UniProtKB - P08835 (ALBU_PIG)
Protein
Albumin
Gene
ALB
Organism
Sus scrofa (Pig)
Status
Functioni
Binds water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 30 | Calcium 1By similarity | 1 | |
Metal bindingi | 33 | CopperBy similarity | 1 | |
Metal bindingi | 37 | Calcium 2By similarity | 1 | |
Metal bindingi | 91 | Zinc; via tele nitrogenBy similarity | 1 | |
Metal bindingi | 267 | Calcium 1By similarity | 1 | |
Metal bindingi | 270 | Zinc; via pros nitrogenBy similarity | 1 | |
Metal bindingi | 272 | Calcium 1By similarity | 1 | |
Metal bindingi | 272 | ZincBy similarity | 1 | |
Metal bindingi | 275 | Calcium 1By similarity | 1 | |
Metal bindingi | 278 | Calcium 2By similarity | 1 | |
Metal bindingi | 282 | Calcium 2By similarity | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- enterobactin binding Source: UniProtKB
- fatty acid binding Source: UniProtKB
- pyridoxal phosphate binding Source: UniProtKB
- small molecule binding Source: AgBase
- toxic substance binding Source: UniProtKB
- zinc ion binding Source: GO_Central
GO - Biological processi
- cellular response to starvation Source: UniProtKB
- maintenance of mitochondrion location Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
Keywordsi
Ligand | Calcium, Copper, Lipid-binding, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Albumin |
Gene namesi | Name:ALB |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: AgBase
Other locations
- cytoplasm Source: GO_Central
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000001075 | 19 – 24 | By similarity | 6 | |
ChainiPRO_0000001076 | 25 – 607 | AlbuminAdd BLAST | 583 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 29 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 77 ↔ 86 | PROSITE-ProRule annotation | ||
Modified residuei | 82 | PhosphoserineBy similarity | 1 | |
Modified residuei | 89 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 99 ↔ 115 | PROSITE-ProRule annotation | ||
Disulfide bondi | 114 ↔ 125 | PROSITE-ProRule annotation | ||
Disulfide bondi | 147 ↔ 192 | PROSITE-ProRule annotation | ||
Disulfide bondi | 191 ↔ 200 | PROSITE-ProRule annotation | ||
Disulfide bondi | 223 ↔ 269 | PROSITE-ProRule annotation | ||
Modified residuei | 228 | N6-succinyllysineBy similarity | 1 | |
Disulfide bondi | 268 ↔ 276 | PROSITE-ProRule annotation | ||
Disulfide bondi | 288 ↔ 302 | PROSITE-ProRule annotation | ||
Disulfide bondi | 301 ↔ 312 | PROSITE-ProRule annotation | ||
Disulfide bondi | 339 ↔ 384 | PROSITE-ProRule annotation | ||
Disulfide bondi | 383 ↔ 392 | PROSITE-ProRule annotation | ||
Disulfide bondi | 415 ↔ 461 | PROSITE-ProRule annotation | ||
Modified residuei | 442 | PhosphoserineBy similarity | 1 | |
Modified residuei | 443 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 445 | PhosphothreonineBy similarity | 1 | |
Disulfide bondi | 460 ↔ 471 | PROSITE-ProRule annotation | ||
Disulfide bondi | 484 ↔ 500 | PROSITE-ProRule annotation | ||
Disulfide bondi | 499 ↔ 510 | PROSITE-ProRule annotation | ||
Modified residuei | 512 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 537 ↔ 582 | PROSITE-ProRule annotation | ||
Modified residuei | 557 | N6-methyllysineBy similarity | 1 | |
Modified residuei | 569 | PhosphothreonineBy similarity | 1 | |
Disulfide bondi | 581 ↔ 590 | PROSITE-ProRule annotation |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Methylation, PhosphoproteinProteomic databases
PaxDbi | P08835 |
PeptideAtlasi | P08835 |
PRIDEi | P08835 |
Expressioni
Tissue specificityi
Plasma.
Interactioni
Subunit structurei
Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity).
