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UniProtKB - P08908 (5HT1A_HUMAN)

Entry version 193 (10 Feb 2021)
Sequence version 3 (01 Apr 1993)
Previous versions | rss
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Protein

5-hydroxytryptamine receptor 1A

Gene

HTR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08908

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390666, Serotonin receptors

SIGNOR Signaling Network Open Resource

More...SIGNORi		P08908

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.3.14, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1A
Short name:
5-HT-1A
Short name:
5-HT1A
Alternative name(s):
G-21
Serotonin receptor 1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTR1A
Synonyms:ADRB2RL1, ADRBRL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5286, HTR1A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		109760, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08908

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000178394.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36ExtracellularBy similarityAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 62Helical; Name=1By similarityAdd BLAST26
Topological domaini63 – 73CytoplasmicBy similarityAdd BLAST11
Transmembranei74 – 98Helical; Name=2By similarityAdd BLAST25
Topological domaini99 – 110ExtracellularBy similarityAdd BLAST12
Transmembranei111 – 132Helical; Name=3By similarityAdd BLAST22
Topological domaini133 – 152CytoplasmicBy similarityAdd BLAST20
Transmembranei153 – 178Helical; Name=4By similarityAdd BLAST26
Topological domaini179 – 191ExtracellularBy similarityAdd BLAST13
Transmembranei192 – 217Helical; Name=5By similarityAdd BLAST26
Topological domaini218 – 345CytoplasmicBy similarityAdd BLAST128
Transmembranei346 – 367Helical; Name=6By similarityAdd BLAST22
Topological domaini368 – 378ExtracellularBy similarityAdd BLAST11
Transmembranei379 – 403Helical; Name=7By similarityAdd BLAST25
Topological domaini404 – 422CytoplasmicBy similarityAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Periodic fever, menstrual cycle-dependent (PFMC)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		3350

MalaCards human disease database

More...MalaCardsi		HTR1A
MIMi614674, phenotype

Open Targets

More...OpenTargetsi		ENSG00000178394

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		498251, Menstrual cycle-dependent periodic fever

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA192

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08908, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL214

Drug and drug target database

More...DrugBanki		DB14010, 5-methoxy-N,N-dimethyltryptamine
DB01614, Acepromazine
DB00866, Alprenolol
DB01616, Alverine
DB00321, Amitriptyline
DB00543, Amoxapine
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB06216, Asenapine
DB04888, Bifeprunox
DB08807, Bopindolol
DB09128, Brexpiprazole
DB01200, Bromocriptine
DB00490, Buspirone
DB00248, Cabergoline
DB09061, Cannabidiol
DB06016, Cariprazine
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB08810, Cinitapride
DB00363, Clozapine
DB04884, Dapoxetine
DB01151, Desipramine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB00988, Dopamine
DB09167, Dosulepin
DB06446, Dotarizine
DB01142, Doxepin
DB00216, Eletriptan
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB01175, Escitalopram
DB04908, Flibanserin
DB12141, Gilteritinib
DB00502, Haloperidol
DB04946, Iloperidone
DB00458, Imipramine
DB01221, Ketamine
DB04970, Lesopitron
DB05509, LI-301
DB00589, Lisuride
DB04948, Lofexidine
DB00408, Loxapine
DB08815, Lurasidone
DB04829, Lysergic acid diethylamide
DB14009, Medical Cannabis
DB00422, Methylphenidate
DB00247, Methysergide
DB06148, Mianserin
DB05339, MN-305
DB01618, Molindone
DB14011, Nabiximols
DB05562, Naluzotan
DB00952, Naratriptan
DB01149, Nefazodone
DB00540, Nortriptyline
DB00334, Olanzapine
DB00904, Ondansetron
DB01267, Paliperidone
DB12061, Pardoprunox
DB00715, Paroxetine
DB01359, Penbutolol
DB01186, Pergolide
DB08922, Perospirone
DB00960, Pindolol
DB01621, Pipotiazine
DB09244, Pirlindole
DB06153, Pizotifen
DB00413, Pramipexole
DB00571, Propranolol
DB01224, Quetiapine
DB06506, Repinotan
DB00734, Risperidone
DB06538, Robalzotan
DB05271, Rotigotine
DB06454, Sarizotan
DB15665, SEP-363856
DB09304, Setiptiline
DB00669, Sumatriptan
DB11755, Tetrahydrocannabivarin
DB01622, Thioproperazine
DB09289, Tianeptine
DB13025, Tiapride
DB00656, Trazodone
DB00726, Trimipramine
DB06684, Vilazodone
DB09068, Vortioxetine
DB06393, Xaliproden
DB01392, Yohimbine
DB00246, Ziprasidone
DB00315, Zolmitriptan

DrugCentral

More...DrugCentrali		P08908

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HTR1A

Domain mapping of disease mutations (DMDM)

More...DMDMi		231454

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000689031 – 4225-hydroxytryptamine receptor 1AAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi109 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08908

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08908

PeptideAtlas

More...PeptideAtlasi		P08908

PRoteomics IDEntifications database

More...PRIDEi		P08908

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52173

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P08908, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08908

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08908

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P08908

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000178394, Expressed in temporal lobe and 36 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P08908, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08908, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000178394, Group enriched (brain, ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; heterodimerizes with GPER1.

