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Entry version 181 (13 Feb 2019)
Sequence version 3 (01 Apr 1993)
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Protein

5-hydroxytryptamine receptor 1A

Gene

HTR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • G protein-coupled serotonin receptor activity Source: UniProtKB
  • neurotransmitter receptor activity Source: GO_Central
  • receptor-receptor interaction Source: ParkinsonsUK-UCL
  • serotonin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

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SIGNORi
P08908

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1A
Short name:
5-HT-1A
Short name:
5-HT1A
Alternative name(s):
G-21
Serotonin receptor 1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTR1A
Synonyms:ADRB2RL1, ADRBRL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000178394.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5286 HTR1A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
109760 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08908

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 36ExtracellularBy similarityAdd BLAST36
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 62Helical; Name=1By similarityAdd BLAST26
Topological domaini63 – 73CytoplasmicBy similarityAdd BLAST11
Transmembranei74 – 98Helical; Name=2By similarityAdd BLAST25
Topological domaini99 – 110ExtracellularBy similarityAdd BLAST12
Transmembranei111 – 132Helical; Name=3By similarityAdd BLAST22
Topological domaini133 – 152CytoplasmicBy similarityAdd BLAST20
Transmembranei153 – 178Helical; Name=4By similarityAdd BLAST26
Topological domaini179 – 191ExtracellularBy similarityAdd BLAST13
Transmembranei192 – 217Helical; Name=5By similarityAdd BLAST26
Topological domaini218 – 345CytoplasmicBy similarityAdd BLAST128
Transmembranei346 – 367Helical; Name=6By similarityAdd BLAST22
Topological domaini368 – 378ExtracellularBy similarityAdd BLAST11
Transmembranei379 – 403Helical; Name=7By similarityAdd BLAST25
Topological domaini404 – 422CytoplasmicBy similarityAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Periodic fever, menstrual cycle-dependent (PFMC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines.
See also OMIM:614674

Organism-specific databases

DisGeNET

More...
DisGeNETi
3350

MalaCards human disease database

More...
MalaCardsi
HTR1A
MIMi614674 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000178394

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
498251 Menstrual cycle-dependent periodic fever

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA192

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL214

Drug and drug target database

More...
DrugBanki
DB01614 Acepromazine
DB00866 Alprenolol
DB01616 Alverine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB04888 Bifeprunox
DB08807 Bopindolol
DB09128 Brexpiprazole
DB01200 Bromocriptine
DB00490 Buspirone
DB00248 Cabergoline
DB06016 Cariprazine
DB00477 Chlorpromazine
DB08810 Cinitapride
DB00363 Clozapine
DB04884 Dapoxetine
DB01151 Desipramine
DB00988 Dopamine
DB01142 Doxepin
DB00216 Eletriptan
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB04908 Flibanserin
DB04946 Iloperidone
DB00458 Imipramine
DB01221 Ketamine
DB04970 Lesopitron
DB05509 LI-301
DB00589 Lisuride
DB00408 Loxapine
DB08815 Lurasidone
DB04829 Lysergic Acid Diethylamide
DB00247 Methysergide
DB06148 Mianserin
DB05339 MN-305
DB01618 Molindone
DB00952 Naratriptan
DB01149 Nefazodone
DB00540 Nortriptyline
DB00334 Olanzapine
DB00904 Ondansetron
DB01267 Paliperidone
DB01359 Penbutolol
DB01186 Pergolide
DB00960 Pindolol
DB01621 Pipotiazine
DB00413 Pramipexole
DB00571 Propranolol
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB05271 Rotigotine
DB05280 SLV 308
DB00669 Sumatriptan
DB01622 Thioproperazine
DB13025 Tiapride
DB00656 Trazodone
DB00726 Trimipramine
DB06684 Vilazodone
DB09068 Vortioxetine
DB01392 Yohimbine
DB00246 Ziprasidone
DB00315 Zolmitriptan

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HTR1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
231454

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000689031 – 4225-hydroxytryptamine receptor 1AAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi109 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P08908

PeptideAtlas

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PeptideAtlasi
P08908

PRoteomics IDEntifications database

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PRIDEi
P08908

ProteomicsDB human proteome resource

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ProteomicsDBi
52173

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08908

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P08908

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000178394 Expressed in 23 organ(s), highest expression level in temporal lobe

