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Protein

Keratin, type I cytoskeletal 13

Gene

Krt13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 13
Alternative name(s):
47 kDa cytokeratin
Cytokeratin-13
Short name:
CK-13
Keratin-13
Short name:
K13
Gene namesi
Name:Krt13
Synonyms:Krt1-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:101925 Krt13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636481 – 437Keratin, type I cytoskeletal 13Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27Omega-N-methylarginineBy similarity1
Modified residuei35Omega-N-methylarginineBy similarity1

Post-translational modificationi

O-glycosylated; glycans consist of single N-acetylglucosamine residues.By similarity

Keywords - PTMi

Glycoprotein, Methylation

Proteomic databases

PaxDbiP08730
PeptideAtlasiP08730
PRIDEiP08730

PTM databases

iPTMnetiP08730
PhosphoSitePlusiP08730

Expressioni

Tissue specificityi

Expressed in the suprabasal layers of internal stratified squamous epithelia that line the oral cavity and the upper digestive tract, including tongue and esophagus.1 Publication

Gene expression databases

BgeeiENSMUSG00000044041 Expressed in 118 organ(s), highest expression level in superior surface of tongue
CleanExiMM_KRT13
GenevisibleiP08730 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13 (By similarity).By similarity

Protein-protein interaction databases

BioGridi201018, 4 interactors
IntActiP08730, 4 interactors
MINTiP08730
STRINGi10090.ENSMUSP00000007275

Structurei

3D structure databases

ProteinModelPortaliP08730
SMRiP08730
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 408IF rodPROSITE-ProRule annotationAdd BLAST313

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 95HeadAdd BLAST95
Regioni96 – 131Coil 1AAdd BLAST36
Regioni132 – 150Linker 1Add BLAST19
Regioni151 – 242Coil 1BAdd BLAST92
Regioni243 – 265Linker 12Add BLAST23
Regioni266 – 404Coil 2Add BLAST139
Regioni405 – 437TailAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 94Gly-richAdd BLAST82

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiP08730
KOiK07604
OMAiDAKMTGF
OrthoDBiEOG091G087I
PhylomeDBiP08730
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P08730-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCRFQSSSM SYGGGFGAGS CQLGGGRNIS SCSSRFVTGG SAGGYGGGMS
60 70 80 90 100
CGFGGGAGGG FGGGFGGGFG GSYGGGFGGG FGDFGGVDGG LLSGNEKITM
110 120 130 140 150
QNLNDRLASY LDKVRALEAA NADLEVKIRD WHLKQSPASP ERDYSAYYKT
160 170 180 190 200
IEELRIKILE ATTDNNRIIL EIDNARLAAD DFRLKYENEL TLRQSVEADI
210 220 230 240 250
NGLRRVLDEL TLAKTDLEMQ IESLNEELAY LKKNHEEEMK EFSNQVVGQV
260 270 280 290 300
NVEMDATPGI DLTRVLAEMR EQYEALAEKN RRDAEEWFQT KSAELNKEVS
310 320 330 340 350
SNAEMIQTSK TEITELRRTL QGLEIELQSQ LSMKAGLEST LAETECRYAL
360 370 380 390 400
QLQQIQGLIS SIEAQLSELR SEMECQNQEY KMLLDIKTRL EQEIATYRSL
410 420 430
LEGQDAKMTG FNSGGNNTTT SNGSPSSNSG RPDFRKY
Length:437
Mass (Da):47,754
Last modified:October 1, 1996 - v2
Checksum:i924128DBAC317E2F
GO
Isoform 2 (identifier: P08730-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-425: Missing.

Note: No experimental confirmation available.
Show »
Length:311
Mass (Da):33,718
Checksum:iBA1E649830FDA92C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016378300 – 425Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13921 Genomic DNA Translation: AAC52150.1
AK132640 mRNA Translation: BAE21276.1
BC060286 mRNA Translation: AAH60286.1
X53320 Genomic DNA Translation: CAA37407.1
X03492 mRNA Translation: CAA27208.1
CCDSiCCDS25409.1 [P08730-1]
PIRiA55682
RefSeqiNP_001300878.1, NM_001313949.1
NP_034792.1, NM_010662.2 [P08730-1]
UniGeneiMm.4646

Genome annotation databases

EnsembliENSMUST00000007275; ENSMUSP00000007275; ENSMUSG00000044041 [P08730-1]
GeneIDi16663
KEGGimmu:16663
UCSCiuc007lkj.1 mouse [P08730-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13921 Genomic DNA Translation: AAC52150.1
AK132640 mRNA Translation: BAE21276.1
BC060286 mRNA Translation: AAH60286.1
X53320 Genomic DNA Translation: CAA37407.1
X03492 mRNA Translation: CAA27208.1
CCDSiCCDS25409.1 [P08730-1]
PIRiA55682
RefSeqiNP_001300878.1, NM_001313949.1
NP_034792.1, NM_010662.2 [P08730-1]
UniGeneiMm.4646

3D structure databases

ProteinModelPortaliP08730
SMRiP08730
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201018, 4 interactors
IntActiP08730, 4 interactors
MINTiP08730
STRINGi10090.ENSMUSP00000007275

PTM databases

iPTMnetiP08730
PhosphoSitePlusiP08730

Proteomic databases

PaxDbiP08730
PeptideAtlasiP08730
PRIDEiP08730

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007275; ENSMUSP00000007275; ENSMUSG00000044041 [P08730-1]
GeneIDi16663
KEGGimmu:16663
UCSCiuc007lkj.1 mouse [P08730-1]

Organism-specific databases

CTDi3860
MGIiMGI:101925 Krt13

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiP08730
KOiK07604
OMAiDAKMTGF
OrthoDBiEOG091G087I
PhylomeDBiP08730
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

PROiPR:P08730
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044041 Expressed in 118 organ(s), highest expression level in superior surface of tongue
CleanExiMM_KRT13
GenevisibleiP08730 MM

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK1C13_MOUSE
AccessioniPrimary (citable) accession number: P08730
Secondary accession number(s): Q3V176, Q6PAI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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