UniProtKB - P08887 (IL6RA_HUMAN)
Interleukin-6 receptor subunit alpha
IL6R
Functioni
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003).
Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (PubMed:30995492, PubMed:31235509).
The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).
1 Publication2 PublicationsSignaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4+ T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (By similarity).
By similarity1 PublicationSoluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:21990364).
The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the proinflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed:21990364).
In complex with IL6, is required for induction of VEGF production (PubMed:12794819).
Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity).
'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity).
By similarity2 PublicationsSoluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:21990364).
The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the proinflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (PubMed:21990364).
In complex with IL6, is required for induction of VEGF production (PubMed:12794819).
Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity).
'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity).
By similarity2 PublicationsActivity regulationi
GO - Molecular functioni
- ciliary neurotrophic factor binding Source: BHF-UCL
- cytokine binding Source: GO_Central
- cytokine receptor activity Source: GO_Central
- enzyme binding Source: UniProtKB
- interleukin-11 binding Source: GO_Central
- interleukin-11 receptor activity Source: GO_Central
- interleukin-6 binding Source: BHF-UCL
- interleukin-6 receptor activity Source: Ensembl
- protein homodimerization activity Source: BHF-UCL
GO - Biological processi
- acute-phase response Source: BHF-UCL
- ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
- cytokine-mediated signaling pathway Source: BHF-UCL
- defense response to Gram-negative bacterium Source: BHF-UCL
- defense response to Gram-positive bacterium Source: BHF-UCL
- endocrine pancreas development Source: BHF-UCL
- extrinsic apoptotic signaling pathway Source: BHF-UCL
- hepatic immune response Source: BHF-UCL
- interleukin-6-mediated signaling pathway Source: ARUK-UCL
- monocyte chemotaxis Source: BHF-UCL
- negative regulation of collagen biosynthetic process Source: BHF-UCL
- negative regulation of interleukin-8 production Source: BHF-UCL
- neutrophil mediated immunity Source: BHF-UCL
- positive regulation of activation of Janus kinase activity Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of chemokine production Source: BHF-UCL
- positive regulation of glomerular mesangial cell proliferation Source: ARUK-UCL
- positive regulation of interleukin-6 production Source: BHF-UCL
- positive regulation of leukocyte chemotaxis Source: BHF-UCL
- positive regulation of MAPK cascade Source: BHF-UCL
- positive regulation of osteoblast differentiation Source: BHF-UCL
- positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- positive regulation of platelet aggregation Source: ARUK-UCL
- positive regulation of smooth muscle cell proliferation Source: BHF-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
- response to cytokine Source: BHF-UCL
- T-helper 17 cell lineage commitment Source: Ensembl
- vascular endothelial growth factor production Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | P08887 |
Reactomei | R-HSA-1059683, Interleukin-6 signaling R-HSA-110056, MAPK3 (ERK1) activation R-HSA-112411, MAPK1 (ERK2) activation R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | P08887 |
SIGNORi | P08887 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-6 receptor subunit alphaCuratedShort name: IL-6 receptor subunit alpha Short name: IL-6R subunit alpha Short name: IL-6R-alpha Short name: IL-6RA Alternative name(s): IL-6R 1 Membrane glycoprotein 80 Short name: gp80 CD_antigen: CD126 Cleaved into the following chain: |
Gene namesi | Name:IL6RImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6019, IL6R |
MIMi | 147880, gene |
neXtProti | NX_P08887 |
VEuPathDBi | HostDB:ENSG00000160712 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: BHF-UCL
