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Entry version 176 (02 Dec 2020)
Sequence version 4 (23 Jan 2007)
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Protein

Histone H3

Gene

his-2

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-201722, Formation of the beta-catenin:TCF transactivating complex
R-CEL-2299718, Condensation of Prophase Chromosomes
R-CEL-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:his-2
ORF Names:T10C6.13
AND
Name:his-6
ORF Names:F45F2.13
AND
Name:his-9
ORF Names:ZK131.3
AND
Name:his-13
ORF Names:ZK131.7
AND
Name:his-17
ORF Names:K06C4.5
AND
Name:his-25
ORF Names:ZK131.2
AND
Name:his-27
ORF Names:K06C4.13
AND
Name:his-32
ORF Names:F17E9.10
AND
Name:his-42
ORF Names:F08G2.3
AND
Name:his-45
ORF Names:B0035.10
AND
Name:his-49
ORF Names:F07B7.5
AND
Name:his-55
ORF Names:F54E12.1
AND
Name:his-59
ORF Names:F55G1.2
AND
Name:his-63
ORF Names:F22B3.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome II, Chromosome IV, Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
B0035.10 ; CE03253 ; WBGene00001919 ; his-45
F07B7.5 ; CE03253 ; WBGene00001923 ; his-49
F08G2.3 ; CE03253 ; WBGene00001916 ; his-42
F17E9.10 ; CE03253 ; WBGene00001906 ; his-32
F22B3.2 ; CE03253 ; WBGene00001937 ; his-63
F45F2.13 ; CE03253 ; WBGene00001880 ; his-6
F54E12.1 ; CE03253 ; WBGene00001929 ; his-55
F55G1.2 ; CE03253 ; WBGene00001933 ; his-59
K06C4.13 ; CE03253 ; WBGene00001901 ; his-27
K06C4.5 ; CE03253 ; WBGene00001891 ; his-17
T10C6.13 ; CE03253 ; WBGene00001876 ; his-2
ZK131.2 ; CE03253 ; WBGene00001899 ; his-25
ZK131.3 ; CE03253 ; WBGene00001883 ; his-9
ZK131.7 ; CE03253 ; WBGene00001887 ; his-13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002212972 – 136Histone H3Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5N6,N6,N6-trimethyllysine; alternate4 Publications1
Modified residuei5N6,N6-dimethyllysine; alternate4 Publications1
Modified residuei5N6-acetyllysine; alternate1 Publication1
Modified residuei5N6-methyllysine; alternate4 Publications1
Modified residuei10N6,N6,N6-trimethyllysine; alternate6 Publications1
Modified residuei10N6,N6-dimethyllysine; alternate6 Publications1
Modified residuei10N6-acetyllysine; alternate2 Publications1
Modified residuei11Phosphoserine7 Publications1
Modified residuei15N6-acetyllysine3 Publications1
Modified residuei24N6-acetyllysine1 Publication1
Modified residuei28N6,N6,N6-trimethyllysine; alternate2 Publications1
Modified residuei28N6,N6-dimethyllysine; alternate2 Publications1
Modified residuei28N6-methyllysine; alternate2 Publications1
Modified residuei29Phosphoserine2 Publications1
Modified residuei37N6,N6,N6-trimethyllysine; alternate3 Publications1
Modified residuei37N6,N6-dimethyllysine; alternate3 Publications1
Modified residuei37N6-methyllysine; alternate3 Publications1
Modified residuei80N6-methyllysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.7 Publications
Acetylation is generally linked to gene activation.By similarity
Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.7 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08898

PeptideAtlas

More...
PeptideAtlasi
P08898

PRoteomics IDEntifications database

More...
PRIDEi
P08898

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08898

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001876, Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
42741, 1 interactor
45065, 3 interactors
49588, 1 interactor
50996, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P08898, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.ZK131.7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P08898

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08898

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P08898

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1745, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01010000222250

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_078295_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08898

Database of Orthologous Groups

More...
OrthoDBi
1564596at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08898

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009072, Histone-fold
IPR007125, Histone_H2A/H2B/H3
IPR000164, Histone_H3/CENP-A

The PANTHER Classification System

More...
PANTHERi
PTHR11426, PTHR11426, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00125, Histone, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00622, HISTONEH3

