UniProtKB - P08842 (STS_HUMAN)

BLAST

>sp|P08842|STS_HUMAN Steryl-sulfatase OS=Homo sapiens OX=9606 GN=STS PE=1 SV=2
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS
GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK
LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT
GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL
NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA
GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS
NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI
IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG
CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT
LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR

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History
Entry version 193 (07 Nov 2018)
Sequence version 2 (01 Apr 1990)
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Protein

Steryl-sulfatase

Gene

STS

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Conversion of sulfated steroid precursors to estrogens during pregnancy.

Catalytic activityⁱ

3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H₂O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.

Cofactorⁱ

Ca²⁺1 PublicationNote: Binds 1 Ca²⁺ ion per subunit.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	35	Calcium1 Publication	1
Metal bindingⁱ	36	Calcium1 Publication	1
Active siteⁱ	75	Nucleophile1 Publication	1
Metal bindingⁱ	75	Calcium; via 3-oxoalanine1 Publication	1
Active siteⁱ	136	1 Publication	1
Metal bindingⁱ	342	Calcium1 Publication	1
Metal bindingⁱ	343	Calcium1 Publication	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
steryl-sulfatase activity Source: Reactome
sulfuric ester hydrolase activity
Source: MGI
Inferred from direct assayⁱ
- 15962010

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

epidermis development
Source: ProtInc
Traceable author statementⁱ
- 9252398
female pregnancy Source: UniProtKB-KW
glycosphingolipid metabolic process Source: Reactome
steroid catabolic process
Source: ProtInc
Traceable author statementⁱ
- 6957717

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Lipid metabolism, Pregnancy, Steroid metabolism
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	3.1.6.2 2681
Reactomeⁱ	R-HSA-1660662 Glycosphingolipid metabolism R-HSA-1663150 The activation of arylsulfatases

Chemistry databases

SwissLipidsⁱ	SLP:000001236

SwissLipidsⁱ

SLP:000001236

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Steryl-sulfatase (EC:3.1.6.2) Alternative name(s): Arylsulfatase C Short name: ASC Steroid sulfatase Steryl-sulfate sulfohydrolase
Gene namesⁱ	Name:STS Synonyms:ARSC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000101846.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11425 STS
MIMⁱ	300747 gene
neXtProtⁱ	NX_P08842

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 184	LumenalAdd BLAST	163
Transmembraneⁱ	185 – 208	HelicalAdd BLAST	24
Topological domainⁱ	209 – 212	Cytoplasmic	4
Transmembraneⁱ	213 – 234	HelicalAdd BLAST	22
Topological domainⁱ	235 – 583	LumenalAdd BLAST	349

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ichthyosis, X-linked (IXL)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.

Keywords - Diseaseⁱ

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	412
MalaCards human disease database More...MalaCardsⁱ	STS
MIMⁱ	308100 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000101846
Orphanetⁱ	461 Recessive X-linked ichthyosis 281090 Syndromic recessive X-linked ichthyosis
PharmGKBⁱ	PA36225

Chemistry databases

ChEMBLⁱ	CHEMBL3559
Drug and drug target database More...DrugBankⁱ	DB02735 2-Amino-3-Oxo-4-Sulfo-Butyric Acid DB06713 Norelgestromin

Polymorphism and mutation databases

BioMutaⁱ	STS
DMDMⁱ	135006

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	1 PublicationAdd BLAST		21
ChainⁱPRO_0000033414	22 – 583	Steryl-sulfataseAdd BLAST		562

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	47	N-linked (GlcNAc...) asparagine2 Publications	1
Modified residueⁱ	75	3-oxoalanine (Cys)1 Publication	1
Disulfide bondⁱ	141 ↔ 148
Disulfide bondⁱ	170 ↔ 242
Glycosylationⁱ	259	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	446 ↔ 489
Disulfide bondⁱ	481 ↔ 487
Disulfide bondⁱ	562 ↔ 570
Disulfide bondⁱ	563 ↔ 572

Post-translational modificationⁱ

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	333	Not glycosylated1 Publication		1
Siteⁱ	459	Not glycosylated1 Publication		1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P08842
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08842
PaxDbⁱ	P08842
PeptideAtlas More...PeptideAtlasⁱ	P08842
PRIDEⁱ	P08842
ProteomicsDBⁱ	52168

PTM databases

GlyConnectⁱ	1770
iPTMnetⁱ	P08842
PhosphoSitePlusⁱ	P08842
SwissPalmⁱ	P08842

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000101846 Expressed in 207 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_STS
Genevisibleⁱ	P08842 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002904