Plasma Membrane
- apical plasma membrane Source: BHF-UCL
- ciliary neurotrophic factor receptor complex Source: BHF-UCL
- external side of plasma membrane Source: GO_Central
- interleukin-6 receptor complex Source: BHF-UCL
- plasma membrane Source: Reactome
Other locations
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 365 | ExtracellularSequence analysisAdd BLAST | 346 | |
Transmembranei | 366 – 386 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 387 – 468 | CytoplasmicSequence analysisAdd BLAST | 82 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Hyper-IgE recurrent infection syndrome 5, autosomal recessive (HIES5)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_084713 | 279 | I → N in HIES5; decreased STAT1 and STAT3 phosphorylation. 1 Publication | 1 | |
Natural variantiVAR_084714 | 280 | H → P in HIES5; unknown pathological significance; no effect on STAT1 and STAT3 phosphorylation. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 55 | N → A: Strongly induces cleavage and sIL6R levels. No effect on IL6R signaling; when associated with A-93, A-221, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-93, A-221, A-245 and A-350. 1 Publication | 1 | |
Mutagenesisi | 57 | T → A: Strongly induces cleavage and sIL6R levels. 1 Publication | 1 | |
Mutagenesisi | 93 | N → A: No effect on cleavage or sIL6R levels. No effect on IL6R signaling; when associated with A-55, A-221, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-221, A-245 and A-350. 1 Publication | 1 | |
Mutagenesisi | 121 | C → S: Complete loss of ligand-binding. 1 Publication | 1 | |
Mutagenesisi | 122 | F → A: No change of ligand-binding and IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 132 | C → A: Complete loss of ligand-binding. 1 Publication | 1 | |
Mutagenesisi | 134 | W → L: Complete loss of ligand-binding. 1 Publication | 1 | |
Mutagenesisi | 140 | P → G: No change of ligand-binding and IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 153 | F → L: No change of ligand-binding and IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 165 | C → L: Complete loss of ligand-binding. 1 Publication | 1 | |
Mutagenesisi | 174 | F → L: No change of ligand-binding and IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 176 | C → A: Complete loss of ligand-binding. 1 Publication | 1 | |
Mutagenesisi | 184 | D → T: 30% decrease of ligand-binding and IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 190 | V → G: 80% decrease of ligand-binding and no IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 193 | C → D: Complete loss of ligand-binding. 1 Publication | 1 | |
Mutagenesisi | 211 | C → A: No change of ligand-binding and IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 217 | D → V: Complete loss of ligand-binding. 1 Publication | 1 | |
Mutagenesisi | 221 | N → A: No effect on cleavage or sIL6R levels. No effect on IL6R signaling; when associated with A-55, A-93, A-245 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-245 and A-350. 1 Publication | 1 | |
Mutagenesisi | 232 | R → S: 30% decrease of ligand-binding and IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 233 | W → Q: 30% decrease of ligand-binding and increase of IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 245 | N → A: Slightly induces cleavage and sIL6R levels.No effect on IL6R signaling; when associated with A-55, A-93, A-221 and A-350. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-221 and A-350. 1 Publication | 1 | |
Mutagenesisi | 254 | E → A: 50% decrease of ligand-binding and IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 277 | C → D: 30% increase of ligand-binding and 100% increase in IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 278 | V → N: 50% Decrease of ligand-binding and 50% increase in IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 279 | I → D: Complete loss of ligand-binding. 1 Publication | 1 | |
Mutagenesisi | 280 | H → I: No change of ligand-binding and no IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 281 | D → G: 70% decrease of ligand-binding and no IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 285 | G → D: 80% decrease of ligand-binding and no IL6 signaling. 1 Publication | 1 | |
