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UniProtKB - P08842 (STS_HUMAN)

Entry version 210 (07 Apr 2021)
Sequence version 2 (01 Apr 1990)
Previous versions | rss
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Protein

Steryl-sulfatase

Gene

STS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=24.8 µM for 3beta-sulfooxy-androst-5-en-17-one (DHEA-S)1 Publication
  1. Vmax=354.4 µmol/min/mg enzyme with 3beta-sulfooxy-androst-5-en-17-one (DHEA-S)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi35Calcium1 Publication1
Metal bindingi36Calcium1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei75Nucleophile1 Publication1
Metal bindingi75Calcium; via 3-oxoalanine1 Publication1
Active sitei1361 Publication1
Metal bindingi342Calcium1 Publication1
Metal bindingi343Calcium1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • arylsulfatase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • steryl-sulfatase activity Source: ProtInc
  • sulfuric ester hydrolase activity Source: MGI
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism, Pregnancy, Steroid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.6.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08842

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1660662, Glycosphingolipid metabolism
R-HSA-1663150, The activation of arylsulfatases

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001236

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Steryl-sulfatase (EC:3.1.6.23 Publications)
Alternative name(s):
Arylsulfatase C
Short name:
ASC
Estrone sulfatase1 Publication
Steroid sulfatase
Steryl-sulfate sulfohydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STS
Synonyms:ARSC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11425, STS

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300747, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08842

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000101846.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 184Lumenal1 PublicationAdd BLAST163
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei185 – 208Helical1 PublicationAdd BLAST24
Topological domaini209 – 212Cytoplasmic1 Publication4
Transmembranei213 – 234Helical1 PublicationAdd BLAST22
Topological domaini235 – 583Lumenal1 PublicationAdd BLAST349

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ichthyosis, X-linked (IXL)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_007240341S → L in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853167EnsemblClinVar.1
Natural variantiVAR_007241372W → R in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853165EnsemblClinVar.1
Natural variantiVAR_014020372W → S in IXL; loss of steryl-sulfatase activity. 1 PublicationCorresponds to variant dbSNP:rs137853168EnsemblClinVar.1
Natural variantiVAR_014021380G → R in IXL; strong decreases of steryl-sulfatase activity. 1 Publication1
Natural variantiVAR_014022444H → R in IXL; loss of steryl-sulfatase activity. 1 PublicationCorresponds to variant dbSNP:rs137853169EnsemblClinVar.1
Natural variantiVAR_007242446C → Y in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853166EnsemblClinVar.1
Natural variantiVAR_014023560Q → P in IXL. 1 Publication1

Keywords - Diseasei

Disease variant, Ichthyosis

Organism-specific databases

DisGeNET

More...DisGeNETi		412

MalaCards human disease database

More...MalaCardsi		STS
MIMi308100, phenotype

Open Targets

More...OpenTargetsi		ENSG00000101846

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		461, Recessive X-linked ichthyosis
281090, Syndromic recessive X-linked ichthyosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36225

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08842, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3559

Drug and drug target database

More...DrugBanki		DB02735, 2-Amino-3-Oxo-4-Sulfo-Butyric Acid
DB02292, Irosustat
DB06713, Norelgestromin
DB09070, Tibolone

DrugCentral

More...DrugCentrali		P08842

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STS

Domain mapping of disease mutations (DMDM)

More...DMDMi		135006

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003341422 – 583Steryl-sulfataseAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei753-oxoalanine (Cys)1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi141 ↔ 148
Disulfide bondi170 ↔ 242
Glycosylationi259N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi446 ↔ 489
Disulfide bondi481 ↔ 487
Disulfide bondi562 ↔ 570
Disulfide bondi563 ↔ 572

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei333Not glycosylated1 Publication1
Sitei459Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P08842

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P08842

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08842

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08842

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08842

PeptideAtlas

More...PeptideAtlasi		P08842

PRoteomics IDEntifications database

More...PRIDEi		P08842

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52168

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1770, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P08842, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08842

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08842

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P08842

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000101846, Expressed in chorionic villus and 221 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08842, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000101846, Tissue enriched (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106905, 27 interactors

Protein interaction database and analysis system

More...IntActi		P08842, 22 interactors

Molecular INTeraction database

More...MINTi		P08842

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000217961

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P08842

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08842, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1583
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08842

