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UniProtKB - P08833 (IBP1_HUMAN)

Entry version 221 (23 Feb 2022)
Sequence version 1 (01 Nov 1988)
Previous versions | rss
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Protein

Insulin-like growth factor-binding protein 1

Gene

IGFBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08833

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation
R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P08833

SIGNOR Signaling Network Open Resource

More...SIGNORi		P08833

Protein family/group databases

MEROPS protease database

More...MEROPSi		I31.951

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 1
Short name:
IBP-1
Short name:
IGF-binding protein 1
Short name:
IGFBP-1
Alternative name(s):
Placental protein 12
Short name:
PP12
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGFBP1
Synonyms:IBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5469, IGFBP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		146730, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08833

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000146678

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3484

Open Targets

More...OpenTargetsi		ENSG00000146678

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29703

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08833, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4178

Drug and drug target database

More...DrugBanki		DB01277, Mecasermin

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IGFBP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		124055

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 253 PublicationsAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001436526 – 259Insulin-like growth factor-binding protein 1Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45Phosphoserine; by FAM20C1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi71 ↔ 84
Disulfide bondi78 ↔ 104
Modified residuei120Phosphoserine1 Publication1
Modified residuei123Phosphoserine1 Publication1
Modified residuei126Phosphoserine2 Publications1
Modified residuei144PhosphoserineCombined sources2 Publications1
Modified residuei156Phosphoserine; by FAM20C1 Publication1
Modified residuei157Phosphothreonine; by FAM20C1 Publication1
Modified residuei158Phosphotyrosine1 Publication1
Disulfide bondi176 ↔ 206
Modified residuei193Phosphothreonine; by FAM20C1 Publication1
Modified residuei194Phosphoserine; by FAM20C3 Publications1
Modified residuei199Phosphoserine; by FAM20C1 Publication1
Disulfide bondi217 ↔ 228
Disulfide bondi230 ↔ 251
Modified residuei242Phosphoserine; by FAM20C1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.3 Publications

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08833

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08833

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08833

PeptideAtlas

More...PeptideAtlasi		P08833

PRoteomics IDEntifications database

More...PRIDEi		P08833

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52167

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08833

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08833

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000146678, Expressed in placenta and 106 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P08833, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08833, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000146678, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds equally well IGF1 and IGF2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109705, 22 interactors

Database of interacting proteins

More...DIPi		DIP-59846N

Protein interaction database and analysis system

More...IntActi		P08833, 27 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000275525

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P08833

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08833, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1259
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08833

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P08833

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 107IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST82
Domaini173 – 251Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi246 – 248Cell attachment site3

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWRP, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157394

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_070833_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08833

Identification of Orthologs from Complete Genome Data

More...OMAi		QPWHCAP

Database of Orthologous Groups

More...OrthoDBi		979270at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08833

TreeFam database of animal gene trees

More...TreeFami		TF331211

Family and domain databases

Conserved Domains Database

More...CDDi		cd00191, TY, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009030, Growth_fac_rcpt_cys_sf
IPR000867, IGFBP-like
IPR022322, IGFBP1
IPR022321, IGFBP_1-6_chordata
IPR017891, Insulin_GF-bd_Cys-rich_CS
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00219, IGFBP, 1 hit
PF00086, Thyroglobulin_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01976, IGFBPFAMILY
PR01977, IGFBPFAMILY1

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00121, IB, 1 hit
SM00211, TY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57184, SSF57184, 1 hit
SSF57610, SSF57610, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00222, IGFBP_N_1, 1 hit
PS51323, IGFBP_N_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 1 hit
PS51162, THYROGLOBULIN_1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P08833-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE 
        60         70         80         90        100
VTRSAGCGCC PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG 
       110        120        130        140        150
QGACVQESDA SAPHAAEAGS PESPESTEIT EEELLDNFHL MAPSEEDHSI 
       160        170        180        190        200
LWDAISTYDG SKALHVTNIK KWKEPCRIEL YRVVESLAKA QETSGEEISK 
       210        220        230        240        250
FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP GSPEIRGDPN 

CQIYFNVQN
Length:259
Mass (Da):27,904
Last modified:November 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AA75AF7DC966012
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J6H2C9J6H2_HUMAN
Insulin-like growth factor-binding ...
IGFBP1
216Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JXF9C9JXF9_HUMAN
Insulin-like growth factor-binding ...
IGFBP1
257Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA52540 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti213H → Q in AAA52540 (PubMed:2454104).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049564114H → D. Corresponds to variant dbSNP:rs41258845Ensembl.1
Natural variantiVAR_011905183V → I1 PublicationCorresponds to variant dbSNP:rs1065782Ensembl.1
Natural variantiVAR_003821253I → M2 PublicationsCorresponds to variant dbSNP:rs4619Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y00856 mRNA Translation: CAA68770.1
M20841 mRNA Translation: AAA52540.1 Frameshift.
X12385 mRNA Translation: CAA30942.1
X13405 mRNA Translation: CAA31771.1
M31145 mRNA Translation: AAA52542.1
M59316 Genomic DNA Translation: AAA52783.1
M23595 M23594 Genomic DNA Translation: AAA52785.1
M74587 Genomic DNA Translation: AAA52784.1
BT019685 mRNA Translation: AAV38491.1
AY434089 Genomic DNA Translation: AAQ96599.1
CH236958 Genomic DNA Translation: EAL23800.1
CH471128 Genomic DNA Translation: EAW61030.1
CH471128 Genomic DNA Translation: EAW61031.1
BC035263 mRNA Translation: AAH35263.2
X15002 mRNA Translation: CAA33110.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5504.1

