Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 210 (23 Feb 2022)
Sequence version 2 (01 Nov 1995)
Previous versions | rss
Add a publicationFeedback
Protein

Adenylate cyclase

Gene

CYR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The presence of GTP-bound RAS2 protein is required in order to elicit a magnesium-dependent adenylyl cyclase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1673MagnesiumBy similarity1
Metal bindingi1716MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processcAMP biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenylate cyclaseCurated (EC:4.6.1.11 Publication)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYR1
Synonyms:CDC35, HSR1, SRA4
Ordered Locus Names:YJL005W
ORF Names:J1401
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000003542, CYR1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YJL005W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1651T → D: Attenuation of the response to Ras proteins. 1 Publication1
Mutagenesisi1651T → I: Weak Ras-independent activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001957312 – 2026Adenylate cyclaseAdd BLAST2025

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei376PhosphothreonineCombined sources1
Modified residuei389PhosphothreonineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei497PhosphoserineCombined sources1
Modified residuei562PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P08678

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08678

PRoteomics IDEntifications database

More...
PRIDEi
P08678

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08678

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
33752, 208 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-695, Adenylyl cyclase complex

Database of interacting proteins

More...
DIPi
DIP-2317N

Protein interaction database and analysis system

More...
IntActi
P08678, 25 interactors

Molecular INTeraction database

More...
MINTi
P08678

STRING: functional protein association networks

More...
STRINGi
4932.YJL005W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P08678, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P08678

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini676 – 755Ras-associatingPROSITE-ProRule annotationAdd BLAST80
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati795 – 814LRR 1Sequence analysisAdd BLAST20
Repeati815 – 838LRR 2Sequence analysisAdd BLAST24
Repeati842 – 862LRR 3Sequence analysisAdd BLAST21
Repeati863 – 885LRR 4Sequence analysisAdd BLAST23
Repeati886 – 908LRR 5Sequence analysisAdd BLAST23
Repeati910 – 931LRR 6Sequence analysisAdd BLAST22
Repeati932 – 955LRR 7Sequence analysisAdd BLAST24
Repeati957 – 976LRR 8Sequence analysisAdd BLAST20
Repeati977 – 999LRR 9Sequence analysisAdd BLAST23
Repeati1001 – 1016LRR 10Sequence analysisAdd BLAST16
Repeati1017 – 1040LRR 11Sequence analysisAdd BLAST24
Repeati1042 – 1062LRR 12Sequence analysisAdd BLAST21
Repeati1063 – 1086LRR 13Sequence analysisAdd BLAST24
Repeati1088 – 1109LRR 14Sequence analysisAdd BLAST22
Repeati1110 – 1132LRR 15Sequence analysisAdd BLAST23
Repeati1134 – 1156LRR 16Sequence analysisAdd BLAST23
Repeati1188 – 1209LRR 17Sequence analysisAdd BLAST22
Repeati1210 – 1232LRR 18Sequence analysisAdd BLAST23
Repeati1233 – 1256LRR 19Sequence analysisAdd BLAST24
Repeati1258 – 1280LRR 20Sequence analysisAdd BLAST23
Repeati1285 – 1308LRR 21Sequence analysisAdd BLAST24
Repeati1319 – 1344LRR 22Sequence analysisAdd BLAST26
Domaini1357 – 1624PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST268
Domaini1668 – 1805Guanylate cyclasePROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 104DisorderedSequence analysisAdd BLAST104
Regioni119 – 160DisorderedSequence analysisAdd BLAST42
Regioni200 – 223DisorderedSequence analysisAdd BLAST24
Regioni247 – 378DisorderedSequence analysisAdd BLAST132
Regioni405 – 429DisorderedSequence analysisAdd BLAST25
Regioni447 – 523DisorderedSequence analysisAdd BLAST77
Regioni559 – 601DisorderedSequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 31Polar residuesSequence analysisAdd BLAST31
Compositional biasi32 – 47Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi56 – 87Polar residuesSequence analysisAdd BLAST32
Compositional biasi144 – 160Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi279 – 333Polar residuesSequence analysisAdd BLAST55
Compositional biasi334 – 348Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi349 – 378Polar residuesSequence analysisAdd BLAST30
Compositional biasi405 – 420Polar residuesSequence analysisAdd BLAST16
Compositional biasi447 – 465Polar residuesSequence analysisAdd BLAST19
Compositional biasi501 – 518Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi571 – 601Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-3 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0618, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161019

