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Protein

Steryl-sulfatase

Gene

STS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Conversion of sulfated steroid precursors to estrogens during pregnancy.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi35Calcium1 Publication1
Metal bindingi36Calcium1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei75Nucleophile1 Publication1
Metal bindingi75Calcium; via 3-oxoalanine1 Publication1
Active sitei1361 Publication1
Metal bindingi342Calcium1 Publication1
Metal bindingi343Calcium1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • steryl-sulfatase activity Source: Reactome
  • sulfuric ester hydrolase activity Source: MGI

GO - Biological processi

  • epidermis development Source: ProtInc
  • female pregnancy Source: UniProtKB-KW
  • glycosphingolipid metabolic process Source: Reactome
  • steroid catabolic process Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism, Pregnancy, Steroid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.6.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001236

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Steryl-sulfatase (EC:3.1.6.2)
Alternative name(s):
Arylsulfatase C
Short name:
ASC
Steroid sulfatase
Steryl-sulfate sulfohydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STS
Synonyms:ARSC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101846.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11425 STS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300747 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08842

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 184LumenalAdd BLAST163
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei185 – 208HelicalAdd BLAST24
Topological domaini209 – 212Cytoplasmic4
Transmembranei213 – 234HelicalAdd BLAST22
Topological domaini235 – 583LumenalAdd BLAST349

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ichthyosis, X-linked (IXL)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.
See also OMIM:308100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_007240341S → L in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853167EnsemblClinVar.1
Natural variantiVAR_007241372W → R in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853165EnsemblClinVar.1
Natural variantiVAR_014020372W → S in IXL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853168EnsemblClinVar.1
Natural variantiVAR_014021380G → R in IXL. 1 Publication1
Natural variantiVAR_014022444H → R in IXL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853169EnsemblClinVar.1
Natural variantiVAR_007242446C → Y in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853166EnsemblClinVar.1
Natural variantiVAR_014023560Q → P in IXL. 1 Publication1

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
412

MalaCards human disease database

More...
MalaCardsi
STS
MIMi308100 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000101846

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
461 Recessive X-linked ichthyosis
281090 Syndromic recessive X-linked ichthyosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36225

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3559

Drug and drug target database

More...
DrugBanki
DB02735 2-Amino-3-Oxo-4-Sulfo-Butyric Acid
DB06713 Norelgestromin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
135006

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003341422 – 583Steryl-sulfataseAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei753-oxoalanine (Cys)1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi141 ↔ 148
Disulfide bondi170 ↔ 242
Glycosylationi259N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi446 ↔ 489
Disulfide bondi481 ↔ 487
Disulfide bondi562 ↔ 570
Disulfide bondi563 ↔ 572

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei333Not glycosylated1 Publication1
Sitei459Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P08842

MaxQB - The MaxQuant DataBase

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MaxQBi
P08842

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P08842

PeptideAtlas

More...
PeptideAtlasi
P08842

PRoteomics IDEntifications database

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PRIDEi
P08842

ProteomicsDB human proteome resource

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ProteomicsDBi
52168

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1770

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P08842

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08842

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P08842

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101846 Expressed in 207 organ(s), highest expression level in chorionic villus

CleanEx database of gene expression profiles

More...
CleanExi
HS_STS

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P08842 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002904

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106905, 27 interactors

Protein interaction database and analysis system

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IntActi
P08842, 1 interactor

Molecular INTeraction database

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MINTi
P08842

STRING: functional protein association networks

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STRINGi
9606.ENSP00000217961

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P08842

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1583
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P08842

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08842

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P08842

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3867 Eukaryota
COG3119 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161153

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000135352

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004283

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P08842

KEGG Orthology (KO)

