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Protein

Steryl-sulfatase

Gene

STS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conversion of sulfated steroid precursors to estrogens during pregnancy.

Catalytic activityi

3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.

Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi35Calcium1 Publication1
Metal bindingi36Calcium1 Publication1
Active sitei75Nucleophile1 Publication1
Metal bindingi75Calcium; via 3-oxoalanine1 Publication1
Active sitei1361 Publication1
Metal bindingi342Calcium1 Publication1
Metal bindingi343Calcium1 Publication1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • steryl-sulfatase activity Source: Reactome
  • sulfuric ester hydrolase activity Source: MGI

GO - Biological processi

  • epidermis development Source: ProtInc
  • female pregnancy Source: UniProtKB-KW
  • glycosphingolipid metabolic process Source: Reactome
  • steroid catabolic process Source: ProtInc

Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism, Pregnancy, Steroid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.6.2 2681
ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases

Chemistry databases

SwissLipidsiSLP:000001236

Names & Taxonomyi

Protein namesi
Recommended name:
Steryl-sulfatase (EC:3.1.6.2)
Alternative name(s):
Arylsulfatase C
Short name:
ASC
Steroid sulfatase
Steryl-sulfate sulfohydrolase
Gene namesi
Name:STS
Synonyms:ARSC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000101846.6
HGNCiHGNC:11425 STS
MIMi300747 gene
neXtProtiNX_P08842

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 184LumenalAdd BLAST163
Transmembranei185 – 208HelicalAdd BLAST24
Topological domaini209 – 212Cytoplasmic4
Transmembranei213 – 234HelicalAdd BLAST22
Topological domaini235 – 583LumenalAdd BLAST349

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Ichthyosis, X-linked (IXL)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.
See also OMIM:308100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007240341S → L in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853167EnsemblClinVar.1
Natural variantiVAR_007241372W → R in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853165EnsemblClinVar.1
Natural variantiVAR_014020372W → S in IXL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853168EnsemblClinVar.1
Natural variantiVAR_014021380G → R in IXL. 1 Publication1
Natural variantiVAR_014022444H → R in IXL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853169EnsemblClinVar.1
Natural variantiVAR_007242446C → Y in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853166EnsemblClinVar.1
Natural variantiVAR_014023560Q → P in IXL. 1 Publication1

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNETi412
MalaCardsiSTS
MIMi308100 phenotype
OpenTargetsiENSG00000101846
Orphaneti461 Recessive X-linked ichthyosis
281090 Syndromic recessive X-linked ichthyosis
PharmGKBiPA36225

Chemistry databases

ChEMBLiCHEMBL3559
DrugBankiDB02735 2-Amino-3-Oxo-4-Sulfo-Butyric Acid
DB06713 Norelgestromin

Polymorphism and mutation databases

BioMutaiSTS
DMDMi135006

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000003341422 – 583Steryl-sulfataseAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagine2 Publications1
Modified residuei753-oxoalanine (Cys)1 Publication1
Disulfide bondi141 ↔ 148
Disulfide bondi170 ↔ 242
Glycosylationi259N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi446 ↔ 489
Disulfide bondi481 ↔ 487
Disulfide bondi562 ↔ 570
Disulfide bondi563 ↔ 572

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei333Not glycosylated1 Publication1
Sitei459Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP08842
MaxQBiP08842
PaxDbiP08842
PeptideAtlasiP08842
PRIDEiP08842
ProteomicsDBi52168

PTM databases

GlyConnecti1770
iPTMnetiP08842
PhosphoSitePlusiP08842
SwissPalmiP08842

Expressioni

Gene expression databases

BgeeiENSG00000101846 Expressed in 207 organ(s), highest expression level in chorionic villus
CleanExiHS_STS
GenevisibleiP08842 HS

Organism-specific databases

HPAiHPA002904

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi106905, 27 interactors
IntActiP08842, 1 interactor
MINTiP08842
STRINGi9606.ENSP00000217961

Chemistry databases

BindingDBiP08842

Structurei

Secondary structure

1583
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08842
SMRiP08842
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08842

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3867 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00760000119062
HOGENOMiHOG000135352
HOVERGENiHBG004283
InParanoidiP08842
KOiK01131
OMAiTNWEGGI
OrthoDBiEOG091G07AL
PhylomeDBiP08842
TreeFamiTF314186

