UniProtKB - P08908 (5HT1A_HUMAN)
Protein
5-hydroxytryptamine receptor 1A
Gene
HTR1A
Organism
Homo sapiens (Human)
Status
Functioni
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.4 Publications
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- G protein-coupled serotonin receptor activity Source: UniProtKB
- neurotransmitter receptor activity Source: GO_Central
- receptor-receptor interaction Source: ParkinsonsUK-UCL
- serotonin binding Source: GO_Central
GO - Biological processi
- adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: UniProtKB
- behavioral fear response Source: UniProtKB
- chemical synaptic transmission Source: GO_Central
- exploration behavior Source: UniProtKB
- gamma-aminobutyric acid signaling pathway Source: Ensembl
- G protein-coupled receptor signaling pathway Source: UniProtKB
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- positive regulation of cell population proliferation Source: ProtInc
- regulation of behavior Source: InterPro
- regulation of dopamine metabolic process Source: UniProtKB
- regulation of hormone secretion Source: InterPro
- regulation of serotonin secretion Source: UniProtKB
- regulation of vasoconstriction Source: InterPro
- serotonin metabolic process Source: UniProtKB
- serotonin receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Behavior |
Enzyme and pathway databases
PathwayCommonsi | P08908 |
Reactomei | R-HSA-390666, Serotonin receptors |
SIGNORi | P08908 |
Protein family/group databases
TCDBi | 9.A.14.3.14, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 1AShort name: 5-HT-1A Short name: 5-HT1A Alternative name(s): G-21 Serotonin receptor 1A |
Gene namesi | Name:HTR1A Synonyms:ADRB2RL1, ADRBRL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5286, HTR1A |
MIMi | 109760, gene |
neXtProti | NX_P08908 |
VEuPathDBi | HostDB:ENSG00000178394.4 |
Subcellular locationi
Plasma membrane
- Cell membrane 4 Publications; Multi-pass membrane protein 4 Publications
Other locations
- dendrite By similarity
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 36 | ExtracellularBy similarityAdd BLAST | 36 | |
Transmembranei | 37 – 62 | Helical; Name=1By similarityAdd BLAST | 26 | |
Topological domaini | 63 – 73 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 74 – 98 | Helical; Name=2By similarityAdd BLAST | 25 | |
Topological domaini | 99 – 110 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 111 – 132 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 133 – 152 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 153 – 178 | Helical; Name=4By similarityAdd BLAST | 26 | |
Topological domaini | 179 – 191 | ExtracellularBy similarityAdd BLAST | 13 | |
Transmembranei | 192 – 217 | Helical; Name=5By similarityAdd BLAST | 26 | |
Topological domaini | 218 – 345 | CytoplasmicBy similarityAdd BLAST | 128 | |
Transmembranei | 346 – 367 | Helical; Name=6By similarityAdd BLAST | 22 | |
Topological domaini | 368 – 378 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 379 – 403 | Helical; Name=7By similarityAdd BLAST | 25 | |
Topological domaini | 404 – 422 | CytoplasmicBy similarityAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePathology & Biotechi
Involvement in diseasei
Periodic fever, menstrual cycle-dependent (PFMC)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines.
