IL6R

Functionⁱ

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

GO - Molecular functionⁱ

ciliary neurotrophic factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12643274
cytokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cytokine receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12748171
growth factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-12 alpha subunit binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-12 receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-23 receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-6 binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12829785
interleukin-6 receptor activity Source: Ensembl
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12633863

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acute-phase response
Source: BHF-UCL
Traceable author statementⁱ
- 12832423
ciliary neurotrophic factor-mediated signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12643274
cytokine-mediated signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 2261637
defense response to Gram-negative bacterium
Source: BHF-UCL
Traceable author statementⁱ
- 16034137
defense response to Gram-positive bacterium
Source: BHF-UCL
Non-traceable author statementⁱ
- 16034137
endocrine pancreas development
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18719127
extrinsic apoptotic signaling pathway
Source: BHF-UCL
Traceable author statementⁱ
- 15100312
hepatic immune response
Source: BHF-UCL
Traceable author statementⁱ
- 12832423
interleukin-6-mediated signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12643274
monocyte chemotaxis
Source: BHF-UCL
Inferred by curatorⁱ
- 10510402
negative regulation of collagen biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 12419823
negative regulation of interleukin-8 production
Source: BHF-UCL
Non-traceable author statementⁱ
- 16034137
neutrophil mediated immunity
Source: BHF-UCL
Traceable author statementⁱ
- 16034137
positive regulation of activated T cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of activation of Janus kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 12419823
positive regulation of cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 2261637
positive regulation of chemokine production
Source: BHF-UCL
Inferred from direct assayⁱ
- 10510402
positive regulation of interferon-gamma production
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of interleukin-6 production
Source: BHF-UCL
Inferred from direct assayⁱ
- 10510402
positive regulation of leukocyte chemotaxis
Source: BHF-UCL
Traceable author statementⁱ
- 15100312
- 16034137
positive regulation of lymphocyte proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of MAPK cascade
Source: BHF-UCL
Inferred from direct assayⁱ
- 12419823
positive regulation of natural killer cell activation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of NK T cell activation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of osteoblast differentiation
Source: BHF-UCL
Traceable author statementⁱ
- 12372336
positive regulation of peptidyl-tyrosine phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 11884403
positive regulation of smooth muscle cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10510402
positive regulation of T-helper 1 type immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of tyrosine phosphorylation of STAT protein
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12643274
response to cytokine
Source: BHF-UCL
Inferred from direct assayⁱ
- 2261637

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1059683 Interleukin-6 signaling R-HSA-110056 MAPK3 (ERK1) activation R-HSA-112411 MAPK1 (ERK2) activation R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SignaLinkⁱ	P08887
SIGNORⁱ	P08887

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-6 receptor subunit alpha Short name: IL-6 receptor subunit alpha Short name: IL-6R subunit alpha Short name: IL-6R-alpha Short name: IL-6RA Alternative name(s): IL-6R 1 Membrane glycoprotein 80 Short name: gp80 CD_antigen: CD126
Gene namesⁱ	Name:IL6R
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160712.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6019 IL6R
MIMⁱ	147880 gene
neXtProtⁱ	NX_P08887

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 365	ExtracellularSequence analysisAdd BLAST	346
Transmembraneⁱ	366 – 386	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	387 – 468	CytoplasmicSequence analysisAdd BLAST	82