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000430_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08678

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKRHYAI

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07302, CHD, 1 hit
cd00143, PP2Cc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1230, 1 hit
3.60.40.10, 1 hit
3.80.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054, A/G_cyclase
IPR013716, Adenylate_cyclase_G-a-bd
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR029787, Nucleotide_cyclase
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom
IPR000159, RA_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08509, Ad_cyc_g-alpha, 1 hit
PF00211, Guanylate_cyc, 1 hit
PF13855, LRR_8, 4 hits
PF00481, PP2C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00789, Ad_cyc_g-alpha, 1 hit
SM00044, CYCc, 1 hit
SM00369, LRR_TYP, 11 hits
SM00332, PP2Cc, 1 hit
SM00314, RA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55073, SSF55073, 1 hit
SSF81606, SSF81606, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50125, GUANYLATE_CYCLASE_2, 1 hit
PS51450, LRR, 15 hits
PS51746, PPM_2, 1 hit
PS50200, RA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P08678-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKPDTGSE ISGPQRQEEQ EQQIEQSSPT EANDRSIHDE VPKVKKRHEQ
60 70 80 90 100
NSGHKSRRNS AYSYYSPRSL SMTKSRESIT PNGMDDVSIS NVEHPRPTEP
110 120 130 140 150
KIKRGPYLLK KTLSSLSMTS ANSTHDDNKD HGYALNSSKT HNYTSTHNHH
160 170 180 190 200
DGHHDHHHVQ FFPNRKPSLA ETLFKRFSGS NSHDGNKSGK ESKVANLSLS
210 220 230 240 250
TVNPAPANRK PSKDSTLSNH LADNVPSTLR RKVSSLVRGS SVHDINNGIA
260 270 280 290 300
DKQIRPKAVA QSENTLHSSD VPNSKRSHRK SFLLGSTSSS SSRRGSNVSS
310 320 330 340 350
MTNSDSASMA TSGSHVLQHN VSNVSPTTKS KDSVNSESAD HTNNKSEKVT
360 370 380 390 400
PEYNENIPEN SNSDNKREAT TPTIETPISC KPSLFRLDTN LEDVTDITKT
410 420 430 440 450
VPPTAVNSTL NSTHGTETAS PKTVIMPEGP RKSVSMADLS VAAAAPNGEF
460 470 480 490 500
TSTSNDRSQW VAPQSWDVET KRKKTKPKGR SKSRRSSIDA DELDPMSPGP
510 520 530 540 550
PSKKDSRHHH DRKDNESMVT AGDSNSSFVD ICKENVPNDS KTALDTKSVN
560 570 580 590 600
RLKSNLAMSP PSIRYAPSNL DGDYDTSSTS SSLPSSSISS EDTSSCSDSS
610 620 630 640 650
SYTNAYMEAN REQDNKTPIL NKTKSYTKKF TSSSVNMNSP DGAQSSGLLL
660 670 680 690 700
QDEKDDEVEC QLEHYYKDFS DLDPKRHYAI RIFNTDDTFT TLSCTPATTV
710 720 730 740 750
EEIIPALKRK FNITAQGNFQ ISLKVGKLSK ILRPTSKPIL IERKLLLLNG
760 770 780 790 800
YRKSDPLHIM GIEDLSFVFK FLFHPVTPSH FTPEQEQRIM RSEFVHVDLR
810 820 830 840 850
NMDLTTPPII FYQHTSEIES LDVSNNANIF LPLEFIESSI KLLSLRMVNI
860 870 880 890 900
RASKFPSNIT KAYKLVSLEL QRNFIRKVPN SIMKLSNLTI LNLQCNELES
910 920 930 940 950
LPAGFVELKN LQLLDLSSNK FMHYPEVINY CTNLLQIDLS YNKIQSLPQS
960 970 980 990 1000
TKYLVKLAKM NLSHNKLNFI GDLSEMTDLR TLNLRYNRIS SIKTNASNLQ
1010 1020 1030 1040 1050
NLFLTDNRIS NFEDTLPKLR ALEIQENPIT SISFKDFYPK NMTSLTLNKA
1060 1070 1080 1090 1100