HPAⁱ

HPA002904

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

Protein-protein interaction databases

BioGridⁱ	106905, 27 interactors
IntActⁱ	P08842, 1 interactor
Molecular INTeraction database More...MINTⁱ	P08842
STRINGⁱ	9606.ENSP00000217961

Chemistry databases

BindingDBⁱ

P08842

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	28 – 36	Combined sources	9
Helixⁱ	43 – 45	Combined sources	3
Beta strandⁱ	48 – 50	Combined sources	3
Helixⁱ	53 – 56	Combined sources	4
Turnⁱ	57 – 61	Combined sources	5
Beta strandⁱ	62 – 69	Combined sources	8
Helixⁱ	75 – 84	Combined sources	10
Helixⁱ	88 – 91	Combined sources	4
Beta strandⁱ	96 – 98	Combined sources	3
Helixⁱ	118 – 124	Combined sources	7
Beta strandⁱ	128 – 134	Combined sources	7
Beta strandⁱ	141 – 143	Combined sources	3
Turnⁱ	144 – 146	Combined sources	3
Helixⁱ	151 – 153	Combined sources	3
Beta strandⁱ	157 – 164	Combined sources	8
Helixⁱ	168 – 170	Combined sources	3
Helixⁱ	179 – 185	Combined sources	7
Helixⁱ	187 – 205	Combined sources	19
Helixⁱ	213 – 241	Combined sources	29
Beta strandⁱ	244 – 246	Combined sources	3
Beta strandⁱ	249 – 254	Combined sources	6
Helixⁱ	260 – 273	Combined sources	14
Turnⁱ	274 – 277	Combined sources	4
Beta strandⁱ	280 – 285	Combined sources	6
Beta strandⁱ	290 – 292	Combined sources	3
Turnⁱ	297 – 299	Combined sources	3
Beta strandⁱ	304 – 306	Combined sources	3
Helixⁱ	307 – 328	Combined sources	22
Helixⁱ	332 – 334	Combined sources	3
Beta strandⁱ	335 – 343	Combined sources	9
Beta strandⁱ	352 – 354	Combined sources	3
Beta strandⁱ	370 – 372	Combined sources	3
Helixⁱ	373 – 376	Combined sources	4
Beta strandⁱ	380 – 383	Combined sources	4
Turnⁱ	385 – 387	Combined sources	3
Helixⁱ	400 – 402	Combined sources	3
Helixⁱ	403 – 411	Combined sources	9
Beta strandⁱ	417 – 419	Combined sources	3
Helixⁱ	427 – 430	Combined sources	4
Beta strandⁱ	440 – 446	Combined sources	7
Beta strandⁱ	449 – 455	Combined sources	7
Beta strandⁱ	464 – 468	Combined sources	5
Turnⁱ	482 – 484	Combined sources	3
Beta strandⁱ	489 – 491	Combined sources	3
Beta strandⁱ	501 – 503	Combined sources	3
Turnⁱ	505 – 507	Combined sources	3
Turnⁱ	518 – 521	Combined sources	4
Helixⁱ	523 – 537	Combined sources	15
Helixⁱ	550 – 553	Combined sources	4
Helixⁱ	557 – 559	Combined sources	3
Beta strandⁱ	563 – 568	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P08842
SMRⁱ	P08842
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P08842

EvolutionaryTraceⁱ

P08842

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sulfatase family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3867 Eukaryota COG3119 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119062
HOGENOMⁱ	HOG000135352
HOVERGENⁱ	HBG004283
InParanoidⁱ	P08842
KEGG Orthology (KO) More...KOⁱ	K01131
OMAⁱ	TNWEGGI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07AL
PhylomeDBⁱ	P08842
TreeFamⁱ	TF314186