Related information in OMIMOrganism-specific databases
DisGeNETi | 3350 |
MalaCardsi | HTR1A |
MIMi | 614674, phenotype |
OpenTargetsi | ENSG00000178394 |
Orphaneti | 498251, Menstrual cycle-dependent periodic fever |
PharmGKBi | PA192 |
Miscellaneous databases
Pharosi | P08908, Tclin |
Chemistry databases
ChEMBLi | CHEMBL214 |
DrugBanki | DB14010, 5-methoxy-N,N-dimethyltryptamine DB01614, Acepromazine DB00866, Alprenolol DB01616, Alverine DB00321, Amitriptyline DB00543, Amoxapine DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB04888, Bifeprunox DB08807, Bopindolol DB09128, Brexpiprazole DB01200, Bromocriptine DB00490, Buspirone DB00248, Cabergoline DB09061, Cannabidiol DB06016, Cariprazine DB00477, Chlorpromazine DB01239, Chlorprothixene DB08810, Cinitapride DB00363, Clozapine DB04884, Dapoxetine DB01151, Desipramine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB00988, Dopamine DB09167, Dosulepin DB06446, Dotarizine DB01142, Doxepin DB00216, Eletriptan DB01049, Ergoloid mesylate DB00696, Ergotamine DB01175, Escitalopram DB04908, Flibanserin DB12141, Gilteritinib DB00502, Haloperidol DB04946, Iloperidone DB00458, Imipramine DB01221, Ketamine DB04970, Lesopitron DB05509, LI-301 DB00589, Lisuride DB04948, Lofexidine DB00408, Loxapine DB08815, Lurasidone DB04829, Lysergic acid diethylamide DB14009, Medical Cannabis DB00422, Methylphenidate DB00247, Methysergide DB06148, Mianserin DB05339, MN-305 DB01618, Molindone DB14011, Nabiximols DB05562, Naluzotan DB00952, Naratriptan DB01149, Nefazodone DB00540, Nortriptyline DB00334, Olanzapine DB00904, Ondansetron DB01267, Paliperidone DB12061, Pardoprunox DB00715, Paroxetine DB01359, Penbutolol DB01186, Pergolide DB08922, Perospirone DB00960, Pindolol DB01621, Pipotiazine DB09244, Pirlindole DB06153, Pizotifen DB00413, Pramipexole DB00571, Propranolol DB01224, Quetiapine DB06506, Repinotan DB00734, Risperidone DB06538, Robalzotan DB05271, Rotigotine DB06454, Sarizotan DB15665, SEP-363856 DB09304, Setiptiline DB00669, Sumatriptan DB11755, Tetrahydrocannabivarin DB01622, Thioproperazine DB09289, Tianeptine DB13025, Tiapride DB00656, Trazodone DB00726, Trimipramine DB06684, Vilazodone DB09068, Vortioxetine DB06393, Xaliproden DB01392, Yohimbine DB00246, Ziprasidone DB00315, Zolmitriptan |
DrugCentrali | P08908 |
GuidetoPHARMACOLOGYi | 1 |
Genetic variation databases
BioMutai | HTR1A |
DMDMi | 231454 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068903 | 1 – 422 | 5-hydroxytryptamine receptor 1AAdd BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 10 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 24 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 109 ↔ 187 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P08908 |
PaxDbi | P08908 |
PeptideAtlasi | P08908 |
PRIDEi | P08908 |
ProteomicsDBi | 52173 |
PTM databases
GlyGeni | P08908, 3 sites |
iPTMneti | P08908 |
PhosphoSitePlusi | P08908 |
SwissPalmi | P08908 |
Expressioni
Tissue specificityi
Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.2 Publications
Gene expression databases
Bgeei | ENSG00000178394, Expressed in temporal lobe and 36 other tissues |
ExpressionAtlasi | P08908, baseline and differential |
Genevisiblei | P08908, HS |
Organism-specific databases
HPAi | ENSG00000178394, Group enriched (brain, ovary) |
Interactioni
Subunit structurei
Heterodimer; heterodimerizes with GPER1.
Interacts with YIF1B (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsP08908
With | #Exp. | IntAct |
---|---|---|
FGFR1 [P11362] | 9 | EBI-6570214,EBI-1028277 |
GALR1 [P47211] | 4 | EBI-6570214,EBI-6624741 |
GPR39 [O43194] | 4 | EBI-6570214,EBI-7165599 |
HTR2A [P28223] | 3 | EBI-6570214,EBI-6656333 |
GO - Molecular functioni
- receptor-receptor interaction Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 109582, 7 interactors |
CORUMi | P08908 |
IntActi | P08908, 6 interactors |
STRINGi | 9606.ENSP00000316244 |
Chemistry databases
BindingDBi | P08908 |
Miscellaneous databases
RNActi | P08908, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 112 – 121 | Agonist bindingBy similarity | 10 | |
Regioni | 358 – 362 | Agonist bindingBy similarity | 5 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 133 – 135 | DRY motif; important for ligand-induced conformation changesBy similarity | 3 | |