Interacts with TASOR (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9823.ENSSSCP00000009549 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 209 | Albumin 1PROSITE-ProRule annotationAdd BLAST | 191 | |
Domaini | 210 – 402 | Albumin 2PROSITE-ProRule annotationAdd BLAST | 193 | |
Domaini | 403 – 600 | Albumin 3PROSITE-ProRule annotationAdd BLAST | 198 |
Sequence similaritiesi
Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502R7EA, Eukaryota |
InParanoidi | P08835 |
OrthoDBi | 906547at2759 |
Family and domain databases
CDDi | cd00015, ALBUMIN, 3 hits |
InterProi | View protein in InterPro IPR000264, ALB/AFP/VDB IPR020858, Serum_albumin-like IPR021177, Serum_albumin/AFP/Afamin IPR020857, Serum_albumin_CS IPR014760, Serum_albumin_N |
PANTHERi | PTHR11385, PTHR11385, 1 hit |
Pfami | View protein in Pfam PF00273, Serum_albumin, 3 hits |
PIRSFi | PIRSF002520, Serum_albumin_subgroup, 1 hit |
PRINTSi | PR00802, SERUMALBUMIN |
SMARTi | View protein in SMART SM00103, ALBUMIN, 3 hits |
SUPFAMi | SSF48552, SSF48552, 3 hits |
PROSITEi | View protein in PROSITE PS00212, ALBUMIN_1, 3 hits PS51438, ALBUMIN_2, 3 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P08835-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKWVTFISLL FLFSSAYSRG VFRRDTYKSE IAHRFKDLGE QYFKGLVLIA
60 70 80 90 100
FSQHLQQCPY EEHVKLVREV TEFAKTCVAD ESAENCDKSI HTLFGDKLCA
110 120 130 140 150
IPSLREHYGD LADCCEKEEP ERNECFLQHK NDNPDIPKLK PDPVALCADF
160 170 180 190 200
QEDEQKFWGK YLYEIARRHP YFYAPELLYY AIIYKDVFSE CCQAADKAAC
210 220 230 240 250
LLPKIEHLRE KVLTSAAKQR LKCASIQKFG ERAFKAWSLA RLSQRFPKAD
260 270 280 290 300
FTEISKIVTD LAKVHKECCH GDLLECADDR ADLAKYICEN QDTISTKLKE
310 320 330 340 350
CCDKPLLEKS HCIAEAKRDE LPADLNPLEH DFVEDKEVCK NYKEAKHVFL
360 370 380 390 400
GTFLYEYSRR HPDYSVSLLL RIAKIYEATL EDCCAKEDPP ACYATVFDKF
410 420 430 440 450
QPLVDEPKNL IKQNCELFEK LGEYGFQNAL IVRYTKKVPQ VSTPTLVEVA
460 470 480 490 500
RKLGLVGSRC CKRPEEERLS CAEDYLSLVL NRLCVLHEKT PVSEKVTKCC
510 520 530 540 550
TESLVNRRPC FSALTPDETY KPKEFVEGTF TFHADLCTLP EDEKQIKKQT
560 570 580 590 600
ALVELLKHKP HATEEQLRTV LGNFAAFVQK CCAAPDHEAC FAVEGPKFVI
EIRGILA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 146 – 151 | LCADFQ → GYAEFE AA sequence (PubMed:2728927).Curated | 6 | |
Sequence conflicti | 155 – 156 | QK → VN AA sequence (PubMed:2728927).Curated | 2 | |
Sequence conflicti | 347 | H → D in CAA30970 (PubMed:3174440).Curated | 1 | |
Sequence conflicti | 347 | H → D in AAA30988 (PubMed:3174440).Curated | 1 | |
Sequence conflicti | 564 | E → D in AAA30988 (PubMed:3174440).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY663543 Genomic DNA Translation: AAT98610.1 X12422 mRNA Translation: CAA30970.1 M36787 mRNA Translation: AAA30988.1 |
PIRi | S01382, ABPGS |
RefSeqi | NP_001005208.1, NM_001005208.1 |
Genome annotation databases
GeneIDi | 396960 |
KEGGi | ssc:396960 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY663543 Genomic DNA Translation: AAT98610.1 X12422 mRNA Translation: CAA30970.1 M36787 mRNA Translation: AAA30988.1 |
PIRi | S01382, ABPGS |
RefSeqi | NP_001005208.1, NM_001005208.1 |
3D structure databases
SMRi | P08835 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000009549 |
Protein family/group databases
Allergomei | 11911, Sus s 1.0101 757, Sus s 1 |
Proteomic databases
PaxDbi | P08835 |
PeptideAtlasi | P08835 |
PRIDEi | P08835 |
Genome annotation databases
GeneIDi | 396960 |
KEGGi | ssc:396960 |
Organism-specific databases
CTDi | 213 |
Phylogenomic databases
eggNOGi | ENOG502R7EA, Eukaryota |
InParanoidi | P08835 |
OrthoDBi | 906547at2759 |
Miscellaneous databases
ChiTaRSi | ALB, pig |
Family and domain databases
CDDi | cd00015, ALBUMIN, 3 hits |
InterProi | View protein in InterPro IPR000264, ALB/AFP/VDB IPR020858, Serum_albumin-like IPR021177, Serum_albumin/AFP/Afamin IPR020857, Serum_albumin_CS IPR014760, Serum_albumin_N |
PANTHERi | PTHR11385, PTHR11385, 1 hit |
Pfami | View protein in Pfam PF00273, Serum_albumin, 3 hits |
PIRSFi | PIRSF002520, Serum_albumin_subgroup, 1 hit |
PRINTSi | PR00802, SERUMALBUMIN |
SMARTi | View protein in SMART SM00103, ALBUMIN, 3 hits |
SUPFAMi | SSF48552, SSF48552, 3 hits |
PROSITEi | View protein in PROSITE PS00212, ALBUMIN_1, 3 hits PS51438, ALBUMIN_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ALBU_PIG | |
Accessioni | P08835Primary (citable) accession number: P08835 Secondary accession number(s): Q29018, Q68NH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | February 1, 2005 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families