UniProtKB - P08680 (HEM0_MOUSE)

BLAST

>sp|P08680|HEM0_MOUSE 5-aminolevulinate synthase, erythroid-specific, mitochondrial OS=Mus musculus OX=10090 GN=Alas2 PE=1 SV=3
MVAAAMLLRSCPVLSQGPTGLLGKVAKTYQFLFSIGRCPILATQGPTCSQIHLKATKAGG
DSPSWAKSHCPFMLSELQDRKSKIVQRAAPEVQEDVKTFKTDLLSTMDSTTRSHSFPSFQ
EPEQTEGAVPHLIQNNMTGSQAFGYDQFFRDKIMEKKQDHTYRVFKTVNRWANAYPFAQH
FSEASMASKDVSVWCSNDYLGISRHPRVLQAIEETLKNHGAGAGGTRNISGTSKFHVELE
QELAELHQKDSALLFSSCFVANDSTLFTLAKLLPGCEIYSDAGNHASMIQGIRNSGAAKF
VFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMDGAICPLEELCDVAHQYGALTFVDEVH
AVGLYGARGAGIGERDGIMHKLDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFT
TSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGFPVIPCPSHIIPIRV
GNAALNSKICDLLLSKHSIYVQAINYPTVPRGEELLRLAPSPHHSPQMMENFVEKLLLAW
TEVGLPLQDVSVAACNFCHRPVHFELMSEWERSYFGNMGPQYVTTYA

Align
Format
Add to basket Added to basket
History
Entry version 169 (07 Nov 2018)
Sequence version 3 (23 Jan 2002)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Gene

Alas2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

Catalytic activityⁱ

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO₂.

Cofactorⁱ

pyridoxal 5'-phosphate

Pathwayⁱ: protoporphyrin-IX biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-aminolevulinate from glycine.
Proteins known to be involved in this subpathway in this organism are:

5-aminolevulinate synthase, nonspecific, mitochondrial (Alas1), 5-aminolevulinate synthase, erythroid-specific, mitochondrial (Alas2), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas1), 5-aminolevulinate synthase (Alas1), 5-aminolevulinate synthase (Alas2), 5-aminolevulinate synthase (Alas2)

This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from glycine, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	163	SubstrateBy similarity	1
Binding siteⁱ	280	SubstrateBy similarity	1
Binding siteⁱ	299	SubstrateBy similarity	1
Binding siteⁱ	332	Pyridoxal phosphateBy similarity	1
Binding siteⁱ	360	Pyridoxal phosphateBy similarity	1
Binding siteⁱ	388	Pyridoxal phosphateBy similarity	1
Active siteⁱ	391	By similarity	1
Binding siteⁱ	420	Pyridoxal phosphate; shared with dimeric partnerBy similarity	1
Binding siteⁱ	421	Pyridoxal phosphate; shared with dimeric partnerBy similarity	1
Binding siteⁱ	508	SubstrateBy similarity	1

GO - Molecular functionⁱ

5-aminolevulinate synthase activity
Source: MGI
Inferred from mutant phenotypeⁱ
- 7620186
coenzyme binding Source: MGI
glycine binding Source: MGI
pyridoxal phosphate binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular iron ion homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
- 10562540
erythrocyte differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9446639
heme biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9446639
hemoglobin biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9446639
protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
response to hypoxia Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase
Biological process	Heme biosynthesis
Ligand	Pyridoxal phosphate

Enzyme and pathway databases

Reactomeⁱ	R-MMU-189451 Heme biosynthesis
UniPathwayⁱ	UPA00251;UER00375

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-aminolevulinate synthase, erythroid-specific, mitochondrial (EC:2.3.1.37) Short name: ALAS-E Alternative name(s): 5-aminolevulinic acid synthase 2 Delta-ALA synthase 2 Delta-aminolevulinate synthase 2
Gene namesⁱ	Name:Alas2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:87990 Alas2

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	391	K → A or H: Abolishes enzyme activity.		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 49	Mitochondrion1 PublicationAdd BLAST		49
ChainⁱPRO_0000001224	50 – 587	5-aminolevulinate synthase, erythroid-specific, mitochondrialAdd BLAST		538

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	391	N6-(pyridoxal phosphate)lysine1 Publication		1

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08680
PaxDbⁱ	P08680
PRIDEⁱ	P08680

PTM databases

PhosphoSitePlusⁱ	P08680

PhosphoSitePlusⁱ

P08680

Expressionⁱ

Tissue specificityⁱ

Erythroid specific.

