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Entry version 198 (16 Oct 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Keratin, type I cytoskeletal 16

Gene

KRT16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P08779

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 16
Alternative name(s):
Cytokeratin-16
Short name:
CK-16
Keratin-16
Short name:
K16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT16
Synonyms:KRT16A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6423 KRT16

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
148067 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08779

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pachyonychia congenita 1 (PC1)12 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017065121M → T in PC1. 1 PublicationCorresponds to variant dbSNP:rs28928894EnsemblClinVar.1
Natural variantiVAR_012855122Q → P in PC1. 1 PublicationCorresponds to variant dbSNP:rs59349773EnsemblClinVar.1
Natural variantiVAR_072436124L → H in PC1. 1 PublicationCorresponds to variant dbSNP:rs58293603EnsemblClinVar.1
Natural variantiVAR_072437124L → P in PC1. 1 PublicationCorresponds to variant dbSNP:rs58293603EnsemblClinVar.1
Natural variantiVAR_013837124L → R in PC1. 1 PublicationCorresponds to variant dbSNP:rs58293603EnsemblClinVar.1
Natural variantiVAR_072438125N → D in PC1. 2 PublicationsCorresponds to variant dbSNP:rs58608173EnsemblClinVar.1
Natural variantiVAR_072439125N → G in PC1; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs587777717EnsemblClinVar.1
Natural variantiVAR_009183125N → S in FNEPPK1 and PC1. 5 PublicationsCorresponds to variant dbSNP:rs60723330EnsemblClinVar.1
Natural variantiVAR_009184127R → C in FNEPPK1 and PC1. 3 PublicationsCorresponds to variant dbSNP:rs59856285EnsemblClinVar.1
Natural variantiVAR_012856127R → P in PC1. 4 PublicationsCorresponds to variant dbSNP:rs57424749EnsemblClinVar.1
Natural variantiVAR_017066128L → Q in PC1. 2 PublicationsCorresponds to variant dbSNP:rs28928895EnsemblClinVar.1
Natural variantiVAR_035440130Missing in PC1. 1 Publication1
Natural variantiVAR_003846132L → P in PC1. 3 PublicationsCorresponds to variant dbSNP:rs60944949EnsemblClinVar.1
Natural variantiVAR_017067354K → N in PC1; late onset. 1 PublicationCorresponds to variant dbSNP:rs59328451EnsemblClinVar.1
Natural variantiVAR_072440421L → P in PC1. 1 Publication1
Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009183125N → S in FNEPPK1 and PC1. 5 PublicationsCorresponds to variant dbSNP:rs60723330EnsemblClinVar.1
Natural variantiVAR_009184127R → C in FNEPPK1 and PC1. 3 PublicationsCorresponds to variant dbSNP:rs59856285EnsemblClinVar.1
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...
DisGeNETi
3868

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
KRT16

MalaCards human disease database

More...
MalaCardsi
KRT16
MIMi167200 phenotype
613000 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000186832

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2199 Epidermolytic palmoplantar keratoderma
448264 Isolated focal non-epidermolytic palmoplantar keratoderma
2309 Pachyonychia congenita

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30210

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P08779

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT16

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23503075

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636621 – 473Keratin, type I cytoskeletal 16Add BLAST473

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P08779

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P08779

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08779

PeptideAtlas

More...
PeptideAtlasi
P08779

PRoteomics IDEntifications database

More...
PRIDEi
P08779

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52166

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08779

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08779

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P08779

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186832 Expressed in 110 organ(s), highest expression level in gingival epithelium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P08779 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08779 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000136
HPA000539

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers (KRT6A or KRT6B) (By similarity).

Interacts with TCHP (PubMed:15731013).

Interacts with TRADD (By similarity).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110066, 59 interactors

Protein interaction database and analysis system

More...
IntActi
P08779, 73 interactors

Molecular INTeraction database

More...
MINTi
P08779

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301653

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08779

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini117 – 428IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 116HeadAdd BLAST116
Regioni117 – 152Coil 1AAdd BLAST36
Regioni153 – 170Linker 1Add BLAST18
Regioni171 – 262Coil 1BAdd BLAST92
Regioni263 – 285Linker 12Add BLAST23
Regioni286 – 424Coil 2Add BLAST139
Regioni425 – 473TailAdd BLAST49

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFTF Eukaryota
ENOG410Y9IV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230975

