UniProtKB - P08833 (IBP1_HUMAN)
Protein
Insulin-like growth factor-binding protein 1
Gene
IGFBP1
Organism
Homo sapiens (Human)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.1 Publication
GO - Molecular functioni
- insulin-like growth factor binding Source: ProtInc
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: UniProtKB
- signaling receptor binding Source: ParkinsonsUK-UCL
GO - Biological processi
- aging Source: Ensembl
- cellular protein metabolic process Source: Reactome
- insulin receptor signaling pathway Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
- PERK-mediated unfolded protein response Source: Reactome
- positive regulation of cell growth Source: Ensembl
- post-translational protein modification Source: Reactome
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
- signal transduction Source: ProtInc
- tissue regeneration Source: Ensembl
Keywordsi
Molecular function | Growth factor binding |
Enzyme and pathway databases
PathwayCommonsi | P08833 |
Reactomei | R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
SignaLinki | P08833 |
SIGNORi | P08833 |
Protein family/group databases
MEROPSi | I31.951 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 1Short name: IBP-1 Short name: IGF-binding protein 1 Short name: IGFBP-1 Alternative name(s): Placental protein 12 Short name: PP12 |
Gene namesi | Name:IGFBP1 Synonyms:IBP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5469, IGFBP1 |
MIMi | 146730, gene |
neXtProti | NX_P08833 |
VEuPathDBi | HostDB:ENSG00000146678.9 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: HPA
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3484 |
OpenTargetsi | ENSG00000146678 |
PharmGKBi | PA29703 |
Miscellaneous databases
Pharosi | P08833, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4178 |
DrugBanki | DB01277, Mecasermin |
Genetic variation databases
BioMutai | IGFBP1 |
DMDMi | 124055 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | 3 PublicationsAdd BLAST | 25 | |
ChainiPRO_0000014365 | 26 – 259 | Insulin-like growth factor-binding protein 1Add BLAST | 234 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 45 | Phosphoserine; by FAM20C1 Publication | 1 | |
Disulfide bondi | 71 ↔ 84 | |||
Disulfide bondi | 78 ↔ 104 | |||
Modified residuei | 120 | Phosphoserine1 Publication | 1 | |
Modified residuei | 123 | Phosphoserine1 Publication | 1 | |
Modified residuei | 126 | Phosphoserine2 Publications | 1 | |
Modified residuei | 144 | PhosphoserineCombined sources2 Publications | 1 | |
Modified residuei | 156 | Phosphoserine; by FAM20C1 Publication | 1 | |
Modified residuei | 157 | Phosphothreonine; by FAM20C1 Publication | 1 | |
Modified residuei | 158 | Phosphotyrosine1 Publication | 1 | |
Disulfide bondi | 176 ↔ 206 | |||
Modified residuei | 193 | Phosphothreonine; by FAM20C1 Publication | 1 | |
Modified residuei | 194 | Phosphoserine; by FAM20C3 Publications | 1 | |
Modified residuei | 199 | Phosphoserine; by FAM20C1 Publication | 1 | |
Disulfide bondi | 217 ↔ 228 | |||
Disulfide bondi | 230 ↔ 251 | |||
Modified residuei | 242 | Phosphoserine; by FAM20C1 Publication | 1 |
Post-translational modificationi
Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.3 Publications
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
MassIVEi | P08833 |
MaxQBi | P08833 |
PaxDbi | P08833 |
PeptideAtlasi | P08833 |
PRIDEi | P08833 |
ProteomicsDBi | 52167 |
PTM databases
iPTMneti | P08833 |
PhosphoSitePlusi | P08833 |
Expressioni
Gene expression databases
Bgeei | ENSG00000146678, Expressed in placenta and 106 other tissues |
ExpressionAtlasi | P08833, baseline and differential |
Genevisiblei | P08833, HS |
Organism-specific databases
HPAi | ENSG00000146678, Group enriched (liver, placenta) |
Interactioni
Subunit structurei
Binds equally well IGF1 and IGF2.
1 PublicationBinary interactionsi
Hide detailsP08833
GO - Molecular functioni
- insulin-like growth factor binding Source: ProtInc
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: UniProtKB
- signaling receptor binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 109705, 20 interactors |
DIPi | DIP-59846N |
IntActi | P08833, 27 interactors |
STRINGi | 9606.ENSP00000275525 |
Chemistry databases
BindingDBi | P08833 |
Miscellaneous databases
RNActi | P08833, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P08833 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08833 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 107 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 173 – 251 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 79 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 246 – 248 | Cell attachment site | 3 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QWRP, Eukaryota |
GeneTreei | ENSGT00940000157394 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P08833 |
OMAi | PWHCAPC |
OrthoDBi | 979270at2759 |
PhylomeDBi | P08833 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR000867, IGFBP-like IPR022322, IGFBP1 IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01977, IGFBPFAMILY1 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P08833-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE
60 70 80 90 100
VTRSAGCGCC PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG
110 120 130 140 150
