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Protein

Annexin A5

Gene

ANXA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium ion binding Source: InterPro
  • calcium-transporting ATPase activity Source: GO_Central
  • heparin binding Source: GO_Central
  • molecular adaptor activity Source: GO_Central
  • peptide hormone binding Source: GO_Central
  • phospholipase inhibitor activity Source: ProtInc
  • phospholipid binding Source: ProtInc
  • receptor tyrosine kinase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-114608 Platelet degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P08758

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.31.1.7 the annexin (annexin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Annexin A5
Alternative name(s):
Anchorin CII
Annexin V
Annexin-5
Calphobindin I
Short name:
CBP-I
Endonexin II
Lipocortin V
Placental anticoagulant protein 4
Short name:
PP4
Placental anticoagulant protein I
Short name:
PAP-I
Thromboplastin inhibitor
Vascular anticoagulant-alpha
Short name:
VAC-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANXA5
Synonyms:ANX5, ENX2, PP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000164111.14

Human Gene Nomenclature Database

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HGNCi
HGNC:543 ANXA5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
131230 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08758

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pregnancy loss, recurrent, 3 (RPRGL3)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.
See also OMIM:614391

Organism-specific databases

DisGeNET

More...
DisGeNETi
308

MalaCards human disease database

More...
MalaCardsi
ANXA5
MIMi614391 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000164111

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24833

Chemistry databases

Drug and drug target database

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DrugBanki
DB02929 K201
DB03484 L-Alpha-Glycerophosphorylethanolamine
DB02497 L-Alpha-Glycerophosphorylserine
DB02846 L-thioproline

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANXA5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
113960

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000674872 – 320Annexin A5Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei37PhosphoserineBy similarity1
Modified residuei70N6-acetyllysineCombined sources1
Modified residuei76N6-acetyllysineCombined sources1
Modified residuei79N6-acetyllysineCombined sources1
Modified residuei97N6-acetyllysineCombined sources1
Modified residuei101N6-acetyllysineCombined sources1
Modified residuei290N6-succinyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, S-nitrosylation, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P08758

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P08758

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P08758

PeptideAtlas

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PeptideAtlasi
P08758

PRoteomics IDEntifications database

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PRIDEi
P08758

ProteomicsDB human proteome resource

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ProteomicsDBi
12610
52165

Consortium for Top Down Proteomics

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TopDownProteomicsi
P08758

2D gel databases

USC-OGP 2-DE database

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OGPi
P08758

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00329801
P08758

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08758

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P08758

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P08758

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000164111 Expressed in 236 organ(s), highest expression level in adipose tissue

CleanEx database of gene expression profiles

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CleanExi
HS_ANXA5

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P08758 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P08758 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB003677
HPA035330

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TINF2Q9BSI42EBI-296601,EBI-717399

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106805, 72 interactors

Protein interaction database and analysis system

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IntActi
P08758, 24 interactors

Molecular INTeraction database

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MINTi
P08758

STRING: functional protein association networks

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STRINGi
9606.ENSP00000296511

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1320
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ANWX-ray2.40A/B2-320[»]
1ANXX-ray1.90A/B/C2-320[»]
1AVHX-ray2.30A/B1-320[»]
1AVRX-ray2.30A1-320[»]
1HAKX-ray3.00A/B1-320[»]
1HVDX-ray2.00A2-320[»]
1HVEX-ray2.30A2-320[»]
1HVFX-ray2.00A2-320[»]
1HVGX-ray3.00A2-320[»]
1SAVX-ray2.50A1-320[»]
2XO2X-ray2.80A1-320[»]
2XO3X-ray2.30A1-320[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P08758

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08758

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P08758

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati24 – 84Annexin 1Add BLAST61
Repeati96 – 156Annexin 2Add BLAST61
Repeati180 – 240Annexin 3Add BLAST61
Repeati255 – 315Annexin 4Add BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi314 – 319[IL]-x-C-x-x-[DE] motif1 Publication6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.1 Publication
A pair of annexin repeats may form one binding site for calcium and phospholipid.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0819 Eukaryota
ENOG410XPUN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155988

