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Protein

Interleukin-3

Gene

IL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
R-HSA-912526 Interleukin receptor SHC signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P08700

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P08700

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-3
Short name:
IL-3
Alternative name(s):
Hematopoietic growth factor
Mast cell growth factor
Short name:
MCGF
Multipotential colony-stimulating factor
P-cell-stimulating factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164399.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6011 IL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147740 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08700

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3562

Open Targets

More...
OpenTargetsi
ENSG00000164399

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29830

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01025 Amlexanox

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124330

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Add BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001551620 – 152Interleukin-3Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 103
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08700

PeptideAtlas

More...
PeptideAtlasi
P08700

PRoteomics IDEntifications database

More...
PRIDEi
P08700

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52158

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P08700

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Activated T-cells, mast cells, natural killer cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164399 Expressed in 3 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_IL3

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08700 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109777, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-6N

Protein interaction database and analysis system

More...
IntActi
P08700, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296870

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JLINMR-A34-144[»]
5UV8X-ray2.70B/I31-152[»]
5UWCX-ray2.40I31-152[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P08700

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P08700

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P08700

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JJGT Eukaryota
ENOG411147A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163393

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000037939

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004103

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08700

KEGG Orthology (KO)

More...
KOi
K04736

Identification of Orthologs from Complete Genome Data

More...
OMAi
NCSNMID

Database of Orthologous Groups

More...
OrthoDBi
1415445at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08700

TreeFam database of animal gene trees

More...
TreeFami
TF338567

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002183 IL-3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02059 IL3, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001939 IL-3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00430 INTERLEUKIN3

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P08700-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRLPVLLLL QLLVRPGLQA PMTQTTPLKT SWVNCSNMID EIITHLKQPP
60 70 80 90 100
LPLLDFNNLN GEDQDILMEN NLRRPNLEAF NRAVKSLQNA SAIESILKNL
110 120 130 140 150
LPCLPLATAA PTRHPIHIKD GDWNEFRRKL TFYLKTLENA QAQQTTLSLA

IF
Length:152
Mass (Da):17,233
Last modified:October 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB46F23FAC1259A4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0340143R → C. Corresponds to variant dbSNP:rs35415145Ensembl.1
Natural variantiVAR_01307115R → H1 PublicationCorresponds to variant dbSNP:rs2069787Ensembl.1
Natural variantiVAR_01307227P → S3 PublicationsCorresponds to variant dbSNP:rs40401Ensembl.1
Natural variantiVAR_03401560N → S. Corresponds to variant dbSNP:rs35482671Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M14743 mRNA Translation: AAA59146.1
M20137 mRNA Translation: AAA59147.1
M17115 mRNA Translation: AAA35725.1
AF365976 Genomic DNA Translation: AAK38378.1
AC004511 Genomic DNA Translation: AAC08706.1
BC066272 mRNA Translation: AAH66272.1
BC066273 mRNA Translation: AAH66273.1
BC066276 mRNA Translation: AAH66276.1
BC069472 mRNA Translation: AAH69472.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4149.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A24427

NCBI Reference Sequences

More...
RefSeqi
NP_000579.2, NM_000588.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.694

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296870; ENSP00000296870; ENSG00000164399

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3562

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3562

UCSC genome browser

More...
UCSCi
uc003kwe.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14743 mRNA Translation: AAA59146.1
M20137 mRNA Translation: AAA59147.1
M17115 mRNA Translation: AAA35725.1
AF365976 Genomic DNA Translation: AAK38378.1
AC004511 Genomic DNA Translation: AAC08706.1
BC066272 mRNA Translation: AAH66272.1
BC066273 mRNA Translation: AAH66273.1
BC066276 mRNA Translation: AAH66276.1
BC069472 mRNA Translation: AAH69472.1
CCDSiCCDS4149.1
PIRiA24427
RefSeqiNP_000579.2, NM_000588.3
UniGeneiHs.694

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JLINMR-A34-144[»]
5UV8X-ray2.70B/I31-152[»]
5UWCX-ray2.40I31-152[»]
ProteinModelPortaliP08700
SMRiP08700
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109777, 3 interactors
DIPiDIP-6N
IntActiP08700, 1 interactor
STRINGi9606.ENSP00000296870

Chemistry databases

DrugBankiDB01025 Amlexanox

Polymorphism and mutation databases

BioMutaiIL3
DMDMi124330

Proteomic databases

PaxDbiP08700
PeptideAtlasiP08700
PRIDEiP08700
ProteomicsDBi52158
TopDownProteomicsiP08700

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3562
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296870; ENSP00000296870; ENSG00000164399
GeneIDi3562
KEGGihsa:3562
UCSCiuc003kwe.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3562
DisGeNETi3562
EuPathDBiHostDB:ENSG00000164399.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL3
HGNCiHGNC:6011 IL3
MIMi147740 gene
neXtProtiNX_P08700
OpenTargetsiENSG00000164399
PharmGKBiPA29830

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JJGT Eukaryota
ENOG411147A LUCA
GeneTreeiENSGT00940000163393
HOGENOMiHOG000037939
HOVERGENiHBG004103
InParanoidiP08700
KOiK04736
OMAiNCSNMID
OrthoDBi1415445at2759
PhylomeDBiP08700
TreeFamiTF338567

Enzyme and pathway databases

ReactomeiR-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP08700
SIGNORiP08700

Miscellaneous databases

EvolutionaryTraceiP08700

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Interleukin_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3562

Protein Ontology

More...
PROi
PR:P08700

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164399 Expressed in 3 organ(s), highest expression level in right lobe of liver
CleanExiHS_IL3
GenevisibleiP08700 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002183 IL-3
PfamiView protein in Pfam
PF02059 IL3, 1 hit
PIRSFiPIRSF001939 IL-3, 1 hit
PRINTSiPR00430 INTERLEUKIN3
SUPFAMiSSF47266 SSF47266, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08700
Secondary accession number(s): Q6GS87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 1, 1989
Last modified: January 16, 2019
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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