Family and domain databases

Gene3Dⁱ	3.40.720.10, 1 hit
InterProⁱ	View protein in InterPro IPR017849 Alkaline_Pase-like_a/b/a IPR017850 Alkaline_phosphatase_core_sf IPR024607 Sulfatase_CS IPR000917 Sulfatase_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00884 Sulfatase, 1 hit
SUPFAMⁱ	SSF53649 SSF53649, 1 hit
PROSITEⁱ	View protein in PROSITE PS00523 SULFATASE_1, 1 hit PS00149 SULFATASE_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P08842-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MPLRKMKIPF LLLFFLWEAE SHAASRPNII LVMADDLGIG DPGCYGNKTI 
        60         70         80         90        100
RTPNIDRLAS GGVKLTQHLA ASPLCTPSRA AFMTGRYPVR SGMASWSRTG 
       110        120        130        140        150
VFLFTASSGG LPTDEITFAK LLKDQGYSTA LIGKWHLGMS CHSKTDFCHH 
       160        170        180        190        200
PLHHGFNYFY GISLTNLRDC KPGEGSVFTT GFKRLVFLPL QIVGVTLLTL 
       210        220        230        240        250
AALNCLGLLH VPLGVFFSLL FLAALILTLF LGFLHYFRPL NCFMMRNYEI 
       260        270        280        290        300
IQQPMSYDNL TQRLTVEAAQ FIQRNTETPF LLVLSYLHVH TALFSSKDFA 
       310        320        330        340        350
GKSQHGVYGD AVEEMDWSVG QILNLLDELR LANDTLIYFT SDQGAHVEEV 
       360        370        380        390        400
SSKGEIHGGS NGIYKGGKAN NWEGGIRVPG ILRWPRVIQA GQKIDEPTSN 
       410        420        430        440        450
MDIFPTVAKL AGAPLPEDRI IDGRDLMPLL EGKSQRSDHE FLFHYCNAYL 
       460        470        480        490        500
NAVRWHPQNS TSIWKAFFFT PNFNPVGSNG CFATHVCFCF GSYVTHHDPP 
       510        520        530        540        550
LLFDISKDPR ERNPLTPASE PRFYEILKVM QEAADRHTQT LPEVPDQFSW 
       560        570        580 
NNFLWKPWLQ LCCPSTGLSC QCDREKQDKR LSR

Length:583

Mass (Da):65,492

Last modified:April 1, 1990 - v2

Checksum:ⁱ74746AFA9D21A0A6

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	23	A → E in AAA60596 (PubMed:3032454).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_007240	341	S → L in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853167EnsemblClinVar.	1
Natural variantⁱVAR_007241	372	W → R in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853165EnsemblClinVar.	1
Natural variantⁱVAR_014020	372	W → S in IXL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853168EnsemblClinVar.	1
Natural variantⁱVAR_014021	380	G → R in IXL. 1 Publication	1
Natural variantⁱVAR_014022	444	H → R in IXL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853169EnsemblClinVar.	1
Natural variantⁱVAR_007242	446	C → Y in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853166EnsemblClinVar.	1
Natural variantⁱVAR_014023	560	Q → P in IXL. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04964 mRNA Translation: AAA60597.1 M16505 mRNA Translation: AAA60596.1 AK314034 mRNA Translation: BAG36744.1 BC075030 mRNA Translation: AAH75030.1 M23945 Genomic DNA Translation: AAA60598.1 M23556 Genomic DNA Translation: AAA60599.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14127.1
PIRⁱ	A32641 KJHUAC
NCBI Reference Sequences More...RefSeqⁱ	NP_000342.2, NM_000351.5 NP_001307679.1, NM_001320750.1 NP_001307680.1, NM_001320751.1 NP_001307681.1, NM_001320752.1 NP_001307682.1, NM_001320753.1 NP_001307683.1, NM_001320754.1
UniGeneⁱ	Hs.522578 Hs.700558 Hs.700559 Hs.740067

Genome annotation databases

Ensemblⁱ	ENST00000217961; ENSP00000217961; ENSG00000101846
GeneIDⁱ	412
KEGGⁱ	hsa:412
UCSC genome browser More...UCSCⁱ	uc004cry.5 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08842	Uncharacterized protein		MACMU		590	UniRef90_P08842
Uncharacterized protein		MACFA		590
Uncharacterized protein		MACNE		590
Uncharacterized protein		PONAB		590
Steroid sulfatase (Microsomal), isozyme S (Fragment)		HUMAN		20
+64

Protein	Similar proteins		Species	Score	Length	Source
P08842	Steryl-sulfatase		RAT		577	UniRef50_P08842
Uncharacterized protein		MACMU		590
Uncharacterized protein		MACFA		590
Uncharacterized protein		MACNE		590
Uncharacterized protein		PAPAN		590
+305

