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UniProtKB - P08842 (STS_HUMAN)
Protein
Steryl-sulfatase
Gene
STS
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
3 PublicationsCatalytic activityi
- EC:3.1.6.22 Publications
Cofactori
Ca2+1 PublicationNote: Binds 1 Ca2+ ion per subunit.1 Publication
Kineticsi
- KM=24.8 µM for 3beta-sulfooxy-androst-5-en-17-one (DHEA-S)1 Publication
- Vmax=354.4 µmol/min/mg enzyme with 3beta-sulfooxy-androst-5-en-17-one (DHEA-S)1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 35 | Calcium1 Publication | 1 | |
Metal bindingi | 36 | Calcium1 Publication | 1 | |
Active sitei | 75 | Nucleophile1 Publication | 1 | |
Metal bindingi | 75 | Calcium; via 3-oxoalanine1 Publication | 1 | |
Active sitei | 136 | 1 Publication | 1 | |
Metal bindingi | 342 | Calcium1 Publication | 1 | |
Metal bindingi | 343 | Calcium1 Publication | 1 |
GO - Molecular functioni
- arylsulfatase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- steryl-sulfatase activity Source: ProtInc
- sulfuric ester hydrolase activity Source: MGI
GO - Biological processi
- epidermis development Source: ProtInc
- female pregnancy Source: UniProtKB-KW
- steroid catabolic process Source: ProtInc
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid metabolism, Pregnancy, Steroid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.6.2, 2681 |
PathwayCommonsi | P08842 |
Reactomei | R-HSA-1660662, Glycosphingolipid metabolism R-HSA-1663150, The activation of arylsulfatases |
SignaLinki | P08842 |
Chemistry databases
SwissLipidsi | SLP:000001236 |
Names & Taxonomyi
Protein namesi | Recommended name: Steryl-sulfatase (EC:3.1.6.23 Publications)Alternative name(s): Arylsulfatase C Short name: ASC Estrone sulfatase1 Publication Steroid sulfatase Steryl-sulfate sulfohydrolase |
Gene namesi | Name:STS Synonyms:ARSC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11425, STS |
MIMi | 300747, gene |
neXtProti | NX_P08842 |
VEuPathDBi | HostDB:ENSG00000101846 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein
Other locations
- microneme membrane 1 Publication; Multi-pass membrane protein
Endoplasmic reticulum
- endoplasmic reticulum Source: ProtInc
- endoplasmic reticulum lumen Source: Reactome
- endoplasmic reticulum membrane Source: Reactome
Endosome
- endosome Source: ProtInc
Golgi apparatus
- Golgi apparatus Source: ProtInc
Lysosome
- lysosome Source: ProtInc
Plasma Membrane
- plasma membrane Source: ProtInc
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: ProtInc
- membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 184 | Lumenal1 PublicationAdd BLAST | 163 | |
Transmembranei | 185 – 208 | Helical1 PublicationAdd BLAST | 24 | |
Topological domaini | 209 – 212 | Cytoplasmic1 Publication | 4 | |
Transmembranei | 213 – 234 | Helical1 PublicationAdd BLAST | 22 | |
Topological domaini | 235 – 583 | Lumenal1 PublicationAdd BLAST | 349 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Endoplasmic reticulum, MembranePathology & Biotechi
Involvement in diseasei
Ichthyosis, X-linked (IXL)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_007240 | 341 | S → L in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853167Ensembl. | 1 | |
Natural variantiVAR_007241 | 372 | W → R in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853165Ensembl. | 1 | |
