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Protein

Granzyme F

Gene

Gzmf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This enzyme is probably necessary for target cell lysis in cell-mediated immune responses.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay systemBy similarity1
Active sitei109Charge relay systemBy similarity1
Active sitei204Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cytolysis Source: UniProtKB-KW
  • granzyme-mediated apoptotic signaling pathway Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processCytolysis

Enzyme and pathway databases

ReactomeiR-MMU-2022377 Metabolism of Angiotensinogen to Angiotensins
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPSiS01.401

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme F (EC:3.4.21.-)
Alternative name(s):
C134
CTL serine protease 3
Cytotoxic cell protease 4
Short name:
CCP4
Cytotoxic serine protease 3
MCSP3
Gene namesi
Name:Gzmf
Synonyms:Ccp4, Ctla-7, Ctla7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:109254 Gzmf

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
PropeptideiPRO_000002740919 – 202 Publications2
ChainiPRO_000002741021 – 248Granzyme FAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 210PROSITE-ProRule annotation
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi175 ↔ 189PROSITE-ProRule annotation
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP08883
PeptideAtlasiP08883
PRIDEiP08883

PTM databases

iPTMnetiP08883
PhosphoSitePlusiP08883

Expressioni

Gene expression databases

BgeeiENSMUSG00000015441 Expressed in 61 organ(s), highest expression level in decidua
CleanExiMM_GZMF
ExpressionAtlasiP08883 baseline and differential
GenevisibleiP08883 MM

Interactioni

Protein-protein interaction databases

BioGridi200139, 1 interactor
IntActiP08883, 1 interactor
MINTiP08883
STRINGi10090.ENSMUSP00000022757

Structurei

3D structure databases

ProteinModelPortaliP08883
SMRiP08883
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 246Peptidase S1PROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118895
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP08883
OMAiWDTVNPG
OrthoDBiEOG091G0G5F
PhylomeDBiP08883
TreeFamiTF333630

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08883-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPILILLTL LLPLRAGAEE IIGGHEVKPH SRPYMARVRF VKDNGKRHSC
60 70 80 90 100
GGFLVQDYFV LTAAHCTGSS MRVILGAHNI RAKEETQQII PVAKAIPHPA
110 120 130 140 150
YDDKDNTSDI MLLKLESKAK RTKAVRPLKL PRPNARVKPG HVCSVAGWGR
160 170 180 190 200
TSINATQRSS CLREAQLIIQ KDKECKKYFY KYFKTMQICA GDPKKIQSTY
210 220 230 240
SGDSGGPLVC NNKAYGVLTY GLNRTIGPGV FTKVVHYLPW ISRNMKLL
Length:248
Mass (Da):27,642
Last modified:November 1, 1988 - v1
Checksum:i02B4BB67F100DC38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36902 mRNA Translation: AAA37488.1
X56989 Genomic DNA Translation: CAA40307.1
M96930 Genomic DNA Translation: AAA37741.1
J03257 mRNA Translation: AAA37738.1
X12823 mRNA Translation: CAA31310.1
X14094 mRNA Translation: CAA32256.1
CCDSiCCDS36936.1
PIRiS24940 S01007
RefSeqiNP_034504.1, NM_010374.3
UniGeneiMm.457976

Genome annotation databases

EnsembliENSMUST00000022757; ENSMUSP00000022757; ENSMUSG00000015441
GeneIDi14943
KEGGimmu:14943
UCSCiuc007ubs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36902 mRNA Translation: AAA37488.1
X56989 Genomic DNA Translation: CAA40307.1
M96930 Genomic DNA Translation: AAA37741.1
J03257 mRNA Translation: AAA37738.1
X12823 mRNA Translation: CAA31310.1
X14094 mRNA Translation: CAA32256.1
CCDSiCCDS36936.1
PIRiS24940 S01007
RefSeqiNP_034504.1, NM_010374.3
UniGeneiMm.457976

3D structure databases

ProteinModelPortaliP08883
SMRiP08883
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200139, 1 interactor
IntActiP08883, 1 interactor
MINTiP08883
STRINGi10090.ENSMUSP00000022757

Protein family/group databases

MEROPSiS01.401

PTM databases

iPTMnetiP08883
PhosphoSitePlusiP08883

Proteomic databases

PaxDbiP08883
PeptideAtlasiP08883
PRIDEiP08883

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022757; ENSMUSP00000022757; ENSMUSG00000015441
GeneIDi14943
KEGGimmu:14943
UCSCiuc007ubs.1 mouse

Organism-specific databases

CTDi14943
MGIiMGI:109254 Gzmf

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118895
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP08883
OMAiWDTVNPG
OrthoDBiEOG091G0G5F
PhylomeDBiP08883
TreeFamiTF333630

Enzyme and pathway databases

ReactomeiR-MMU-2022377 Metabolism of Angiotensinogen to Angiotensins
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

ChiTaRSiGzmf mouse
PROiPR:P08883
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015441 Expressed in 61 organ(s), highest expression level in decidua
CleanExiMM_GZMF
ExpressionAtlasiP08883 baseline and differential
GenevisibleiP08883 MM

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRAF_MOUSE
AccessioniPrimary (citable) accession number: P08883
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: November 7, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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