Interacts with YIF1B (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109582, 7 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P08908

Protein interaction database and analysis system

More...IntActi		P08908, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000316244

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P08908

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08908, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni112 – 121Agonist bindingBy similarity10
Regioni358 – 362Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi133 – 135DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi396 – 400NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154484

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08908

Identification of Orthologs from Complete Genome Data

More...OMAi		DPGYTIY

Database of Orthologous Groups

More...OrthoDBi		703991at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08908

TreeFam database of animal gene trees

More...TreeFami		TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000610, 5HT1A_rcpt
IPR002231, 5HT_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...PANTHERi		PTHR24247:SF20, PTHR24247:SF20, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00512, 5HT1ARECEPTR
PR01101, 5HTRECEPTOR
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P08908-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA 
        60         70         80         90        100
VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN 
       110        120        130        140        150
KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP 
       160        170        180        190        200
RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST 
       210        220        230        240        250
FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP 
       260        270        280        290        300
KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN 
       310        320        330        340        350
SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII 
       360        370        380        390        400
MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY 
       410        420 
AYFNKDFQNA FKKIIKCKFC RQ
Length:422
Mass (Da):46,107
Last modified:April 1, 1993 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i762664FCF62CFD8F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RA34D6RA34_HUMAN
5-hydroxytryptamine receptor 1A
HTR1A
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152 – 154RAA → PR in AAA36440 (PubMed:3041227).Curated3
Sequence conflicti152 – 154RAA → PR in CAA31908 (PubMed:3041227).Curated3
Sequence conflicti172M → I in AAA36440 (PubMed:3041227).Curated1
Sequence conflicti172M → I in CAA31908 (PubMed:3041227).Curated1
Sequence conflicti200 – 202TFG → RPR no nucleotide entry (PubMed:8393041).Curated3
Sequence conflicti228K → R no nucleotide entry (PubMed:8393041).Curated1
Sequence conflicti244A → AA no nucleotide entry (PubMed:8393041).Curated1
Sequence conflicti355I → T no nucleotide entry (PubMed:8393041).Curated1
Sequence conflicti363 – 365IVA → MRP no nucleotide entry (PubMed:8393041).Curated3
Sequence conflicti418K → N in AAA36440 (PubMed:3041227).Curated1
Sequence conflicti418K → N in CAA31908 (PubMed:3041227).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00344616P → L1 PublicationCorresponds to variant dbSNP:rs1800041EnsemblClinVar.1
Natural variantiVAR_01182622G → S1 PublicationCorresponds to variant dbSNP:rs1799920Ensembl.1
Natural variantiVAR_01182728I → V1 PublicationCorresponds to variant dbSNP:rs1799921EnsemblClinVar.1
Natural variantiVAR_011828184P → L. Corresponds to variant dbSNP:rs1800043Ensembl.1
Natural variantiVAR_011829220R → L. Corresponds to variant dbSNP:rs1800044Ensembl.1
Natural variantiVAR_011830273G → D1 PublicationCorresponds to variant dbSNP:rs1800042EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M28269 Genomic DNA Translation: AAA36440.1
X13556 Genomic DNA Translation: CAA31908.1
X57829 Genomic DNA Translation: CAA40962.1
M83181 Genomic DNA Translation: AAA66493.1
AB041403 Genomic DNA Translation: BAA94488.1
AF498978 mRNA Translation: AAM21125.1
BC069159 mRNA Translation: AAH69159.1
Z11168 Genomic DNA Translation: CAA77560.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34168.1

Protein sequence database of the Protein Information Resource

More...PIRi		I38209

NCBI Reference Sequences

More...RefSeqi		NP_000515.2, NM_000524.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000323865; ENSP00000316244; ENSG00000178394

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3350

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3350

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28269 Genomic DNA Translation: AAA36440.1
X13556 Genomic DNA Translation: CAA31908.1
X57829 Genomic DNA Translation: CAA40962.1
M83181 Genomic DNA Translation: AAA66493.1
AB041403 Genomic DNA Translation: BAA94488.1
AF498978 mRNA Translation: AAM21125.1
BC069159 mRNA Translation: AAH69159.1
Z11168 Genomic DNA Translation: CAA77560.1
CCDSiCCDS34168.1
PIRiI38209
RefSeqiNP_000515.2, NM_000524.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi109582, 7 interactors
CORUMiP08908
IntActiP08908, 6 interactors
STRINGi9606.ENSP00000316244

