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UniProtKB - P08887 (IL6RA_HUMAN)

Entry version 227 (22 Apr 2020)
Sequence version 1 (01 Nov 1988)
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Protein

Interleukin-6 receptor subunit alpha

Gene

IL6R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.1 Publication
Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1059683 Interleukin-6 signaling [P08887-2]
R-HSA-110056 MAPK3 (ERK1) activation [P08887-2]
R-HSA-112411 MAPK1 (ERK2) activation [P08887-2]
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9616222 Transcriptional regulation of granulopoiesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P08887

SIGNOR Signaling Network Open Resource

More...SIGNORi		P08887

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-6 receptor subunit alpha
Short name:
IL-6 receptor subunit alpha
Short name:
IL-6R subunit alpha
Short name:
IL-6R-alpha
Short name:
IL-6RA
Alternative name(s):
IL-6R 1
Membrane glycoprotein 80
Short name:
gp80
CD_antigen: CD126
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL6R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6019 IL6R

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		147880 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08887

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 365ExtracellularSequence analysisAdd BLAST346
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387 – 468CytoplasmicSequence analysisAdd BLAST82

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi121C → S: Complete loss of ligand-binding. 1 Publication1
Mutagenesisi122F → A: No change of ligand-binding and IL6 signaling. 1 Publication1
Mutagenesisi132C → A: Complete loss of ligand-binding. 1 Publication1
Mutagenesisi134W → L: Complete loss of ligand-binding. 1 Publication1
Mutagenesisi140P → G: No change of ligand-binding and IL6 signaling. 1 Publication1
Mutagenesisi153F → L: No change of ligand-binding and IL6 signaling. 1 Publication1
Mutagenesisi165C → L: Complete loss of ligand-binding. 1 Publication1
Mutagenesisi174F → L: No change of ligand-binding and IL6 signaling. 1 Publication1
Mutagenesisi176C → A: Complete loss of ligand-binding. 1 Publication1
Mutagenesisi184D → T: 30% decrease of ligand-binding and IL6 signaling. 1 Publication1
Mutagenesisi190V → G: 80% decrease of ligand-binding and no IL6 signaling. 1 Publication1
Mutagenesisi193C → D: Complete loss of ligand-binding. 1 Publication1
Mutagenesisi211C → A: No change of ligand-binding and IL6 signaling. 1 Publication1
Mutagenesisi217D → V: Complete loss of ligand-binding. 1 Publication1
Mutagenesisi232R → S: 30% decrease of ligand-binding and IL6 signaling. 1 Publication1
Mutagenesisi233W → Q: 30% decrease of ligand-binding and increase of IL6 signaling. 1 Publication1
Mutagenesisi254E → A: 50% decrease of ligand-binding and IL6 signaling. 1 Publication1
Mutagenesisi277C → D: 30% increase of ligand-binding and 100% increase in IL6 signaling. 1 Publication1
Mutagenesisi278V → N: 50% Decrease of ligand-binding and 50% increase in IL6 signaling. 1 Publication1
Mutagenesisi279I → D: Complete loss of ligand-binding. 1 Publication1
Mutagenesisi280H → I: No change of ligand-binding and no IL6 signaling. 1 Publication1
Mutagenesisi281D → G: 70% decrease of ligand-binding and no IL6 signaling. 1 Publication1
Mutagenesisi285G → D: 80% decrease of ligand-binding and no IL6 signaling. 1 Publication1
Mutagenesisi291Q → K: Complete loss of ligand-binding. 1 Publication1
Mutagenesisi293R → G: Complete loss of ligand-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3570

MalaCards human disease database

More...MalaCardsi		IL6R
MIMi614689 phenotype
614752 phenotype

Open Targets

More...OpenTargetsi		ENSG00000160712

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29835

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08887 Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2364155

Drug and drug target database

More...DrugBanki		DB11767 Sarilumab
DB06273 Tocilizumab

DrugCentral

More...DrugCentrali		P08887

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1708

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IL6R

Domain mapping of disease mutations (DMDM)

More...DMDMi		124343

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001089520 – 468Interleukin-6 receptor subunit alphaAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 193PROSITE-ProRule annotation1 Publication
Disulfide bondi47 ↔ 96PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi55N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi93N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi121 ↔ 132PROSITE-ProRule annotation1 Publication
Disulfide bondi165 ↔ 176PROSITE-ProRule annotation1 Publication
Glycosylationi221N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A short soluble form may also be released from the membrane by proteolysis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei245Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08887

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08887

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08887

PeptideAtlas

More...PeptideAtlasi		P08887

PRoteomics IDEntifications database

More...PRIDEi		P08887

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52171 [P08887-1]
52172 [P08887-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08887

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08887

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160712 Expressed in blood and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P08887 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08887 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160712 Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Hexamer of two molecules each of IL6, IL6R and IL6ST (PubMed:28265003).