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08779

KEGG Orthology (KO)

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KOi
K07604

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHQTRPI

Database of Orthologous Groups

More...
OrthoDBi
798081at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08779

TreeFam database of animal gene trees

More...
TreeFami
TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR002957 Keratin_I

The PANTHER Classification System

More...
PANTHERi
PTHR23239 PTHR23239, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038 Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01248 TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P08779-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTCSRQFTS SSSMKGSCGI GGGIGGGSSR ISSVLAGGSC RAPSTYGGGL
60 70 80 90 100
SVSSRFSSGG ACGLGGGYGG GFSSSSSFGS GFGGGYGGGL GAGFGGGLGA
110 120 130 140 150
GFGGGFAGGD GLLVGSEKVT MQNLNDRLAS YLDKVRALEE ANADLEVKIR
160 170 180 190 200
DWYQRQRPSE IKDYSPYFKT IEDLRNKIIA ATIENAQPIL QIDNARLAAD
210 220 230 240 250
DFRTKYEHEL ALRQTVEADV NGLRRVLDEL TLARTDLEMQ IEGLKEELAY
260 270 280 290 300
LRKNHEEEML ALRGQTGGDV NVEMDAAPGV DLSRILNEMR DQYEQMAEKN
310 320 330 340 350
RRDAETWFLS KTEELNKEVA SNSELVQSSR SEVTELRRVL QGLEIELQSQ
360 370 380 390 400
LSMKASLENS LEETKGRYCM QLSQIQGLIG SVEEQLAQLR CEMEQQSQEY
410 420 430 440 450
QILLDVKTRL EQEIATYRRL LEGEDAHLSS QQASGQSYSS REVFTSSSSS
460 470
SSRQTRPILK EQSSSSFSQG QSS
Length:473
Mass (Da):51,268
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA8CE9F4716A88A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENW6K7ENW6_HUMAN
Keratin, type I cytoskeletal 16
KRT16
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENV3K7ENV3_HUMAN
Keratin, type I cytoskeletal 16
KRT16
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2T → A in AAB35421 (PubMed:7487986).Curated1
Sequence conflicti26G → A in AAA59460 (PubMed:2431270).Curated1
Sequence conflicti38G → A in AAA59460 (PubMed:2431270).Curated1
Sequence conflicti41 – 43RAP → PA in AAA59460 (PubMed:2431270).Curated3
Sequence conflicti49 – 50GL → A in AAA59460 (PubMed:2431270).Curated2
Sequence conflicti187 – 189QPI → HAL in AAA59460 (PubMed:2431270).Curated3
Sequence conflicti208 – 211HELA → ARTG in AAA59460 (PubMed:2431270).Curated4
Sequence conflicti352S → R in AAA59460 (PubMed:2431270).Curated1
Sequence conflicti452 – 460SRQTRPILK → AVRPGPSS in AAA59460 (PubMed:2431270).Curated9

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 50924.66 Da from positions 1 - 473. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012854104 – 107Missing Rare variant; found as somatic mutation in a patient with localized epidermolytic hyperkeratosis in the right palm and the right sole; unknown pathological significance. 1 Publication4
Natural variantiVAR_017065121M → T in PC1. 1 PublicationCorresponds to variant dbSNP:rs28928894EnsemblClinVar.1
Natural variantiVAR_012855122Q → P in PC1. 1 PublicationCorresponds to variant dbSNP:rs59349773EnsemblClinVar.1
Natural variantiVAR_072436124L → H in PC1. 1 PublicationCorresponds to variant dbSNP:rs58293603EnsemblClinVar.1
Natural variantiVAR_072437124L → P in PC1. 1 PublicationCorresponds to variant dbSNP:rs58293603EnsemblClinVar.1
Natural variantiVAR_013837124L → R in PC1. 1 PublicationCorresponds to variant dbSNP:rs58293603EnsemblClinVar.1
Natural variantiVAR_072438125N → D in PC1. 2 PublicationsCorresponds to variant dbSNP:rs58608173EnsemblClinVar.1
Natural variantiVAR_072439125N → G in PC1; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs587777717EnsemblClinVar.1
Natural variantiVAR_009183125N → S in FNEPPK1 and PC1. 5 PublicationsCorresponds to variant dbSNP:rs60723330EnsemblClinVar.1
Natural variantiVAR_009184127R → C in FNEPPK1 and PC1. 3 PublicationsCorresponds to variant dbSNP:rs59856285EnsemblClinVar.1
Natural variantiVAR_012856127R → P in PC1. 4 PublicationsCorresponds to variant dbSNP:rs57424749EnsemblClinVar.1
Natural variantiVAR_017066128L → Q in PC1. 2 PublicationsCorresponds to variant dbSNP:rs28928895EnsemblClinVar.1
Natural variantiVAR_035440130Missing in PC1. 1 Publication1
Natural variantiVAR_003846132L → P in PC1. 3 PublicationsCorresponds to variant dbSNP:rs60944949EnsemblClinVar.1
Natural variantiVAR_017067354K → N in PC1; late onset. 1 PublicationCorresponds to variant dbSNP:rs59328451EnsemblClinVar.1
Natural variantiVAR_072440421L → P in PC1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M28439
, M28432, M28433, M28434, M28435, M28436, M28437, M28438 Genomic DNA Translation: AAA59460.1
S79867 mRNA Translation: AAB35421.1
AF061809 Genomic DNA Translation: AAD15829.1
AF061812 mRNA Translation: AAC99326.1
AK290853 mRNA Translation: BAF83542.1
CH471152 Genomic DNA Translation: EAW60749.1
BC039169 mRNA Translation: AAH39169.1
S78514 Genomic DNA Translation: AAB34564.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11401.1

