IGFBP1

Functionⁱ

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.1 Publication

GO - Molecular functionⁱ

insulin-like growth factor binding
Source: ProtInc
Traceable author statementⁱ
- 2454104
insulin-like growth factor I binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21550830
insulin-like growth factor II binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21550830
signaling receptor binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
cellular protein metabolic process Source: Reactome
insulin receptor signaling pathway Source: Ensembl
negative regulation of canonical Wnt signaling pathway
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302
PERK-mediated unfolded protein response Source: Reactome
positive regulation of cell growth Source: Ensembl
post-translational protein modification Source: Reactome
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 2454104
tissue regeneration Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding

Molecular function

Growth factor binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380994 ATF4 activates genes R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation
SignaLinkⁱ	P08833
SIGNORⁱ	P08833

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.951

MEROPSⁱ

I31.951

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 1 Short name: IBP-1 Short name: IGF-binding protein 1 Short name: IGFBP-1 Alternative name(s): Placental protein 12 Short name: PP12
Gene namesⁱ	Name:IGFBP1 Synonyms:IBP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000146678.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5469 IGFBP1
MIMⁱ	146730 gene
neXtProtⁱ	NX_P08833

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3484
Open Targets More...OpenTargetsⁱ	ENSG00000146678
PharmGKBⁱ	PA29703

Chemistry databases

ChEMBLⁱ	CHEMBL4178

ChEMBLⁱ

CHEMBL4178

Polymorphism and mutation databases

BioMutaⁱ	IGFBP1
DMDMⁱ	124055

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	3 PublicationsAdd BLAST		25
ChainⁱPRO_0000014365	26 – 259	Insulin-like growth factor-binding protein 1Add BLAST		234

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	45	Phosphoserine; by FAM20C1 Publication	1
Disulfide bondⁱ	71 ↔ 84
Disulfide bondⁱ	78 ↔ 104
Modified residueⁱ	120	Phosphoserine1 Publication	1
Modified residueⁱ	123	Phosphoserine1 Publication	1
Modified residueⁱ	126	Phosphoserine2 Publications	1
Modified residueⁱ	144	PhosphoserineCombined sources2 Publications	1
Modified residueⁱ	156	Phosphoserine; by FAM20C1 Publication	1
Modified residueⁱ	157	Phosphothreonine; by FAM20C1 Publication	1
Modified residueⁱ	158	Phosphotyrosine1 Publication	1
Disulfide bondⁱ	176 ↔ 206
Modified residueⁱ	193	Phosphothreonine; by FAM20C1 Publication	1
Modified residueⁱ	194	Phosphoserine; by FAM20C3 Publications	1
Modified residueⁱ	199	Phosphoserine; by FAM20C1 Publication	1
Disulfide bondⁱ	217 ↔ 228
Disulfide bondⁱ	230 ↔ 251
Modified residueⁱ	242	Phosphoserine; by FAM20C1 Publication	1

Post-translational modificationⁱ

Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.3 Publications

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08833
PaxDbⁱ	P08833
PeptideAtlas More...PeptideAtlasⁱ	P08833
PRIDEⁱ	P08833
ProteomicsDBⁱ	52167

PTM databases

iPTMnetⁱ	P08833
PhosphoSitePlusⁱ	P08833

Miscellaneous databases

PMAP-CutDBⁱ	P08833

PMAP-CutDBⁱ

P08833

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000146678 Expressed in 89 organ(s), highest expression level in placenta
CleanExⁱ	HS_IGFBP1
ExpressionAtlasⁱ	P08833 baseline and differential
Genevisibleⁱ	P08833 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004445 HPA046972 HPA050640

HPAⁱ

CAB004445
HPA046972
HPA050640

Interactionⁱ

Subunit structureⁱ

Binds equally well IGF1 and IGF2.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FAM20C	Q8IXL6	2	EBI-13646303,EBI-7147442
IGF1	P05019	2	EBI-13646303,EBI-7902275

GO - Molecular functionⁱ

insulin-like growth factor binding
Source: ProtInc
Traceable author statementⁱ
- 2454104
insulin-like growth factor I binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21550830
insulin-like growth factor II binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21550830
signaling receptor binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109705, 20 interactors
Database of interacting proteins More...DIPⁱ	DIP-59846N
IntActⁱ	P08833, 4 interactors
STRINGⁱ	9606.ENSP00000275525

