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UniProtKB - P08664 (MERB_SERMA)
Protein
Alkylmercury lyase
Gene
merB
Organism
Serratia marcescens
Status
Functioni
Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase.
Catalytic activityi
- EC:4.99.1.2
GO - Molecular functioni
- alkylmercury lyase activity Source: UniProtKB-UniRule
GO - Biological processi
- organomercury catabolic process Source: InterPro
- response to mercury ion Source: UniProtKB-UniRule
Keywordsi
Molecular function | Lyase |
Biological process | Mercuric resistance |
Ligand | Mercury |
Enzyme and pathway databases
BRENDAi | 4.99.1.2, 5690 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:merB |
Encoded oni | Plasmid pDU1358 |
Organismi | Serratia marcescens |
Taxonomic identifieri | 615 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Yersiniaceae › Serratia |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220360 | 1 – 212 | Alkylmercury lyaseAdd BLAST | 212 |
Family & Domainsi
Sequence similaritiesi
Belongs to the MerB family.Curated
Family and domain databases
HAMAPi | MF_00714, MerB, 1 hit |
InterProi | View protein in InterPro IPR004927, MerB IPR024259, MerB_HTH_dom IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF12324, HTH_15, 1 hit PF03243, MerB, 1 hit |
PIRSFi | PIRSF001458, MerB, 1 hit |
PRINTSi | PR01699, ORGNOHGLYASE |
SUPFAMi | SSF46785, SSF46785, 1 hit |
i Sequence
Sequence statusi: Complete.
P08664-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLAPYILER LTSVNRTNGT ADLLVPLLRE LAKGRPVSRT TLAGILDWPA
60 70 80 90 100
ERVAAVLEQA TSTEYDKDGN IIGYGLTLRE TSYVFEIDDR RLYAWCALDT
110 120 130 140 150
LIFPALIGRT ARVSSHCAAT GAPVSLTVSP SEIQAVEPAG MAVSLVLPQE
160 170 180 190 200
AADVRQSFCC HVHFFASVPT AEDWASKHQG LEGLAIVSVH EAFGLGQEFN
210
RHLLQTMSSR TP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15049 Genomic DNA Translation: AAA88369.1 |
PIRi | B29010 |
RefSeqi | WP_000761850.1, NZ_LR890658.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15049 Genomic DNA Translation: AAA88369.1 |
PIRi | B29010 |
RefSeqi | WP_000761850.1, NZ_LR890658.1 |
3D structure databases
BMRBi | P08664 |
SMRi | P08664 |
ModBasei | Search... |
Enzyme and pathway databases
BRENDAi | 4.99.1.2, 5690 |
Family and domain databases
HAMAPi | MF_00714, MerB, 1 hit |
InterProi | View protein in InterPro IPR004927, MerB IPR024259, MerB_HTH_dom IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF12324, HTH_15, 1 hit PF03243, MerB, 1 hit |
PIRSFi | PIRSF001458, MerB, 1 hit |
PRINTSi | PR01699, ORGNOHGLYASE |
SUPFAMi | SSF46785, SSF46785, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MERB_SERMA | |
Accessioni | P08664Primary (citable) accession number: P08664 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 1, 1988 | |
Last modified: | September 29, 2021 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
PlasmidDocuments
- SIMILARITY comments
Index of protein domains and families