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	121	C → S: Complete loss of ligand-binding. 1 Publication	1
Mutagenesisⁱ	122	F → A: No change of ligand-binding and IL6 signaling. 1 Publication	1
Mutagenesisⁱ	132	C → A: Complete loss of ligand-binding. 1 Publication	1
Mutagenesisⁱ	134	W → L: Complete loss of ligand-binding. 1 Publication	1
Mutagenesisⁱ	140	P → G: No change of ligand-binding and IL6 signaling. 1 Publication	1
Mutagenesisⁱ	153	F → L: No change of ligand-binding and IL6 signaling. 1 Publication	1
Mutagenesisⁱ	165	C → L: Complete loss of ligand-binding. 1 Publication	1
Mutagenesisⁱ	174	F → L: No change of ligand-binding and IL6 signaling. 1 Publication	1
Mutagenesisⁱ	176	C → A: Complete loss of ligand-binding. 1 Publication	1
Mutagenesisⁱ	184	D → T: 30% decrease of ligand-binding and IL6 signaling. 1 Publication	1
Mutagenesisⁱ	190	V → G: 80% decrease of ligand-binding and no IL6 signaling. 1 Publication	1
Mutagenesisⁱ	193	C → D: Complete loss of ligand-binding. 1 Publication	1
Mutagenesisⁱ	211	C → A: No change of ligand-binding and IL6 signaling. 1 Publication	1
Mutagenesisⁱ	217	D → V: Complete loss of ligand-binding. 1 Publication	1
Mutagenesisⁱ	232	R → S: 30% decrease of ligand-binding and IL6 signaling. 1 Publication	1
Mutagenesisⁱ	233	W → Q: 30% decrease of ligand-binding and increase of IL6 signaling. 1 Publication	1
Mutagenesisⁱ	254	E → A: 50% decrease of ligand-binding and IL6 signaling. 1 Publication	1
Mutagenesisⁱ	277	C → D: 30% increase of ligand-binding and 100% increase in IL6 signaling. 1 Publication	1
Mutagenesisⁱ	278	V → N: 50% Decrease of ligand-binding and 50% increase in IL6 signaling. 1 Publication	1
Mutagenesisⁱ	279	I → D: Complete loss of ligand-binding. 1 Publication	1
Mutagenesisⁱ	280	H → I: No change of ligand-binding and no IL6 signaling. 1 Publication	1
Mutagenesisⁱ	281	D → G: 70% decrease of ligand-binding and no IL6 signaling. 1 Publication	1
Mutagenesisⁱ	285	G → D: 80% decrease of ligand-binding and no IL6 signaling. 1 Publication	1
Mutagenesisⁱ	291	Q → K: Complete loss of ligand-binding. 1 Publication	1
Mutagenesisⁱ	293	R → G: Complete loss of ligand-binding. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3570
MalaCards human disease database More...MalaCardsⁱ	IL6R
MIMⁱ	614689 phenotype 614752 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000160712
PharmGKBⁱ	PA29835

Chemistry databases

ChEMBLⁱ	CHEMBL2364155
Drug and drug target database More...DrugBankⁱ	DB06273 Tocilizumab
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1708

Polymorphism and mutation databases

BioMutaⁱ	IL6R
DMDMⁱ	124343

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	1 PublicationAdd BLAST		19
ChainⁱPRO_0000010895	20 – 468	Interleukin-6 receptor subunit alphaAdd BLAST		449

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	25 ↔ 193	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	47 ↔ 96	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	55	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	93	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	121 ↔ 132	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	165 ↔ 176	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	221	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

A short soluble form may also be released from the membrane by proteolysis.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	245	Not glycosylated1 Publication		1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08887
PaxDbⁱ	P08887
PeptideAtlas More...PeptideAtlasⁱ	P08887
PRIDEⁱ	P08887
ProteomicsDBⁱ	52171 52172 [P08887-2]

PTM databases

iPTMnetⁱ	P08887
PhosphoSitePlusⁱ	P08887

Miscellaneous databases

PMAP-CutDBⁱ	P08887

PMAP-CutDBⁱ

P08887

Expressionⁱ

Tissue specificityⁱ

Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.

Gene expression databases

Bgeeⁱ	ENSG00000160712 Expressed in 218 organ(s), highest expression level in blood
CleanExⁱ	HS_IL6R
ExpressionAtlasⁱ	P08887 baseline and differential
Genevisibleⁱ	P08887 HS

Interactionⁱ

Subunit structureⁱ

Hexamer of two molecules each of IL6, IL6R and IL6ST.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IL6	P05231	6	EBI-299383,EBI-720533
K2	Q2HRC7	3	EBI-299383,EBI-9007403	From Human herpesvirus 8 type P (isolate GK18).
PSMD9	O00233	3	EBI-16630231,EBI-750973

GO - Molecular functionⁱ

ciliary neurotrophic factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12643274
cytokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12748171
growth factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-12 alpha subunit binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-12 receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-23 receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-6 binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12829785
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12633863

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109784, 19 interactors
Database of interacting proteins More...DIPⁱ	DIP-162N
ELMⁱ	P08887
IntActⁱ	P08887, 7 interactors
Molecular INTeraction database More...MINTⁱ	P08887
STRINGⁱ	9606.ENSP00000357470

