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Protein

Annexin A5

Gene

ANXA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium ion binding Source: InterPro
  • calcium-transporting ATPase activity Source: GO_Central
  • heparin binding Source: GO_Central
  • molecular adaptor activity Source: GO_Central
  • peptide hormone binding Source: GO_Central
  • phospholipase inhibitor activity Source: ProtInc
  • phospholipid binding Source: ProtInc
  • receptor tyrosine kinase binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
SignaLinkiP08758

Protein family/group databases

TCDBi1.A.31.1.7 the annexin (annexin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A5
Alternative name(s):
Anchorin CII
Annexin V
Annexin-5
Calphobindin I
Short name:
CBP-I
Endonexin II
Lipocortin V
Placental anticoagulant protein 4
Short name:
PP4
Placental anticoagulant protein I
Short name:
PAP-I
Thromboplastin inhibitor
Vascular anticoagulant-alpha
Short name:
VAC-alpha
Gene namesi
Name:ANXA5
Synonyms:ANX5, ENX2, PP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164111.14
HGNCiHGNC:543 ANXA5
MIMi131230 gene
neXtProtiNX_P08758

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Pregnancy loss, recurrent, 3 (RPRGL3)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.
See also OMIM:614391

Organism-specific databases

DisGeNETi308
MalaCardsiANXA5
MIMi614391 phenotype
OpenTargetsiENSG00000164111
PharmGKBiPA24833

Chemistry databases

DrugBankiDB02929 K201
DB03484 L-Alpha-Glycerophosphorylethanolamine
DB02497 L-Alpha-Glycerophosphorylserine
DB02846 L-thioproline

Polymorphism and mutation databases

BioMutaiANXA5
DMDMi113960

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000674872 – 320Annexin A5Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Cross-linki29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei37PhosphoserineBy similarity1
Modified residuei70N6-acetyllysineCombined sources1
Modified residuei76N6-acetyllysineCombined sources1
Modified residuei79N6-acetyllysineCombined sources1
Modified residuei97N6-acetyllysineCombined sources1
Modified residuei101N6-acetyllysineCombined sources1
Modified residuei290N6-succinyllysineBy similarity1

Post-translational modificationi

S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, S-nitrosylation, Ubl conjugation

Proteomic databases

EPDiP08758
PaxDbiP08758
PeptideAtlasiP08758
PRIDEiP08758
ProteomicsDBi12610
52165
TopDownProteomicsiP08758

2D gel databases

OGPiP08758
REPRODUCTION-2DPAGEiIPI00329801
P08758

PTM databases

iPTMnetiP08758
PhosphoSitePlusiP08758
SwissPalmiP08758

Expressioni

Gene expression databases

BgeeiENSG00000164111 Expressed in 236 organ(s), highest expression level in adipose tissue
CleanExiHS_ANXA5
ExpressionAtlasiP08758 baseline and differential
GenevisibleiP08758 HS

Organism-specific databases

HPAiCAB003677
HPA035330

Interactioni

Subunit structurei

Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TINF2Q9BSI42EBI-296601,EBI-717399

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106805, 70 interactors
IntActiP08758, 23 interactors
MINTiP08758
STRINGi9606.ENSP00000296511

Structurei

Secondary structure

1320
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08758
SMRiP08758
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08758

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 84Annexin 1Add BLAST61
Repeati96 – 156Annexin 2Add BLAST61
Repeati180 – 240Annexin 3Add BLAST61
Repeati255 – 315Annexin 4Add BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi314 – 319[IL]-x-C-x-x-[DE] motif1 Publication6

Domaini

The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.1 Publication
A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP08758
KOiK16646
OMAiFAETLYY
OrthoDBiEOG091G0H6H
PhylomeDBiP08758
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002392 ANX5
PANTHERiPTHR10502:SF26 PTHR10502:SF26, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00201 ANNEXINV
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P08758-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQVLRGTVT DFPGFDERAD AETLRKAMKG LGTDEESILT LLTSRSNAQR
60 70 80 90 100
QEISAAFKTL FGRDLLDDLK SELTGKFEKL IVALMKPSRL YDAYELKHAL
110 120 130 140 150
KGAGTNEKVL TEIIASRTPE ELRAIKQVYE EEYGSSLEDD VVGDTSGYYQ
160 170 180 190 200
RMLVVLLQAN RDPDAGIDEA QVEQDAQALF QAGELKWGTD EEKFITIFGT
210 220 230 240 250
RSVSHLRKVF DKYMTISGFQ IEETIDRETS GNLEQLLLAV VKSIRSIPAY
260 270 280 290 300
LAETLYYAMK GAGTDDHTLI RVMVSRSEID LFNIRKEFRK NFATSLYSMI
310 320
KGDTSGDYKK ALLLLCGEDD
Length:320
Mass (Da):35,937
Last modified:January 23, 2007 - v2
Checksum:i45E14E3964BA4D1A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBL5D6RBL5_HUMAN
Annexin
ANXA5
260Annotation score:
D6RBE9D6RBE9_HUMAN
Annexin
ANXA5
220Annotation score:
E9PHT9E9PHT9_HUMAN
Annexin
ANXA5
163Annotation score:
D6RCN3D6RCN3_HUMAN
Annexin A5
ANXA5
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135S → L in CAG38759 (Ref. 10) Curated1
Sequence conflicti279I → T in AAH18671 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18366 mRNA Translation: AAA35570.1
D00172 mRNA Translation: BAA00122.1
X12454 mRNA Translation: CAA30985.1
J03745 mRNA Translation: AAA52386.1
M21731 mRNA Translation: AAA36166.1
M19384 mRNA Translation: AAB59545.1
U01691
, U01681, U01682, U01683, U01685, U01686, U01687, U01689, U01690 Genomic DNA Translation: AAB40047.1
U05770
, U05760, U05761, U05762, U05764, U05765, U05766, U05767, U05768, U05769 Genomic DNA Translation: AAB60648.1
AK312644 mRNA Translation: BAG35528.1
CR536522 mRNA Translation: CAG38759.1
CR541842 mRNA Translation: CAG46640.1
AC096730 Genomic DNA Translation: AAY40954.1
CH471056 Genomic DNA Translation: EAX05257.1
CH471056 Genomic DNA Translation: EAX05258.1
BC001429 mRNA Translation: AAH01429.1
BC004993 mRNA Translation: AAH04993.1
BC012804 mRNA Translation: AAH12804.1
BC012822 mRNA Translation: AAH12822.1
BC018671 mRNA Translation: AAH18671.1
CCDSiCCDS3720.1
PIRiD29250 AQHUP
RefSeqiNP_001145.1, NM_001154.3
UniGeneiHs.480653