Natural variantiVAR_014020 | 372 | W → S in IXL; loss of steryl-sulfatase activity. 1 PublicationCorresponds to variant dbSNP:rs137853168Ensembl. | 1 | |
Natural variantiVAR_014021 | 380 | G → R in IXL; strong decreases of steryl-sulfatase activity. 1 Publication | 1 | |
Natural variantiVAR_014022 | 444 | H → R in IXL; loss of steryl-sulfatase activity. 1 PublicationCorresponds to variant dbSNP:rs137853169Ensembl. | 1 | |
Natural variantiVAR_007242 | 446 | C → Y in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853166Ensembl. | 1 | |
Natural variantiVAR_014023 | 560 | Q → P in IXL. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, IchthyosisOrganism-specific databases
DisGeNETi | 412 |
MalaCardsi | STS |
MIMi | 308100, phenotype |
OpenTargetsi | ENSG00000101846 |
Orphaneti | 461, Recessive X-linked ichthyosis 281090, Syndromic recessive X-linked ichthyosis |
PharmGKBi | PA36225 |
Miscellaneous databases
Pharosi | P08842, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3559 |
DrugBanki | DB02735, 2-Amino-3-Oxo-4-Sulfo-Butyric Acid DB02292, Irosustat DB06713, Norelgestromin DB09070, Tibolone |
DrugCentrali | P08842 |
Genetic variation databases
BioMutai | STS |
DMDMi | 135006 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000033414 | 22 – 583 | Steryl-sulfataseAdd BLAST | 562 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 47 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Modified residuei | 75 | 3-oxoalanine (Cys)1 Publication | 1 | |
Disulfide bondi | 141 ↔ 148 | |||
Disulfide bondi | 170 ↔ 242 | |||
Glycosylationi | 259 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 446 ↔ 489 | |||
Disulfide bondi | 481 ↔ 487 | |||
Disulfide bondi | 562 ↔ 570 | |||
Disulfide bondi | 563 ↔ 572 |
Post-translational modificationi
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 333 | Not glycosylated1 Publication | 1 | |
Sitei | 459 | Not glycosylated1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P08842 |
jPOSTi | P08842 |
MassIVEi | P08842 |
MaxQBi | P08842 |
PaxDbi | P08842 |
PeptideAtlasi | P08842 |
PRIDEi | P08842 |
ProteomicsDBi | 52168 |
PTM databases
GlyConnecti | 1770, 2 N-Linked glycans (1 site) |
GlyGeni | P08842, 4 sites, 2 N-linked glycans (1 site) |
iPTMneti | P08842 |
PhosphoSitePlusi | P08842 |
SwissPalmi | P08842 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101846, Expressed in chorionic villus and 222 other tissues |
Genevisiblei | P08842, HS |
Organism-specific databases
HPAi | ENSG00000101846, Tissue enhanced (placenta) |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 106905, 36 interactors |
IntActi | P08842, 22 interactors |
MINTi | P08842 |
STRINGi | 9606.ENSP00000217961 |
Chemistry databases
BindingDBi | P08842 |
Miscellaneous databases
RNActi | P08842, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P08842 |
SMRi | P08842 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08842 |
Family & Domainsi
Sequence similaritiesi
Belongs to the sulfatase family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3867, Eukaryota |
GeneTreei | ENSGT00940000161153 |
HOGENOMi | CLU_006332_13_4_1 |
InParanoidi | P08842 |
OMAi | VFQIHKY |
OrthoDBi | 873694at2759 |
PhylomeDBi | P08842 |
TreeFami | TF314186 |
Family and domain databases
Gene3Di | 3.40.720.10, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR024607, Sulfatase_CS IPR000917, Sulfatase_N |
Pfami | View protein in Pfam PF00884, Sulfatase, 1 hit |
