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Protein

Potassium channel toxin alpha-KTx 2.1

Gene
N/A
Organism
Centruroides noxius (Mexican scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks voltage-gated potassium channels (mKv1.1/KCNA1 (Kd>25 nM), rKv1.2/KCNA2 (Kd=2 nM), mKv1.3/KCNA3 (Kd=1 nM), hKv1.5/KCNA5 (Kd>25 nM) and mKv3.1/KCNC1 (Kd>25 nM)) and calcium-activated potassium channels (KCa1.1/KCNMA1 and KCa3.1/KCNN4, Kd>25 nM).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei28Basic residue of the functional dyadBy similarity1
Sitei37Aromatic residue of the functional dyadBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCalcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 2.1Curated
Alternative name(s):
Noxiustoxin2 Publications
Short name:
NTx1 Publication
Toxin II.11
OrganismiCentruroides noxius (Mexican scorpion)
Taxonomic identifieri6878 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeCentruroides

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449051 – 39Potassium channel toxin alpha-KTx 2.11 PublicationAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 291 PublicationImported
Disulfide bondi13 ↔ 341 PublicationImported
Disulfide bondi17 ↔ 361 PublicationImported
Modified residuei39Asparagine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08815
SMRiP08815
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08815

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 34Interaction with Ca(2+)-activated K(+) channelsSequence analysis9

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).1 Publication

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR001947 Scorpion_toxinS_K_inh
PfamiView protein in Pfam
PF00451 Toxin_2, 1 hit
PRINTSiPR00286 CHARYBDTOXIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586 Scorpion_toxinS, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P08815-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
TIINVKCTSP KQCSKPCKEL YGSSAGAKCM NGKCKCYNN
Length:39
Mass (Da):4,202
Last modified:July 19, 2004 - v3
Checksum:i131DC4A78D497E0D
GO

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SXMNMR-A1-39[»]
ProteinModelPortaliP08815
SMRiP08815
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP08815

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR001947 Scorpion_toxinS_K_inh
PfamiView protein in Pfam
PF00451 Toxin_2, 1 hit
PRINTSiPR00286 CHARYBDTOXIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586 Scorpion_toxinS, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKAX21_CENNO
AccessioniPrimary (citable) accession number: P08815
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 19, 2004
Last modified: December 20, 2017
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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