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00428, H3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113, SSF47113, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00322, HISTONE_H3_1, 1 hit
PS00959, HISTONE_H3_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P08898-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARTKQTARK STGGKAPRKQ LATKAARKSA PASGGVKKPH RYRPGTVALR
60 70 80 90 100
EIRRYQKSTE LLIRRAPFQR LVREIAQDFK TDLRFQSSAV MALQEACEAY
110 120 130
LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA
Length:136
Mass (Da):15,376
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40D7DE0EF5BA6F1F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti97C → A. 1
Natural varianti101L → I. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15634 Genomic DNA Translation: CAA33644.1
FO081018 Genomic DNA Translation: CCD68531.1
FO081059 Genomic DNA Translation: CCD68868.1
FO081135 Genomic DNA Translation: CCD69390.1
FO081223 Genomic DNA Translation: CCD70027.1
FO081551 Genomic DNA Translation: CCD72363.1
FO081551 Genomic DNA Translation: CCD72373.1
Z68336 Genomic DNA Translation: CAA92733.1
Z73102 Genomic DNA Translation: CAA97411.1
Z81495 Genomic DNA Translation: CAB04057.1
Z82271 Genomic DNA Translation: CAB05209.1
Z83245 Genomic DNA Translation: CAB05831.1
Z83245 Genomic DNA Translation: CAB05833.1
Z83245 Genomic DNA Translation: CAB05834.1
Z93388 Genomic DNA Translation: CAB07653.1
AF304122 mRNA Translation: AAG50235.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S04241, HSKW3

NCBI Reference Sequences

More...
RefSeqi
NP_001263958.1, NM_001277029.1
NP_496890.1, NM_064489.1
NP_496894.1, NM_064493.5
NP_496895.1, NM_064494.1
NP_496899.1, NM_064498.1
NP_501204.1, NM_068803.3
NP_501407.1, NM_069006.3
NP_502134.1, NM_069733.3
NP_502138.1, NM_069737.1
NP_502153.1, NM_069752.3
NP_505199.1, NM_072798.1
NP_505276.1, NM_072875.1
NP_505292.1, NM_072891.1
NP_505297.1, NM_072896.3
NP_507033.1, NM_074632.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
B0035.10.1; B0035.10.1; WBGene00001919
F07B7.5.1; F07B7.5.1; WBGene00001923
F08G2.3.1; F08G2.3.1; WBGene00001916
F17E9.10.1; F17E9.10.1; WBGene00001906
F22B3.2.1; F22B3.2.1; WBGene00001937
F45F2.13.1; F45F2.13.1; WBGene00001880
F54E12.1.1; F54E12.1.1; WBGene00001929
F55G1.2.1; F55G1.2.1; WBGene00001933
K06C4.13.1; K06C4.13.1; WBGene00001901
K06C4.5.1; K06C4.5.1; WBGene00001891
T10C6.13.1; T10C6.13.1; WBGene00001876
ZK131.2.1; ZK131.2.1; WBGene00001899
ZK131.3.1; ZK131.3.1; WBGene00001883
ZK131.7.1; ZK131.7.1; WBGene00001887

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
13221387
175030
175031
177628
180074
181821
184113
184804
186250
186325
191668
191672
191673
246024

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_B0035.10
cel:CELE_F07B7.5
cel:CELE_F17E9.10
cel:CELE_F22B3.2
cel:CELE_F45F2.13
cel:CELE_F54E12.1
cel:CELE_F55G1.2
cel:CELE_K03A1.1
cel:CELE_K06C4.13
cel:CELE_K06C4.5
cel:CELE_T10C6.13
cel:CELE_ZK131.2
cel:CELE_ZK131.3
cel:CELE_ZK131.7

UCSC genome browser

More...
UCSCi
ZK131.7, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15634 Genomic DNA Translation: CAA33644.1
FO081018 Genomic DNA Translation: CCD68531.1
FO081059 Genomic DNA Translation: CCD68868.1
FO081135 Genomic DNA Translation: CCD69390.1
FO081223 Genomic DNA Translation: CCD70027.1
FO081551 Genomic DNA Translation: CCD72363.1
FO081551 Genomic DNA Translation: CCD72373.1
Z68336 Genomic DNA Translation: CAA92733.1
Z73102 Genomic DNA Translation: CAA97411.1
Z81495 Genomic DNA Translation: CAB04057.1
Z82271 Genomic DNA Translation: CAB05209.1
Z83245 Genomic DNA Translation: CAB05831.1
Z83245 Genomic DNA Translation: CAB05833.1
Z83245 Genomic DNA Translation: CAB05834.1
Z93388 Genomic DNA Translation: CAB07653.1
AF304122 mRNA Translation: AAG50235.1
PIRiS04241, HSKW3
RefSeqiNP_001263958.1, NM_001277029.1
NP_496890.1, NM_064489.1
NP_496894.1, NM_064493.5
NP_496895.1, NM_064494.1
NP_496899.1, NM_064498.1
NP_501204.1, NM_068803.3
NP_501407.1, NM_069006.3
NP_502134.1, NM_069733.3
NP_502138.1, NM_069737.1
NP_502153.1, NM_069752.3
NP_505199.1, NM_072798.1
NP_505276.1, NM_072875.1
NP_505292.1, NM_072891.1
NP_505297.1, NM_072896.3
NP_507033.1, NM_074632.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3N9LX-ray2.80B2-16[»]
3N9NX-ray2.30B/C2-33[»]
3N9OX-ray2.31B2-16[»]
C2-18[»]
3N9PX-ray2.39B/C2-33[»]
3N9QX-ray2.30B2-16[»]
C20-36[»]
BMRBiP08898
SMRiP08898
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi42741, 1 interactor
45065, 3 interactors
49588, 1 interactor
50996, 1 interactor
IntActiP08898, 1 interactor
STRINGi6239.ZK131.7

