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Protein

Alcohol dehydrogenase 1

Gene

alcA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi154Zinc 1; catalyticBy similarity1
Binding sitei202NADBy similarity1
Binding sitei207NADBy similarity1
Binding sitei343NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 184NADBy similarity7
Nucleotide bindingi271 – 273NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: AspGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • acetaldehyde catabolic process Source: AspGD
  • cellular response to farnesol Source: AspGD
  • ethanol catabolic process Source: AspGD
  • NADH oxidation Source: GO_Central
  • threonine catabolic process Source: AspGD

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase I
Short name:
ADH I
Gene namesi
Name:alcA
ORF Names:AN8979
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607191 – 350Alcohol dehydrogenase 1Add BLAST350

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi162425.CADANIAP00007876

Structurei

3D structure databases

ProteinModelPortaliP08843
SMRiP08843
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685
InParanoidiP08843
KOiK13953
OMAiQYAHNVF
OrthoDBiEOG092C2Q8E

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P08843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPTMQWAQ VAEKVGGPLV YKQIPVPKPG PDQILVKIRY SGVCHTDLHA
60 70 80 90 100
MMGHWPIPVK MPLVGGHEGA GIVVAKGELV HEFEIGDQAG IKWLNGSCGE
110 120 130 140 150
CEFCRQSDDP LCARAQLSGY TVDGTFQQYA LGKASHASKI PAGVPLDAAA
160 170 180 190 200
PVLCAGITVY KGLKEAGVRP GQTVAIVGAG GGLGSLAQQY AKAMGIRVVA
210 220 230 240 250
VDGGDEKRAM CESLGTETYV DFTKSKDLVA DVKAATPDGL GAHAVILLAV
260 270 280 290 300
SEKPFQQATE YVRSRGTIVA IGLPPDAYLK APVINTVVRM ITIKGSYVGN
310 320 330 340 350
RQDGVEALDF FARGLIKAPF KTAPLKDLPK IYELMEQGRI AGRYVLEMPE
Length:350
Mass (Da):37,153
Last modified:May 1, 2007 - v2
Checksum:i730F216F16217AC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → C in AAA33291 (PubMed:3297923).Curated1
Sequence conflicti146L → V in AAA33291 (PubMed:3297923).Curated1
Sequence conflicti233 – 239KAATPDG → RHGRGC in AAA33291 (PubMed:3297923).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16196 Genomic DNA Translation: AAA33291.1
AACD01000168 Genomic DNA Translation: EAA64311.1
BN001307 Genomic DNA Translation: CBF84526.1
PIRiA29054
RefSeqiXP_682248.1, XM_677156.1

Genome annotation databases

EnsemblFungiiCBF84526; CBF84526; ANIA_08979
EAA64311; EAA64311; AN8979.2
GeneIDi2868277
KEGGiani:AN8979.2

Similar proteinsi

Entry informationi

Entry nameiADH1_EMENI
AccessioniPrimary (citable) accession number: P08843
Secondary accession number(s): C8VL73, Q5ARV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: May 1, 2007
Last modified: June 20, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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