Mutagenesisi | 291 | Q → K: Complete loss of ligand-binding. 1 Publication | 1 | |
Mutagenesisi | 293 | R → G: Complete loss of ligand-binding. 1 Publication | 1 | |
Mutagenesisi | 350 | N → A: No effect on IL6R signaling; when associated with A-55, A-93, A-221 and A-245. Loss of cleavage by ADAM17; when associated with A-55, A-93, A-221 and A-245. 1 Publication | 1 | |
Mutagenesisi | 352 | T → A: No effect on IL6R signaling. 1 Publication | 1 | |
Mutagenesisi | 355 – 356 | PV → IE: Abolishes cleavage by ADAM17. 1 Publication | 2 | |
Mutagenesisi | 355 | P → I or D: Reduces cleavage by ADAM17. 1 Publication | 1 | |
Mutagenesisi | 356 | V → E or G: Abolishes cleavage by ADAM17. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3570 |
MalaCardsi | IL6R |
MIMi | 614689, phenotype 614752, phenotype 618944, phenotype |
OpenTargetsi | ENSG00000160712 |
PharmGKBi | PA29835 |
Miscellaneous databases
Pharosi | P08887, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2364155 |
DrugBanki | DB11767, Sarilumab DB15762, Satralizumab DB06273, Tocilizumab |
DrugCentrali | P08887 |
GuidetoPHARMACOLOGYi | 1708 |
Genetic variation databases
BioMutai | IL6R |
DMDMi | 124343 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000010895 | 20 – 468 | Interleukin-6 receptor subunit alphaAdd BLAST | 449 | |
ChainiPRO_0000450730 | 20 – 355 | Soluble interleukin-6 receptor subunit alphaAdd BLAST | 336 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 ↔ 193 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 47 ↔ 96 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 55 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 93 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 121 ↔ 132 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 165 ↔ 176 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 221 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 245 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 350 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 352 | O-linked (GlcNAc) threonine1 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 245 | Not glycosylated1 Publication | 1 | |
Sitei | 355 – 356 | Cleavage; by ADAM10 and ADAM171 Publication | 2 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P08887 |
MassIVEi | P08887 |
MaxQBi | P08887 |
PaxDbi | P08887 |
PeptideAtlasi | P08887 |
PRIDEi | P08887 |
ProteomicsDBi | 52171 [P08887-1] 52172 [P08887-2] |
PTM databases
GlyGeni | P08887, 9 sites, 3 O-linked glycans (3 sites) |
iPTMneti | P08887 |
PhosphoSitePlusi | P08887 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000160712, Expressed in liver and 229 other tissues |
ExpressionAtlasi | P08887, baseline and differential |
Genevisiblei | P08887, HS |
Organism-specific databases
HPAi | ENSG00000160712, Tissue enhanced (liver, skeletal muscle) |
Interactioni
Subunit structurei
Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6 to associate with the signaling subunit IL6ST (PubMed:12829785, PubMed:28265003).
Interacts (via N-terminal ectodomain) with SORL1; this interaction may affect IL6-binding to IL6R, hence decrease IL6 'classic-signaling' (PubMed:28265003).
2 PublicationsAlso interacts with SORL1; this interaction leads to soluble IL6R internalization. May form a trimeric complex with the soluble SORL1 ectodomain and circulating IL6 receptor; this interaction might stabilize circulating IL6, hence promote IL6 'trans-signaling,.
1 PublicationAlso interacts with SORL1; this interaction leads to soluble IL6R internalization. May form a trimeric complex with the soluble SORL1 ectodomain and circulating IL6 receptor; this interaction might stabilize circulating IL6, hence promote IL6 'trans-signaling,.
1 PublicationBinary interactionsi
P08887
Isoform 2 [P08887-2]
With | #Exp. | IntAct |
---|---|---|
PSMD9 [O00233] | 3 | EBI-16630231,EBI-750973 |
GO - Molecular functioni
- ciliary neurotrophic factor binding Source: BHF-UCL
- cytokine binding Source: GO_Central
- enzyme binding Source: UniProtKB
- interleukin-11 binding Source: GO_Central
- interleukin-6 binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 109784, 23 interactors |
DIPi | DIP-162N |
ELMi | P08887 |
IntActi | P08887, 18 interactors |
MINTi | P08887 |