Chemistry databases

BindingDBⁱ

P08833

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	175 – 193	Combined sources	19
Beta strandⁱ	199 – 201	Combined sources	3
Beta strandⁱ	210 – 212	Combined sources	3
Beta strandⁱ	214 – 217	Combined sources	4
Beta strandⁱ	222 – 224	Combined sources	3
Beta strandⁱ	228 – 231	Combined sources	4
Turnⁱ	233 – 235	Combined sources	3
Beta strandⁱ	245 – 247	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P08833
SMRⁱ	P08833
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P08833

EvolutionaryTraceⁱ

P08833

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	26 – 107	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		82
Domainⁱ	173 – 251	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		79

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	246 – 248	Cell attachment site		3

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IITJ Eukaryota ENOG4111H9A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P08833
OMAⁱ	WCVYPWS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EIN
PhylomeDBⁱ	P08833
TreeFamⁱ	TF331211

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR000867 IGFBP-like IPR022322 IGFBP1 IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01977 IGFBPFAMILY1
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P08833-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE 
        60         70         80         90        100
VTRSAGCGCC PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG 
       110        120        130        140        150
QGACVQESDA SAPHAAEAGS PESPESTEIT EEELLDNFHL MAPSEEDHSI 
       160        170        180        190        200
LWDAISTYDG SKALHVTNIK KWKEPCRIEL YRVVESLAKA QETSGEEISK 
       210        220        230        240        250
FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP GSPEIRGDPN 

CQIYFNVQN

Length:259

Mass (Da):27,904

Last modified:November 1, 1988 - v1

Checksum:ⁱ8AA75AF7DC966012

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JXF9	C9JXF9_HUMAN	Insulin-like growth factor-binding ... Insulin-like growth factor-binding protein 1	IGFBP1	257	Annotation score:
C9J6H2	C9J6H2_HUMAN	Insulin-like growth factor-binding ... Insulin-like growth factor-binding protein 1	IGFBP1	216	Annotation score:

Sequence cautionⁱ

The sequence AAA52540 differs from that shown. Reason: Frameshift at positions 55 and 71.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	213	H → Q in AAA52540 (PubMed:2454104).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049564	114	H → D. Corresponds to variant dbSNP:rs41258845Ensembl.	1
Natural variantⁱVAR_011905	183	V → I1 PublicationCorresponds to variant dbSNP:rs1065782Ensembl.	1
Natural variantⁱVAR_003821	253	I → M2 PublicationsCorresponds to variant dbSNP:rs4619Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00856 mRNA Translation: CAA68770.1 M20841 mRNA Translation: AAA52540.1 Frameshift. X12385 mRNA Translation: CAA30942.1 X13405 mRNA Translation: CAA31771.1 M31145 mRNA Translation: AAA52542.1 M59316 Genomic DNA Translation: AAA52783.1 M23595 , M23592, M23593, M23594 Genomic DNA Translation: AAA52785.1 M74587 Genomic DNA Translation: AAA52784.1 BT019685 mRNA Translation: AAV38491.1 AY434089 Genomic DNA Translation: AAQ96599.1 CH236958 Genomic DNA Translation: EAL23800.1 CH471128 Genomic DNA Translation: EAW61030.1 CH471128 Genomic DNA Translation: EAW61031.1 BC035263 mRNA Translation: AAH35263.2 X15002 mRNA Translation: CAA33110.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5504.1
PIRⁱ	A31867 IOHU1
NCBI Reference Sequences More...RefSeqⁱ	NP_000587.1, NM_000596.2
UniGeneⁱ	Hs.642938

Genome annotation databases

Ensemblⁱ	ENST00000275525; ENSP00000275525; ENSG00000146678
GeneIDⁱ	3484
KEGGⁱ	hsa:3484
UCSC genome browser More...UCSCⁱ	uc003tnp.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08833	Insulin-like growth factor binding protein 1 (Fragment)		HUMAN		258	UniRef100_P08833
UPI0000DD0865		HUMAN		94

Protein	Similar proteins		Species	Score	Length	Source
P08833	Insulin-like growth factor binding protein 1 (Fragment)		HUMAN		258	UniRef90_P08833
Uncharacterized protein		RHIRO		283
Uncharacterized protein		RHIBE		261
Insulin like growth factor binding protein 1		MACMU		281
Uncharacterized protein		MACFA		281
+25

Protein	Similar proteins		Species	Score	Length	Source
P08833	Insulin-like growth factor binding protein 1 (Fragment)		HUMAN		258	UniRef50_P08833
Uncharacterized protein		RHIRO		283
Uncharacterized protein		RHIBE		261
Uncharacterized protein		PONAB		281
Insulin-like growth factor-binding protein 1		PANTR		281
+26

