UniProtKB - P08896 (LALB2_HORSE)
Protein
Alpha-lactalbumin B/C
Gene
N/A
Organism
Equus caballus (Horse)
Status
Functioni
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 78 – 89 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- lactose synthase activity Source: InterPro
GO - Biological processi
- lactose biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Milk protein |
Biological process | Lactose biosynthesis |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-lactalbumin B/CAlternative name(s): Lactose synthase B protein |
Organismi | Equus caballus (Horse) |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208837 | 1 – 123 | Alpha-lactalbumin B/CAdd BLAST | 123 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 6 ↔ 120 | PROSITE-ProRule annotation | ||
Disulfide bondi | 28 ↔ 111 | PROSITE-ProRule annotation | ||
Disulfide bondi | 61 ↔ 77 | PROSITE-ProRule annotation | ||
Disulfide bondi | 73 ↔ 91 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PeptideAtlasi | P08896 |
Expressioni
Tissue specificityi
Mammary gland specific. Secreted in milk.
Interactioni
Subunit structurei
Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 123 | C-type lysozymePROSITE-ProRule annotationAdd BLAST | 123 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation
Phylogenomic databases
OMAi | KCELSQV |
Family and domain databases
InterProi | View protein in InterPro IPR001916, Glyco_hydro_22 IPR019799, Glyco_hydro_22_CS IPR000545, Lactalbumin IPR023346, Lysozyme-like_dom_sf |
PANTHERi | PTHR11407:SF32, PTHR11407:SF32, 1 hit |
Pfami | View protein in Pfam PF00062, Lys, 1 hit |
PRINTSi | PR00136, LACTALBUMIN PR00135, LYZLACT |
SMARTi | View protein in SMART SM00263, LYZ1, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS00128, GLYCOSYL_HYDROL_F22_1, 1 hit PS51348, GLYCOSYL_HYDROL_F22_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P08896-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
KQFTKCQLSQ VLKSMDGYKG VTLPEWICTI FHNSGYDTQT IVKNNGKTEY
60 70 80 90 100
GLFEINNKMW CRDNQILPSR NICGISCNKF LDDDLTDDVM CAKKDLDSEG
110 120
IDYWLAHKPL CSEKLEQWLC EEL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 95 | D → I in component C. | 1 |
Sequence databases
PIRi | A26541 |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | A26541 |
3D structure databases
SMRi | P08896 |
ModBasei | Search... |
Protein family/group databases
Allergomei | 1498, Equ c ALA |
Proteomic databases
PeptideAtlasi | P08896 |
Phylogenomic databases
OMAi | KCELSQV |
Family and domain databases
InterProi | View protein in InterPro IPR001916, Glyco_hydro_22 IPR019799, Glyco_hydro_22_CS IPR000545, Lactalbumin IPR023346, Lysozyme-like_dom_sf |
PANTHERi | PTHR11407:SF32, PTHR11407:SF32, 1 hit |
Pfami | View protein in Pfam PF00062, Lys, 1 hit |
PRINTSi | PR00136, LACTALBUMIN PR00135, LYZLACT |
SMARTi | View protein in SMART SM00263, LYZ1, 1 hit |
SUPFAMi | SSF53955, SSF53955, 1 hit |
PROSITEi | View protein in PROSITE PS00128, GLYCOSYL_HYDROL_F22_1, 1 hit PS51348, GLYCOSYL_HYDROL_F22_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LALB2_HORSE | |
Accessioni | P08896Primary (citable) accession number: P08896 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | April 7, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families