QLSSIPGELL TKLSFLEKLE LNQNNLTRLP QEISKLTKLV FLSVARNKLE
1110 1120 1130 1140 1150
YIPPELSQLK SLRTLDLHSN NIRDFVDGME NLELTSLNIS SNAFGNSSLE
1160 1170 1180 1190 1200
NSFYHNMSYG SKLSKSLMFF IAADNQFDDA MWPLFNCFVN LKVLNLSYNN
1210 1220 1230 1240 1250
FSDVSHMKLE SITELYLSGN KLTTLSGDTV LKWSSLKTLM LNSNQMLSLP
1260 1270 1280 1290 1300
AELSNLSQLS VFDVGANQLK YNISNYHYDW NWRNNKELKY LNFSGNRRFE
1310 1320 1330 1340 1350
IKSFISHDID ADLSDLTVLP QLKVLGLMDV TLNTTKVPDE NVNFRLRTTA
1360 1370 1380 1390 1400
SIINGMRYGV ADTLGQRDYV SSRDVTFERF RGNDDECLLC LHDSKNQNAD
1410 1420 1430 1440 1450
YGHNISRIVR DIYDKILIRQ LERYGDETDD NIKTALRFSF LQLNKEINGM
1460 1470 1480 1490 1500
LNSVDNGADV ANLSYADLLS GACSTVIYIR GKKLFAANLG DCMAILSKNN
1510 1520 1530 1540 1550
GDYQTLTKQH LPTKREEYER IRISGGYVNN GKLDGVVDVS RAVGFFDLLP
1560 1570 1580 1590 1600
HIHASPDISV VTLTKADEML IVATHKLWEY MDVDTVCDIA RENSTDPLRA
1610 1620 1630 1640 1650
AAELKDHAMA YGCTENITIL CLALYENIQQ QNRFTLNKNS LMTRRSTFED
1660 1670 1680 1690 1700
TTLRRLQPEI SPPTGNLAMV FTDIKSSTFL WELFPNAMRT AIKTHNDIMR
1710 1720 1730 1740 1750
RQLRIYGGYE VKTEGDAFMV AFPTPTSGLT WCLSVQLKLL DAQWPEEITS
1760 1770 1780 1790 1800
VQDGCQVTDR NGNIIYQGLS VRMGIHWGCP VPELDLVTQR MDYLGPMVNK
1810 1820 1830 1840 1850
AARVQGVADG GQIAMSSDFY SEFNKIMKYH ERVVKGKESL KEVYGEEIIG
1860 1870 1880 1890 1900
EVLEREIAML ESIGWAFFDF GEHKLKGLET KELVTIAYPK ILASRHEFAS
1910 1920 1930 1940 1950
EDEQSKLINE TMLFRLRVIS NRLESIMSAL SGGFIELDSR TEGSYIKFNP
1960 1970 1980 1990 2000
KVENGIMQSI SEKDALLFFD HVITRIESSV ALLHLRQQRC SGLEICRNDK
2010 2020
TSARSNIFNV VDELLQMVKN AKDLST
Length:2,026
Mass (Da):227,834
Last modified:November 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBEAB7419AB6989D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti262S → L in AAA34549 (PubMed:2934138).Curated1
Sequence conflicti548S → L in AAA34549 (PubMed:2934138).Curated1
Sequence conflicti592D → H in AAA34549 (PubMed:2934138).Curated1
Sequence conflicti709R → I in AAA34549 (PubMed:2934138).Curated1
Sequence conflicti962L → P in AAA34549 (PubMed:2934138).Curated1
Sequence conflicti1388L → S in AAA34549 (PubMed:2934138).Curated1
Sequence conflicti1427E → D in CAA27175 (Ref. 4) Curated1
Sequence conflicti1461A → T in CAA27175 (Ref. 4) Curated1
Sequence conflicti1566A → S in AAA34549 (PubMed:2934138).Curated1
Sequence conflicti1735V → G in AAA34549 (PubMed:2934138).Curated1
Sequence conflicti1956I → V in CAA27175 (Ref. 4) Curated1
Sequence conflicti1996C → F in AAA34549 (PubMed:2934138).Curated1
Sequence conflicti2009 – 2026NVVDE…KDLST → MLLTNFYKWLRTQRIYQLEF CS in CAA27175 (Ref. 4) CuratedAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M12057 Genomic DNA Translation: AAA34549.1
Z49280 Genomic DNA Translation: CAA89295.1
X87611 Genomic DNA Translation: CAA60917.1
X03449 Genomic DNA Translation: CAA27175.1
BK006943 Genomic DNA Translation: DAA08786.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S56776, OYBY