QGACVQESDA SAPHAAEAGS PESPESTEIT EEELLDNFHL MAPSEEDHSI
160 170 180 190 200
LWDAISTYDG SKALHVTNIK KWKEPCRIEL YRVVESLAKA QETSGEEISK
210 220 230 240 250
FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP GSPEIRGDPN
CQIYFNVQN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J6H2 | C9J6H2_HUMAN | Insulin-like growth factor-binding ... | IGFBP1 | 216 | Annotation score: | ||
C9JXF9 | C9JXF9_HUMAN | Insulin-like growth factor-binding ... | IGFBP1 | 257 | Annotation score: |
Sequence cautioni
The sequence AAA52540 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 213 | H → Q in AAA52540 (PubMed:2454104).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049564 | 114 | H → D. Corresponds to variant dbSNP:rs41258845Ensembl. | 1 | |
Natural variantiVAR_011905 | 183 | V → I1 PublicationCorresponds to variant dbSNP:rs1065782Ensembl. | 1 | |
Natural variantiVAR_003821 | 253 | I → M2 PublicationsCorresponds to variant dbSNP:rs4619Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00856 mRNA Translation: CAA68770.1 M20841 mRNA Translation: AAA52540.1 Frameshift. X12385 mRNA Translation: CAA30942.1 X13405 mRNA Translation: CAA31771.1 M31145 mRNA Translation: AAA52542.1 M59316 Genomic DNA Translation: AAA52783.1 M23595 , M23592, M23593, M23594 Genomic DNA Translation: AAA52785.1 M74587 Genomic DNA Translation: AAA52784.1 BT019685 mRNA Translation: AAV38491.1 AY434089 Genomic DNA Translation: AAQ96599.1 CH236958 Genomic DNA Translation: EAL23800.1 CH471128 Genomic DNA Translation: EAW61030.1 CH471128 Genomic DNA Translation: EAW61031.1 BC035263 mRNA Translation: AAH35263.2 X15002 mRNA Translation: CAA33110.1 |
CCDSi | CCDS5504.1 |
PIRi | A31867, IOHU1 |
RefSeqi | NP_000587.1, NM_000596.2 |
Genome annotation databases
Ensembli | ENST00000275525; ENSP00000275525; ENSG00000146678 |
GeneIDi | 3484 |
KEGGi | hsa:3484 |
UCSCi | uc003tnp.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00856 mRNA Translation: CAA68770.1 M20841 mRNA Translation: AAA52540.1 Frameshift. X12385 mRNA Translation: CAA30942.1 X13405 mRNA Translation: CAA31771.1 M31145 mRNA Translation: AAA52542.1 M59316 Genomic DNA Translation: AAA52783.1 M23595 , M23592, M23593, M23594 Genomic DNA Translation: AAA52785.1 M74587 Genomic DNA Translation: AAA52784.1 BT019685 mRNA Translation: AAV38491.1 AY434089 Genomic DNA Translation: AAQ96599.1 CH236958 Genomic DNA Translation: EAL23800.1 CH471128 Genomic DNA Translation: EAW61030.1 CH471128 Genomic DNA Translation: EAW61031.1 BC035263 mRNA Translation: AAH35263.2 X15002 mRNA Translation: CAA33110.1 |
CCDSi | CCDS5504.1 |
PIRi | A31867, IOHU1 |
RefSeqi | NP_000587.1, NM_000596.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ZT3 | X-ray | 1.80 | A | 172-251 | [»] | |
1ZT5 | X-ray | 1.82 | A | 172-251 | [»] | |
2DSQ | X-ray | 2.80 | G/H | 166-259 | [»] | |
SMRi | P08833 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109705, 20 interactors |
DIPi | DIP-59846N |
IntActi | P08833, 27 interactors |
STRINGi | 9606.ENSP00000275525 |
Chemistry databases
BindingDBi | P08833 |
ChEMBLi | CHEMBL4178 |
DrugBanki | DB01277, Mecasermin |
Protein family/group databases
MEROPSi | I31.951 |
PTM databases
iPTMneti | P08833 |
PhosphoSitePlusi | P08833 |
Genetic variation databases
BioMutai | IGFBP1 |
DMDMi | 124055 |
Proteomic databases
MassIVEi | P08833 |
MaxQBi | P08833 |
PaxDbi | P08833 |
PeptideAtlasi | P08833 |
PRIDEi | P08833 |
ProteomicsDBi | 52167 |
Protocols and materials databases
Antibodypediai | 3841, 644 antibodies |
DNASUi | 3484 |
Genome annotation databases
Ensembli | ENST00000275525; ENSP00000275525; ENSG00000146678 |
GeneIDi | 3484 |
KEGGi | hsa:3484 |
UCSCi | uc003tnp.4, human |
Organism-specific databases
CTDi | 3484 |
DisGeNETi | 3484 |
GeneCardsi | IGFBP1 |
HGNCi | HGNC:5469, IGFBP1 |
HPAi | ENSG00000146678, Group enriched (liver, placenta) |
MIMi | 146730, gene |
neXtProti | NX_P08833 |
OpenTargetsi | ENSG00000146678 |
PharmGKBi | PA29703 |
VEuPathDBi | HostDB:ENSG00000146678.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWRP, Eukaryota |
GeneTreei | ENSGT00940000157394 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P08833 |
OMAi | PWHCAPC |
OrthoDBi | 979270at2759 |
PhylomeDBi | P08833 |
TreeFami | TF331211 |
Enzyme and pathway databases
PathwayCommonsi | P08833 |
Reactomei | R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
SignaLinki | P08833 |
SIGNORi | P08833 |
Miscellaneous databases
BioGRID-ORCSi | 3484, 8 hits in 876 CRISPR screens |
ChiTaRSi | IGFBP1, human |
EvolutionaryTracei | P08833 |
GeneWikii | IGFBP1 |
GenomeRNAii | 3484 |
Pharosi | P08833, Tchem |
PROi | PR:P08833 |
RNActi | P08833, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000146678, Expressed in placenta and 106 other tissues |
ExpressionAtlasi | P08833, baseline and differential |
Genevisiblei | P08833, HS |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR000867, IGFBP-like IPR022322, IGFBP1 IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01977, IGFBPFAMILY1 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP1_HUMAN | |
Accessioni | P08833Primary (citable) accession number: P08833 Secondary accession number(s): A4D2F4, D3DVL9, Q8IYP5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | February 10, 2021 | |
This is version 217 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references