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Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-BTA-448706 Interleukin-1 processing
R-BTA-9020702 Interleukin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:IL1A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:30130 IL1A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152511 – 112Add BLAST112
ChainiPRO_0000015252113 – 268Interleukin-1 alphaAdd BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineBy similarity1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP08831

Expressioni

Gene expression databases

BgeeiENSBTAG00000010349

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013665

Structurei

3D structure databases

ProteinModelPortaliP08831
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI Eukaryota
ENOG411151X LUCA
GeneTreeiENSGT00390000013353
HOGENOMiHOG000113034
HOVERGENiHBG002432
InParanoidiP08831
KOiK04383
OMAiNQKSFYD
OrthoDBiEOG091G0MAP
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR003295 IL-1_alpha
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR45409 PTHR45409, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01358 INTRLEUKIN1A
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCYSENED YSSEIDHLSL NQKSFYDASY EPLREDQMNK
60 70 80 90 100
FMSLDTSETS KTSKLSFKEN VVMVAASGKI LKKRRLSLNQ FITDDDLEAI
110 120 130 140 150
ANNTEEEIIK PRSAHYSFQS NVKYNFMRVI HQECILNDAL NQSIIRDMSG
160 170 180 190 200
PYLTATTLNN LEEAVKFDMV AYVSEEDSQL PVTLRISKTQ LFVSAQNEDE
210 220 230 240 250
PVLLKEMPET PKIIKDETNL LFFWEKHGSM DYFKSVAHPK LFIATKQEKL
260
VHMASGPPSI TDFQILEK
Length:268
Mass (Da):30,833
Last modified:November 1, 1988 - v1
Checksum:iFCA914210DF864AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36182 mRNA Translation: AAA30590.1
X12497 mRNA Translation: CAA31017.1
M37210 mRNA Translation: AAA30583.1
PIRiJL0009 ICBO1A
RefSeqiNP_776517.1, NM_174092.1
UniGeneiBt.191

Genome annotation databases

EnsembliENSBTAT00000013665; ENSBTAP00000013665; ENSBTAG00000010349
GeneIDi281250
KEGGibta:281250

Similar proteinsi

Entry informationi

Entry nameiIL1A_BOVIN
AccessioniPrimary (citable) accession number: P08831
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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