NCBI Reference Sequences

More...
RefSeqi
NP_012529.3, NM_001181439.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YJL005W_mRNA; YJL005W; YJL005W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853452

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YJL005W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12057 Genomic DNA Translation: AAA34549.1
Z49280 Genomic DNA Translation: CAA89295.1
X87611 Genomic DNA Translation: CAA60917.1
X03449 Genomic DNA Translation: CAA27175.1
BK006943 Genomic DNA Translation: DAA08786.1
PIRiS56776, OYBY
RefSeqiNP_012529.3, NM_001181439.3

3D structure databases

SMRiP08678
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi33752, 208 interactors
ComplexPortaliCPX-695, Adenylyl cyclase complex
DIPiDIP-2317N
IntActiP08678, 25 interactors
MINTiP08678
STRINGi4932.YJL005W

PTM databases

iPTMnetiP08678

Proteomic databases

MaxQBiP08678
PaxDbiP08678
PRIDEiP08678

Genome annotation databases

EnsemblFungiiYJL005W_mRNA; YJL005W; YJL005W
GeneIDi853452
KEGGisce:YJL005W

Organism-specific databases

SGDiS000003542, CYR1
VEuPathDBiFungiDB:YJL005W

Phylogenomic databases

eggNOGiKOG0618, Eukaryota
GeneTreeiENSGT00940000161019
HOGENOMiCLU_000430_3_0_1
InParanoidiP08678
OMAiPKRHYAI

Enzyme and pathway databases

ReactomeiR-SCE-6803207, TP53 Regulates Transcription of Caspase Activators and Caspases

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P08678
RNActiP08678, protein

Family and domain databases

CDDicd07302, CHD, 1 hit
cd00143, PP2Cc, 1 hit
Gene3Di3.30.70.1230, 1 hit
3.60.40.10, 1 hit
3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001054, A/G_cyclase
IPR013716, Adenylate_cyclase_G-a-bd
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR029787, Nucleotide_cyclase
IPR036457, PPM-type_dom_sf
IPR001932, PPM-type_phosphatase_dom
IPR000159, RA_dom
PfamiView protein in Pfam
PF08509, Ad_cyc_g-alpha, 1 hit
PF00211, Guanylate_cyc, 1 hit
PF13855, LRR_8, 4 hits
PF00481, PP2C, 1 hit
SMARTiView protein in SMART
SM00789, Ad_cyc_g-alpha, 1 hit
SM00044, CYCc, 1 hit
SM00369, LRR_TYP, 11 hits
SM00332, PP2Cc, 1 hit
SM00314, RA, 1 hit
SUPFAMiSSF55073, SSF55073, 1 hit
SSF81606, SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS50125, GUANYLATE_CYCLASE_2, 1 hit
PS51450, LRR, 15 hits
PS51746, PPM_2, 1 hit
PS50200, RA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYAA_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08678
Secondary accession number(s): D6VWH0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1995
Last modified: February 23, 2022
This is version 210 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again