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Protein

Lysozyme C-2

Gene

Lyz2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz2 is active against a range of Gram-positive and Gram-negative bacteria. More effective than Lyz1 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria.PROSITE-ProRule annotation1 Publication

Miscellaneous

Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

pH dependencei

Optimum pH is 5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53PROSITE-ProRule annotation1
Active sitei71PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase, Milk protein

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6803157 Antimicrobial peptides

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme C-2 (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Lysozyme C type M
Gene namesi
Name:Lyz2
Synonyms:Lyz, Lyzs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:96897 Lyz2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice display increased inflammation in response to M.luteus infection, impaired digestion of M.luteus cell walls, decreased clearance of P.aeruginosa from infected airways, increased susceptibility to K.pneumoniae infection and increased bacterial burden and mortality following infection with various Gram-negative bacteria. Lyz2 is non-immunogenic in wild-type mice but is rendered immunogenic in mutants.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001847219 – 148Lysozyme C-2Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 146PROSITE-ProRule annotation1 Publication
Disulfide bondi48 ↔ 134PROSITE-ProRule annotation1 Publication
Disulfide bondi83 ↔ 99PROSITE-ProRule annotation1 Publication
Disulfide bondi95 ↔ 113PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP08905
PaxDbiP08905
PeptideAtlasiP08905
PRIDEiP08905

PTM databases

iPTMnetiP08905
PhosphoSitePlusiP08905

Expressioni

Tissue specificityi

Expressed weakly in myeloblasts, moderately in immature macrophages, and strongly in both mature macrophages and macrophage-rich tissues.

Gene expression databases

BgeeiENSMUSG00000069516 Expressed in 244 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_LYZ2
ExpressionAtlasiP08905 baseline and differential
GenevisibleiP08905 MM

Interactioni

Subunit structurei

Monomer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP08905, 4 interactors
MINTiP08905
STRINGi10090.ENSMUSP00000089801

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08905
SMRiP08905
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08905

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD Eukaryota
ENOG4111QHM LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP08905
KOiK13915
OMAiKWESNYN
OrthoDBiEOG091G0R9V
PhylomeDBiP08905
TreeFamiTF324882

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
IPR030056 Lysozyme_C
PANTHERiPTHR11407:SF28 PTHR11407:SF28, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08905-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLLTLGLL LLSVTAQAKV YERCEFARTL KRNGMAGYYG VSLADWVCLA
60 70 80 90 100
QHESNYNTRA TNYNRGDQST DYGIFQINSR YWCNDGKTPR AVNACGINCS
110 120 130 140
ALLQDDITAA IQCAKRVVRD PQGIRAWVAW RAHCQNRDLS QYIRNCGV
Length:148
Mass (Da):16,689
Last modified:November 1, 1990 - v2
Checksum:i5C768DDCD8071BAF
GO

Sequence cautioni

The sequence BAE30022 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE31835 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE34954 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21050
, M21047, M21048, M21049 Genomic DNA Translation: AAA39473.1
AK148516 mRNA Translation: BAE28595.1
AK150998 mRNA Translation: BAE30022.1 Different initiation.
AK153244 mRNA Translation: BAE31835.1 Different initiation.
AK153475 mRNA Translation: BAE32025.1
AK159276 mRNA Translation: BAE34954.1 Different initiation.
AK159640 mRNA Translation: BAE35253.1
BC002069 mRNA Translation: AAH02069.1
BC019611 mRNA Translation: AAH19611.1
BC054463 mRNA Translation: AAH54463.1
CCDSiCCDS48694.1
PIRiA31239
RefSeqiNP_059068.1, NM_017372.3
UniGeneiMm.45436

Genome annotation databases

EnsembliENSMUST00000092163; ENSMUSP00000089801; ENSMUSG00000069516
GeneIDi17105
KEGGimmu:17105
UCSCiuc007hda.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21050
, M21047, M21048, M21049 Genomic DNA Translation: AAA39473.1
AK148516 mRNA Translation: BAE28595.1
AK150998 mRNA Translation: BAE30022.1 Different initiation.
AK153244 mRNA Translation: BAE31835.1 Different initiation.
AK153475 mRNA Translation: BAE32025.1
AK159276 mRNA Translation: BAE34954.1 Different initiation.
AK159640 mRNA Translation: BAE35253.1
BC002069 mRNA Translation: AAH02069.1
BC019611 mRNA Translation: AAH19611.1
BC054463 mRNA Translation: AAH54463.1
CCDSiCCDS48694.1
PIRiA31239
RefSeqiNP_059068.1, NM_017372.3
UniGeneiMm.45436

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IVMNMR-A19-148[»]
ProteinModelPortaliP08905
SMRiP08905
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08905, 4 interactors
MINTiP08905
STRINGi10090.ENSMUSP00000089801

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

PTM databases

iPTMnetiP08905
PhosphoSitePlusiP08905

Proteomic databases

MaxQBiP08905
PaxDbiP08905
PeptideAtlasiP08905
PRIDEiP08905

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092163; ENSMUSP00000089801; ENSMUSG00000069516
GeneIDi17105
KEGGimmu:17105
UCSCiuc007hda.1 mouse

Organism-specific databases

CTDi17105
MGIiMGI:96897 Lyz2

Phylogenomic databases

eggNOGiENOG410IXGD Eukaryota
ENOG4111QHM LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP08905
KOiK13915
OMAiKWESNYN
OrthoDBiEOG091G0R9V
PhylomeDBiP08905
TreeFamiTF324882

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6803157 Antimicrobial peptides

Miscellaneous databases

EvolutionaryTraceiP08905
PROiPR:P08905
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069516 Expressed in 244 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_LYZ2
ExpressionAtlasiP08905 baseline and differential
GenevisibleiP08905 MM

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
IPR030056 Lysozyme_C
PANTHERiPTHR11407:SF28 PTHR11407:SF28, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYZ2_MOUSE
AccessioniPrimary (citable) accession number: P08905
Secondary accession number(s): Q3TXG2
, Q3U5Q2, Q3U690, Q8VE78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1990
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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