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000158803

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG061815

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P08758

KEGG Orthology (KO)

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KOi
K16646

Identification of Orthologs from Complete Genome Data

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OMAi
FAETLYY

Database of Orthologous Groups

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OrthoDBi
856254at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P08758

TreeFam database of animal gene trees

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TreeFami
TF105452

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.220.10, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002392 ANX5

The PANTHER Classification System

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PANTHERi
PTHR10502:SF26 PTHR10502:SF26, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00191 Annexin, 4 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00196 ANNEXIN
PR00201 ANNEXINV

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00335 ANX, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00223 ANNEXIN, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P08758-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQVLRGTVT DFPGFDERAD AETLRKAMKG LGTDEESILT LLTSRSNAQR
60 70 80 90 100
QEISAAFKTL FGRDLLDDLK SELTGKFEKL IVALMKPSRL YDAYELKHAL
110 120 130 140 150
KGAGTNEKVL TEIIASRTPE ELRAIKQVYE EEYGSSLEDD VVGDTSGYYQ
160 170 180 190 200
RMLVVLLQAN RDPDAGIDEA QVEQDAQALF QAGELKWGTD EEKFITIFGT
210 220 230 240 250
RSVSHLRKVF DKYMTISGFQ IEETIDRETS GNLEQLLLAV VKSIRSIPAY
260 270 280 290 300
LAETLYYAMK GAGTDDHTLI RVMVSRSEID LFNIRKEFRK NFATSLYSMI
310 320
KGDTSGDYKK ALLLLCGEDD
Length:320
Mass (Da):35,937
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45E14E3964BA4D1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBL5D6RBL5_HUMAN
Annexin
ANXA5
260Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBE9D6RBE9_HUMAN
Annexin
ANXA5
220Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHT9E9PHT9_HUMAN
Annexin
ANXA5
163Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCN3D6RCN3_HUMAN
Annexin A5
ANXA5
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135S → L in CAG38759 (Ref. 10) Curated1
Sequence conflicti279I → T in AAH18671 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M18366 mRNA Translation: AAA35570.1
D00172 mRNA Translation: BAA00122.1
X12454 mRNA Translation: CAA30985.1
J03745 mRNA Translation: AAA52386.1
M21731 mRNA Translation: AAA36166.1
M19384 mRNA Translation: AAB59545.1
U01691
, U01681, U01682, U01683, U01685, U01686, U01687, U01689, U01690 Genomic DNA Translation: AAB40047.1
U05770
, U05760, U05761, U05762, U05764, U05765, U05766, U05767, U05768, U05769 Genomic DNA Translation: AAB60648.1
AK312644 mRNA Translation: BAG35528.1
CR536522 mRNA Translation: CAG38759.1
CR541842 mRNA Translation: CAG46640.1
AC096730 Genomic DNA Translation: AAY40954.1
CH471056 Genomic DNA Translation: EAX05257.1
CH471056 Genomic DNA Translation: EAX05258.1
BC001429 mRNA Translation: AAH01429.1
BC004993 mRNA Translation: AAH04993.1
BC012804 mRNA Translation: AAH12804.1
BC012822 mRNA Translation: AAH12822.1
BC018671 mRNA Translation: AAH18671.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3720.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D29250 AQHUP

NCBI Reference Sequences

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RefSeqi
NP_001145.1, NM_001154.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.480653

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296511; ENSP00000296511; ENSG00000164111