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P08908 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P08908 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018073

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; heterodimerizes with GPER1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FGFR1P113626EBI-6570214,EBI-1028277

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109582, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P08908

Protein interaction database and analysis system

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IntActi
P08908, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000316244

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P08908

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P08908

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni112 – 121Agonist bindingBy similarity10
Regioni358 – 362Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi133 – 135DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi396 – 400NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154484

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000239242

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG106962

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P08908

KEGG Orthology (KO)

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KOi
K04153

Identification of Orthologs from Complete Genome Data

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OMAi
YQVLNKW

Database of Orthologous Groups

More...
OrthoDBi
703991at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P08908

TreeFam database of animal gene trees

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TreeFami
TF316350

Family and domain databases

Conserved Domains Database

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CDDi
cd15330 7tmA_5-HT1A_vertebrates, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000610 5HT1A_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

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PANTHERi
PTHR24247:SF20 PTHR24247:SF20, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00512 5HT1ARECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P08908-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA
60 70 80 90 100
VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN
110 120 130 140 150
KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP
160 170 180 190 200
RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST
210 220 230 240 250
FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP
260 270 280 290 300
KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN
310 320 330 340 350
SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII
360 370 380 390 400
MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY
410 420
AYFNKDFQNA FKKIIKCKFC RQ
Length:422
Mass (Da):46,107
Last modified:April 1, 1993 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i762664FCF62CFD8F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RA34D6RA34_HUMAN
5-hydroxytryptamine receptor 1A
HTR1A
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152 – 154RAA → PR in AAA36440 (PubMed:3041227).Curated3
Sequence conflicti152 – 154RAA → PR in CAA31908 (PubMed:3041227).Curated3
Sequence conflicti172M → I in AAA36440 (PubMed:3041227).Curated1
Sequence conflicti172M → I in CAA31908 (PubMed:3041227).Curated1
Sequence conflicti200 – 202TFG → RPR no nucleotide entry (PubMed:8393041).Curated3
Sequence conflicti228K → R no nucleotide entry (PubMed:8393041).Curated1
Sequence conflicti244A → AA no nucleotide entry (PubMed:8393041).Curated1
Sequence conflicti355I → T no nucleotide entry (PubMed:8393041).Curated1
Sequence conflicti363 – 365IVA → MRP no nucleotide entry (PubMed:8393041).Curated3
Sequence conflicti418K → N in AAA36440 (PubMed:3041227).Curated1
Sequence conflicti418K → N in CAA31908 (PubMed:3041227).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00344616P → L1 PublicationCorresponds to variant dbSNP:rs1800041Ensembl.1
Natural variantiVAR_01182622G → S1 PublicationCorresponds to variant dbSNP:rs1799920Ensembl.1
Natural variantiVAR_01182728I → V1 PublicationCorresponds to variant dbSNP:rs1799921Ensembl.1
Natural variantiVAR_011828184P → L. Corresponds to variant dbSNP:rs1800043Ensembl.1
Natural variantiVAR_011829220R → L. Corresponds to variant dbSNP:rs1800044Ensembl.1
Natural variantiVAR_011830273G → D1 PublicationCorresponds to variant dbSNP:rs1800042Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M28269 Genomic DNA Translation: AAA36440.1
X13556 Genomic DNA Translation: CAA31908.1
X57829 Genomic DNA Translation: CAA40962.1
M83181 Genomic DNA Translation: AAA66493.1
AB041403 Genomic DNA Translation: BAA94488.1
AF498978 mRNA Translation: AAM21125.1
BC069159 mRNA Translation: AAH69159.1
Z11168 Genomic DNA Translation: CAA77560.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34168.1

Protein sequence database of the Protein Information Resource

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PIRi
I38209

NCBI Reference Sequences

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RefSeqi
NP_000515.2, NM_000524.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.247940

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000323865; ENSP00000316244; ENSG00000178394