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	34 – 37	Combined sources	4
Beta strandⁱ	43 – 46	Combined sources	4
Beta strandⁱ	56 – 63	Combined sources	8
Beta strandⁱ	65 – 68	Combined sources	4
Beta strandⁱ	72 – 83	Combined sources	12
Helixⁱ	88 – 90	Combined sources	3
Beta strandⁱ	92 – 101	Combined sources	10
Beta strandⁱ	105 – 110	Combined sources	6
Beta strandⁱ	120 – 125	Combined sources	6
Beta strandⁱ	130 – 134	Combined sources	5
Beta strandⁱ	145 – 157	Combined sources	13
Beta strandⁱ	159 – 168	Combined sources	10
Turnⁱ	169 – 172	Combined sources	4
Beta strandⁱ	173 – 178	Combined sources	6
Beta strandⁱ	187 – 196	Combined sources	10
Beta strandⁱ	199 – 202	Combined sources	4
Beta strandⁱ	206 – 209	Combined sources	4
Turnⁱ	210 – 212	Combined sources	3
Beta strandⁱ	220 – 226	Combined sources	7
Beta strandⁱ	234 – 239	Combined sources	6
Beta strandⁱ	247 – 249	Combined sources	3
Beta strandⁱ	251 – 259	Combined sources	9
Beta strandⁱ	266 – 269	Combined sources	4
Helixⁱ	271 – 273	Combined sources	3
Beta strandⁱ	275 – 281	Combined sources	7
Beta strandⁱ	288 – 296	Combined sources	9
Turnⁱ	297 – 299	Combined sources	3
Beta strandⁱ	310 – 312	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P08887
SMRⁱ	P08887
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P08887

EvolutionaryTraceⁱ

P08887

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	26 – 112	Ig-like C2-typeAdd BLAST	87
Domainⁱ	113 – 217	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	105
Domainⁱ	218 – 316	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	99

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	303 – 307	WSXWS motif		5

Domainⁱ

The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesⁱ

Belongs to the type I cytokine receptor family. Type 3 subfamily.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410II5K Eukaryota ENOG4111XGC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063103
HOVERGENⁱ	HBG052118
InParanoidⁱ	P08887
KEGG Orthology (KO) More...KOⁱ	K05055
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07XD
PhylomeDBⁱ	P08887
TreeFamⁱ	TF331210

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR003530 Hematopoietin_rcpt_L_F3_CS IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013151 Immunoglobulin IPR015321 TypeI_recpt_CBD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00047 ig, 1 hit PF09240 IL6Ra-bind, 1 hit
SMARTⁱ	View protein in SMART SM00060 FN3, 1 hit SM00409 IG, 1 hit SM00408 IGc2, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF49265 SSF49265, 2 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 2 hits PS01354 HEMATOPO_REC_L_F3, 1 hit PS50835 IG_LIKE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P08887-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV 
        60         70         80         90        100
EPEDNATVHW VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG 
       110        120        130        140        150
RPAGTVHLLV DVPPEEPQLS CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV 
       160        170        180        190        200
RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS 
       210        220        230        240        250
KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR 
       260        270        280        290        300
LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ 
       310        320        330        340        350
GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN 
       360        370        380        390        400
ATSLPVQDSS SVPLPTFLVA GGSLAFGTLL CIAIVLRFKK TWKLRALKEG 
       410        420        430        440        450
KTSMHPPYSL GQLVPERPRP TPVLVPLISP PVSPSSLGSD NTSSHNRPDA 
       460 
RDPRSPYDIS NTDYFFPR

Length:468

Mass (Da):51,548

Last modified:November 1, 1988 - v1

Checksum:ⁱ62AA239FA14F1B8B

GO

Isoform 2 (identifier: P08887-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
356-365: VQDSSSVPLP → GSRRRGSCGL
366-468: Missing.

« Hide

        10         20         30         40         50
MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV 
        60         70         80         90        100
EPEDNATVHW VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG 
       110        120        130        140        150
RPAGTVHLLV DVPPEEPQLS CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV 
       160        170        180        190        200
RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS 
       210        220        230        240        250
KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR 
       260        270        280        290        300
LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ 
       310        320        330        340        350
GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN 
       360 
ATSLPGSRRR GSCGL

Show »