SUPFAMi | SSF53649, SSF53649, 1 hit |
PROSITEi | View protein in PROSITE PS00523, SULFATASE_1, 1 hit PS00149, SULFATASE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P08842-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLRKMKIPF LLLFFLWEAE SHAASRPNII LVMADDLGIG DPGCYGNKTI
60 70 80 90 100
RTPNIDRLAS GGVKLTQHLA ASPLCTPSRA AFMTGRYPVR SGMASWSRTG
110 120 130 140 150
VFLFTASSGG LPTDEITFAK LLKDQGYSTA LIGKWHLGMS CHSKTDFCHH
160 170 180 190 200
PLHHGFNYFY GISLTNLRDC KPGEGSVFTT GFKRLVFLPL QIVGVTLLTL
210 220 230 240 250
AALNCLGLLH VPLGVFFSLL FLAALILTLF LGFLHYFRPL NCFMMRNYEI
260 270 280 290 300
IQQPMSYDNL TQRLTVEAAQ FIQRNTETPF LLVLSYLHVH TALFSSKDFA
310 320 330 340 350
GKSQHGVYGD AVEEMDWSVG QILNLLDELR LANDTLIYFT SDQGAHVEEV
360 370 380 390 400
SSKGEIHGGS NGIYKGGKAN NWEGGIRVPG ILRWPRVIQA GQKIDEPTSN
410 420 430 440 450
MDIFPTVAKL AGAPLPEDRI IDGRDLMPLL EGKSQRSDHE FLFHYCNAYL
460 470 480 490 500
NAVRWHPQNS TSIWKAFFFT PNFNPVGSNG CFATHVCFCF GSYVTHHDPP
510 520 530 540 550
LLFDISKDPR ERNPLTPASE PRFYEILKVM QEAADRHTQT LPEVPDQFSW
560 570 580
NNFLWKPWLQ LCCPSTGLSC QCDREKQDKR LSR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A590UJL0 | A0A590UJL0_HUMAN | Steryl-sulfatase | STS | 578 | Annotation score: | ||
A0A590UJY9 | A0A590UJY9_HUMAN | Steryl-sulfatase | STS | 423 | Annotation score: | ||
A0A590UJT4 | A0A590UJT4_HUMAN | Steryl-sulfatase | STS | 466 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | A → E in AAA60596 (PubMed:3032454).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_007240 | 341 | S → L in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853167Ensembl. | 1 | |
Natural variantiVAR_007241 | 372 | W → R in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853165Ensembl. | 1 | |
Natural variantiVAR_014020 | 372 | W → S in IXL; loss of steryl-sulfatase activity. 1 PublicationCorresponds to variant dbSNP:rs137853168Ensembl. | 1 | |
Natural variantiVAR_014021 | 380 | G → R in IXL; strong decreases of steryl-sulfatase activity. 1 Publication | 1 | |
Natural variantiVAR_014022 | 444 | H → R in IXL; loss of steryl-sulfatase activity. 1 PublicationCorresponds to variant dbSNP:rs137853169Ensembl. | 1 | |
Natural variantiVAR_007242 | 446 | C → Y in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853166Ensembl. | 1 | |
Natural variantiVAR_081729 | 476 | V → M Does not affect steryl-sulfatase activity. 1 PublicationCorresponds to variant dbSNP:rs183370963Ensembl. | 1 | |
Natural variantiVAR_014023 | 560 | Q → P in IXL. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04964 mRNA Translation: AAA60597.1 M16505 mRNA Translation: AAA60596.1 AK314034 mRNA Translation: BAG36744.1 BC075030 mRNA Translation: AAH75030.1 M23945 Genomic DNA Translation: AAA60598.1 M23556 Genomic DNA Translation: AAA60599.1 |
PIRi | A32641, KJHUAC |
RefSeqi | NP_000342.2, NM_000351.5 NP_001307679.1, NM_001320750.1 NP_001307680.1, NM_001320751.1 NP_001307681.1, NM_001320752.1 NP_001307682.1, NM_001320753.1 NP_001307683.1, NM_001320754.1 |
Genome annotation databases
GeneIDi | 412 |
KEGGi | hsa:412 |
UCSCi | uc004cry.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Steroid sulfatase entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04964 mRNA Translation: AAA60597.1 M16505 mRNA Translation: AAA60596.1 AK314034 mRNA Translation: BAG36744.1 BC075030 mRNA Translation: AAH75030.1 M23945 Genomic DNA Translation: AAA60598.1 M23556 Genomic DNA Translation: AAA60599.1 |