STRINGi | 9606.ENSP00000357470 |
Miscellaneous databases
RNActi | P08887, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P08887 |
SASBDBi | P08887 |
SMRi | P08887 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08887 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 112 | Ig-like C2-typeAdd BLAST | 87 | |
Domaini | 113 – 217 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 218 – 316 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 99 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 303 – 328 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 421 – 468 | DisorderedSequence analysisAdd BLAST | 48 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 303 – 307 | WSXWS motif | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 311 – 328 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RY0M, Eukaryota |
GeneTreei | ENSGT00940000161919 |
HOGENOMi | CLU_051451_0_0_1 |
InParanoidi | P08887 |
OrthoDBi | 783799at2759 |
PhylomeDBi | P08887 |
TreeFami | TF331210 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003530, Hematopoietin_rcpt_L_F3_CS IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR015321, TypeI_recpt_CBD |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF09240, IL6Ra-bind, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 1 hit SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01354, HEMATOPO_REC_L_F3, 1 hit PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV
60 70 80 90 100
EPEDNATVHW VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG
110 120 130 140 150
RPAGTVHLLV DVPPEEPQLS CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV
160 170 180 190 200
RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS
210 220 230 240 250
KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR
260 270 280 290 300
LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ
310 320 330 340 350
GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN
360 370 380 390 400
ATSLPVQDSS SVPLPTFLVA GGSLAFGTLL CIAIVLRFKK TWKLRALKEG
410 420 430 440 450
KTSMHPPYSL GQLVPERPRP TPVLVPLISP PVSPSSLGSD NTSSHNRPDA
460
RDPRSPYDIS NTDYFFPR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WTB5 | A0A087WTB5_HUMAN | Interleukin-6 receptor subunit alph... | IL6R | 352 | Annotation score: | ||
H0Y949 | H0Y949_HUMAN | Interleukin-6 receptor subunit alph... | IL6R | 190 | Annotation score: | ||
H0Y9B1 | H0Y9B1_HUMAN | Interleukin-6 receptor subunit alph... | IL6R | 294 | Annotation score: | ||
D6R9R8 | D6R9R8_HUMAN | Interleukin-6 receptor subunit alph... | IL6R | 170 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 210 | G → D in BAD97302 (Ref. 5) Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_084713 | 279 | I → N in HIES5; decreased STAT1 and STAT3 phosphorylation. 1 Publication | 1 | |
Natural variantiVAR_084714 | 280 | H → P in HIES5; unknown pathological significance; no effect on STAT1 and STAT3 phosphorylation. 1 Publication | 1 | |
Natural variantiVAR_021995 | 358 | D → A Significantly associated with circulating levels of IL6 and soluble IL6R; increases cleavage by ADAM17. 3 PublicationsCorresponds to variant dbSNP:rs2228145EnsemblClinVar. | 1 | |
Natural variantiVAR_049166 | 385 | V → I. Corresponds to variant dbSNP:rs2228146Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001682 | 356 – 365 | VQDSSSVPLP → GSRRRGSCGL in isoform 2. 3 Publications | 10 | |
Alternative sequenceiVSP_001683 | 366 – 468 | Missing in isoform 2. 3 PublicationsAdd BLAST | 103 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12830 mRNA Translation: CAA31312.1 X58298 mRNA Translation: CAA41231.1 AK293013 mRNA Translation: BAF85702.1 AK312730 mRNA Translation: BAG35601.1 AK223582 mRNA Translation: BAD97302.1 AL162591 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53200.1 BC089410 mRNA Translation: AAH89410.1 S72848 mRNA Translation: AAC60635.1 |
CCDSi | CCDS1067.1 [P08887-1] CCDS1068.1 [P08887-2] |
PIRi | A41242 |
RefSeqi | NP_000556.1, NM_000565.3 [P08887-1] NP_001193795.1, NM_001206866.1 NP_852004.1, NM_181359.2 [P08887-2] |
Genome annotation databases
Ensembli | ENST00000344086; ENSP00000340589; ENSG00000160712 [P08887-2] ENST00000368485; ENSP00000357470; ENSG00000160712 |
GeneIDi | 3570 |
KEGGi | hsa:3570 |