Protein sequence database of the Protein Information Resource

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PIRi
A33652
JC4313

NCBI Reference Sequences

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RefSeqi
NP_005548.2, NM_005557.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000301653; ENSP00000301653; ENSG00000186832

Database of genes from NCBI RefSeq genomes

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GeneIDi
3868

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3868

UCSC genome browser

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UCSCi
uc002hxg.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28439
, M28432, M28433, M28434, M28435, M28436, M28437, M28438 Genomic DNA Translation: AAA59460.1
S79867 mRNA Translation: AAB35421.1
AF061809 Genomic DNA Translation: AAD15829.1
AF061812 mRNA Translation: AAC99326.1
AK290853 mRNA Translation: BAF83542.1
CH471152 Genomic DNA Translation: EAW60749.1
BC039169 mRNA Translation: AAH39169.1
S78514 Genomic DNA Translation: AAB34564.1
CCDSiCCDS11401.1
PIRiA33652
JC4313
RefSeqiNP_005548.2, NM_005557.3

3D structure databases

SMRiP08779
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110066, 59 interactors
IntActiP08779, 73 interactors
MINTiP08779
STRINGi9606.ENSP00000301653

Chemistry databases

DrugBankiDB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

PTM databases

iPTMnetiP08779
PhosphoSitePlusiP08779
SwissPalmiP08779

Polymorphism and mutation databases

BioMutaiKRT16
DMDMi23503075

Proteomic databases

jPOSTiP08779
MassIVEiP08779
PaxDbiP08779
PeptideAtlasiP08779
PRIDEiP08779
ProteomicsDBi52166

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3868

Genome annotation databases

EnsembliENST00000301653; ENSP00000301653; ENSG00000186832
GeneIDi3868
KEGGihsa:3868
UCSCiuc002hxg.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3868
DisGeNETi3868

GeneCards: human genes, protein and diseases

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GeneCardsi
KRT16
GeneReviewsiKRT16
HGNCiHGNC:6423 KRT16
HPAiCAB000136
HPA000539
MalaCardsiKRT16
MIMi148067 gene
167200 phenotype
613000 phenotype
neXtProtiNX_P08779
OpenTargetsiENSG00000186832
Orphaneti2199 Epidermolytic palmoplantar keratoderma
448264 Isolated focal non-epidermolytic palmoplantar keratoderma
2309 Pachyonychia congenita
PharmGKBiPA30210

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00940000154602
HOGENOMiHOG000230975
InParanoidiP08779
KOiK07604
OMAiGHQTRPI
OrthoDBi798081at2759
PhylomeDBiP08779
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SIGNORiP08779

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KRT16 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Keratin_16

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3868
PharosiP08779

Protein Ontology

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PROi
PR:P08779

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000186832 Expressed in 110 organ(s), highest expression level in gingival epithelium
ExpressionAtlasiP08779 baseline and differential
GenevisibleiP08779 HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C16_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08779
Secondary accession number(s): A8K488
, P30654, Q16402, Q9UBG8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 198 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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