Interacts (via N-terminal ectodomain) with SORL1; this interaction may affect IL6-binding to IL6R, hence decrease IL6 cis-signaling (PubMed:28265003). The soluble form of IL6R also interacts with SORL1; this interaction leads to soluble IL6R internalization (PubMed:28265003). May form a trimeric complex with the soluble SORL1 ectodomain and circulating IL6 receptor; this interaction might stabilize circulating IL6, hence promote IL6 trans signaling (PubMed:28265003).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109784, 19 interactors

Database of interacting proteins

More...DIPi		DIP-162N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P08887

Protein interaction database and analysis system

More...IntActi		P08887, 17 interactors

Molecular INTeraction database

More...MINTi		P08887

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357470

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08887 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08887

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P08887

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 112Ig-like C2-typeAdd BLAST87
Domaini113 – 217Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST105
Domaini218 – 316Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi303 – 307WSXWS motif5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 3 subfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410II5K Eukaryota
ENOG4111XGC LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161919

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_051451_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08887

KEGG Orthology (KO)

More...KOi		K05055

Database of Orthologous Groups

More...OrthoDBi		783799at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08887

TreeFam database of animal gene trees

More...TreeFami		TF331210

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR015321 TypeI_recpt_CBD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00047 ig, 1 hit
PF09240 IL6Ra-bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853 FN3, 2 hits
PS01354 HEMATOPO_REC_L_F3, 1 hit
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P08887-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV 
        60         70         80         90        100
EPEDNATVHW VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG 
       110        120        130        140        150
RPAGTVHLLV DVPPEEPQLS CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV 
       160        170        180        190        200
RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS 
       210        220        230        240        250
KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR 
       260        270        280        290        300
LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ 
       310        320        330        340        350
GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN 
       360        370        380        390        400
ATSLPVQDSS SVPLPTFLVA GGSLAFGTLL CIAIVLRFKK TWKLRALKEG 
       410        420        430        440        450
KTSMHPPYSL GQLVPERPRP TPVLVPLISP PVSPSSLGSD NTSSHNRPDA 
       460 
RDPRSPYDIS NTDYFFPR
Length:468
Mass (Da):51,548
Last modified:November 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62AA239FA14F1B8B
GO
Isoform 2 (identifier: P08887-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     356-365: VQDSSSVPLP → GSRRRGSCGL
     366-468: Missing.

Show »
Length:365
Mass (Da):40,237
Checksum:iECC8FC9E142823F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y949H0Y949_HUMAN
Interleukin-6 receptor subunit alph...
IL6R
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9B1H0Y9B1_HUMAN
Interleukin-6 receptor subunit alph...
IL6R
294Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTB5A0A087WTB5_HUMAN
Interleukin-6 receptor subunit alph...
IL6R
352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9R8D6R9R8_HUMAN
Interleukin-6 receptor subunit alph...
IL6R
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti210G → D in BAD97302 (Ref. 5) Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in IL6R determine soluble IL6R serum levels [MIMi:614689].
Genetic variations in IL6R define the IL6 serum level quantitative trait locus [MIMi:614752].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021995358D → A Significantly associated with circulating levels of IL6 and soluble IL6R. 2 PublicationsCorresponds to variant dbSNP:rs2228145EnsemblClinVar.1
Natural variantiVAR_049166385V → I. Corresponds to variant dbSNP:rs2228146Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001682356 – 365VQDSSSVPLP → GSRRRGSCGL in isoform 2. 3 Publications10
Alternative sequenceiVSP_001683366 – 468Missing in isoform 2. 3 PublicationsAdd BLAST103

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X12830 mRNA Translation: CAA31312.1
X58298 mRNA Translation: CAA41231.1
AK293013 mRNA Translation: BAF85702.1
AK312730 mRNA Translation: BAG35601.1
AK223582 mRNA Translation: BAD97302.1
AL162591 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53200.1
BC089410 mRNA Translation: AAH89410.1
S72848 mRNA Translation: AAC60635.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1067.1 [P08887-1]
CCDS1068.1 [P08887-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A41242