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P08842

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3867, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161153

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006332_13_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08842

Identification of Orthologs from Complete Genome Data

More...OMAi		CFHTHVC

Database of Orthologous Groups

More...OrthoDBi		873694at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08842

TreeFam database of animal gene trees

More...TreeFami		TF314186

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.720.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017850, Alkaline_phosphatase_core_sf
IPR024607, Sulfatase_CS
IPR000917, Sulfatase_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00884, Sulfatase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53649, SSF53649, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00523, SULFATASE_1, 1 hit
PS00149, SULFATASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P08842-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLRKMKIPF LLLFFLWEAE SHAASRPNII LVMADDLGIG DPGCYGNKTI 
        60         70         80         90        100
RTPNIDRLAS GGVKLTQHLA ASPLCTPSRA AFMTGRYPVR SGMASWSRTG 
       110        120        130        140        150
VFLFTASSGG LPTDEITFAK LLKDQGYSTA LIGKWHLGMS CHSKTDFCHH 
       160        170        180        190        200
PLHHGFNYFY GISLTNLRDC KPGEGSVFTT GFKRLVFLPL QIVGVTLLTL 
       210        220        230        240        250
AALNCLGLLH VPLGVFFSLL FLAALILTLF LGFLHYFRPL NCFMMRNYEI 
       260        270        280        290        300
IQQPMSYDNL TQRLTVEAAQ FIQRNTETPF LLVLSYLHVH TALFSSKDFA 
       310        320        330        340        350
GKSQHGVYGD AVEEMDWSVG QILNLLDELR LANDTLIYFT SDQGAHVEEV 
       360        370        380        390        400
SSKGEIHGGS NGIYKGGKAN NWEGGIRVPG ILRWPRVIQA GQKIDEPTSN 
       410        420        430        440        450
MDIFPTVAKL AGAPLPEDRI IDGRDLMPLL EGKSQRSDHE FLFHYCNAYL 
       460        470        480        490        500
NAVRWHPQNS TSIWKAFFFT PNFNPVGSNG CFATHVCFCF GSYVTHHDPP 
       510        520        530        540        550
LLFDISKDPR ERNPLTPASE PRFYEILKVM QEAADRHTQT LPEVPDQFSW 
       560        570        580 
NNFLWKPWLQ LCCPSTGLSC QCDREKQDKR LSR
Length:583
Mass (Da):65,492
Last modified:April 1, 1990 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74746AFA9D21A0A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A590UJL0A0A590UJL0_HUMAN
Steryl-sulfatase
STS
578Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJT4A0A590UJT4_HUMAN
Steryl-sulfatase
STS
466Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A590UJY9A0A590UJY9_HUMAN
Steryl-sulfatase
STS
423Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23A → E in AAA60596 (PubMed:3032454).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007240341S → L in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853167EnsemblClinVar.1
Natural variantiVAR_007241372W → R in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853165EnsemblClinVar.1
Natural variantiVAR_014020372W → S in IXL; loss of steryl-sulfatase activity. 1 PublicationCorresponds to variant dbSNP:rs137853168EnsemblClinVar.1
Natural variantiVAR_014021380G → R in IXL; strong decreases of steryl-sulfatase activity. 1 Publication1
Natural variantiVAR_014022444H → R in IXL; loss of steryl-sulfatase activity. 1 PublicationCorresponds to variant dbSNP:rs137853169EnsemblClinVar.1
Natural variantiVAR_007242446C → Y in IXL; loss of steryl-sulfatase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853166EnsemblClinVar.1
Natural variantiVAR_081729476V → M Does not affect steryl-sulfatase activity. 1 PublicationCorresponds to variant dbSNP:rs183370963Ensembl.1
Natural variantiVAR_014023560Q → P in IXL. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04964 mRNA Translation: AAA60597.1
M16505 mRNA Translation: AAA60596.1
AK314034 mRNA Translation: BAG36744.1
BC075030 mRNA Translation: AAH75030.1
M23945 Genomic DNA Translation: AAA60598.1
M23556 Genomic DNA Translation: AAA60599.1