Length:365

Mass (Da):40,237

Checksum:ⁱECC8FC9E142823F2

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WTB5	A0A087WTB5_HUMAN	Interleukin-6 receptor subunit alph... Interleukin-6 receptor subunit alpha	IL6R	352	Annotation score:
H0Y949	H0Y949_HUMAN	Interleukin-6 receptor subunit alph... Interleukin-6 receptor subunit alpha	IL6R	190	Annotation score:
H0Y9B1	H0Y9B1_HUMAN	Interleukin-6 receptor subunit alph... Interleukin-6 receptor subunit alpha	IL6R	294	Annotation score:
D6R9R8	D6R9R8_HUMAN	Interleukin-6 receptor subunit alph... Interleukin-6 receptor subunit alpha	IL6R	170	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	210	G → D in BAD97302 (Ref. 5) Curated		1

Polymorphismⁱ

Genetic variations in IL6R determine soluble IL6R serum levels [MIMⁱ:614689].

Genetic variations in IL6R define the IL6 serum level quantitative trait locus [MIMⁱ:614752].

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_021995	358	D → A Significantly associated with circulating levels of IL6 and soluble IL6R. 2 PublicationsCorresponds to variant dbSNP:rs2228145EnsemblClinVar.		1
Natural variantⁱVAR_049166	385	V → I. Corresponds to variant dbSNP:rs2228146Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001682	356 – 365	VQDSSSVPLP → GSRRRGSCGL in isoform 2. 3 Publications		10
Alternative sequenceⁱVSP_001683	366 – 468	Missing in isoform 2. 3 PublicationsAdd BLAST		103

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12830 mRNA Translation: CAA31312.1 X58298 mRNA Translation: CAA41231.1 AK293013 mRNA Translation: BAF85702.1 AK312730 mRNA Translation: BAG35601.1 AK223582 mRNA Translation: BAD97302.1 AL162591 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53200.1 BC089410 mRNA Translation: AAH89410.1 S72848 mRNA Translation: AAC60635.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1067.1 [P08887-1] CCDS1068.1 [P08887-2]
PIRⁱ	A41242
NCBI Reference Sequences More...RefSeqⁱ	NP_000556.1, NM_000565.3 [P08887-1] NP_001193795.1, NM_001206866.1 NP_852004.1, NM_181359.2 [P08887-2]
UniGeneⁱ	Hs.135087

Genome annotation databases

Ensemblⁱ	ENST00000344086; ENSP00000340589; ENSG00000160712 [P08887-2] ENST00000368485; ENSP00000357470; ENSG00000160712 [P08887-1]
GeneIDⁱ	3570
KEGGⁱ	hsa:3570
UCSC genome browser More...UCSCⁱ	uc001fez.2 human [P08887-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08887	Interleukin 6 receptor		HUMAN		468	UniRef100_P08887

Protein	Similar proteins		Species	Score	Length	Source
P08887	Interleukin 6 receptor		HUMAN		468	UniRef90_P08887
Uncharacterized protein		COLAP		568
Uncharacterized protein		RHIBE		499
Uncharacterized protein		RHIRO		468
Uncharacterized protein		PANPA		468
+22
P08887-2	Uncharacterized protein		Cebus capucinus imitator		366	UniRef90_P08887-2
Uncharacterized protein		PANPA		365
Uncharacterized protein		MANLE		365
Uncharacterized protein		PAPAN		365
Interleukin 6 receptor		GORGO		365
+21

Protein	Similar proteins		Species	Score	Length	Source
P08887	Interleukin 6 receptor		HUMAN		468	UniRef50_P08887
Uncharacterized protein		COLAP		568
Uncharacterized protein		RHIBE		499
Uncharacterized protein		MANLE		468
IL6R isoform 2		PONAB		468
+24
P08887-2	Uncharacterized protein		Cebus capucinus imitator		366	UniRef50_P08887-2
Uncharacterized protein		PAPAN		365
Interleukin 6 receptor		GORGO		365
IL6R isoform 3		PONAB		365
IL6R isoform 2		PANTR		365
+43

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12830 mRNA Translation: CAA31312.1 X58298 mRNA Translation: CAA41231.1 AK293013 mRNA Translation: BAF85702.1 AK312730 mRNA Translation: BAG35601.1 AK223582 mRNA Translation: BAD97302.1 AL162591 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53200.1 BC089410 mRNA Translation: AAH89410.1 S72848 mRNA Translation: AAC60635.1
CCDSⁱ	CCDS1067.1 [P08887-1] CCDS1068.1 [P08887-2]
PIRⁱ	A41242
RefSeqⁱ	NP_000556.1, NM_000565.3 [P08887-1] NP_001193795.1, NM_001206866.1 NP_852004.1, NM_181359.2 [P08887-2]
UniGeneⁱ	Hs.135087