Motifi | 396 – 400 | NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity | 5 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000154484 |
HOGENOMi | CLU_009579_11_1_1 |
InParanoidi | P08908 |
OMAi | DPGYTIY |
OrthoDBi | 703991at2759 |
PhylomeDBi | P08908 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR000610, 5HT1A_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF20, PTHR24247:SF20, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00512, 5HT1ARECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P08908-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA
60 70 80 90 100
VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN
110 120 130 140 150
KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP
160 170 180 190 200
RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST
210 220 230 240 250
FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP
260 270 280 290 300
KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN
310 320 330 340 350
SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII
360 370 380 390 400
MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY
410 420
AYFNKDFQNA FKKIIKCKFC RQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RA34 | D6RA34_HUMAN | 5-hydroxytryptamine receptor 1A | HTR1A | 41 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 152 – 154 | RAA → PR in AAA36440 (PubMed:3041227).Curated | 3 | |
Sequence conflicti | 152 – 154 | RAA → PR in CAA31908 (PubMed:3041227).Curated | 3 | |
Sequence conflicti | 172 | M → I in AAA36440 (PubMed:3041227).Curated | 1 | |
Sequence conflicti | 172 | M → I in CAA31908 (PubMed:3041227).Curated | 1 | |
Sequence conflicti | 200 – 202 | TFG → RPR no nucleotide entry (PubMed:8393041).Curated | 3 | |
Sequence conflicti | 228 | K → R no nucleotide entry (PubMed:8393041).Curated | 1 | |
Sequence conflicti | 244 | A → AA no nucleotide entry (PubMed:8393041).Curated | 1 | |
Sequence conflicti | 355 | I → T no nucleotide entry (PubMed:8393041).Curated | 1 | |
Sequence conflicti | 363 – 365 | IVA → MRP no nucleotide entry (PubMed:8393041).Curated | 3 | |
Sequence conflicti | 418 | K → N in AAA36440 (PubMed:3041227).Curated | 1 | |
Sequence conflicti | 418 | K → N in CAA31908 (PubMed:3041227).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003446 | 16 | P → L1 PublicationCorresponds to variant dbSNP:rs1800041EnsemblClinVar. | 1 | |
Natural variantiVAR_011826 | 22 | G → S1 PublicationCorresponds to variant dbSNP:rs1799920Ensembl. | 1 | |
Natural variantiVAR_011827 | 28 | I → V1 PublicationCorresponds to variant dbSNP:rs1799921EnsemblClinVar. | 1 | |
Natural variantiVAR_011828 | 184 | P → L. Corresponds to variant dbSNP:rs1800043Ensembl. | 1 | |
Natural variantiVAR_011829 | 220 | R → L. Corresponds to variant dbSNP:rs1800044Ensembl. | 1 | |
Natural variantiVAR_011830 | 273 | G → D1 PublicationCorresponds to variant dbSNP:rs1800042EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M28269 Genomic DNA Translation: AAA36440.1 X13556 Genomic DNA Translation: CAA31908.1 X57829 Genomic DNA Translation: CAA40962.1 M83181 Genomic DNA Translation: AAA66493.1 AB041403 Genomic DNA Translation: BAA94488.1 AF498978 mRNA Translation: AAM21125.1 BC069159 mRNA Translation: AAH69159.1 Z11168 Genomic DNA Translation: CAA77560.1 |
CCDSi | CCDS34168.1 |
PIRi | I38209 |
RefSeqi | NP_000515.2, NM_000524.3 |
Genome annotation databases
Ensembli | ENST00000323865; ENSP00000316244; ENSG00000178394 |
GeneIDi | 3350 |
KEGGi | hsa:3350 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M28269 Genomic DNA Translation: AAA36440.1 X13556 Genomic DNA Translation: CAA31908.1 X57829 Genomic DNA Translation: CAA40962.1 M83181 Genomic DNA Translation: AAA66493.1 AB041403 Genomic DNA Translation: BAA94488.1 AF498978 mRNA Translation: AAM21125.1 BC069159 mRNA Translation: AAH69159.1 Z11168 Genomic DNA Translation: CAA77560.1 |
CCDSi | CCDS34168.1 |
PIRi | I38209 |
RefSeqi | NP_000515.2, NM_000524.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 109582, 7 interactors |
CORUMi | P08908 |
IntActi | P08908, 6 interactors |
STRINGi | 9606.ENSP00000316244 |
Chemistry databases
BindingDBi | P08908 |
ChEMBLi | CHEMBL214 |
