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Protein

Luciferin 4-monooxygenase

Gene
N/A
Organism
Photinus pyralis (Common eastern firefly) (Lampyris pyralis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produces green light with a wavelength of 562 nm.By similarity

Catalytic activityi

D-firefly luciferin + O2 + ATP = firefly oxyluciferin + CO2 + AMP + diphosphate + light.By similarity

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase, Photoprotein
Biological processLuminescence
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi1.13.12.7 4775
6.2.1.3 4775
SABIO-RKiP08659

Names & Taxonomyi

Protein namesi
Recommended name:
Luciferin 4-monooxygenase (EC:1.13.12.7By similarity)
Short name:
Luciferase
OrganismiPhotinus pyralis (Common eastern firefly) (Lampyris pyralis)
Taxonomic identifieri7054 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaColeopteraPolyphagaElateriformiaElateroideaLampyridaeLampyrinaePhotinus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5567

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001931471 – 550Luciferin 4-monooxygenaseAdd BLAST550

Proteomic databases

PRIDEiP08659

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ELMiP08659
IntActiP08659, 1 interactor
MINTiP08659

Chemistry databases

BindingDBiP08659

Structurei

Secondary structure

1550
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08659
SMRiP08659
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08659

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi548 – 550Microbody targeting signal3

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.8.10, 1 hit
InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR027380 Luciferase-like_N_sf
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P08659-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDAKNIKKG PAPFYPLEDG TAGEQLHKAM KRYALVPGTI AFTDAHIEVN
60 70 80 90 100
ITYAEYFEMS VRLAEAMKRY GLNTNHRIVV CSENSLQFFM PVLGALFIGV
110 120 130 140 150
AVAPANDIYN ERELLNSMNI SQPTVVFVSK KGLQKILNVQ KKLPIIQKII
160 170 180 190 200
IMDSKTDYQG FQSMYTFVTS HLPPGFNEYD FVPESFDRDK TIALIMNSSG
210 220 230 240 250
STGLPKGVAL PHRTACVRFS HARDPIFGNQ IIPDTAILSV VPFHHGFGMF
260 270 280 290 300
TTLGYLICGF RVVLMYRFEE ELFLRSLQDY KIQSALLVPT LFSFFAKSTL
310 320 330 340 350
IDKYDLSNLH EIASGGAPLS KEVGEAVAKR FHLPGIRQGY GLTETTSAIL
360 370 380 390 400
ITPEGDDKPG AVGKVVPFFE AKVVDLDTGK TLGVNQRGEL CVRGPMIMSG
410 420 430 440 450
YVNNPEATNA LIDKDGWLHS GDIAYWDEDE HFFIVDRLKS LIKYKGYQVA
460 470 480 490 500
PAELESILLQ HPNIFDAGVA GLPDDDAGEL PAAVVVLEHG KTMTEKEIVD
510 520 530 540 550
YVASQVTTAK KLRGGVVFVD EVPKGLTGKL DARKIREILI KAKKGGKSKL
Length:550
Mass (Da):60,745
Last modified:January 1, 1988 - v1
Checksum:iE380FCE9D56ACCDE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361A → G in CAA59281 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15077 Genomic DNA Translation: AAA29795.1
X84846 Genomic DNA Translation: CAA59281.1
X84848 Genomic DNA Translation: CAA59283.1
U03687 Unassigned DNA Translation: AAA03561.1
U89934 Genomic DNA Translation: AAB64396.1
U89935 Genomic DNA Translation: AAB64399.1
PIRiA26772

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Firefly luciferase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15077 Genomic DNA Translation: AAA29795.1
X84846 Genomic DNA Translation: CAA59281.1
X84848 Genomic DNA Translation: CAA59283.1
U03687 Unassigned DNA Translation: AAA03561.1
U89934 Genomic DNA Translation: AAB64396.1
U89935 Genomic DNA Translation: AAB64399.1
PIRiA26772

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BA3X-ray2.20A1-550[»]
1LCIX-ray2.00A1-550[»]
3IEPX-ray2.10A1-550[»]
3IERX-ray2.05A1-550[»]
3IESX-ray2.00A1-550[»]
3RIXX-ray1.70A1-550[»]
4E5DX-ray2.20A1-550[»]
4G36X-ray2.62A/B1-550[»]
4G37X-ray2.40A/B1-550[»]
5DV9X-ray2.40A1-550[»]
5DWVX-ray2.30A1-550[»]
5GYZX-ray2.40A4-438[»]
5GZ2X-ray2.00A3-438[»]
5KYTX-ray2.00A/B1-550[»]
5KYVX-ray2.50A/B1-550[»]
5WYSX-ray3.00A1-550[»]
ProteinModelPortaliP08659
SMRiP08659
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP08659
IntActiP08659, 1 interactor
MINTiP08659

Chemistry databases

BindingDBiP08659
ChEMBLiCHEMBL5567

Proteomic databases

PRIDEiP08659

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.13.12.7 4775
6.2.1.3 4775
SABIO-RKiP08659

Miscellaneous databases

EvolutionaryTraceiP08659

Family and domain databases

Gene3Di4.10.8.10, 1 hit
InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR027380 Luciferase-like_N_sf
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLUCI_PHOPY
AccessioniPrimary (citable) accession number: P08659
Secondary accession number(s): Q27755
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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