Chemistry databases

BindingDBiP08908
ChEMBLiCHEMBL214
DrugBankiDB14010, 5-methoxy-N,N-dimethyltryptamine
DB01614, Acepromazine
DB00866, Alprenolol
DB01616, Alverine
DB00321, Amitriptyline
DB00543, Amoxapine
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB06216, Asenapine
DB04888, Bifeprunox
DB08807, Bopindolol
DB09128, Brexpiprazole
DB01200, Bromocriptine
DB00490, Buspirone
DB00248, Cabergoline
DB09061, Cannabidiol
DB06016, Cariprazine
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB08810, Cinitapride
DB00363, Clozapine
DB04884, Dapoxetine
DB01151, Desipramine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB00988, Dopamine
DB09167, Dosulepin
DB06446, Dotarizine
DB01142, Doxepin
DB00216, Eletriptan
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB01175, Escitalopram
DB04908, Flibanserin
DB12141, Gilteritinib
DB00502, Haloperidol
DB04946, Iloperidone
DB00458, Imipramine
DB01221, Ketamine
DB04970, Lesopitron
DB05509, LI-301
DB00589, Lisuride
DB04948, Lofexidine
DB00408, Loxapine
DB08815, Lurasidone
DB04829, Lysergic acid diethylamide
DB14009, Medical Cannabis
DB00422, Methylphenidate
DB00247, Methysergide
DB06148, Mianserin
DB05339, MN-305
DB01618, Molindone
DB14011, Nabiximols
DB05562, Naluzotan
DB00952, Naratriptan
DB01149, Nefazodone
DB00540, Nortriptyline
DB00334, Olanzapine
DB00904, Ondansetron
DB01267, Paliperidone
DB12061, Pardoprunox
DB00715, Paroxetine
DB01359, Penbutolol
DB01186, Pergolide
DB08922, Perospirone
DB00960, Pindolol
DB01621, Pipotiazine
DB09244, Pirlindole
DB06153, Pizotifen
DB00413, Pramipexole
DB00571, Propranolol
DB01224, Quetiapine
DB06506, Repinotan
DB00734, Risperidone
DB06538, Robalzotan
DB05271, Rotigotine
DB06454, Sarizotan
DB15665, SEP-363856
DB09304, Setiptiline
DB00669, Sumatriptan
DB11755, Tetrahydrocannabivarin
DB01622, Thioproperazine
DB09289, Tianeptine
DB13025, Tiapride
DB00656, Trazodone
DB00726, Trimipramine
DB06684, Vilazodone
DB09068, Vortioxetine
DB06393, Xaliproden
DB01392, Yohimbine
DB00246, Ziprasidone
DB00315, Zolmitriptan
DrugCentraliP08908
GuidetoPHARMACOLOGYi1

Protein family/group databases

TCDBi9.A.14.3.14, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP08908, 3 sites
iPTMnetiP08908
PhosphoSitePlusiP08908
SwissPalmiP08908

Genetic variation databases

BioMutaiHTR1A
DMDMi231454

Proteomic databases

MassIVEiP08908
PaxDbiP08908
PeptideAtlasiP08908
PRIDEiP08908
ProteomicsDBi52173

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2959, 309 antibodies

The DNASU plasmid repository

More...DNASUi		3350

Genome annotation databases

EnsembliENST00000323865; ENSP00000316244; ENSG00000178394
GeneIDi3350
KEGGihsa:3350

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3350
DisGeNETi3350

GeneCards: human genes, protein and diseases

More...GeneCardsi		HTR1A
HGNCiHGNC:5286, HTR1A
HPAiENSG00000178394, Group enriched (brain, ovary)
MalaCardsiHTR1A
MIMi109760, gene
614674, phenotype
neXtProtiNX_P08908
OpenTargetsiENSG00000178394
Orphaneti498251, Menstrual cycle-dependent periodic fever
PharmGKBiPA192
VEuPathDBiHostDB:ENSG00000178394.4

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00940000154484
HOGENOMiCLU_009579_11_1_1
InParanoidiP08908
OMAiDPGYTIY
OrthoDBi703991at2759
PhylomeDBiP08908
TreeFamiTF316350

Enzyme and pathway databases

PathwayCommonsiP08908
ReactomeiR-HSA-390666, Serotonin receptors
SIGNORiP08908

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3350, 3 hits in 870 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3350
PharosiP08908, Tclin

Protein Ontology

More...PROi		PR:P08908
RNActiP08908, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000178394, Expressed in temporal lobe and 36 other tissues
ExpressionAtlasiP08908, baseline and differential
GenevisibleiP08908, HS

Family and domain databases

InterProiView protein in InterPro
IPR000610, 5HT1A_rcpt
IPR002231, 5HT_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF20, PTHR24247:SF20, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00512, 5HT1ARECEPTR
PR01101, 5HTRECEPTOR
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5HT1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08908
Secondary accession number(s): Q6LAE7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 1, 1993
Last modified: February 10, 2021
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  6. Human entries with genetic variants
    List of human entries with genetic variants
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