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1N26	X-ray	2.40	A	20-344	[»]
	1N2Q	model	-	C/D	20-344	[»]
	1P9M	X-ray	3.65	C	115-315	[»]
	2ARW	NMR	-	A	212-336	[»]
	5FUC	X-ray	2.70	C/D	111-322	[»]
ProteinModelPortalⁱ	P08887
SMRⁱ	P08887
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109784, 19 interactors
DIPⁱ	DIP-162N
ELMⁱ	P08887
IntActⁱ	P08887, 7 interactors
MINTⁱ	P08887
STRINGⁱ	9606.ENSP00000357470

Chemistry databases

ChEMBLⁱ	CHEMBL2364155
DrugBankⁱ	DB06273 Tocilizumab
GuidetoPHARMACOLOGYⁱ	1708

PTM databases

iPTMnetⁱ	P08887
PhosphoSitePlusⁱ	P08887

Polymorphism and mutation databases

BioMutaⁱ	IL6R
DMDMⁱ	124343

Proteomic databases

MaxQBⁱ	P08887
PaxDbⁱ	P08887
PeptideAtlasⁱ	P08887
PRIDEⁱ	P08887
ProteomicsDBⁱ	52171 52172 [P08887-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3570
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000344086; ENSP00000340589; ENSG00000160712 [P08887-2] ENST00000368485; ENSP00000357470; ENSG00000160712 [P08887-1]
GeneIDⁱ	3570
KEGGⁱ	hsa:3570
UCSCⁱ	uc001fez.2 human [P08887-1]

Organism-specific databases

CTDⁱ	3570
DisGeNETⁱ	3570
EuPathDBⁱ	HostDB:ENSG00000160712.12
GeneCardsⁱ	IL6R
HGNCⁱ	HGNC:6019 IL6R
MalaCardsⁱ	IL6R
MIMⁱ	147880 gene 614689 phenotype 614752 phenotype
neXtProtⁱ	NX_P08887
OpenTargetsⁱ	ENSG00000160712
PharmGKBⁱ	PA29835
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410II5K Eukaryota ENOG4111XGC LUCA
GeneTreeⁱ	ENSGT00530000063103
HOVERGENⁱ	HBG052118
InParanoidⁱ	P08887
KOⁱ	K05055
OrthoDBⁱ	EOG091G07XD
PhylomeDBⁱ	P08887
TreeFamⁱ	TF331210

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1059683 Interleukin-6 signaling R-HSA-110056 MAPK3 (ERK1) activation R-HSA-112411 MAPK1 (ERK2) activation R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SignaLinkⁱ	P08887
SIGNORⁱ	P08887

Miscellaneous databases

ChiTaRSⁱ	IL6R human
EvolutionaryTraceⁱ	P08887
GeneWikiⁱ	Interleukin-6_receptor
GenomeRNAiⁱ	3570
PMAP-CutDBⁱ	P08887
Protein Ontology More...PROⁱ	PR:P08887
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160712 Expressed in 218 organ(s), highest expression level in blood
CleanExⁱ	HS_IL6R
ExpressionAtlasⁱ	P08887 baseline and differential
Genevisibleⁱ	P08887 HS

Family and domain databases

CDDⁱ	cd00063 FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR003530 Hematopoietin_rcpt_L_F3_CS IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013151 Immunoglobulin IPR015321 TypeI_recpt_CBD
Pfamⁱ	View protein in Pfam PF00047 ig, 1 hit PF09240 IL6Ra-bind, 1 hit
SMARTⁱ	View protein in SMART SM00060 FN3, 1 hit SM00409 IG, 1 hit SM00408 IGc2, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF49265 SSF49265, 2 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 2 hits PS01354 HEMATOPO_REC_L_F3, 1 hit PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL6RA_HUMAN
Accessionⁱ	P08887Primary (citable) accession number: P08887 Secondary accession number(s): A8KAE8 , B2R6V4, Q16202, Q53EQ7, Q5FWG2, Q5VZ23
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
	Last sequence update:	November 1, 1988
	Last modified:	November 7, 2018
	This is version 215 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P08887 (IL6RA_HUMAN)

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Interleukin-6 receptor subunit alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Molecular functionⁱ

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Pathology & Biotechⁱ

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Keywords - PTMⁱ

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