MANE-Selecti | ENST00000368485.8; ENSP00000357470.3; NM_000565.4; NP_000556.1 |
UCSCi | uc001fez.2, human [P08887-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12830 mRNA Translation: CAA31312.1 X58298 mRNA Translation: CAA41231.1 AK293013 mRNA Translation: BAF85702.1 AK312730 mRNA Translation: BAG35601.1 AK223582 mRNA Translation: BAD97302.1 AL162591 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53200.1 BC089410 mRNA Translation: AAH89410.1 S72848 mRNA Translation: AAC60635.1 |
CCDSi | CCDS1067.1 [P08887-1] CCDS1068.1 [P08887-2] |
PIRi | A41242 |
RefSeqi | NP_000556.1, NM_000565.3 [P08887-1] NP_001193795.1, NM_001206866.1 NP_852004.1, NM_181359.2 [P08887-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1N26 | X-ray | 2.40 | A | 20-344 | [»] | |
1P9M | X-ray | 3.65 | C | 115-315 | [»] | |
2ARW | NMR | - | A | 212-336 | [»] | |
5FUC | X-ray | 2.70 | C/D | 111-322 | [»] | |
7DC8 | X-ray | 2.76 | C/F | 111-320 | [»] | |
BMRBi | P08887 | |||||
SASBDBi | P08887 | |||||
SMRi | P08887 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109784, 23 interactors |
DIPi | DIP-162N |
ELMi | P08887 |
IntActi | P08887, 18 interactors |
MINTi | P08887 |
STRINGi | 9606.ENSP00000357470 |
Chemistry databases
ChEMBLi | CHEMBL2364155 |
DrugBanki | DB11767, Sarilumab DB15762, Satralizumab DB06273, Tocilizumab |
DrugCentrali | P08887 |
GuidetoPHARMACOLOGYi | 1708 |
PTM databases
GlyGeni | P08887, 9 sites, 3 O-linked glycans (3 sites) |
iPTMneti | P08887 |
PhosphoSitePlusi | P08887 |
Genetic variation databases
BioMutai | IL6R |
DMDMi | 124343 |
Proteomic databases
jPOSTi | P08887 |
MassIVEi | P08887 |
MaxQBi | P08887 |
PaxDbi | P08887 |
PeptideAtlasi | P08887 |
PRIDEi | P08887 |
ProteomicsDBi | 52171 [P08887-1] 52172 [P08887-2] |
Protocols and materials databases
ABCDi | P08887, 138 sequenced antibodies |
Antibodypediai | 20397, 1063 antibodies from 42 providers |
CPTCi | P08887, 1 antibody |
DNASUi | 3570 |
Genome annotation databases
Ensembli | ENST00000344086; ENSP00000340589; ENSG00000160712 [P08887-2] ENST00000368485; ENSP00000357470; ENSG00000160712 |
GeneIDi | 3570 |
KEGGi | hsa:3570 |
MANE-Selecti | ENST00000368485.8; ENSP00000357470.3; NM_000565.4; NP_000556.1 |
UCSCi | uc001fez.2, human [P08887-1] |
Organism-specific databases
CTDi | 3570 |
DisGeNETi | 3570 |
GeneCardsi | IL6R |
HGNCi | HGNC:6019, IL6R |
HPAi | ENSG00000160712, Tissue enhanced (liver, skeletal muscle) |
MalaCardsi | IL6R |
MIMi | 147880, gene 614689, phenotype 614752, phenotype 618944, phenotype |
neXtProti | NX_P08887 |
OpenTargetsi | ENSG00000160712 |
PharmGKBi | PA29835 |
VEuPathDBi | HostDB:ENSG00000160712 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RY0M, Eukaryota |
GeneTreei | ENSGT00940000161919 |
HOGENOMi | CLU_051451_0_0_1 |
InParanoidi | P08887 |
OrthoDBi | 783799at2759 |
PhylomeDBi | P08887 |
TreeFami | TF331210 |
Enzyme and pathway databases
PathwayCommonsi | P08887 |
Reactomei | R-HSA-1059683, Interleukin-6 signaling R-HSA-110056, MAPK3 (ERK1) activation R-HSA-112411, MAPK1 (ERK2) activation R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | P08887 |
SIGNORi | P08887 |
Miscellaneous databases
BioGRID-ORCSi | 3570, 7 hits in 1042 CRISPR screens |
ChiTaRSi | IL6R, human |
EvolutionaryTracei | P08887 |
GeneWikii | Interleukin-6_receptor |
GenomeRNAii | 3570 |
Pharosi | P08887, Tclin |
PROi | PR:P08887 |
RNActi | P08887, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160712, Expressed in liver and 229 other tissues |
ExpressionAtlasi | P08887, baseline and differential |
Genevisiblei | P08887, HS |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003530, Hematopoietin_rcpt_L_F3_CS IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR015321, TypeI_recpt_CBD |
Pfami | View protein in Pfam PF00047, ig, 1 hit PF09240, IL6Ra-bind, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 1 hit SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01354, HEMATOPO_REC_L_F3, 1 hit PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL6RA_HUMAN | |
Accessioni | P08887Primary (citable) accession number: P08887 Secondary accession number(s): A8KAE8 Q5VZ23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 236 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families