Protein sequence database of the Protein Information Resource

More...PIRi		A31867, IOHU1

NCBI Reference Sequences

More...RefSeqi		NP_000587.1, NM_000596.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000275525; ENSP00000275525; ENSG00000146678

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3484

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3484

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000275525.8; ENSP00000275525.3; NM_000596.4; NP_000587.1

UCSC genome browser

More...UCSCi		uc003tnp.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00856 mRNA Translation: CAA68770.1
M20841 mRNA Translation: AAA52540.1 Frameshift.
X12385 mRNA Translation: CAA30942.1
X13405 mRNA Translation: CAA31771.1
M31145 mRNA Translation: AAA52542.1
M59316 Genomic DNA Translation: AAA52783.1
M23595 M23594 Genomic DNA Translation: AAA52785.1
M74587 Genomic DNA Translation: AAA52784.1
BT019685 mRNA Translation: AAV38491.1
AY434089 Genomic DNA Translation: AAQ96599.1
CH236958 Genomic DNA Translation: EAL23800.1
CH471128 Genomic DNA Translation: EAW61030.1
CH471128 Genomic DNA Translation: EAW61031.1
BC035263 mRNA Translation: AAH35263.2
X15002 mRNA Translation: CAA33110.1
CCDSiCCDS5504.1
PIRiA31867, IOHU1
RefSeqiNP_000587.1, NM_000596.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZT3X-ray1.80A172-251[»]
1ZT5X-ray1.82A172-251[»]
2DSQX-ray2.80G/H166-259[»]
SMRiP08833
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109705, 22 interactors
DIPiDIP-59846N
IntActiP08833, 27 interactors
STRINGi9606.ENSP00000275525

Chemistry databases

BindingDBiP08833
ChEMBLiCHEMBL4178
DrugBankiDB01277, Mecasermin

Protein family/group databases

MEROPSiI31.951

PTM databases

iPTMnetiP08833
PhosphoSitePlusiP08833

Genetic variation databases

BioMutaiIGFBP1
DMDMi124055

Proteomic databases

MassIVEiP08833
MaxQBiP08833
PaxDbiP08833
PeptideAtlasiP08833
PRIDEiP08833
ProteomicsDBi52167

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3841, 679 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		3484

Genome annotation databases

EnsembliENST00000275525; ENSP00000275525; ENSG00000146678
GeneIDi3484
KEGGihsa:3484
MANE-SelectiENST00000275525.8; ENSP00000275525.3; NM_000596.4; NP_000587.1
UCSCiuc003tnp.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3484
DisGeNETi3484

GeneCards: human genes, protein and diseases

More...GeneCardsi		IGFBP1
HGNCiHGNC:5469, IGFBP1
HPAiENSG00000146678, Tissue enriched (liver)
MIMi146730, gene
neXtProtiNX_P08833
OpenTargetsiENSG00000146678
PharmGKBiPA29703
VEuPathDBiHostDB:ENSG00000146678

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWRP, Eukaryota
GeneTreeiENSGT00940000157394
HOGENOMiCLU_070833_3_0_1
InParanoidiP08833
OMAiQPWHCAP
OrthoDBi979270at2759
PhylomeDBiP08833
TreeFamiTF331211

Enzyme and pathway databases

PathwayCommonsiP08833
ReactomeiR-HSA-380994, ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation
R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
SignaLinkiP08833
SIGNORiP08833

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3484, 10 hits in 1039 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IGFBP1, human
EvolutionaryTraceiP08833

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IGFBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3484
PharosiP08833, Tchem

Protein Ontology

More...PROi		PR:P08833
RNActiP08833, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000146678, Expressed in placenta and 106 other tissues
ExpressionAtlasiP08833, baseline and differential
GenevisibleiP08833, HS

Family and domain databases

CDDicd00191, TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030, Growth_fac_rcpt_cys_sf
IPR000867, IGFBP-like
IPR022322, IGFBP1
IPR022321, IGFBP_1-6_chordata
IPR017891, Insulin_GF-bd_Cys-rich_CS
IPR000716, Thyroglobulin_1
IPR036857, Thyroglobulin_1_sf
PfamiView protein in Pfam
PF00219, IGFBP, 1 hit
PF00086, Thyroglobulin_1, 1 hit
PRINTSiPR01976, IGFBPFAMILY
PR01977, IGFBPFAMILY1
SMARTiView protein in SMART
SM00121, IB, 1 hit
SM00211, TY, 1 hit
SUPFAMiSSF57184, SSF57184, 1 hit
SSF57610, SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222, IGFBP_N_1, 1 hit
PS51323, IGFBP_N_2, 1 hit
PS00484, THYROGLOBULIN_1_1, 1 hit
PS51162, THYROGLOBULIN_1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIBP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08833
Secondary accession number(s): A4D2F4, D3DVL9, Q8IYP5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: February 23, 2022
This is version 221 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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