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Protein

Insulin-like growth factor-binding protein 1

Gene

IGFBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.1 Publication

GO - Molecular functioni

  • insulin-like growth factor binding Source: ProtInc
  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: UniProtKB
  • signaling receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-HSA-380994 ATF4 activates genes
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SignaLinkiP08833
SIGNORiP08833

Protein family/group databases

MEROPSiI31.951

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 1
Short name:
IBP-1
Short name:
IGF-binding protein 1
Short name:
IGFBP-1
Alternative name(s):
Placental protein 12
Short name:
PP12
Gene namesi
Name:IGFBP1
Synonyms:IBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146678.9
HGNCiHGNC:5469 IGFBP1
MIMi146730 gene
neXtProtiNX_P08833

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3484
OpenTargetsiENSG00000146678
PharmGKBiPA29703

Chemistry databases

ChEMBLiCHEMBL4178

Polymorphism and mutation databases

BioMutaiIGFBP1
DMDMi124055

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 253 PublicationsAdd BLAST25
ChainiPRO_000001436526 – 259Insulin-like growth factor-binding protein 1Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45Phosphoserine; by FAM20C1 Publication1
Disulfide bondi71 ↔ 84
Disulfide bondi78 ↔ 104
Modified residuei120Phosphoserine1 Publication1
Modified residuei123Phosphoserine1 Publication1
Modified residuei126Phosphoserine2 Publications1
Modified residuei144PhosphoserineCombined sources2 Publications1
Modified residuei156Phosphoserine; by FAM20C1 Publication1
Modified residuei157Phosphothreonine; by FAM20C1 Publication1
Modified residuei158Phosphotyrosine1 Publication1
Disulfide bondi176 ↔ 206
Modified residuei193Phosphothreonine; by FAM20C1 Publication1
Modified residuei194Phosphoserine; by FAM20C3 Publications1
Modified residuei199Phosphoserine; by FAM20C1 Publication1
Disulfide bondi217 ↔ 228
Disulfide bondi230 ↔ 251
Modified residuei242Phosphoserine; by FAM20C1 Publication1

Post-translational modificationi

Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.3 Publications

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP08833
PaxDbiP08833
PeptideAtlasiP08833
PRIDEiP08833
ProteomicsDBi52167

PTM databases

iPTMnetiP08833
PhosphoSitePlusiP08833

Miscellaneous databases

PMAP-CutDBiP08833

Expressioni

Gene expression databases

BgeeiENSG00000146678
CleanExiHS_IGFBP1
ExpressionAtlasiP08833 baseline and differential
GenevisibleiP08833 HS

Organism-specific databases

HPAiCAB004445
HPA046972
HPA050640

Interactioni

Subunit structurei

Binds equally well IGF1 and IGF2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • insulin-like growth factor binding Source: ProtInc
  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: UniProtKB
  • signaling receptor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi109705, 20 interactors
DIPiDIP-59846N
IntActiP08833, 4 interactors
STRINGi9606.ENSP00000275525

Chemistry databases

BindingDBiP08833

Structurei

Secondary structure

1259
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi175 – 193Combined sources19
Beta strandi199 – 201Combined sources3
Beta strandi210 – 212Combined sources3
Beta strandi214 – 217Combined sources4
Beta strandi222 – 224Combined sources3
Beta strandi228 – 231Combined sources4
Turni233 – 235Combined sources3
Beta strandi245 – 247Combined sources3

3D structure databases

ProteinModelPortaliP08833
SMRiP08833
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08833

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 107IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST82
Domaini173 – 251Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi246 – 248Cell attachment site3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IITJ Eukaryota
ENOG4111H9A LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP08833
OMAiGLCWCVY
OrthoDBiEOG091G0EIN
PhylomeDBiP08833
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR022322 IGFBP1
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01977 IGFBPFAMILY1
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE
60 70 80 90 100
VTRSAGCGCC PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG
110 120 130 140 150
QGACVQESDA SAPHAAEAGS PESPESTEIT EEELLDNFHL MAPSEEDHSI
160 170 180 190 200
LWDAISTYDG SKALHVTNIK KWKEPCRIEL YRVVESLAKA QETSGEEISK
210 220 230 240 250
FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP GSPEIRGDPN

CQIYFNVQN
Length:259
Mass (Da):27,904
Last modified:November 1, 1988 - v1
Checksum:i8AA75AF7DC966012
GO

Sequence cautioni

The sequence AAA52540 differs from that shown. Reason: Frameshift at positions 55 and 71.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213H → Q in AAA52540 (PubMed:2454104).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049564114H → D. Corresponds to variant dbSNP:rs41258845Ensembl.1
Natural variantiVAR_011905183V → I1 PublicationCorresponds to variant dbSNP:rs1065782Ensembl.1
Natural variantiVAR_003821253I → M2 PublicationsCorresponds to variant dbSNP:rs4619Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00856 mRNA Translation: CAA68770.1
M20841 mRNA Translation: AAA52540.1 Frameshift.
X12385 mRNA Translation: CAA30942.1
X13405 mRNA Translation: CAA31771.1
M31145 mRNA Translation: AAA52542.1
M59316 Genomic DNA Translation: AAA52783.1
M23595
, M23592, M23593, M23594 Genomic DNA Translation: AAA52785.1
M74587 Genomic DNA Translation: AAA52784.1
BT019685 mRNA Translation: AAV38491.1
AY434089 Genomic DNA Translation: AAQ96599.1
CH236958 Genomic DNA Translation: EAL23800.1
CH471128 Genomic DNA Translation: EAW61030.1
CH471128 Genomic DNA Translation: EAW61031.1
BC035263 mRNA Translation: AAH35263.2
X15002 mRNA Translation: CAA33110.1
CCDSiCCDS5504.1
PIRiA31867 IOHU1
RefSeqiNP_000587.1, NM_000596.2
UniGeneiHs.642938

Genome annotation databases

EnsembliENST00000275525; ENSP00000275525; ENSG00000146678
GeneIDi3484
KEGGihsa:3484
UCSCiuc003tnp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIBP1_HUMAN
AccessioniPrimary (citable) accession number: P08833
Secondary accession number(s): A4D2F4, D3DVL9, Q8IYP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: June 20, 2018
This is version 201 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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