DrugBanki | DB14010, 5-methoxy-N,N-dimethyltryptamine DB01614, Acepromazine DB00866, Alprenolol DB01616, Alverine DB00321, Amitriptyline DB00543, Amoxapine DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB06216, Asenapine DB04888, Bifeprunox DB08807, Bopindolol DB09128, Brexpiprazole DB01200, Bromocriptine DB00490, Buspirone DB00248, Cabergoline DB09061, Cannabidiol DB06016, Cariprazine DB00477, Chlorpromazine DB01239, Chlorprothixene DB08810, Cinitapride DB00363, Clozapine DB04884, Dapoxetine DB01151, Desipramine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB00988, Dopamine DB09167, Dosulepin DB06446, Dotarizine DB01142, Doxepin DB00216, Eletriptan DB01049, Ergoloid mesylate DB00696, Ergotamine DB01175, Escitalopram DB04908, Flibanserin DB12141, Gilteritinib DB00502, Haloperidol DB04946, Iloperidone DB00458, Imipramine DB01221, Ketamine DB04970, Lesopitron DB05509, LI-301 DB00589, Lisuride DB04948, Lofexidine DB00408, Loxapine DB08815, Lurasidone DB04829, Lysergic acid diethylamide DB14009, Medical Cannabis DB00422, Methylphenidate DB00247, Methysergide DB06148, Mianserin DB05339, MN-305 DB01618, Molindone DB14011, Nabiximols DB05562, Naluzotan DB00952, Naratriptan DB01149, Nefazodone DB00540, Nortriptyline DB00334, Olanzapine DB00904, Ondansetron DB01267, Paliperidone DB12061, Pardoprunox DB00715, Paroxetine DB01359, Penbutolol DB01186, Pergolide DB08922, Perospirone DB00960, Pindolol DB01621, Pipotiazine DB09244, Pirlindole DB06153, Pizotifen DB00413, Pramipexole DB00571, Propranolol DB01224, Quetiapine DB06506, Repinotan DB00734, Risperidone DB06538, Robalzotan DB05271, Rotigotine DB06454, Sarizotan DB15665, SEP-363856 DB09304, Setiptiline DB00669, Sumatriptan DB11755, Tetrahydrocannabivarin DB01622, Thioproperazine DB09289, Tianeptine DB13025, Tiapride DB00656, Trazodone DB00726, Trimipramine DB06684, Vilazodone DB09068, Vortioxetine DB06393, Xaliproden DB01392, Yohimbine DB00246, Ziprasidone DB00315, Zolmitriptan |
DrugCentrali | P08908 |
GuidetoPHARMACOLOGYi | 1 |
Protein family/group databases
TCDBi | 9.A.14.3.14, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P08908, 3 sites |
iPTMneti | P08908 |
PhosphoSitePlusi | P08908 |
SwissPalmi | P08908 |
Genetic variation databases
BioMutai | HTR1A |
DMDMi | 231454 |
Proteomic databases
MassIVEi | P08908 |
PaxDbi | P08908 |
PeptideAtlasi | P08908 |
PRIDEi | P08908 |
ProteomicsDBi | 52173 |
Protocols and materials databases
Antibodypediai | 2959, 309 antibodies |
DNASUi | 3350 |
Genome annotation databases
Ensembli | ENST00000323865; ENSP00000316244; ENSG00000178394 |
GeneIDi | 3350 |
KEGGi | hsa:3350 |
Organism-specific databases
CTDi | 3350 |
DisGeNETi | 3350 |
GeneCardsi | HTR1A |
HGNCi | HGNC:5286, HTR1A |
HPAi | ENSG00000178394, Group enriched (brain, ovary) |
MalaCardsi | HTR1A |
MIMi | 109760, gene 614674, phenotype |
neXtProti | NX_P08908 |
OpenTargetsi | ENSG00000178394 |
Orphaneti | 498251, Menstrual cycle-dependent periodic fever |
PharmGKBi | PA192 |
VEuPathDBi | HostDB:ENSG00000178394.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000154484 |
HOGENOMi | CLU_009579_11_1_1 |
InParanoidi | P08908 |
OMAi | DPGYTIY |
OrthoDBi | 703991at2759 |
PhylomeDBi | P08908 |
TreeFami | TF316350 |
Enzyme and pathway databases
PathwayCommonsi | P08908 |
Reactomei | R-HSA-390666, Serotonin receptors |
SIGNORi | P08908 |
Miscellaneous databases
BioGRID-ORCSi | 3350, 3 hits in 870 CRISPR screens |
GenomeRNAii | 3350 |
Pharosi | P08908, Tclin |
PROi | PR:P08908 |
RNActi | P08908, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178394, Expressed in temporal lobe and 36 other tissues |
ExpressionAtlasi | P08908, baseline and differential |
Genevisiblei | P08908, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000610, 5HT1A_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF20, PTHR24247:SF20, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00512, 5HT1ARECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 5HT1A_HUMAN | |
Accessioni | P08908Primary (citable) accession number: P08908 Secondary accession number(s): Q6LAE7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | April 1, 1993 | |
Last modified: | February 10, 2021 | |
This is version 193 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries