UniProtKB - P08865 (RSSA_HUMAN)
40S ribosomal protein SA
RPSA
Functioni
Miscellaneous
GO - Molecular functioni
- laminin binding Source: UniProtKB-UniRule
- laminin receptor activity Source: UniProtKB-UniRule
- ribosome binding Source: UniProtKB
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: FlyBase
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- cell adhesion Source: ProtInc
- cytoplasmic translation Source: GO_Central
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- ribosomal small subunit assembly Source: GO_Central
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: GO_Central
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Host cell receptor for virus entry, Receptor, Ribonucleoprotein, Ribosomal protein |
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P08865 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | P08865 |
Names & Taxonomyi
Protein namesi | Recommended name: 40S ribosomal protein SAUniRule annotationAlternative name(s): 37 kDa laminin receptor precursorUniRule annotation Short name: 37LRPUniRule annotation 37/67 kDa laminin receptorUniRule annotation Short name: LRP/LRUniRule annotation 67 kDa laminin receptorUniRule annotation Short name: 67LRUniRule annotation Colon carcinoma laminin-binding protein Laminin receptor 1UniRule annotation Short name: LamRUniRule annotation Laminin-binding protein precursor p40UniRule annotation Short name: LBP/p40UniRule annotation Multidrug resistance-associated protein MGr1-Ag NEM/1CHD4 Small ribosomal subunit protein uS21 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6502, RPSA |
MIMi | 150370, gene |
neXtProti | NX_P08865 |
VEuPathDBi | HostDB:ENSG00000168028.13 |
Subcellular locationi
Plasma membrane
Nucleus
- Nucleus UniRule annotation
Cytoplasm and Cytosol
Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane.UniRule annotation
Cytosol
- cytosol Source: Reactome
- cytosolic small ribosomal subunit Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Asplenia, isolated congenital (ICAS)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075092 | 54 | T → N in ICAS; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs397514762EnsemblClinVar. | 1 | |
Natural variantiVAR_075093 | 58 | L → F in ICAS; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs397514763EnsemblClinVar. | 1 | |
Natural variantiVAR_075094 | 180 | R → G in ICAS; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs397514760EnsemblClinVar. | 1 | |
Natural variantiVAR_075095 | 180 | R → W in ICAS; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs397514760EnsemblClinVar. | 1 | |
Natural variantiVAR_075097 | 186 | R → C in ICAS; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs397514761EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 3921 |
MalaCardsi | RPSA |
MIMi | 271400, phenotype |
OpenTargetsi | ENSG00000168028 |
Orphaneti | 101351, Familial isolated congenital asplenia |
PharmGKBi | PA30287 |
Miscellaneous databases
Pharosi | P08865, Tbio |
Chemistry databases
ChEMBLi | CHEMBL6119 |
DrugBanki | DB09130, Copper DB04985, Tigapotide |
Genetic variation databases
BioMutai | RPSA |
DMDMi | 125969 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedUniRule annotationCombined sources1 Publication | |||
ChainiPRO_0000134358 | 2 – 295 | 40S ribosomal protein SAAdd BLAST | 294 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineUniRule annotationCombined sources1 Publication | 1 | |
Modified residuei | 43 | PhosphoserineCombined sources | 1 | |
Modified residuei | 52 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 89 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 89 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 97 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 115 – 116 | Cleavage; by ST3; site 1UniRule annotation | 2 | |
Sitei | 133 – 134 | Cleavage; by ST3; site 2UniRule annotation | 2 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P08865 |
jPOSTi | P08865 |
MassIVEi | P08865 |
MaxQBi | P08865 |
PaxDbi | P08865 |
PeptideAtlasi | P08865 |
PRIDEi | P08865 |
ProteomicsDBi | 52170 |
TopDownProteomicsi | P08865 |
PTM databases
iPTMneti | P08865 |
MetOSitei | P08865 |
PhosphoSitePlusi | P08865 |
SwissPalmi | P08865 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168028, Expressed in right uterine tube and 112 other tissues |
ExpressionAtlasi | P08865, baseline and differential |
Genevisiblei | P08865, HS |
Organism-specific databases
HPAi | ENSG00000168028, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (37LRP) and homodimer (67LR).
Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
Interacts with RPS21.
Interacts with several laminins including at least LAMB1.
Interacts with MDK (By similarity). The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat).
Interacts with PPP1CA only in the presence of PPP1R16B.
UniRule annotation10 Publications(Microbial infection) 67LR interacts with capsid protein of Adeno-associated virus 2,3,8 and 9.
1 Publication(Microbial infection) 67LR interacts with envelope protein of dengue virus.
1 PublicationBinary interactionsi
Hide detailsP08865
GO - Molecular functioni
- laminin binding Source: UniProtKB-UniRule
- laminin receptor activity Source: UniProtKB-UniRule
Protein-protein interaction databases
BioGRIDi | 110115, 311 interactors |
ComplexPortali | CPX-5223, 40S cytosolic small ribosomal subunit |
CORUMi | P08865 |
DIPi | DIP-32878N |
IntActi | P08865, 120 interactors |
MINTi | P08865 |
STRINGi | 9606.ENSP00000346067 |
Miscellaneous databases
RNActi | P08865, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P08865 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08865 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 230 – 232 | [DE]-W-[ST] 1 | 3 | |
Repeati | 247 – 249 | [DE]-W-[ST] 2 | 3 | |
Repeati | 266 – 268 | [DE]-W-[ST] 3 | 3 | |
Repeati | 275 – 277 | [DE]-W-[ST] 4 | 3 | |
Repeati | 293 – 295 | [DE]-W-[ST] 5 | 3 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 54 – 113 | Interaction with PPP1R16B1 PublicationAdd BLAST | 60 | |
Regioni | 161 – 180 | Laminin-bindingAdd BLAST | 20 | |
Regioni | 205 – 229 | Laminin-bindingAdd BLAST | 25 | |
Regioni | 242 – 295 | Laminin-bindingAdd BLAST | 54 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0830, Eukaryota |
GeneTreei | ENSGT00950000183099 |
InParanoidi | P08865 |
OrthoDBi | 1129610at2759 |
PhylomeDBi | P08865 |
TreeFami | TF300100 |
Family and domain databases
CDDi | cd01425, RPS2, 1 hit |
HAMAPi | MF_03015, Ribosomal_S2_euk, 1 hit MF_03016, Ribosomal_S2_laminin_receptor, 1 hit |
InterProi | View protein in InterPro IPR027504, 40S_ribosomal_SA IPR032281, 40S_SA_C IPR001865, Ribosomal_S2 IPR018130, Ribosomal_S2_CS IPR027498, Ribosomal_S2_euk IPR005707, Ribosomal_S2_euk/arc IPR023591, Ribosomal_S2_flav_dom_sf |
PANTHERi | PTHR11489, PTHR11489, 1 hit |
Pfami | View protein in Pfam PF16122, 40S_SA_C, 1 hit PF00318, Ribosomal_S2, 2 hits |
PRINTSi | PR00395, RIBOSOMALS2 |
SUPFAMi | SSF52313, SSF52313, 1 hit |
TIGRFAMsi | TIGR01012, uS2_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00962, RIBOSOMAL_S2_1, 1 hit PS00963, RIBOSOMAL_S2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSGALDVLQM KEEDVLKFLA AGTHLGGTNL DFQMEQYIYK RKSDGIYIIN
60 70 80 90 100
LKRTWEKLLL AARAIVAIEN PADVSVISSR NTGQRAVLKF AAATGATPIA
110 120 130 140 150
GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT
160 170 180 190 200
DSPLRYVDIA IPCNNKGAHS VGLMWWMLAR EVLRMRGTIS REHPWEVMPD
210 220 230 240 250
LYFYRDPEEI EKEEQAAAEK AVTKEEFQGE WTAPAPEFTA TQPEVADWSE
260 270 280 290
GVQVPSVPIQ QFPTEDWSAQ PATEDWSAAP TAQATEWVGA TTDWS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DG17 | A0A0C4DG17_HUMAN | 40S ribosomal protein SA | RPSA hCG_1997894 | 300 | Annotation score: | ||
C9J9K3 | C9J9K3_HUMAN | 40S ribosomal protein SA | RPSA | 263 | Annotation score: | ||
F8WD59 | F8WD59_HUMAN | 40S ribosomal protein SA | RPSA | 116 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 60 | L → V in CAA43469 (Ref. 9) Curated | 1 | |
Sequence conflicti | 84 | Q → QVCGTV in CAA33112 (PubMed:2543954).Curated | 1 | |
Sequence conflicti | 115 | A → T in AAH50688 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 135 | T → S in AAH70263 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 211 | E → G in AAB22299 (PubMed:1534510).Curated | 1 | |
Sequence conflicti | 214 | E → G in AAH66941 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 228 | Q → L in AAB22299 (PubMed:1534510).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075092 | 54 | T → N in ICAS; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs397514762EnsemblClinVar. | 1 | |
Natural variantiVAR_075093 | 58 | L → F in ICAS; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs397514763EnsemblClinVar. | 1 | |
Natural variantiVAR_025522 | 117 | R → W1 PublicationCorresponds to variant dbSNP:rs17856150Ensembl. | 1 | |
Natural variantiVAR_075094 | 180 | R → G in ICAS; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs397514760EnsemblClinVar. | 1 | |
Natural variantiVAR_075095 | 180 | R → W in ICAS; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs397514760EnsemblClinVar. | 1 | |
Natural variantiVAR_075096 | 185 | M → V1 PublicationCorresponds to variant dbSNP:rs1214087389Ensembl. | 1 | |
Natural variantiVAR_075097 | 186 | R → C in ICAS; reduced protein levels. 1 PublicationCorresponds to variant dbSNP:rs397514761EnsemblClinVar. | 1 | |
Natural variantiVAR_075098 | 257 | V → G1 PublicationCorresponds to variant dbSNP:rs369708612Ensembl. | 1 | |
Natural variantiVAR_075099 | 278 | A → T1 PublicationCorresponds to variant dbSNP:rs143085301Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03799 mRNA Translation: AAA36161.1 X15005 mRNA Translation: CAA33112.1 S37431 mRNA Translation: AAB22299.1 U43901 Genomic DNA Translation: AAC50652.1 AF503367 mRNA Translation: AAM33304.1 BT007219 mRNA Translation: AAP35883.1 BC005391 mRNA Translation: AAH05391.1 BC008867 mRNA Translation: AAH08867.1 BC010418 mRNA Translation: AAH10418.1 BC013827 mRNA Translation: AAH13827.1 BC034537 mRNA Translation: AAH34537.1 BC050688 mRNA Translation: AAH50688.1 BC053370 mRNA Translation: AAH53370.1 BC062714 mRNA Translation: AAH62714.1 BC066941 mRNA Translation: AAH66941.1 BC068062 mRNA Translation: AAH68062.1 BC070263 mRNA Translation: AAH70263.1 BC071693 mRNA Translation: AAH71693.1 BC071968 mRNA Translation: AAH71968.1 BC071969 mRNA Translation: AAH71969.1 BC071970 mRNA Translation: AAH71970.1 BC073863 mRNA Translation: AAH73863.1 BC107567 mRNA Translation: AAI07568.1 X61156 mRNA Translation: CAA43469.1 U36484 Genomic DNA Translation: AAC50313.1 M14199 mRNA Translation: AAA36165.1 AB007146 Genomic DNA Translation: BAA25812.1 |
CCDSi | CCDS2686.1 |
PIRi | A31233 |
RefSeqi | NP_001291217.1, NM_001304288.1 NP_002286.2, NM_002295.5 |
Genome annotation databases
Ensembli | ENST00000301821; ENSP00000346067; ENSG00000168028 |
GeneIDi | 3921 |
KEGGi | hsa:3921 |
UCSCi | uc003cjp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03799 mRNA Translation: AAA36161.1 X15005 mRNA Translation: CAA33112.1 S37431 mRNA Translation: AAB22299.1 U43901 Genomic DNA Translation: AAC50652.1 AF503367 mRNA Translation: AAM33304.1 BT007219 mRNA Translation: AAP35883.1 BC005391 mRNA Translation: AAH05391.1 BC008867 mRNA Translation: AAH08867.1 BC010418 mRNA Translation: AAH10418.1 BC013827 mRNA Translation: AAH13827.1 BC034537 mRNA Translation: AAH34537.1 BC050688 mRNA Translation: AAH50688.1 BC053370 mRNA Translation: AAH53370.1 BC062714 mRNA Translation: AAH62714.1 BC066941 mRNA Translation: AAH66941.1 BC068062 mRNA Translation: AAH68062.1 BC070263 mRNA Translation: AAH70263.1 BC071693 mRNA Translation: AAH71693.1 BC071968 mRNA Translation: AAH71968.1 BC071969 mRNA Translation: AAH71969.1 BC071970 mRNA Translation: AAH71970.1 BC073863 mRNA Translation: AAH73863.1 BC107567 mRNA Translation: AAI07568.1 X61156 mRNA Translation: CAA43469.1 U36484 Genomic DNA Translation: AAC50313.1 M14199 mRNA Translation: AAA36165.1 AB007146 Genomic DNA Translation: BAA25812.1 |
CCDSi | CCDS2686.1 |
PIRi | A31233 |
RefSeqi | NP_001291217.1, NM_001304288.1 NP_002286.2, NM_002295.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3BCH | X-ray | 2.15 | A | 2-220 | [»] | |
4UG0 | electron microscopy | - | SA | 1-295 | [»] | |
4V6X | electron microscopy | 5.00 | AA | 1-295 | [»] | |
5A2Q | electron microscopy | 3.90 | A | 1-295 | [»] | |
5AJ0 | electron microscopy | 3.50 | BA | 1-295 | [»] | |
5FLX | electron microscopy | 3.90 | A | 1-295 | [»] | |
5LKS | electron microscopy | 3.60 | SA | 1-295 | [»] | |
5OA3 | electron microscopy | 4.30 | A | 1-295 | [»] | |
5T2C | electron microscopy | 3.60 | Ao | 1-295 | [»] | |
5VYC | X-ray | 6.00 | A1/A2/A3/A4/A5/A6 | 1-295 | [»] | |
6EK0 | electron microscopy | 2.90 | SA | 1-295 | [»] | |
6FEC | electron microscopy | 6.30 | f | 2-209 | [»] | |
6G18 | electron microscopy | 3.60 | A | 1-295 | [»] | |
6G4S | electron microscopy | 4.00 | A | 1-295 | [»] | |
6G51 | electron microscopy | 4.10 | A | 1-295 | [»] | |
6G53 | electron microscopy | 4.50 | A | 1-295 | [»] | |
6G5H | electron microscopy | 3.60 | A | 1-295 | [»] | |
6G5I | electron microscopy | 3.50 | A | 1-295 | [»] | |
6IP5 | electron microscopy | 3.90 | 2n | 1-295 | [»] | |
6IP6 | electron microscopy | 4.50 | 2n | 1-295 | [»] | |
6IP8 | electron microscopy | 3.90 | 2n | 1-295 | [»] | |
6OLE | electron microscopy | 3.10 | SA | 3-223 | [»] | |
6OLF | electron microscopy | 3.90 | SA | 3-223 | [»] | |
6OLG | electron microscopy | 3.40 | BA | 5-219 | [»] | |
6OLI | electron microscopy | 3.50 | SA | 3-223 | [»] | |
6OLZ | electron microscopy | 3.90 | BA | 5-219 | [»] | |
6OM0 | electron microscopy | 3.10 | SA | 3-223 | [»] | |
6OM7 | electron microscopy | 3.70 | SA | 3-223 | [»] | |
6QZP | electron microscopy | 2.90 | SA | 3-223 | [»] | |
6XA1 | electron microscopy | 2.80 | SA | 2-217 | [»] | |
6Y0G | electron microscopy | 3.20 | SA | 1-295 | [»] | |
6Y2L | electron microscopy | 3.00 | SA | 1-295 | [»] | |
6Y57 | electron microscopy | 3.50 | SA | 1-295 | [»] | |
6YBD | electron microscopy | 3.30 | N | 1-295 | [»] | |
6YBW | electron microscopy | 3.10 | N | 1-295 | [»] | |
6Z6L | electron microscopy | 3.00 | SA | 1-295 | [»] | |
6Z6M | electron microscopy | 3.10 | SA | 1-295 | [»] | |
6Z6N | electron microscopy | 2.90 | SA | 1-295 | [»] | |
6ZLW | electron microscopy | 2.60 | B | 1-295 | [»] | |
6ZM7 | electron microscopy | 2.70 | SA | 1-295 | [»] | |
6ZME | electron microscopy | 3.00 | SA | 1-295 | [»] | |
6ZMI | electron microscopy | 2.60 | SA | 1-295 | [»] | |
6ZMO | electron microscopy | 3.10 | SA | 1-295 | [»] | |
6ZMT | electron microscopy | 3.00 | B | 1-295 | [»] | |
6ZMW | electron microscopy | 3.70 | N | 1-295 | [»] | |
6ZN5 | electron microscopy | 3.20 | B | 2-207 | [»] | |
6ZOJ | electron microscopy | 2.80 | A | 1-295 | [»] | |
6ZOK | electron microscopy | 2.80 | A | 1-295 | [»] | |
6ZON | electron microscopy | 3.00 | a | 1-295 | [»] | |
6ZP4 | electron microscopy | 2.90 | a | 1-295 | [»] | |
6ZVH | electron microscopy | 2.90 | A | 3-223 | [»] | |
6ZVJ | electron microscopy | 3.80 | a | 2-217 | [»] | |
6ZXD | electron microscopy | 3.20 | A | 1-295 | [»] | |
6ZXE | electron microscopy | 3.00 | A | 1-295 | [»] | |
6ZXF | electron microscopy | 3.70 | A | 1-295 | [»] | |
6ZXG | electron microscopy | 2.60 | A | 1-295 | [»] | |
6ZXH | electron microscopy | 2.70 | A | 1-295 | [»] | |
7A09 | electron microscopy | 3.50 | a | 1-295 | [»] | |
7K5I | electron microscopy | 2.90 | A | 1-295 | [»] | |
SMRi | P08865 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110115, 311 interactors |
ComplexPortali | CPX-5223, 40S cytosolic small ribosomal subunit |
CORUMi | P08865 |
DIPi | DIP-32878N |
IntActi | P08865, 120 interactors |
MINTi | P08865 |
STRINGi | 9606.ENSP00000346067 |
Chemistry databases
ChEMBLi | CHEMBL6119 |
DrugBanki | DB09130, Copper DB04985, Tigapotide |
PTM databases
iPTMneti | P08865 |
MetOSitei | P08865 |
PhosphoSitePlusi | P08865 |
SwissPalmi | P08865 |
Genetic variation databases
BioMutai | RPSA |
DMDMi | 125969 |
Proteomic databases
EPDi | P08865 |
jPOSTi | P08865 |
MassIVEi | P08865 |
MaxQBi | P08865 |
PaxDbi | P08865 |
PeptideAtlasi | P08865 |
PRIDEi | P08865 |
ProteomicsDBi | 52170 |
TopDownProteomicsi | P08865 |
Protocols and materials databases
Antibodypediai | 4030, 383 antibodies |
DNASUi | 3921 |
Genome annotation databases
Ensembli | ENST00000301821; ENSP00000346067; ENSG00000168028 |
GeneIDi | 3921 |
KEGGi | hsa:3921 |
UCSCi | uc003cjp.4, human |
Organism-specific databases
CTDi | 3921 |
DisGeNETi | 3921 |
GeneCardsi | RPSA |
HGNCi | HGNC:6502, RPSA |
HPAi | ENSG00000168028, Low tissue specificity |
MalaCardsi | RPSA |
MIMi | 150370, gene 271400, phenotype |
neXtProti | NX_P08865 |
OpenTargetsi | ENSG00000168028 |
Orphaneti | 101351, Familial isolated congenital asplenia |
PharmGKBi | PA30287 |
VEuPathDBi | HostDB:ENSG00000168028.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0830, Eukaryota |
GeneTreei | ENSGT00950000183099 |
InParanoidi | P08865 |
OrthoDBi | 1129610at2759 |
PhylomeDBi | P08865 |
TreeFami | TF300100 |
Enzyme and pathway databases
PathwayCommonsi | P08865 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | P08865 |
Miscellaneous databases
BioGRID-ORCSi | 3921, 733 hits in 997 CRISPR screens |
ChiTaRSi | RPSA, human |
EvolutionaryTracei | P08865 |
GeneWikii | Ribosomal_protein_SA |
GenomeRNAii | 3921 |
Pharosi | P08865, Tbio |
PROi | PR:P08865 |
RNActi | P08865, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168028, Expressed in right uterine tube and 112 other tissues |
ExpressionAtlasi | P08865, baseline and differential |
Genevisiblei | P08865, HS |
Family and domain databases
CDDi | cd01425, RPS2, 1 hit |
HAMAPi | MF_03015, Ribosomal_S2_euk, 1 hit MF_03016, Ribosomal_S2_laminin_receptor, 1 hit |
InterProi | View protein in InterPro IPR027504, 40S_ribosomal_SA IPR032281, 40S_SA_C IPR001865, Ribosomal_S2 IPR018130, Ribosomal_S2_CS IPR027498, Ribosomal_S2_euk IPR005707, Ribosomal_S2_euk/arc IPR023591, Ribosomal_S2_flav_dom_sf |
PANTHERi | PTHR11489, PTHR11489, 1 hit |
Pfami | View protein in Pfam PF16122, 40S_SA_C, 1 hit PF00318, Ribosomal_S2, 2 hits |
PRINTSi | PR00395, RIBOSOMALS2 |
SUPFAMi | SSF52313, SSF52313, 1 hit |
TIGRFAMsi | TIGR01012, uS2_euk_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00962, RIBOSOMAL_S2_1, 1 hit PS00963, RIBOSOMAL_S2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RSSA_HUMAN | |
Accessioni | P08865Primary (citable) accession number: P08865 Secondary accession number(s): P11085 Q86VC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 232 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families