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UniProtKB - P08821 (DBH1_BACSU)
Protein
DNA-binding protein HU 1
Gene
hupA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Binds evenly across chromosome, does not display a preference for AT content (PubMed:21085634).
1 PublicationGO - Molecular functioni
- DNA binding Source: GO_Central
GO - Biological processi
- chromosome condensation Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA condensation |
Enzyme and pathway databases
BioCyci | BSUB:BSU22790-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-binding protein HU 1Alternative name(s): DNA-binding protein II HB |
Gene namesi | Name:hupA Synonyms:dbpA, hbs, hbsU Ordered Locus Names:BSU22790 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000104913 | 1 – 92 | DNA-binding protein HU 1Add BLAST | 92 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 4 | Phosphothreonine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P08821 |
PaxDbi | P08821 |
PRIDEi | P08821 |
PTM databases
iPTMneti | P08821 |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
IntActi | P08821, 1 interactor |
MINTi | P08821 |
STRINGi | 224308.BSU22790 |
Family & Domainsi
Sequence similaritiesi
Belongs to the bacterial histone-like protein family.Curated
Phylogenomic databases
eggNOGi | COG0776, Bacteria |
InParanoidi | P08821 |
OMAi | PAHEGIN |
PhylomeDBi | P08821 |
Family and domain databases
Gene3Di | 4.10.520.10, 1 hit |
InterProi | View protein in InterPro IPR000119, Hist_DNA-bd IPR020816, Histone-like_DNA-bd_CS IPR010992, IHF-like_DNA-bd_dom_sf |
PANTHERi | PTHR33175, PTHR33175, 1 hit |
Pfami | View protein in Pfam PF00216, Bac_DNA_binding, 1 hit |
PRINTSi | PR01727, DNABINDINGHU |
SMARTi | View protein in SMART SM00411, BHL, 1 hit |
SUPFAMi | SSF47729, SSF47729, 1 hit |
PROSITEi | View protein in PROSITE PS00045, HISTONE_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
P08821-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKTELINAV AEASELSKKD ATKAVDSVFD TILDALKNGD KIQLIGFGNF
60 70 80 90
EVRERSARKG RNPQTGEEIE IPASKVPAFK PGKALKDAVA GK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 40 | D → K AA sequence (PubMed:3595600).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66448 Genomic DNA Translation: CAA47064.1 X52418 Genomic DNA Translation: CAA36669.1 M73504 Genomic DNA Translation: AAA22536.1 M73503 Genomic DNA Translation: AAA22535.1 M80926 Genomic DNA Translation: AAB59030.1 AL009126 Genomic DNA Translation: CAB14195.1 |
PIRi | JC1208 S00015 |
RefSeqi | NP_390160.1, NC_000964.3 WP_003153447.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14195; CAB14195; BSU_22790 |
GeneIDi | 64304059 66325938 938995 |
KEGGi | bsu:BSU22790 |
PATRICi | fig|224308.179.peg.2484 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66448 Genomic DNA Translation: CAA47064.1 X52418 Genomic DNA Translation: CAA36669.1 M73504 Genomic DNA Translation: AAA22536.1 M73503 Genomic DNA Translation: AAA22535.1 M80926 Genomic DNA Translation: AAB59030.1 AL009126 Genomic DNA Translation: CAB14195.1 |
PIRi | JC1208 S00015 |
RefSeqi | NP_390160.1, NC_000964.3 WP_003153447.1, NZ_JNCM01000036.1 |
3D structure databases
AlphaFoldDBi | P08821 |
SMRi | P08821 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P08821, 1 interactor |
MINTi | P08821 |
STRINGi | 224308.BSU22790 |
PTM databases
iPTMneti | P08821 |
Proteomic databases
jPOSTi | P08821 |
PaxDbi | P08821 |
PRIDEi | P08821 |
Genome annotation databases
EnsemblBacteriai | CAB14195; CAB14195; BSU_22790 |
GeneIDi | 64304059 66325938 938995 |
KEGGi | bsu:BSU22790 |
PATRICi | fig|224308.179.peg.2484 |
Phylogenomic databases
eggNOGi | COG0776, Bacteria |
InParanoidi | P08821 |
OMAi | PAHEGIN |
PhylomeDBi | P08821 |
Enzyme and pathway databases
BioCyci | BSUB:BSU22790-MONOMER |
Miscellaneous databases
PROi | PR:P08821 |
Family and domain databases
Gene3Di | 4.10.520.10, 1 hit |
InterProi | View protein in InterPro IPR000119, Hist_DNA-bd IPR020816, Histone-like_DNA-bd_CS IPR010992, IHF-like_DNA-bd_dom_sf |
PANTHERi | PTHR33175, PTHR33175, 1 hit |
Pfami | View protein in Pfam PF00216, Bac_DNA_binding, 1 hit |
PRINTSi | PR01727, DNABINDINGHU |
SMARTi | View protein in SMART SM00411, BHL, 1 hit |
SUPFAMi | SSF47729, SSF47729, 1 hit |
PROSITEi | View protein in PROSITE PS00045, HISTONE_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DBH1_BACSU | |
Accessioni | P08821Primary (citable) accession number: P08821 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | August 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families