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Steroid sulfatase entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04964 mRNA Translation: AAA60597.1 M16505 mRNA Translation: AAA60596.1 AK314034 mRNA Translation: BAG36744.1 BC075030 mRNA Translation: AAH75030.1 M23945 Genomic DNA Translation: AAA60598.1 M23556 Genomic DNA Translation: AAA60599.1
CCDSⁱ	CCDS14127.1
PIRⁱ	A32641 KJHUAC
RefSeqⁱ	NP_000342.2, NM_000351.5 NP_001307679.1, NM_001320750.1 NP_001307680.1, NM_001320751.1 NP_001307681.1, NM_001320752.1 NP_001307682.1, NM_001320753.1 NP_001307683.1, NM_001320754.1
UniGeneⁱ	Hs.522578 Hs.700558 Hs.700559 Hs.740067

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1P49	X-ray	2.60	A	22-583	[»]
ProteinModelPortalⁱ	P08842
SMRⁱ	P08842
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106905, 27 interactors
IntActⁱ	P08842, 1 interactor
MINTⁱ	P08842
STRINGⁱ	9606.ENSP00000217961

Chemistry databases

BindingDBⁱ	P08842
ChEMBLⁱ	CHEMBL3559
DrugBankⁱ	DB02735 2-Amino-3-Oxo-4-Sulfo-Butyric Acid DB06713 Norelgestromin
SwissLipidsⁱ	SLP:000001236

PTM databases

GlyConnectⁱ	1770
iPTMnetⁱ	P08842
PhosphoSitePlusⁱ	P08842
SwissPalmⁱ	P08842

Polymorphism and mutation databases

BioMutaⁱ	STS
DMDMⁱ	135006

Proteomic databases

EPDⁱ	P08842
MaxQBⁱ	P08842
PaxDbⁱ	P08842
PeptideAtlasⁱ	P08842
PRIDEⁱ	P08842
ProteomicsDBⁱ	52168

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000217961; ENSP00000217961; ENSG00000101846
GeneIDⁱ	412
KEGGⁱ	hsa:412
UCSCⁱ	uc004cry.5 human

Organism-specific databases

CTDⁱ	412
DisGeNETⁱ	412
EuPathDBⁱ	HostDB:ENSG00000101846.6
GeneCardsⁱ	STS
HGNCⁱ	HGNC:11425 STS
HPAⁱ	HPA002904
MalaCardsⁱ	STS
MIMⁱ	300747 gene 308100 phenotype
neXtProtⁱ	NX_P08842
OpenTargetsⁱ	ENSG00000101846
Orphanetⁱ	461 Recessive X-linked ichthyosis 281090 Syndromic recessive X-linked ichthyosis
PharmGKBⁱ	PA36225
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3867 Eukaryota COG3119 LUCA
GeneTreeⁱ	ENSGT00760000119062
HOGENOMⁱ	HOG000135352
HOVERGENⁱ	HBG004283
InParanoidⁱ	P08842
KOⁱ	K01131
OMAⁱ	TNWEGGI
OrthoDBⁱ	EOG091G07AL
PhylomeDBⁱ	P08842
TreeFamⁱ	TF314186

Enzyme and pathway databases

BRENDAⁱ	3.1.6.2 2681
Reactomeⁱ	R-HSA-1660662 Glycosphingolipid metabolism R-HSA-1663150 The activation of arylsulfatases

Miscellaneous databases

ChiTaRSⁱ	STS human
EvolutionaryTraceⁱ	P08842
GeneWikiⁱ	Steroid_sulfatase
GenomeRNAiⁱ	412
Protein Ontology More...PROⁱ	PR:P08842
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000101846 Expressed in 207 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_STS
Genevisibleⁱ	P08842 HS

Family and domain databases

Gene3Dⁱ	3.40.720.10, 1 hit
InterProⁱ	View protein in InterPro IPR017849 Alkaline_Pase-like_a/b/a IPR017850 Alkaline_phosphatase_core_sf IPR024607 Sulfatase_CS IPR000917 Sulfatase_N
Pfamⁱ	View protein in Pfam PF00884 Sulfatase, 1 hit
SUPFAMⁱ	SSF53649 SSF53649, 1 hit
PROSITEⁱ	View protein in PROSITE PS00523 SULFATASE_1, 1 hit PS00149 SULFATASE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STS_HUMAN
Accessionⁱ	P08842Primary (citable) accession number: P08842 Secondary accession number(s): B2RA47
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
	Last sequence update:	April 1, 1990
	Last modified:	November 7, 2018
	This is version 193 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

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Supporting data

UniProtKB - P08842 (STS_HUMAN)

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Steryl-sulfatase

STS

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Endosome

Golgi apparatus

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