PTM databases

iPTMnetiP08898

Proteomic databases

PaxDbiP08898
PeptideAtlasiP08898
PRIDEiP08898

Genome annotation databases

EnsemblMetazoaiB0035.10.1; B0035.10.1; WBGene00001919
F07B7.5.1; F07B7.5.1; WBGene00001923
F08G2.3.1; F08G2.3.1; WBGene00001916
F17E9.10.1; F17E9.10.1; WBGene00001906
F22B3.2.1; F22B3.2.1; WBGene00001937
F45F2.13.1; F45F2.13.1; WBGene00001880
F54E12.1.1; F54E12.1.1; WBGene00001929
F55G1.2.1; F55G1.2.1; WBGene00001933
K06C4.13.1; K06C4.13.1; WBGene00001901
K06C4.5.1; K06C4.5.1; WBGene00001891
T10C6.13.1; T10C6.13.1; WBGene00001876
ZK131.2.1; ZK131.2.1; WBGene00001899
ZK131.3.1; ZK131.3.1; WBGene00001883
ZK131.7.1; ZK131.7.1; WBGene00001887
GeneIDi13221387
175030
175031
177628
180074
181821
184113
184804
186250
186325
191668
191672
191673
246024
KEGGicel:CELE_B0035.10
cel:CELE_F07B7.5
cel:CELE_F17E9.10
cel:CELE_F22B3.2
cel:CELE_F45F2.13
cel:CELE_F54E12.1
cel:CELE_F55G1.2
cel:CELE_K03A1.1
cel:CELE_K06C4.13
cel:CELE_K06C4.5
cel:CELE_T10C6.13
cel:CELE_ZK131.2
cel:CELE_ZK131.3
cel:CELE_ZK131.7
UCSCiZK131.7, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
13221387
175030
175031
177628
180074
181821
184113
184804
186250
186325
191668
191672
191673
246024
WormBaseiB0035.10 ; CE03253 ; WBGene00001919 ; his-45
F07B7.5 ; CE03253 ; WBGene00001923 ; his-49
F08G2.3 ; CE03253 ; WBGene00001916 ; his-42
F17E9.10 ; CE03253 ; WBGene00001906 ; his-32
F22B3.2 ; CE03253 ; WBGene00001937 ; his-63
F45F2.13 ; CE03253 ; WBGene00001880 ; his-6
F54E12.1 ; CE03253 ; WBGene00001929 ; his-55
F55G1.2 ; CE03253 ; WBGene00001933 ; his-59
K06C4.13 ; CE03253 ; WBGene00001901 ; his-27
K06C4.5 ; CE03253 ; WBGene00001891 ; his-17
T10C6.13 ; CE03253 ; WBGene00001876 ; his-2
ZK131.2 ; CE03253 ; WBGene00001899 ; his-25
ZK131.3 ; CE03253 ; WBGene00001883 ; his-9
ZK131.7 ; CE03253 ; WBGene00001887 ; his-13

Phylogenomic databases

eggNOGiKOG1745, Eukaryota
GeneTreeiENSGT01010000222250
HOGENOMiCLU_078295_4_0_1
InParanoidiP08898
OrthoDBi1564596at2759
PhylomeDBiP08898

Enzyme and pathway databases

ReactomeiR-CEL-201722, Formation of the beta-catenin:TCF transactivating complex
R-CEL-2299718, Condensation of Prophase Chromosomes
R-CEL-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Miscellaneous databases

EvolutionaryTraceiP08898

Protein Ontology

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PROi
PR:P08898

Gene expression databases

BgeeiWBGene00001876, Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072, Histone-fold
IPR007125, Histone_H2A/H2B/H3
IPR000164, Histone_H3/CENP-A
PANTHERiPTHR11426, PTHR11426, 1 hit
PfamiView protein in Pfam
PF00125, Histone, 1 hit
PRINTSiPR00622, HISTONEH3
SMARTiView protein in SMART
SM00428, H3, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00322, HISTONE_H3_1, 1 hit
PS00959, HISTONE_H3_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08898
Secondary accession number(s): Q9TW44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: December 2, 2020
This is version 176 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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