PIRi | A32641, KJHUAC |
RefSeqi | NP_000342.2, NM_000351.5 NP_001307679.1, NM_001320750.1 NP_001307680.1, NM_001320751.1 NP_001307681.1, NM_001320752.1 NP_001307682.1, NM_001320753.1 NP_001307683.1, NM_001320754.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1P49 | X-ray | 2.60 | A | 22-583 | [»] | |
AlphaFoldDBi | P08842 | |||||
SMRi | P08842 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106905, 36 interactors |
IntActi | P08842, 22 interactors |
MINTi | P08842 |
STRINGi | 9606.ENSP00000217961 |
Chemistry databases
BindingDBi | P08842 |
ChEMBLi | CHEMBL3559 |
DrugBanki | DB02735, 2-Amino-3-Oxo-4-Sulfo-Butyric Acid DB02292, Irosustat DB06713, Norelgestromin DB09070, Tibolone |
DrugCentrali | P08842 |
SwissLipidsi | SLP:000001236 |
PTM databases
GlyConnecti | 1770, 2 N-Linked glycans (1 site) |
GlyGeni | P08842, 4 sites, 2 N-linked glycans (1 site) |
iPTMneti | P08842 |
PhosphoSitePlusi | P08842 |
SwissPalmi | P08842 |
Genetic variation databases
BioMutai | STS |
DMDMi | 135006 |
Proteomic databases
EPDi | P08842 |
jPOSTi | P08842 |
MassIVEi | P08842 |
MaxQBi | P08842 |
PaxDbi | P08842 |
PeptideAtlasi | P08842 |
PRIDEi | P08842 |
ProteomicsDBi | 52168 |
Protocols and materials databases
Antibodypediai | 363, 258 antibodies from 32 providers |
DNASUi | 412 |
Genome annotation databases
GeneIDi | 412 |
KEGGi | hsa:412 |
UCSCi | uc004cry.5, human |
Organism-specific databases
CTDi | 412 |
DisGeNETi | 412 |
GeneCardsi | STS |
HGNCi | HGNC:11425, STS |
HPAi | ENSG00000101846, Tissue enhanced (placenta) |
MalaCardsi | STS |
MIMi | 300747, gene 308100, phenotype |
neXtProti | NX_P08842 |
OpenTargetsi | ENSG00000101846 |
Orphaneti | 461, Recessive X-linked ichthyosis 281090, Syndromic recessive X-linked ichthyosis |
PharmGKBi | PA36225 |
VEuPathDBi | HostDB:ENSG00000101846 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3867, Eukaryota |
GeneTreei | ENSGT00940000161153 |
HOGENOMi | CLU_006332_13_4_1 |
InParanoidi | P08842 |
OMAi | VFQIHKY |
OrthoDBi | 873694at2759 |
PhylomeDBi | P08842 |
TreeFami | TF314186 |
Enzyme and pathway databases
BRENDAi | 3.1.6.2, 2681 |
PathwayCommonsi | P08842 |
Reactomei | R-HSA-1660662, Glycosphingolipid metabolism R-HSA-1663150, The activation of arylsulfatases |
SignaLinki | P08842 |
Miscellaneous databases
BioGRID-ORCSi | 412, 8 hits in 703 CRISPR screens |
ChiTaRSi | STS, human |
EvolutionaryTracei | P08842 |
GeneWikii | Steroid_sulfatase |
GenomeRNAii | 412 |
Pharosi | P08842, Tchem |
PROi | PR:P08842 |
RNActi | P08842, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101846, Expressed in chorionic villus and 222 other tissues |
Genevisiblei | P08842, HS |
Family and domain databases
Gene3Di | 3.40.720.10, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR024607, Sulfatase_CS IPR000917, Sulfatase_N |
Pfami | View protein in Pfam PF00884, Sulfatase, 1 hit |
SUPFAMi | SSF53649, SSF53649, 1 hit |
PROSITEi | View protein in PROSITE PS00523, SULFATASE_1, 1 hit PS00149, SULFATASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STS_HUMAN | |
Accessioni | P08842Primary (citable) accession number: P08842 Secondary accession number(s): B2RA47 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | April 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 214 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families