Gene expression databases

Bgeeⁱ	ENSMUSG00000025270 Expressed in 183 organ(s), highest expression level in blood
CleanExⁱ	MM_ALAS2
ExpressionAtlasⁱ	P08680 baseline and differential
Genevisibleⁱ	P08680 MM

Interactionⁱ

Subunit structureⁱ

Interacts with SUCLA2 (By similarity). Homodimer.By similarity

Protein-protein interaction databases

BioGridⁱ	198059, 1 interactor
IntActⁱ	P08680, 4 interactors
STRINGⁱ	10090.ENSMUSP00000066040

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	5 – 8	Combined sources	4
Beta strandⁱ	14 – 16	Combined sources	3
Turnⁱ	23 – 27	Combined sources	5
Helixⁱ	28 – 32	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P08680
SMRⁱ	P08680
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P08680

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG1360 Eukaryota COG0156 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063111
HOGENOMⁱ	HOG000221020
HOVERGENⁱ	HBG005954
InParanoidⁱ	P08680
KEGG Orthology (KO) More...KOⁱ	K00643
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G043U
PhylomeDBⁱ	P08680
TreeFamⁱ	TF300724

Family and domain databases

Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 1 hit
InterProⁱ	View protein in InterPro IPR010961 4pyrrol_synth_NH2levulA_synth IPR015118 5aminolev_synth_preseq IPR001917 Aminotrans_II_pyridoxalP_BS IPR004839 Aminotransferase_I/II IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00155 Aminotran_1_2, 1 hit PF09029 Preseq_ALAS, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
TIGRFAMsⁱ	TIGR01821 5aminolev_synth, 1 hit
PROSITEⁱ	View protein in PROSITE PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P08680-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVAAAMLLRS CPVLSQGPTG LLGKVAKTYQ FLFSIGRCPI LATQGPTCSQ 
        60         70         80         90        100
IHLKATKAGG DSPSWAKSHC PFMLSELQDR KSKIVQRAAP EVQEDVKTFK 
       110        120        130        140        150
TDLLSTMDST TRSHSFPSFQ EPEQTEGAVP HLIQNNMTGS QAFGYDQFFR 
       160        170        180        190        200
DKIMEKKQDH TYRVFKTVNR WANAYPFAQH FSEASMASKD VSVWCSNDYL 
       210        220        230        240        250
GISRHPRVLQ AIEETLKNHG AGAGGTRNIS GTSKFHVELE QELAELHQKD 
       260        270        280        290        300
SALLFSSCFV ANDSTLFTLA KLLPGCEIYS DAGNHASMIQ GIRNSGAAKF 
       310        320        330        340        350
VFRHNDPGHL KKLLEKSDPK TPKIVAFETV HSMDGAICPL EELCDVAHQY 
       360        370        380        390        400
GALTFVDEVH AVGLYGARGA GIGERDGIMH KLDIISGTLG KAFGCVGGYI 
       410        420        430        440        450
ASTRDLVDMV RSYAAGFIFT TSLPPMVLSG ALESVRLLKG EEGQALRRAH 
       460        470        480        490        500
QRNVKHMRQL LMDRGFPVIP CPSHIIPIRV GNAALNSKIC DLLLSKHSIY 
       510        520        530        540        550
VQAINYPTVP RGEELLRLAP SPHHSPQMME NFVEKLLLAW TEVGLPLQDV 
       560        570        580 
SVAACNFCHR PVHFELMSEW ERSYFGNMGP QYVTTYA

Length:587

Mass (Da):64,753

Last modified:January 23, 2002 - v3

Checksum:ⁱA878D79FAD5B9856

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A2AFM1	A2AFM1_MOUSE		5-aminolevulinate synthase 5-aminolevulinate synthase, EC 2.3.1.37 (5-aminolevulinic acid synthase) (Delta-ALA synthase) (Delta-aminolevulinate synthase)	Alas2	572	Annotation score:

Sequence cautionⁱ

The sequence AAA37207 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	61 – 75	Missing in AAA37207 (PubMed:3557128).CuratedAdd BLAST	15
Sequence conflictⁱ	66	A → R in BAB22254 (PubMed:16141072).Curated	1
Sequence conflictⁱ	171	W → R in AAA91866 (Ref. 2) Curated	1
Sequence conflictⁱ	338	C → V in AAA91866 (Ref. 2) Curated	1
Sequence conflictⁱ	368 – 372	RGAGI → GVQVS in AAA91866 (Ref. 2) Curated	5
Sequence conflictⁱ	427	V → M in AAA37207 (PubMed:3557128).Curated	1
Sequence conflictⁱ	479	R → W in AAA91866 (Ref. 2) Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M15268 mRNA Translation: AAA37207.1 Different initiation. M63244 mRNA Translation: AAA91866.1 AK002642 mRNA Translation: BAB22254.1 AK077610 mRNA Translation: BAC36898.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41173.1
PIRⁱ	A29040 SYMSAL
NCBI Reference Sequences More...RefSeqⁱ	NP_001095916.1, NM_001102446.1 NP_033783.1, NM_009653.3
UniGeneⁱ	Mm.302724

