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UniProtKB - P08773 (DCHM_BPT4)
Protein
Deoxycytidylate 5-hydroxymethyltransferase
Gene
42
Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Functioni
Catalytic activityi
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMPEC:2.1.2.8
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 148 | Sequence analysis | 1 |
GO - Molecular functioni
- deoxycytidylate 5-hydroxymethyltransferase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
BRENDAi | 2.1.2.8, 732 |
Names & Taxonomyi
Protein namesi | Recommended name: Deoxycytidylate 5-hydroxymethyltransferase (EC:2.1.2.8)Short name: Deoxycytidylate hydroxymethylase Alternative name(s): dCMP hydroxymethylase Short name: dCMP HMase |
Gene namesi | Name:42 |
Organismi | Enterobacteria phage T4 (Bacteriophage T4) |
Taxonomic identifieri | 10665 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Uroviricota › Caudoviricetes › Caudovirales › Myoviridae › Tevenvirinae › Tequatrovirus |
Virus hosti | Escherichia coli [TaxID: 562] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000141068 | 1 – 246 | Deoxycytidylate 5-hydroxymethyltransferaseAdd BLAST | 246 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P08773 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08773 |
Family & Domainsi
Sequence similaritiesi
Belongs to the thymidylate synthase family.Curated
Family and domain databases
Gene3Di | 3.30.572.10, 1 hit |
InterProi | View protein in InterPro IPR014619, Deoxycytidylate_hydroxyMease IPR045097, Thymidate_synth/dCMP_Mease IPR023451, Thymidate_synth/dCMP_Mease_dom IPR036926, Thymidate_synth/dCMP_Mease_sf |
PANTHERi | PTHR11548, PTHR11548, 1 hit |
Pfami | View protein in Pfam PF00303, Thymidylat_synt, 1 hit |
PIRSFi | PIRSF036750, dCMP_HMase, 1 hit |
SUPFAMi | SSF55831, SSF55831, 1 hit |
i Sequence
Sequence statusi: Complete.
P08773-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISDSMTVEE IRLHLGLALK EKDFVVDKTG VKTIEIIGAS FVADEPFIFG
60 70 80 90 100
ALNDEYIQRE LEWYKSKSLF VKDIPGETPK IWQQVASSKG EINSNYGWAI
110 120 130 140 150
WSEDNYAQYD MCLAELGQNP DSRRGIMIYT RPSMQFDYNK DGMSDFMCTN
160 170 180 190 200
TVQYLIRDKK INAVVNMRSN DVVFGFRNDY AWQKYVLDKL VSDLNAGDST
210 220 230 240
RQYKAGSIIW NVGSLHVYSR HFYLVDHWWK TGETHISKKD YVGKYA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 164 | V → L in AAA88467 (PubMed:2832395).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00148 Genomic DNA Translation: CAA68342.1 AF158101 Genomic DNA Translation: AAD42467.1 M22767 Genomic DNA Translation: AAA88468.1 M22766 Genomic DNA Translation: AAA88467.1 M37159 Genomic DNA Translation: AAA21709.1 X03139 Genomic DNA Translation: CAA26907.1 |
PIRi | JS0786, SZBPT4 |
RefSeqi | NP_049659.1, NC_000866.4 |
Genome annotation databases
GeneIDi | 1258746 |
KEGGi | vg:1258746 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00148 Genomic DNA Translation: CAA68342.1 AF158101 Genomic DNA Translation: AAD42467.1 M22767 Genomic DNA Translation: AAA88468.1 M22766 Genomic DNA Translation: AAA88467.1 M37159 Genomic DNA Translation: AAA21709.1 X03139 Genomic DNA Translation: CAA26907.1 |
PIRi | JS0786, SZBPT4 |
RefSeqi | NP_049659.1, NC_000866.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B49 | X-ray | 2.30 | A/C | 1-246 | [»] | |
1B5D | X-ray | 2.20 | A/B | 1-246 | [»] | |
1B5E | X-ray | 1.60 | A/B | 1-246 | [»] | |
6A9A | X-ray | 1.90 | A | 1-246 | [»] | |
6A9B | X-ray | 2.01 | A | 1-246 | [»] | |
6L18 | X-ray | 1.90 | A | 1-246 | [»] | |
SMRi | P08773 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
DrugBanki | DB03798, 2'-Deoxycytidine-5'-Monophosphate |
Genome annotation databases
GeneIDi | 1258746 |
KEGGi | vg:1258746 |
Enzyme and pathway databases
BRENDAi | 2.1.2.8, 732 |
Miscellaneous databases
EvolutionaryTracei | P08773 |
Family and domain databases
Gene3Di | 3.30.572.10, 1 hit |
InterProi | View protein in InterPro IPR014619, Deoxycytidylate_hydroxyMease IPR045097, Thymidate_synth/dCMP_Mease IPR023451, Thymidate_synth/dCMP_Mease_dom IPR036926, Thymidate_synth/dCMP_Mease_sf |
PANTHERi | PTHR11548, PTHR11548, 1 hit |
Pfami | View protein in Pfam PF00303, Thymidylat_synt, 1 hit |
PIRSFi | PIRSF036750, dCMP_HMase, 1 hit |
SUPFAMi | SSF55831, SSF55831, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DCHM_BPT4 | |
Accessioni | P08773Primary (citable) accession number: P08773 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families