Genome annotation databases

EnsembliENST00000296511; ENSP00000296511; ENSG00000164111
GeneIDi308
KEGGihsa:308

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18366 mRNA Translation: AAA35570.1
D00172 mRNA Translation: BAA00122.1
X12454 mRNA Translation: CAA30985.1
J03745 mRNA Translation: AAA52386.1
M21731 mRNA Translation: AAA36166.1
M19384 mRNA Translation: AAB59545.1
U01691
, U01681, U01682, U01683, U01685, U01686, U01687, U01689, U01690 Genomic DNA Translation: AAB40047.1
U05770
, U05760, U05761, U05762, U05764, U05765, U05766, U05767, U05768, U05769 Genomic DNA Translation: AAB60648.1
AK312644 mRNA Translation: BAG35528.1
CR536522 mRNA Translation: CAG38759.1
CR541842 mRNA Translation: CAG46640.1
AC096730 Genomic DNA Translation: AAY40954.1
CH471056 Genomic DNA Translation: EAX05257.1
CH471056 Genomic DNA Translation: EAX05258.1
BC001429 mRNA Translation: AAH01429.1
BC004993 mRNA Translation: AAH04993.1
BC012804 mRNA Translation: AAH12804.1
BC012822 mRNA Translation: AAH12822.1
BC018671 mRNA Translation: AAH18671.1
CCDSiCCDS3720.1
PIRiD29250 AQHUP
RefSeqiNP_001145.1, NM_001154.3
UniGeneiHs.480653

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ANWX-ray2.40A/B2-320[»]
1ANXX-ray1.90A/B/C2-320[»]
1AVHX-ray2.30A/B1-320[»]
1AVRX-ray2.30A1-320[»]
1HAKX-ray3.00A/B1-320[»]
1HVDX-ray2.00A2-320[»]
1HVEX-ray2.30A2-320[»]
1HVFX-ray2.00A2-320[»]
1HVGX-ray3.00A2-320[»]
1SAVX-ray2.50A1-320[»]
2XO2X-ray2.80A1-320[»]
2XO3X-ray2.30A1-320[»]
ProteinModelPortaliP08758
SMRiP08758
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106805, 70 interactors
IntActiP08758, 23 interactors
MINTiP08758
STRINGi9606.ENSP00000296511

Chemistry databases

DrugBankiDB02929 K201
DB03484 L-Alpha-Glycerophosphorylethanolamine
DB02497 L-Alpha-Glycerophosphorylserine
DB02846 L-thioproline

Protein family/group databases

TCDBi1.A.31.1.7 the annexin (annexin) family

PTM databases

iPTMnetiP08758
PhosphoSitePlusiP08758
SwissPalmiP08758

Polymorphism and mutation databases

BioMutaiANXA5
DMDMi113960

2D gel databases

OGPiP08758
REPRODUCTION-2DPAGEiIPI00329801
P08758

Proteomic databases

EPDiP08758
PaxDbiP08758
PeptideAtlasiP08758
PRIDEiP08758
ProteomicsDBi12610
52165
TopDownProteomicsiP08758

Protocols and materials databases

DNASUi308
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296511; ENSP00000296511; ENSG00000164111
GeneIDi308
KEGGihsa:308

Organism-specific databases

CTDi308
DisGeNETi308
EuPathDBiHostDB:ENSG00000164111.14
GeneCardsiANXA5
HGNCiHGNC:543 ANXA5
HPAiCAB003677
HPA035330
MalaCardsiANXA5
MIMi131230 gene
614391 phenotype
neXtProtiNX_P08758
OpenTargetsiENSG00000164111
PharmGKBiPA24833
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP08758
KOiK16646
OMAiFAETLYY
OrthoDBiEOG091G0H6H
PhylomeDBiP08758
TreeFamiTF105452

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
SignaLinkiP08758

Miscellaneous databases

ChiTaRSiANXA5 human
EvolutionaryTraceiP08758
GeneWikiiAnnexin_A5
GenomeRNAii308
PROiPR:P08758
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164111 Expressed in 236 organ(s), highest expression level in adipose tissue
CleanExiHS_ANXA5
ExpressionAtlasiP08758 baseline and differential
GenevisibleiP08758 HS

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002392 ANX5
PANTHERiPTHR10502:SF26 PTHR10502:SF26, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00201 ANNEXINV
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANXA5_HUMAN
AccessioniPrimary (citable) accession number: P08758
Secondary accession number(s): D3DNW7
, Q6FHB3, Q6FI16, Q8WV69, Q9UDH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 211 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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