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Protein

Luciferin 4-monooxygenase

Gene
N/A
Organism
Photinus pyralis (Common eastern firefly) (Lampyris pyralis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produces green light with a wavelength of 562 nm.By similarity

Catalytic activityi

D-firefly luciferin + O2 + ATP = firefly oxyluciferin + CO2 + AMP + diphosphate + light.By similarity

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase, Photoprotein
Biological processLuminescence
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi1.13.12.7 4775
6.2.1.3 4775
SABIO-RKiP08659

Names & Taxonomyi

Protein namesi
Recommended name:
Luciferin 4-monooxygenase (EC:1.13.12.7By similarity)
Short name:
Luciferase
OrganismiPhotinus pyralis (Common eastern firefly) (Lampyris pyralis)
Taxonomic identifieri7054 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaColeopteraPolyphagaElateriformiaElateroideaLampyridaeLampyrinaePhotinus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5567

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001931471 – 550Luciferin 4-monooxygenaseAdd BLAST550

Proteomic databases

PRIDEiP08659

Interactioni

GO - Molecular functioni

  • chaperone binding Source: CAFA

Protein-protein interaction databases

ELMiP08659
IntActiP08659, 1 interactor
MINTiP08659

Chemistry databases

BindingDBiP08659

Structurei

Secondary structure

1550
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Beta strandi7 – 9Combined sources3
Helixi22 – 34Combined sources13
Beta strandi40 – 44Combined sources5
Turni45 – 47Combined sources3
Beta strandi50 – 52Combined sources3
Helixi53 – 70Combined sources18
Beta strandi77 – 81Combined sources5
Turni86 – 88Combined sources3
Helixi89 – 97Combined sources9
Beta strandi101 – 104Combined sources4
Helixi111 – 121Combined sources11
Beta strandi124 – 128Combined sources5
Helixi130 – 132Combined sources3
Helixi133 – 142Combined sources10
Beta strandi148 – 151Combined sources4
Beta strandi161 – 163Combined sources3
Helixi164 – 171Combined sources8
Turni178 – 180Combined sources3
Turni188 – 190Combined sources3
Beta strandi191 – 197Combined sources7
Beta strandi201 – 204Combined sources4
Beta strandi207 – 211Combined sources5
Helixi212 – 222Combined sources11
Turni225 – 227Combined sources3
Beta strandi236 – 239Combined sources4
Helixi246 – 258Combined sources13
Beta strandi261 – 264Combined sources4
Helixi270 – 279Combined sources10
Beta strandi283 – 287Combined sources5
Helixi289 – 297Combined sources9
Helixi300 – 303Combined sources4
Beta strandi311 – 314Combined sources4
Helixi321 – 330Combined sources10
Beta strandi337 – 341Combined sources5
Helixi343 – 345Combined sources3
Beta strandi346 – 351Combined sources6
Beta strandi363 – 365Combined sources3
Beta strandi370 – 374Combined sources5
Turni376 – 378Combined sources3
Beta strandi388 – 394Combined sources7
Beta strandi399 – 401Combined sources3
Helixi405 – 411Combined sources7
Turni414 – 416Combined sources3
Beta strandi418 – 426Combined sources9
Beta strandi432 – 434Combined sources3
Helixi438 – 440Combined sources3
Beta strandi442 – 444Combined sources3
Beta strandi447 – 449Combined sources3
Helixi451 – 459Combined sources9
Beta strandi464 – 474Combined sources11
Turni475 – 477Combined sources3
Beta strandi478 – 487Combined sources10
Helixi495 – 505Combined sources11
Helixi508 – 510Combined sources3
Beta strandi515 – 521Combined sources7
Beta strandi528 – 530Combined sources3
Helixi532 – 542Combined sources11
Turni544 – 546Combined sources3

3D structure databases

ProteinModelPortaliP08659
SMRiP08659
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08659

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi548 – 550Microbody targeting signal3

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.8.10, 1 hit
InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR027380 Luciferase-like_N_sf
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P08659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDAKNIKKG PAPFYPLEDG TAGEQLHKAM KRYALVPGTI AFTDAHIEVN
60 70 80 90 100
ITYAEYFEMS VRLAEAMKRY GLNTNHRIVV CSENSLQFFM PVLGALFIGV
110 120 130 140 150
AVAPANDIYN ERELLNSMNI SQPTVVFVSK KGLQKILNVQ KKLPIIQKII
160 170 180 190 200
IMDSKTDYQG FQSMYTFVTS HLPPGFNEYD FVPESFDRDK TIALIMNSSG
210 220 230 240 250
STGLPKGVAL PHRTACVRFS HARDPIFGNQ IIPDTAILSV VPFHHGFGMF
260 270 280 290 300
TTLGYLICGF RVVLMYRFEE ELFLRSLQDY KIQSALLVPT LFSFFAKSTL
310 320 330 340 350
IDKYDLSNLH EIASGGAPLS KEVGEAVAKR FHLPGIRQGY GLTETTSAIL
360 370 380 390 400
ITPEGDDKPG AVGKVVPFFE AKVVDLDTGK TLGVNQRGEL CVRGPMIMSG
410 420 430 440 450
YVNNPEATNA LIDKDGWLHS GDIAYWDEDE HFFIVDRLKS LIKYKGYQVA
460 470 480 490 500
PAELESILLQ HPNIFDAGVA GLPDDDAGEL PAAVVVLEHG KTMTEKEIVD
510 520 530 540 550
YVASQVTTAK KLRGGVVFVD EVPKGLTGKL DARKIREILI KAKKGGKSKL
Length:550
Mass (Da):60,745
Last modified:January 1, 1988 - v1
Checksum:iE380FCE9D56ACCDE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti361A → G in CAA59281 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15077 Genomic DNA Translation: AAA29795.1
X84846 Genomic DNA Translation: CAA59281.1
X84848 Genomic DNA Translation: CAA59283.1
U03687 Unassigned DNA Translation: AAA03561.1
U89934 Genomic DNA Translation: AAB64396.1
U89935 Genomic DNA Translation: AAB64399.1
PIRiA26772

Similar proteinsi

Entry informationi

Entry nameiLUCI_PHOPY
AccessioniPrimary (citable) accession number: P08659
Secondary accession number(s): Q27755
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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