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Protein

40S ribosomal protein S17

Gene

RPS17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S17Curated
Alternative name(s):
Small ribosomal subunit protein eS171 Publication
Gene namesi
Name:RPS17Imported
Synonyms:RPS17LImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000182774.10
HGNCiHGNC:10397 RPS17
MIMi180472 gene
neXtProtiNX_P08708

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 4 (DBA4)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:612527

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNETi6218
GeneReviewsiRPS17
MalaCardsiRPS17
MIMi612527 phenotype
OpenTargetsiENSG00000182774
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34797

Polymorphism and mutation databases

DMDMi338819320

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001415252 – 13540S ribosomal protein S17Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19N6-succinyllysineBy similarity1
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei113PhosphoserineCombined sources1
Modified residuei130PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP08708
PaxDbiP08708
PeptideAtlasiP08708
PRIDEiP08708
ProteomicsDBi52159
52521
TopDownProteomicsiP08708

PTM databases

iPTMnetiP08708
PhosphoSitePlusiP08708
SwissPalmiP08708

Expressioni

Gene expression databases

BgeeiENSG00000182774 Expressed in 237 organ(s), highest expression level in material anatomical entity
CleanExiHS_RPS17
ExpressionAtlasiP08708 baseline and differential
GenevisibleiP08708 HS

Organism-specific databases

HPAiHPA055060

Interactioni

Protein-protein interaction databases

BioGridi112132, 111 interactors
CORUMiP08708
IntActiP08708, 37 interactors
MINTiP08708
STRINGi9606.ENSP00000346046

Structurei

3D structure databases

ProteinModelPortaliP08708
SMRiP08708
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0187 Eukaryota
COG1383 LUCA
GeneTreeiENSGT00390000012886
HOGENOMiHOG000227166
HOVERGENiHBG001708
InParanoidiP08708
KOiK02962
OrthoDBiEOG091G0TNU
PhylomeDBiP08708
TreeFamiTF317992

Family and domain databases

Gene3Di1.10.60.20, 1 hit
HAMAPiMF_00511 Ribosomal_S17e, 1 hit
InterProiView protein in InterPro
IPR001210 Ribosomal_S17e
IPR018273 Ribosomal_S17e_CS
IPR036401 RPS17e-like_sf
PANTHERiPTHR10732 PTHR10732, 1 hit
PfamiView protein in Pfam
PF00833 Ribosomal_S17e, 1 hit
SUPFAMiSSF116820 SSF116820, 1 hit
PROSITEiView protein in PROSITE
PS00712 RIBOSOMAL_S17E, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P08708-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRVRTKTVK KAARVIIEKY YTRLGNDFHT NKRVCEEIAI IPSKKLRNKI
60 70 80 90 100
AGYVTHLMKR IQRGPVRGIS IKLQEEERER RDNYVPEVSA LDQEIIEVDP
110 120 130
DTKEMLKLLD FGSLSNLQVT QPTVGMNFKT PRGPV
Length:135
Mass (Da):15,550
Last modified:January 23, 2007 - v2
Checksum:i299AD605C5401325
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN88H0YN88_HUMAN
40S ribosomal protein S17
RPS17
136Annotation score:
A0A075B716A0A075B716_HUMAN
40S ribosomal protein S17
RPS17
191Annotation score:
H0YN73H0YN73_HUMAN
40S ribosomal protein S17
RPS17
59Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03447836E → K. Corresponds to variant dbSNP:rs1043734Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13932 mRNA Translation: AAA60284.1
M18000 Genomic DNA Translation: AAA60285.1
AK026570 mRNA Translation: BAB15501.1
AK311951 mRNA Translation: BAG34891.1
AC245033 Genomic DNA No translation available.
CH471188 Genomic DNA Translation: EAW62454.1
BC009407 mRNA Translation: AAH09407.1
BC019899 mRNA Translation: AAH19899.1
BC022370 mRNA Translation: AAH22370.1
BC049824 mRNA Translation: AAH49824.1
BC070222 mRNA Translation: AAH70222.1
BC062715 mRNA Translation: AAH62715.1
BC071928 mRNA Translation: AAH71928.1
CCDSiCCDS10320.1
PIRiJT0405 R4HU17
RefSeqiNP_001012.1, NM_001021.4
UniGeneiHs.433427
Hs.512525

Genome annotation databases

EnsembliENST00000330244; ENSP00000346046; ENSG00000182774
ENST00000617731; ENSP00000483755; ENSG00000278229
GeneIDi6218
KEGGihsa:6218