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00856 mRNA Translation: CAA68770.1 M20841 mRNA Translation: AAA52540.1 Frameshift. X12385 mRNA Translation: CAA30942.1 X13405 mRNA Translation: CAA31771.1 M31145 mRNA Translation: AAA52542.1 M59316 Genomic DNA Translation: AAA52783.1 M23595 , M23592, M23593, M23594 Genomic DNA Translation: AAA52785.1 M74587 Genomic DNA Translation: AAA52784.1 BT019685 mRNA Translation: AAV38491.1 AY434089 Genomic DNA Translation: AAQ96599.1 CH236958 Genomic DNA Translation: EAL23800.1 CH471128 Genomic DNA Translation: EAW61030.1 CH471128 Genomic DNA Translation: EAW61031.1 BC035263 mRNA Translation: AAH35263.2 X15002 mRNA Translation: CAA33110.1
CCDSⁱ	CCDS5504.1
PIRⁱ	A31867 IOHU1
RefSeqⁱ	NP_000587.1, NM_000596.2
UniGeneⁱ	Hs.642938

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ZT3	X-ray	1.80	A	172-251	[»]
	1ZT5	X-ray	1.82	A	172-251	[»]
	2DSQ	X-ray	2.80	G/H	166-259	[»]
ProteinModelPortalⁱ	P08833
SMRⁱ	P08833
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109705, 20 interactors
DIPⁱ	DIP-59846N
IntActⁱ	P08833, 4 interactors
STRINGⁱ	9606.ENSP00000275525

Chemistry databases

BindingDBⁱ	P08833
ChEMBLⁱ	CHEMBL4178

Protein family/group databases

MEROPSⁱ	I31.951

MEROPSⁱ

I31.951

PTM databases

iPTMnetⁱ	P08833
PhosphoSitePlusⁱ	P08833

Polymorphism and mutation databases

BioMutaⁱ	IGFBP1
DMDMⁱ	124055

Proteomic databases

MaxQBⁱ	P08833
PaxDbⁱ	P08833
PeptideAtlasⁱ	P08833
PRIDEⁱ	P08833
ProteomicsDBⁱ	52167

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3484
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000275525; ENSP00000275525; ENSG00000146678
GeneIDⁱ	3484
KEGGⁱ	hsa:3484
UCSCⁱ	uc003tnp.4 human

Organism-specific databases

CTDⁱ	3484
DisGeNETⁱ	3484
EuPathDBⁱ	HostDB:ENSG00000146678.9
GeneCardsⁱ	IGFBP1
HGNCⁱ	HGNC:5469 IGFBP1
HPAⁱ	CAB004445 HPA046972 HPA050640
MIMⁱ	146730 gene
neXtProtⁱ	NX_P08833
OpenTargetsⁱ	ENSG00000146678
PharmGKBⁱ	PA29703
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IITJ Eukaryota ENOG4111H9A LUCA
GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P08833
OMAⁱ	WCVYPWS
OrthoDBⁱ	EOG091G0EIN
PhylomeDBⁱ	P08833
TreeFamⁱ	TF331211

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380994 ATF4 activates genes R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation
SignaLinkⁱ	P08833
SIGNORⁱ	P08833

Miscellaneous databases

ChiTaRSⁱ	IGFBP1 human
EvolutionaryTraceⁱ	P08833
GeneWikiⁱ	IGFBP1
GenomeRNAiⁱ	3484
PMAP-CutDBⁱ	P08833
Protein Ontology More...PROⁱ	PR:P08833
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000146678 Expressed in 89 organ(s), highest expression level in placenta
CleanExⁱ	HS_IGFBP1
ExpressionAtlasⁱ	P08833 baseline and differential
Genevisibleⁱ	P08833 HS

Family and domain databases

CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR000867 IGFBP-like IPR022322 IGFBP1 IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit
Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01977 IGFBPFAMILY1
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP1_HUMAN
Accessionⁱ	P08833Primary (citable) accession number: P08833 Secondary accession number(s): A4D2F4, D3DVL9, Q8IYP5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
	Last sequence update:	November 1, 1988
	Last modified:	November 7, 2018
	This is version 203 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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Help

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Supporting data

UniProtKB - P08833 (IBP1_HUMAN)

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Insulin-like growth factor-binding protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