Protein sequence database of the Protein Information Resource

More...PIRi		A32641, KJHUAC

NCBI Reference Sequences

More...RefSeqi		NP_000342.2, NM_000351.5
NP_001307679.1, NM_001320750.1
NP_001307680.1, NM_001320751.1
NP_001307681.1, NM_001320752.1
NP_001307682.1, NM_001320753.1
NP_001307683.1, NM_001320754.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000674499; ENSP00000501360; ENSG00000101846

Database of genes from NCBI RefSeq genomes

More...GeneIDi		412

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:412

UCSC genome browser

More...UCSCi		uc004cry.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Steroid sulfatase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04964 mRNA Translation: AAA60597.1
M16505 mRNA Translation: AAA60596.1
AK314034 mRNA Translation: BAG36744.1
BC075030 mRNA Translation: AAH75030.1
M23945 Genomic DNA Translation: AAA60598.1
M23556 Genomic DNA Translation: AAA60599.1
PIRiA32641, KJHUAC
RefSeqiNP_000342.2, NM_000351.5
NP_001307679.1, NM_001320750.1
NP_001307680.1, NM_001320751.1
NP_001307681.1, NM_001320752.1
NP_001307682.1, NM_001320753.1
NP_001307683.1, NM_001320754.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P49X-ray2.60A22-583[»]
SMRiP08842
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106905, 27 interactors
IntActiP08842, 22 interactors
MINTiP08842
STRINGi9606.ENSP00000217961

Chemistry databases

BindingDBiP08842
ChEMBLiCHEMBL3559
DrugBankiDB02735, 2-Amino-3-Oxo-4-Sulfo-Butyric Acid
DB02292, Irosustat
DB06713, Norelgestromin
DB09070, Tibolone
DrugCentraliP08842
SwissLipidsiSLP:000001236

PTM databases

GlyConnecti1770, 2 N-Linked glycans (1 site)
GlyGeniP08842, 4 sites
iPTMnetiP08842
PhosphoSitePlusiP08842
SwissPalmiP08842

Genetic variation databases

BioMutaiSTS
DMDMi135006

Proteomic databases

EPDiP08842
jPOSTiP08842
MassIVEiP08842
MaxQBiP08842
PaxDbiP08842
PeptideAtlasiP08842
PRIDEiP08842
ProteomicsDBi52168

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		363, 256 antibodies

Genome annotation databases

EnsembliENST00000674499; ENSP00000501360; ENSG00000101846
GeneIDi412
KEGGihsa:412
UCSCiuc004cry.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		412
DisGeNETi412

GeneCards: human genes, protein and diseases

More...GeneCardsi		STS
HGNCiHGNC:11425, STS
HPAiENSG00000101846, Tissue enriched (placenta)
MalaCardsiSTS
MIMi300747, gene
308100, phenotype
neXtProtiNX_P08842
OpenTargetsiENSG00000101846
Orphaneti461, Recessive X-linked ichthyosis
281090, Syndromic recessive X-linked ichthyosis
PharmGKBiPA36225
VEuPathDBiHostDB:ENSG00000101846.6

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3867, Eukaryota
GeneTreeiENSGT00940000161153
HOGENOMiCLU_006332_13_4_1
InParanoidiP08842
OMAiCFHTHVC
OrthoDBi873694at2759
PhylomeDBiP08842
TreeFamiTF314186

Enzyme and pathway databases

BRENDAi3.1.6.2, 2681
PathwayCommonsiP08842
ReactomeiR-HSA-1660662, Glycosphingolipid metabolism
R-HSA-1663150, The activation of arylsulfatases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		412, 4 hits in 618 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STS, human
EvolutionaryTraceiP08842

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Steroid_sulfatase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		412
PharosiP08842, Tchem

Protein Ontology

More...PROi		PR:P08842
RNActiP08842, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000101846, Expressed in chorionic villus and 221 other tissues
GenevisibleiP08842, HS

Family and domain databases

Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017850, Alkaline_phosphatase_core_sf
IPR024607, Sulfatase_CS
IPR000917, Sulfatase_N
PfamiView protein in Pfam
PF00884, Sulfatase, 1 hit
SUPFAMiSSF53649, SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00523, SULFATASE_1, 1 hit
PS00149, SULFATASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08842
Secondary accession number(s): B2RA47
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 1, 1990
Last modified: April 7, 2021
This is version 210 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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