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Diamond-Blackfan Anemia mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13932 mRNA Translation: AAA60284.1
M18000 Genomic DNA Translation: AAA60285.1
AK026570 mRNA Translation: BAB15501.1
AK311951 mRNA Translation: BAG34891.1
AC245033 Genomic DNA No translation available.
CH471188 Genomic DNA Translation: EAW62454.1
BC009407 mRNA Translation: AAH09407.1
BC019899 mRNA Translation: AAH19899.1
BC022370 mRNA Translation: AAH22370.1
BC049824 mRNA Translation: AAH49824.1
BC070222 mRNA Translation: AAH70222.1
BC062715 mRNA Translation: AAH62715.1
BC071928 mRNA Translation: AAH71928.1
CCDSiCCDS10320.1
PIRiJT0405 R4HU17
RefSeqiNP_001012.1, NM_001021.4
UniGeneiHs.433427
Hs.512525

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SR1-135[»]
4V6Xelectron microscopy5.00AR1-135[»]
5A2Qelectron microscopy3.90R1-135[»]
5AJ0electron microscopy3.50BR1-135[»]
5FLXelectron microscopy3.90R1-135[»]
5LKSelectron microscopy3.60SR1-135[»]
5OA3electron microscopy4.30R1-135[»]
5T2Celectron microscopy3.60Az1-135[»]
5VYCX-ray6.00R1/R2/R3/R4/R5/R61-135[»]
6EK0electron microscopy2.90SR1-135[»]
6FECelectron microscopy6.30e1-126[»]
6G18electron microscopy3.60R1-135[»]
6G4Selectron microscopy4.00R1-135[»]
6G4Welectron microscopy4.50R1-135[»]
6G51electron microscopy4.10R1-135[»]
6G53electron microscopy4.50R1-135[»]
6G5Helectron microscopy3.60R1-135[»]
6G5Ielectron microscopy3.50R1-135[»]
ProteinModelPortaliP08708
SMRiP08708
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112132, 111 interactors
CORUMiP08708
IntActiP08708, 37 interactors
MINTiP08708
STRINGi9606.ENSP00000346046

PTM databases

iPTMnetiP08708
PhosphoSitePlusiP08708
SwissPalmiP08708

Polymorphism and mutation databases

DMDMi338819320

Proteomic databases

EPDiP08708
PaxDbiP08708
PeptideAtlasiP08708
PRIDEiP08708
ProteomicsDBi52159
52521
TopDownProteomicsiP08708

Protocols and materials databases

DNASUi6218
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330244; ENSP00000346046; ENSG00000182774
ENST00000617731; ENSP00000483755; ENSG00000278229
GeneIDi6218
KEGGihsa:6218

Organism-specific databases

CTDi6218
DisGeNETi6218
EuPathDBiHostDB:ENSG00000182774.10
GeneCardsiRPS17
GeneReviewsiRPS17
HGNCiHGNC:10397 RPS17
HPAiHPA055060
MalaCardsiRPS17
MIMi180472 gene
612527 phenotype
neXtProtiNX_P08708
OpenTargetsiENSG00000182774
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34797
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0187 Eukaryota
COG1383 LUCA
GeneTreeiENSGT00390000012886
HOGENOMiHOG000227166
HOVERGENiHBG001708
InParanoidiP08708
KOiK02962
OrthoDBiEOG091G0TNU
PhylomeDBiP08708
TreeFamiTF317992

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiRPS17 human
GeneWikiiRPS17
GenomeRNAii6218
PROiPR:P08708
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182774 Expressed in 237 organ(s), highest expression level in material anatomical entity
CleanExiHS_RPS17
ExpressionAtlasiP08708 baseline and differential
GenevisibleiP08708 HS

Family and domain databases

Gene3Di1.10.60.20, 1 hit
HAMAPiMF_00511 Ribosomal_S17e, 1 hit
InterProiView protein in InterPro
IPR001210 Ribosomal_S17e
IPR018273 Ribosomal_S17e_CS
IPR036401 RPS17e-like_sf
PANTHERiPTHR10732 PTHR10732, 1 hit
PfamiView protein in Pfam
PF00833 Ribosomal_S17e, 1 hit
SUPFAMiSSF116820 SSF116820, 1 hit
PROSITEiView protein in PROSITE
PS00712 RIBOSOMAL_S17E, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRS17_HUMAN
AccessioniPrimary (citable) accession number: P08708
Secondary accession number(s): B2R4U4, P0CW22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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