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Protein

Interleukin-3

Gene

IL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

GO - Molecular functioni

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cytokine-mediated signaling pathway Source: GO_Central
  • embryonic hemopoiesis Source: DFLAT
  • fever generation Source: GO_Central
  • immune response Source: InterPro
  • MAPK cascade Source: Reactome
  • nervous system development Source: ProtInc
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  • positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
  • regulation of cytokine-mediated signaling pathway Source: Reactome

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP08700
SIGNORiP08700

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-3
Short name:
IL-3
Alternative name(s):
Hematopoietic growth factor
Mast cell growth factor
Short name:
MCGF
Multipotential colony-stimulating factor
P-cell-stimulating factor
Gene namesi
Name:IL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164399.4
HGNCiHGNC:6011 IL3
MIMi147740 gene
neXtProtiNX_P08700

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3562
OpenTargetsiENSG00000164399
PharmGKBiPA29830

Chemistry databases

DrugBankiDB01025 Amlexanox

Polymorphism and mutation databases

BioMutaiIL3
DMDMi124330

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001551620 – 152Interleukin-3Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi35 ↔ 103
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP08700
PeptideAtlasiP08700
PRIDEiP08700
ProteomicsDBi52158
TopDownProteomicsiP08700

Expressioni

Tissue specificityi

Activated T-cells, mast cells, natural killer cells.

Gene expression databases

BgeeiENSG00000164399
CleanExiHS_IL3
GenevisibleiP08700 HS

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109777, 3 interactors
DIPiDIP-6N
IntActiP08700, 1 interactor
STRINGi9606.ENSP00000296870

Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 46Combined sources12
Helixi56 – 58Combined sources3
Helixi61 – 68Combined sources8
Helixi70 – 72Combined sources3
Helixi73 – 84Combined sources12
Beta strandi87 – 89Combined sources3
Helixi91 – 97Combined sources7
Helixi101 – 103Combined sources3
Helixi123 – 140Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JLINMR-A34-144[»]
5UV8X-ray2.70B/I31-152[»]
5UWCX-ray2.40I31-152[»]
ProteinModelPortaliP08700
SMRiP08700
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08700

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JJGT Eukaryota
ENOG411147A LUCA
GeneTreeiENSGT00730000111772
HOGENOMiHOG000037939
HOVERGENiHBG004103
InParanoidiP08700
KOiK04736
OMAiNCSNMID
OrthoDBiEOG091G0W94
PhylomeDBiP08700
TreeFamiTF338567

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002183 IL-3
PfamiView protein in Pfam
PF02059 IL3, 1 hit
PIRSFiPIRSF001939 IL-3, 1 hit
PRINTSiPR00430 INTERLEUKIN3
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLPVLLLL QLLVRPGLQA PMTQTTPLKT SWVNCSNMID EIITHLKQPP
60 70 80 90 100
LPLLDFNNLN GEDQDILMEN NLRRPNLEAF NRAVKSLQNA SAIESILKNL
110 120 130 140 150
LPCLPLATAA PTRHPIHIKD GDWNEFRRKL TFYLKTLENA QAQQTTLSLA

IF
Length:152
Mass (Da):17,233
Last modified:October 1, 1989 - v2
Checksum:iBB46F23FAC1259A4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0340143R → C. Corresponds to variant dbSNP:rs35415145Ensembl.1
Natural variantiVAR_01307115R → H1 PublicationCorresponds to variant dbSNP:rs2069787Ensembl.1
Natural variantiVAR_01307227P → S3 PublicationsCorresponds to variant dbSNP:rs40401Ensembl.1
Natural variantiVAR_03401560N → S. Corresponds to variant dbSNP:rs35482671Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14743 mRNA Translation: AAA59146.1
M20137 mRNA Translation: AAA59147.1
M17115 mRNA Translation: AAA35725.1
AF365976 Genomic DNA Translation: AAK38378.1
AC004511 Genomic DNA Translation: AAC08706.1
BC066272 mRNA Translation: AAH66272.1
BC066273 mRNA Translation: AAH66273.1
BC066276 mRNA Translation: AAH66276.1
BC069472 mRNA Translation: AAH69472.1
CCDSiCCDS4149.1
PIRiA24427
RefSeqiNP_000579.2, NM_000588.3
UniGeneiHs.694

Genome annotation databases

EnsembliENST00000296870; ENSP00000296870; ENSG00000164399
GeneIDi3562
KEGGihsa:3562
UCSCiuc003kwe.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL3_HUMAN
AccessioniPrimary (citable) accession number: P08700
Secondary accession number(s): Q6GS87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 1, 1989
Last modified: June 20, 2018
This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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