Database of genes from NCBI RefSeq genomes

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GeneIDi
3350

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3350

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28269 Genomic DNA Translation: AAA36440.1
X13556 Genomic DNA Translation: CAA31908.1
X57829 Genomic DNA Translation: CAA40962.1
M83181 Genomic DNA Translation: AAA66493.1
AB041403 Genomic DNA Translation: BAA94488.1
AF498978 mRNA Translation: AAM21125.1
BC069159 mRNA Translation: AAH69159.1
Z11168 Genomic DNA Translation: CAA77560.1
CCDSiCCDS34168.1
PIRiI38209
RefSeqiNP_000515.2, NM_000524.3
UniGeneiHs.247940

3D structure databases

ProteinModelPortaliP08908
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109582, 6 interactors
CORUMiP08908
IntActiP08908, 3 interactors
STRINGi9606.ENSP00000316244

Chemistry databases

BindingDBiP08908
ChEMBLiCHEMBL214
DrugBankiDB01614 Acepromazine
DB00866 Alprenolol
DB01616 Alverine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00714 Apomorphine
DB01238 Aripiprazole
DB06216 Asenapine
DB04888 Bifeprunox
DB08807 Bopindolol
DB09128 Brexpiprazole
DB01200 Bromocriptine
DB00490 Buspirone
DB00248 Cabergoline
DB06016 Cariprazine
DB00477 Chlorpromazine
DB08810 Cinitapride
DB00363 Clozapine
DB04884 Dapoxetine
DB01151 Desipramine
DB00988 Dopamine
DB01142 Doxepin
DB00216 Eletriptan
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB04908 Flibanserin
DB04946 Iloperidone
DB00458 Imipramine
DB01221 Ketamine
DB04970 Lesopitron
DB05509 LI-301
DB00589 Lisuride
DB00408 Loxapine
DB08815 Lurasidone
DB04829 Lysergic Acid Diethylamide
DB00247 Methysergide
DB06148 Mianserin
DB05339 MN-305
DB01618 Molindone
DB00952 Naratriptan
DB01149 Nefazodone
DB00540 Nortriptyline
DB00334 Olanzapine
DB00904 Ondansetron
DB01267 Paliperidone
DB01359 Penbutolol
DB01186 Pergolide
DB00960 Pindolol
DB01621 Pipotiazine
DB00413 Pramipexole
DB00571 Propranolol
DB01224 Quetiapine
DB00734 Risperidone
DB00268 Ropinirole
DB05271 Rotigotine
DB05280 SLV 308
DB00669 Sumatriptan
DB01622 Thioproperazine
DB13025 Tiapride
DB00656 Trazodone
DB00726 Trimipramine
DB06684 Vilazodone
DB09068 Vortioxetine
DB01392 Yohimbine
DB00246 Ziprasidone
DB00315 Zolmitriptan
GuidetoPHARMACOLOGYi1

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiP08908
PhosphoSitePlusiP08908

Polymorphism and mutation databases

BioMutaiHTR1A
DMDMi231454

Proteomic databases

PaxDbiP08908
PeptideAtlasiP08908
PRIDEiP08908
ProteomicsDBi52173

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3350
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323865; ENSP00000316244; ENSG00000178394
GeneIDi3350
KEGGihsa:3350

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3350
DisGeNETi3350
EuPathDBiHostDB:ENSG00000178394.4

GeneCards: human genes, protein and diseases

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GeneCardsi
HTR1A
HGNCiHGNC:5286 HTR1A
HPAiHPA018073
MalaCardsiHTR1A
MIMi109760 gene
614674 phenotype
neXtProtiNX_P08908
OpenTargetsiENSG00000178394
Orphaneti498251 Menstrual cycle-dependent periodic fever
PharmGKBiPA192

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000154484
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP08908
KOiK04153
OMAiYQVLNKW
OrthoDBi703991at2759
PhylomeDBiP08908
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP08908

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3350

Protein Ontology

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PROi
PR:P08908

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000178394 Expressed in 23 organ(s), highest expression level in temporal lobe
ExpressionAtlasiP08908 baseline and differential
GenevisibleiP08908 HS

Family and domain databases

CDDicd15330 7tmA_5-HT1A_vertebrates, 1 hit
InterProiView protein in InterPro
IPR000610 5HT1A_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF20 PTHR24247:SF20, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00512 5HT1ARECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5HT1A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08908
Secondary accession number(s): Q6LAE7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 1, 1993
Last modified: February 13, 2019
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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