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR024607 Sulfatase_CS
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00523 SULFATASE_1, 1 hit
PS00149 SULFATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08842-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLRKMKIPF LLLFFLWEAE SHAASRPNII LVMADDLGIG DPGCYGNKTI
60 70 80 90 100
RTPNIDRLAS GGVKLTQHLA ASPLCTPSRA AFMTGRYPVR SGMASWSRTG
110 120 130 140 150
VFLFTASSGG LPTDEITFAK LLKDQGYSTA LIGKWHLGMS CHSKTDFCHH
160 170 180 190 200
PLHHGFNYFY GISLTNLRDC KPGEGSVFTT GFKRLVFLPL QIVGVTLLTL
210 220 230 240 250
AALNCLGLLH VPLGVFFSLL FLAALILTLF LGFLHYFRPL NCFMMRNYEI
260 270 280 290 300
IQQPMSYDNL TQRLTVEAAQ FIQRNTETPF LLVLSYLHVH TALFSSKDFA
310 320 330 340 350
GKSQHGVYGD AVEEMDWSVG QILNLLDELR LANDTLIYFT SDQGAHVEEV
360 370 380 390 400
SSKGEIHGGS NGIYKGGKAN NWEGGIRVPG ILRWPRVIQA GQKIDEPTSN
410 420 430 440 450
MDIFPTVAKL AGAPLPEDRI IDGRDLMPLL EGKSQRSDHE FLFHYCNAYL
460 470 480 490 500
NAVRWHPQNS TSIWKAFFFT PNFNPVGSNG CFATHVCFCF GSYVTHHDPP
510 520 530 540 550
LLFDISKDPR ERNPLTPASE PRFYEILKVM QEAADRHTQT LPEVPDQFSW
560 570 580
NNFLWKPWLQ LCCPSTGLSC QCDREKQDKR LSR
Length:583
Mass (Da):65,492
Last modified:April 1, 1990 - v2
Checksum:i74746AFA9D21A0A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23A → E in AAA60596 (PubMed:3032454).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007240341S → L in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853167EnsemblClinVar.1
Natural variantiVAR_007241372W → R in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853165EnsemblClinVar.1
Natural variantiVAR_014020372W → S in IXL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853168EnsemblClinVar.1
Natural variantiVAR_014021380G → R in IXL. 1 Publication1
Natural variantiVAR_014022444H → R in IXL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853169EnsemblClinVar.1
Natural variantiVAR_007242446C → Y in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853166EnsemblClinVar.1
Natural variantiVAR_014023560Q → P in IXL. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04964 mRNA Translation: AAA60597.1
M16505 mRNA Translation: AAA60596.1
AK314034 mRNA Translation: BAG36744.1
BC075030 mRNA Translation: AAH75030.1
M23945 Genomic DNA Translation: AAA60598.1
M23556 Genomic DNA Translation: AAA60599.1
CCDSiCCDS14127.1
PIRiA32641 KJHUAC
RefSeqiNP_000342.2, NM_000351.5
NP_001307679.1, NM_001320750.1
NP_001307680.1, NM_001320751.1
NP_001307681.1, NM_001320752.1
NP_001307682.1, NM_001320753.1
NP_001307683.1, NM_001320754.1
UniGeneiHs.522578
Hs.700558
Hs.700559
Hs.740067

Genome annotation databases

EnsembliENST00000217961; ENSP00000217961; ENSG00000101846
GeneIDi412
KEGGihsa:412
UCSCiuc004cry.5 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Steroid sulfatase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04964 mRNA Translation: AAA60597.1
M16505 mRNA Translation: AAA60596.1
AK314034 mRNA Translation: BAG36744.1
BC075030 mRNA Translation: AAH75030.1
M23945 Genomic DNA Translation: AAA60598.1
M23556 Genomic DNA Translation: AAA60599.1
CCDSiCCDS14127.1
PIRiA32641 KJHUAC
RefSeqiNP_000342.2, NM_000351.5
NP_001307679.1, NM_001320750.1
NP_001307680.1, NM_001320751.1
NP_001307681.1, NM_001320752.1
NP_001307682.1, NM_001320753.1
NP_001307683.1, NM_001320754.1
UniGeneiHs.522578
Hs.700558
Hs.700559
Hs.740067

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P49X-ray2.60A22-583[»]
ProteinModelPortaliP08842
SMRiP08842
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106905, 27 interactors
IntActiP08842, 1 interactor
MINTiP08842
STRINGi9606.ENSP00000217961

Chemistry databases

BindingDBiP08842
ChEMBLiCHEMBL3559
DrugBankiDB02735 2-Amino-3-Oxo-4-Sulfo-Butyric Acid
DB06713 Norelgestromin
SwissLipidsiSLP:000001236

PTM databases

GlyConnecti1770
iPTMnetiP08842
PhosphoSitePlusiP08842
SwissPalmiP08842

Polymorphism and mutation databases

BioMutaiSTS
DMDMi135006

Proteomic databases

EPDiP08842
MaxQBiP08842
PaxDbiP08842
PeptideAtlasiP08842
PRIDEiP08842
ProteomicsDBi52168

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217961; ENSP00000217961; ENSG00000101846
GeneIDi412
KEGGihsa:412
UCSCiuc004cry.5 human

Organism-specific databases

CTDi412
DisGeNETi412
EuPathDBiHostDB:ENSG00000101846.6
GeneCardsiSTS
HGNCiHGNC:11425 STS
HPAiHPA002904
MalaCardsiSTS
MIMi300747 gene
308100 phenotype
neXtProtiNX_P08842
OpenTargetsiENSG00000101846
Orphaneti461 Recessive X-linked ichthyosis
281090 Syndromic recessive X-linked ichthyosis
PharmGKBiPA36225
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3867 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00760000119062
HOGENOMiHOG000135352
HOVERGENiHBG004283
InParanoidiP08842
KOiK01131
OMAiTNWEGGI
OrthoDBiEOG091G07AL
PhylomeDBiP08842
TreeFamiTF314186

Enzyme and pathway databases

BRENDAi3.1.6.2 2681
ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases

Miscellaneous databases

ChiTaRSiSTS human
EvolutionaryTraceiP08842
GeneWikiiSteroid_sulfatase
GenomeRNAii412
PROiPR:P08842
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101846 Expressed in 207 organ(s), highest expression level in chorionic villus
CleanExiHS_STS
GenevisibleiP08842 HS

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR024607 Sulfatase_CS
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00523 SULFATASE_1, 1 hit
PS00149 SULFATASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTS_HUMAN
AccessioniPrimary (citable) accession number: P08842
Secondary accession number(s): B2RA47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 1, 1990
Last modified: November 7, 2018
This is version 193 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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