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KOi
K01131

Identification of Orthologs from Complete Genome Data

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OMAi
TNWEGGI

Database of Orthologous Groups

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OrthoDBi
EOG091G07AL

Database for complete collections of gene phylogenies

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PhylomeDBi
P08842

TreeFam database of animal gene trees

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TreeFami
TF314186

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.720.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR024607 Sulfatase_CS
IPR000917 Sulfatase_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00884 Sulfatase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53649 SSF53649, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00523 SULFATASE_1, 1 hit
PS00149 SULFATASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P08842-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLRKMKIPF LLLFFLWEAE SHAASRPNII LVMADDLGIG DPGCYGNKTI
60 70 80 90 100
RTPNIDRLAS GGVKLTQHLA ASPLCTPSRA AFMTGRYPVR SGMASWSRTG
110 120 130 140 150
VFLFTASSGG LPTDEITFAK LLKDQGYSTA LIGKWHLGMS CHSKTDFCHH
160 170 180 190 200
PLHHGFNYFY GISLTNLRDC KPGEGSVFTT GFKRLVFLPL QIVGVTLLTL
210 220 230 240 250
AALNCLGLLH VPLGVFFSLL FLAALILTLF LGFLHYFRPL NCFMMRNYEI
260 270 280 290 300
IQQPMSYDNL TQRLTVEAAQ FIQRNTETPF LLVLSYLHVH TALFSSKDFA
310 320 330 340 350
GKSQHGVYGD AVEEMDWSVG QILNLLDELR LANDTLIYFT SDQGAHVEEV
360 370 380 390 400
SSKGEIHGGS NGIYKGGKAN NWEGGIRVPG ILRWPRVIQA GQKIDEPTSN
410 420 430 440 450
MDIFPTVAKL AGAPLPEDRI IDGRDLMPLL EGKSQRSDHE FLFHYCNAYL
460 470 480 490 500
NAVRWHPQNS TSIWKAFFFT PNFNPVGSNG CFATHVCFCF GSYVTHHDPP
510 520 530 540 550
LLFDISKDPR ERNPLTPASE PRFYEILKVM QEAADRHTQT LPEVPDQFSW
560 570 580
NNFLWKPWLQ LCCPSTGLSC QCDREKQDKR LSR
Length:583
Mass (Da):65,492
Last modified:April 1, 1990 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74746AFA9D21A0A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23A → E in AAA60596 (PubMed:3032454).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007240341S → L in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853167EnsemblClinVar.1
Natural variantiVAR_007241372W → R in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853165EnsemblClinVar.1
Natural variantiVAR_014020372W → S in IXL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853168EnsemblClinVar.1
Natural variantiVAR_014021380G → R in IXL. 1 Publication1
Natural variantiVAR_014022444H → R in IXL; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs137853169EnsemblClinVar.1
Natural variantiVAR_007242446C → Y in IXL; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs137853166EnsemblClinVar.1
Natural variantiVAR_014023560Q → P in IXL. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04964 mRNA Translation: AAA60597.1
M16505 mRNA Translation: AAA60596.1
AK314034 mRNA Translation: BAG36744.1
BC075030 mRNA Translation: AAH75030.1
M23945 Genomic DNA Translation: AAA60598.1
M23556 Genomic DNA Translation: AAA60599.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14127.1

Protein sequence database of the Protein Information Resource

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PIRi
A32641 KJHUAC

NCBI Reference Sequences

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RefSeqi
NP_000342.2, NM_000351.5
NP_001307679.1, NM_001320750.1
NP_001307680.1, NM_001320751.1
NP_001307681.1, NM_001320752.1
NP_001307682.1, NM_001320753.1
NP_001307683.1, NM_001320754.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.522578
Hs.700558
Hs.700559
Hs.740067

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000217961; ENSP00000217961; ENSG00000101846

Database of genes from NCBI RefSeq genomes

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GeneIDi
412

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:412

UCSC genome browser

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UCSCi
uc004cry.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Steroid sulfatase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04964 mRNA Translation: AAA60597.1
M16505 mRNA Translation: AAA60596.1
AK314034 mRNA Translation: BAG36744.1
BC075030 mRNA Translation: AAH75030.1
M23945 Genomic DNA Translation: AAA60598.1
M23556 Genomic DNA Translation: AAA60599.1
CCDSiCCDS14127.1
PIRiA32641 KJHUAC
RefSeqiNP_000342.2, NM_000351.5
NP_001307679.1, NM_001320750.1
NP_001307680.1, NM_001320751.1
NP_001307681.1, NM_001320752.1
NP_001307682.1, NM_001320753.1
NP_001307683.1, NM_001320754.1
UniGeneiHs.522578
Hs.700558
Hs.700559
Hs.740067

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P49X-ray2.60A22-583[»]
ProteinModelPortaliP08842
SMRiP08842
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106905, 27 interactors
IntActiP08842, 1 interactor
MINTiP08842
STRINGi9606.ENSP00000217961

Chemistry databases

BindingDBiP08842
ChEMBLiCHEMBL3559
DrugBankiDB02735 2-Amino-3-Oxo-4-Sulfo-Butyric Acid
DB06713 Norelgestromin
SwissLipidsiSLP:000001236

PTM databases

GlyConnecti1770
iPTMnetiP08842
PhosphoSitePlusiP08842
SwissPalmiP08842

Polymorphism and mutation databases

BioMutaiSTS
DMDMi135006

Proteomic databases

EPDiP08842
MaxQBiP08842
PaxDbiP08842
PeptideAtlasiP08842
PRIDEiP08842
ProteomicsDBi52168

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217961; ENSP00000217961; ENSG00000101846
GeneIDi412
KEGGihsa:412
UCSCiuc004cry.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
412
DisGeNETi412
EuPathDBiHostDB:ENSG00000101846.6

GeneCards: human genes, protein and diseases

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GeneCardsi
STS
HGNCiHGNC:11425 STS
HPAiHPA002904
MalaCardsiSTS
MIMi300747 gene
308100 phenotype
neXtProtiNX_P08842
OpenTargetsiENSG00000101846
Orphaneti461 Recessive X-linked ichthyosis
281090 Syndromic recessive X-linked ichthyosis
PharmGKBiPA36225

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3867 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00940000161153
HOGENOMiHOG000135352
HOVERGENiHBG004283
InParanoidiP08842
KOiK01131
OMAiTNWEGGI
OrthoDBiEOG091G07AL
PhylomeDBiP08842
TreeFamiTF314186

Enzyme and pathway databases

BRENDAi3.1.6.2 2681
ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STS human
EvolutionaryTraceiP08842

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Steroid_sulfatase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
412

Protein Ontology

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PROi
PR:P08842

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000101846 Expressed in 207 organ(s), highest expression level in chorionic villus
CleanExiHS_STS
GenevisibleiP08842 HS

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR024607 Sulfatase_CS
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00523 SULFATASE_1, 1 hit
PS00149 SULFATASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08842
Secondary accession number(s): B2RA47
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 1, 1990
Last modified: December 5, 2018
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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