Database of genes from NCBI RefSeq genomes

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GeneIDi
308

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:308

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18366 mRNA Translation: AAA35570.1
D00172 mRNA Translation: BAA00122.1
X12454 mRNA Translation: CAA30985.1
J03745 mRNA Translation: AAA52386.1
M21731 mRNA Translation: AAA36166.1
M19384 mRNA Translation: AAB59545.1
U01691
, U01681, U01682, U01683, U01685, U01686, U01687, U01689, U01690 Genomic DNA Translation: AAB40047.1
U05770
, U05760, U05761, U05762, U05764, U05765, U05766, U05767, U05768, U05769 Genomic DNA Translation: AAB60648.1
AK312644 mRNA Translation: BAG35528.1
CR536522 mRNA Translation: CAG38759.1
CR541842 mRNA Translation: CAG46640.1
AC096730 Genomic DNA Translation: AAY40954.1
CH471056 Genomic DNA Translation: EAX05257.1
CH471056 Genomic DNA Translation: EAX05258.1
BC001429 mRNA Translation: AAH01429.1
BC004993 mRNA Translation: AAH04993.1
BC012804 mRNA Translation: AAH12804.1
BC012822 mRNA Translation: AAH12822.1
BC018671 mRNA Translation: AAH18671.1
CCDSiCCDS3720.1
PIRiD29250 AQHUP
RefSeqiNP_001145.1, NM_001154.3
UniGeneiHs.480653

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ANWX-ray2.40A/B2-320[»]
1ANXX-ray1.90A/B/C2-320[»]
1AVHX-ray2.30A/B1-320[»]
1AVRX-ray2.30A1-320[»]
1HAKX-ray3.00A/B1-320[»]
1HVDX-ray2.00A2-320[»]
1HVEX-ray2.30A2-320[»]
1HVFX-ray2.00A2-320[»]
1HVGX-ray3.00A2-320[»]
1SAVX-ray2.50A1-320[»]
2XO2X-ray2.80A1-320[»]
2XO3X-ray2.30A1-320[»]
ProteinModelPortaliP08758
SMRiP08758
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106805, 72 interactors
IntActiP08758, 24 interactors
MINTiP08758
STRINGi9606.ENSP00000296511

Chemistry databases

DrugBankiDB02929 K201
DB03484 L-Alpha-Glycerophosphorylethanolamine
DB02497 L-Alpha-Glycerophosphorylserine
DB02846 L-thioproline

Protein family/group databases

TCDBi1.A.31.1.7 the annexin (annexin) family

PTM databases

iPTMnetiP08758
PhosphoSitePlusiP08758
SwissPalmiP08758

Polymorphism and mutation databases

BioMutaiANXA5
DMDMi113960

2D gel databases

OGPiP08758
REPRODUCTION-2DPAGEiIPI00329801
P08758

Proteomic databases

EPDiP08758
jPOSTiP08758
PaxDbiP08758
PeptideAtlasiP08758
PRIDEiP08758
ProteomicsDBi12610
52165
TopDownProteomicsiP08758

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
308
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296511; ENSP00000296511; ENSG00000164111
GeneIDi308
KEGGihsa:308

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
308
DisGeNETi308
EuPathDBiHostDB:ENSG00000164111.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANXA5
HGNCiHGNC:543 ANXA5
HPAiCAB003677
HPA035330
MalaCardsiANXA5
MIMi131230 gene
614391 phenotype
neXtProtiNX_P08758
OpenTargetsiENSG00000164111
PharmGKBiPA24833

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00940000155988
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP08758
KOiK16646
OMAiFAETLYY
OrthoDBi856254at2759
PhylomeDBiP08758
TreeFamiTF105452

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
SignaLinkiP08758

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANXA5 human
EvolutionaryTraceiP08758

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Annexin_A5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
308

Protein Ontology

More...
PROi
PR:P08758

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164111 Expressed in 236 organ(s), highest expression level in adipose tissue
CleanExiHS_ANXA5
ExpressionAtlasiP08758 baseline and differential
GenevisibleiP08758 HS

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002392 ANX5
PANTHERiPTHR10502:SF26 PTHR10502:SF26, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00201 ANNEXINV
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANXA5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08758
Secondary accession number(s): D3DNW7
, Q6FHB3, Q6FI16, Q8WV69, Q9UDH9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 213 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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