NCBI Reference Sequences

More...RefSeqi		NP_000556.1, NM_000565.3 [P08887-1]
NP_001193795.1, NM_001206866.1
NP_852004.1, NM_181359.2 [P08887-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000344086; ENSP00000340589; ENSG00000160712 [P08887-2]
ENST00000368485; ENSP00000357470; ENSG00000160712 [P08887-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3570

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3570

UCSC genome browser

More...UCSCi		uc001fez.2 human [P08887-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12830 mRNA Translation: CAA31312.1
X58298 mRNA Translation: CAA41231.1
AK293013 mRNA Translation: BAF85702.1
AK312730 mRNA Translation: BAG35601.1
AK223582 mRNA Translation: BAD97302.1
AL162591 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53200.1
BC089410 mRNA Translation: AAH89410.1
S72848 mRNA Translation: AAC60635.1
CCDSiCCDS1067.1 [P08887-1]
CCDS1068.1 [P08887-2]
PIRiA41242
RefSeqiNP_000556.1, NM_000565.3 [P08887-1]
NP_001193795.1, NM_001206866.1
NP_852004.1, NM_181359.2 [P08887-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N26X-ray2.40A20-344[»]
1N2Qmodel-C/D20-344[»]
1P9MX-ray3.65C115-315[»]
2ARWNMR-A212-336[»]
5FUCX-ray2.70C/D111-322[»]
SMRiP08887
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109784, 19 interactors
DIPiDIP-162N
ELMiP08887
IntActiP08887, 17 interactors
MINTiP08887
STRINGi9606.ENSP00000357470

Chemistry databases

ChEMBLiCHEMBL2364155
DrugBankiDB11767 Sarilumab
DB06273 Tocilizumab
DrugCentraliP08887
GuidetoPHARMACOLOGYi1708

PTM databases

iPTMnetiP08887
PhosphoSitePlusiP08887

Polymorphism and mutation databases

BioMutaiIL6R
DMDMi124343

Proteomic databases

MassIVEiP08887
MaxQBiP08887
PaxDbiP08887
PeptideAtlasiP08887
PRIDEiP08887
ProteomicsDBi52171 [P08887-1]
52172 [P08887-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P08887

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20397 951 antibodies

The DNASU plasmid repository

More...DNASUi		3570

Genome annotation databases

EnsembliENST00000344086; ENSP00000340589; ENSG00000160712 [P08887-2]
ENST00000368485; ENSP00000357470; ENSG00000160712 [P08887-1]
GeneIDi3570
KEGGihsa:3570
UCSCiuc001fez.2 human [P08887-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3570
DisGeNETi3570

GeneCards: human genes, protein and diseases

More...GeneCardsi		IL6R
HGNCiHGNC:6019 IL6R
HPAiENSG00000160712 Tissue enhanced (skeletal)
MalaCardsiIL6R
MIMi147880 gene
614689 phenotype
614752 phenotype
neXtProtiNX_P08887
OpenTargetsiENSG00000160712
PharmGKBiPA29835

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410II5K Eukaryota
ENOG4111XGC LUCA
GeneTreeiENSGT00940000161919
HOGENOMiCLU_051451_0_0_1
InParanoidiP08887
KOiK05055
OrthoDBi783799at2759
PhylomeDBiP08887
TreeFamiTF331210

Enzyme and pathway databases

ReactomeiR-HSA-1059683 Interleukin-6 signaling [P08887-2]
R-HSA-110056 MAPK3 (ERK1) activation [P08887-2]
R-HSA-112411 MAPK1 (ERK2) activation [P08887-2]
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9616222 Transcriptional regulation of granulopoiesis
SignaLinkiP08887
SIGNORiP08887

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IL6R human
EvolutionaryTraceiP08887

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Interleukin-6_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3570
PharosiP08887 Tclin

Protein Ontology

More...PROi		PR:P08887
RNActiP08887 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160712 Expressed in blood and 217 other tissues
ExpressionAtlasiP08887 baseline and differential
GenevisibleiP08887 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF09240 IL6Ra-bind, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01354 HEMATOPO_REC_L_F3, 1 hit
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL6RA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08887
Secondary accession number(s): A8KAE8
, B2R6V4, Q16202, Q53EQ7, Q5FWG2, Q5VZ23
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: April 22, 2020
This is version 227 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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