Genome annotation databases

Ensemblⁱ	ENSMUST00000066337; ENSMUSP00000066040; ENSMUSG00000025270
GeneIDⁱ	11656
KEGGⁱ	mmu:11656
UCSC genome browser More...UCSCⁱ	uc009uoj.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08680	5-aminolevulinate synthase		MOUSE		587	UniRef100_P08680
5-aminolevulinate synthase		MOUSE		402

Protein	Similar proteins		Species	Score	Length	Source
P08680	5-aminolevulinate synthase, erythroid-specific, mitochondrial		RAT		587	UniRef90_P08680
5-aminolevulinate synthase		MOUSE		587
5-aminolevulinate synthase (Fragment)		CRIGR		577
5-aminolevulinate synthase		MESAU		587
UPI00038C4F1F		MICOH		587
+15

Protein	Similar proteins		Species	Score	Length	Source
P08680	5-aminolevulinate synthase, erythroid-specific, mitochondrial		RAT		587	UniRef50_P08680
5-aminolevulinate synthase, erythroid-specific, mitochondrial		DANRE		583
5-aminolevulinate synthase, erythroid-specific, mitochondrial		OPSTA		582
5-aminolevulinate synthase		MOUSE		587
5-aminolevulinate synthase (Fragment)		CRIGR		577
+62

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M15268 mRNA Translation: AAA37207.1 Different initiation. M63244 mRNA Translation: AAA91866.1 AK002642 mRNA Translation: BAB22254.1 AK077610 mRNA Translation: BAC36898.1
CCDSⁱ	CCDS41173.1
PIRⁱ	A29040 SYMSAL
RefSeqⁱ	NP_001095916.1, NM_001102446.1 NP_033783.1, NM_009653.3
UniGeneⁱ	Mm.302724

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1H7D	NMR	-	A	1-49	[»]
	1H7J	NMR	-	A	1-26	[»]
ProteinModelPortalⁱ	P08680
SMRⁱ	P08680
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198059, 1 interactor
IntActⁱ	P08680, 4 interactors
STRINGⁱ	10090.ENSMUSP00000066040

PTM databases

PhosphoSitePlusⁱ	P08680

PhosphoSitePlusⁱ

P08680

Proteomic databases

MaxQBⁱ	P08680
PaxDbⁱ	P08680
PRIDEⁱ	P08680

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000066337; ENSMUSP00000066040; ENSMUSG00000025270
GeneIDⁱ	11656
KEGGⁱ	mmu:11656
UCSCⁱ	uc009uoj.1 mouse

Organism-specific databases

CTDⁱ	212
MGIⁱ	MGI:87990 Alas2

Phylogenomic databases

eggNOGⁱ	KOG1360 Eukaryota COG0156 LUCA
GeneTreeⁱ	ENSGT00530000063111
HOGENOMⁱ	HOG000221020
HOVERGENⁱ	HBG005954
InParanoidⁱ	P08680
KOⁱ	K00643
OrthoDBⁱ	EOG091G043U
PhylomeDBⁱ	P08680
TreeFamⁱ	TF300724

Enzyme and pathway databases

UniPathwayⁱ	UPA00251;UER00375
Reactomeⁱ	R-MMU-189451 Heme biosynthesis

Miscellaneous databases

EvolutionaryTraceⁱ	P08680
Protein Ontology More...PROⁱ	PR:P08680
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025270 Expressed in 183 organ(s), highest expression level in blood
CleanExⁱ	MM_ALAS2
ExpressionAtlasⁱ	P08680 baseline and differential
Genevisibleⁱ	P08680 MM

Family and domain databases

Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 1 hit
InterProⁱ	View protein in InterPro IPR010961 4pyrrol_synth_NH2levulA_synth IPR015118 5aminolev_synth_preseq IPR001917 Aminotrans_II_pyridoxalP_BS IPR004839 Aminotransferase_I/II IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
Pfamⁱ	View protein in Pfam PF00155 Aminotran_1_2, 1 hit PF09029 Preseq_ALAS, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
TIGRFAMsⁱ	TIGR01821 5aminolev_synth, 1 hit
PROSITEⁱ	View protein in PROSITE PS00599 AA_TRANSFER_CLASS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HEM0_MOUSE
Accessionⁱ	P08680Primary (citable) accession number: P08680 Secondary accession number(s): Q64452, Q9DCN0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	January 23, 2002
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P08680 (HEM0_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Alas2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protoporphyrin-IX biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: protoporphyrin-IX biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