF		423	UniRef90_P08908
5-hydroxytryptamine receptor 1A		VULVU		423
5-hydroxytryptamine receptor 1A		GORGO		422
5-hydroxytryptamine receptor 1A		HORSE		422
5-hydroxytryptamine receptor 1A		PANTR		422
+110

Protein	Similar proteins		Species	Score	Length	Source
P08908	5-hydroxytryptamine receptor 1A		CANLF		423	UniRef50_P08908
5-hydroxytryptamine receptor 1A		VULVU		423
5-hydroxytryptamine receptor 1A		GORGO		422
5-hydroxytryptamine receptor 1A		PANTR		422
5-hydroxytryptamine receptor 1A		HORSE		422
+163

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M28269 Genomic DNA Translation: AAA36440.1 X13556 Genomic DNA Translation: CAA31908.1 X57829 Genomic DNA Translation: CAA40962.1 M83181 Genomic DNA Translation: AAA66493.1 AB041403 Genomic DNA Translation: BAA94488.1 AF498978 mRNA Translation: AAM21125.1 BC069159 mRNA Translation: AAH69159.1 Z11168 Genomic DNA Translation: CAA77560.1
CCDSⁱ	CCDS34168.1
PIRⁱ	I38209
RefSeqⁱ	NP_000515.2, NM_000524.3
UniGeneⁱ	Hs.247940

3D structure databases

ProteinModelPortalⁱ	P08908
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109582, 6 interactors
CORUMⁱ	P08908
IntActⁱ	P08908, 2 interactors
STRINGⁱ	9606.ENSP00000316244

Chemistry databases

BindingDBⁱ	P08908
ChEMBLⁱ	CHEMBL214
DrugBankⁱ	DB01614 Acepromazine DB00866 Alprenolol DB01616 Alverine DB00321 Amitriptyline DB00543 Amoxapine DB00714 Apomorphine DB01238 Aripiprazole DB06216 Asenapine DB04888 Bifeprunox DB08807 Bopindolol DB09128 Brexpiprazole DB01200 Bromocriptine DB00490 Buspirone DB00248 Cabergoline DB06016 Cariprazine DB00477 Chlorpromazine DB08810 Cinitapride DB00363 Clozapine DB04884 Dapoxetine DB01151 Desipramine DB00988 Dopamine DB01142 Doxepin DB00216 Eletriptan DB01049 Ergoloid mesylate DB00696 Ergotamine DB04908 Flibanserin DB04946 Iloperidone DB00458 Imipramine DB01221 Ketamine DB04970 Lesopitron DB05509 LI-301 DB00589 Lisuride DB00408 Loxapine DB08815 Lurasidone DB04829 Lysergic Acid Diethylamide DB00247 Methysergide DB06148 Mianserin DB05339 MN-305 DB01618 Molindone DB00952 Naratriptan DB01149 Nefazodone DB00540 Nortriptyline DB00334 Olanzapine DB00904 Ondansetron DB01267 Paliperidone DB01359 Penbutolol DB01186 Pergolide DB00960 Pindolol DB01621 Pipotiazine DB00413 Pramipexole DB00571 Propranolol DB01224 Quetiapine DB00734 Risperidone DB00268 Ropinirole DB05271 Rotigotine DB05280 SLV 308 DB00669 Sumatriptan DB01622 Thioproperazine DB13025 Tiapride DB00656 Trazodone DB00726 Trimipramine DB06684 Vilazodone DB09068 Vortioxetine DB01392 Yohimbine DB00246 Ziprasidone DB00315 Zolmitriptan
GuidetoPHARMACOLOGYⁱ	1

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P08908
PhosphoSitePlusⁱ	P08908

Polymorphism and mutation databases

BioMutaⁱ	HTR1A
DMDMⁱ	231454

Proteomic databases

PaxDbⁱ	P08908
PeptideAtlasⁱ	P08908
PRIDEⁱ	P08908
ProteomicsDBⁱ	52173

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3350
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000323865; ENSP00000316244; ENSG00000178394
GeneIDⁱ	3350
KEGGⁱ	hsa:3350

Organism-specific databases

CTDⁱ	3350
DisGeNETⁱ	3350
EuPathDBⁱ	HostDB:ENSG00000178394.4
GeneCardsⁱ	HTR1A
HGNCⁱ	HGNC:5286 HTR1A
HPAⁱ	HPA018073
MalaCardsⁱ	HTR1A
MIMⁱ	109760 gene 614674 phenotype
neXtProtⁱ	NX_P08908
OpenTargetsⁱ	ENSG00000178394
Orphanetⁱ	498251 Menstrual cycle-dependent periodic fever
PharmGKBⁱ	PA192
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P08908
KOⁱ	K04153
OMAⁱ	YQVLNKW
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P08908
TreeFamⁱ	TF316350

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P08908

Miscellaneous databases

GenomeRNAiⁱ	3350
Protein Ontology More...PROⁱ	PR:P08908
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000178394 Expressed in 23 organ(s), highest expression level in temporal lobe
CleanExⁱ	HS_HTR1A
ExpressionAtlasⁱ	P08908 baseline and differential
Genevisibleⁱ	P08908 HS

Family and domain databases

CDDⁱ	cd15330 7tmA_5-HT1A_vertebrates, 1 hit
InterProⁱ	View protein in InterPro IPR000610 5HT1A_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF20 PTHR24247:SF20, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00512 5HT1ARECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	5HT1A_HUMAN
Accessionⁱ	P08908Primary (citable) accession number: P08908 Secondary accession number(s): Q6LAE7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
	Last sequence update:	April 1, 1993
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P08908 (5HT1A_HUMAN)

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5-hydroxytryptamine receptor 1A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