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UniProtKB - P08651 (NFIC_HUMAN)

Entry version 211 (23 Feb 2022)
Sequence version 2 (01 Jun 2001)
Previous versions | rss
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Protein

Nuclear factor 1 C-type

Gene

NFIC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1 – 195CTF/NF-IPROSITE-ProRule annotationAdd BLAST195

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processDNA replication, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08651

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-73980, RNA Polymerase III Transcription Termination
R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P08651

SIGNOR Signaling Network Open Resource

More...SIGNORi		P08651

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear factor 1 C-type
Short name:
NF1-C
Short name:
Nuclear factor 1/C
Alternative name(s):
CCAAT-box-binding transcription factor
Short name:
CTF
Nuclear factor I/C
Short name:
NF-I/C
Short name:
NFI-C
TGGCA-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFIC
Synonyms:NFI
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7786, NFIC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600729, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08651

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000141905

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4782

Open Targets

More...OpenTargetsi		ENSG00000141905

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31592

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08651, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NFIC

Domain mapping of disease mutations (DMDM)

More...DMDMi		14195672

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001001991 – 508Nuclear factor 1 C-typeAdd BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei300PhosphotyrosineBy similarity1
Modified residuei302PhosphoserineBy similarity1
Modified residuei304PhosphoserineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei365Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei365Omega-N-methylarginine; alternateCombined sources1
Modified residuei395Asymmetric dimethylarginineCombined sources1
Modified residuei451Omega-N-methylarginineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P08651

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P08651

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08651

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08651

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08651

PeptideAtlas

More...PeptideAtlasi		P08651

PRoteomics IDEntifications database

More...PRIDEi		P08651

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52148 [P08651-1]
52149 [P08651-2]
52150 [P08651-3]
52151 [P08651-4]
52152 [P08651-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P08651, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08651

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08651

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000141905, Expressed in parotid gland and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P08651, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08651, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000141905, Tissue enriched (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a homodimer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110854, 61 interactors

Database of interacting proteins

More...DIPi		DIP-44692N

Protein interaction database and analysis system

More...IntActi		P08651, 29 interactors

Molecular INTeraction database

More...MINTi		P08651

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000396843

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08651, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni190 – 209DisorderedSequence analysisAdd BLAST20
Regioni267 – 348DisorderedSequence analysisAdd BLAST82
Regioni438 – 495DisorderedSequence analysisAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi404 – 4129aaTAD1 Publication9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi194 – 209Polar residuesSequence analysisAdd BLAST16
Compositional biasi267 – 281Polar residuesSequence analysisAdd BLAST15
Compositional biasi297 – 317Polar residuesSequence analysisAdd BLAST21
Compositional biasi329 – 348Polar residuesSequence analysisAdd BLAST20
Compositional biasi462 – 484Polar residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CTF/NF-I family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3663, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182916

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012576_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08651

Identification of Orthologs from Complete Genome Data

More...OMAi		YFVRERX

Database of Orthologous Groups

More...OrthoDBi		967862at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08651

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000647, CTF/NFI
IPR020604, CTF/NFI_DNA-bd-dom
IPR019739, CTF/NFI_DNA-bd_CS
IPR019548, CTF/NFI_DNA-bd_N
IPR003619, MAD_homology1_Dwarfin-type

The PANTHER Classification System

More...PANTHERi		PTHR11492, PTHR11492, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00859, CTF_NFI, 1 hit
PF03165, MH1, 1 hit
PF10524, NfI_DNAbd_pre-N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00523, DWA, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00349, CTF_NFI_1, 1 hit
PS51080, CTF_NFI_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 4 (identifier: P08651-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS 
        60         70         80         90        100
KDEERAVKDE LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK 
       110        120        130        140        150
APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER 
       160        170        180        190        200
LVKAAQCGHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSGSPRTGMG 
       210        220        230        240        250
SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG 
       260        270        280        290        300
ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY 
       310        320        330        340        350
TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT 
       360        370        380        390        400
QHHRPVIAVH SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL 
       410        420        430        440        450
NPQDPLKDLV SLACDPASQQ PGPLNGSGQL KMPSHCLSAQ MLAPPPPGLP 
       460        470        480        490        500
RLALPPATKP ATTSEGGATS PTSPSYSPPD TSPANRSFVG LGPRDPAGIY 

QAQSWYLG
Length:508
Mass (Da):55,675
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D0F97DA0F3AF992
GO
Isoform 1 (identifier: P08651-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M

Show »
Length:499
Mass (Da):54,682
Checksum:iB6A59BD10B4B6D1B
GO
Isoform 2 (identifier: P08651-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

Show »
Length:430
Mass (Da):47,901
Checksum:i99820E6484D655B3
GO
Isoform 3 (identifier: P08651-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     188-211: Missing.
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

Show »
Length:406
Mass (Da):45,413
Checksum:iEA00A93762A9FAC1
GO
Isoform 5 (identifier: P08651-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-503: Missing.

Show »
Length:428
Mass (Da):47,629
Checksum:i239F7A15BBEA2539
GO
Isoform 6 (identifier: P08651-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-508: LNGSGQLKMP...IYQAQSWYLG → PTLRPTRPLQTVPLWD

Show »
Length:439
Mass (Da):48,894
Checksum:i5A9A6B88FAF84891
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YEX4A0A286YEX4_HUMAN
Nuclear factor 1
NFIC
530Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti130L → P in BAH12681 (PubMed:14702039).Curated1
Sequence conflicti212D → V in CAA63440 (PubMed:8710515).Curated1
Sequence conflicti329E → K in BAH12681 (PubMed:14702039).Curated1
Sequence conflicti353H → Y in BAH12681 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057656417A → S. Corresponds to variant dbSNP:rs10412720Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0035521 – 10MYSSPLCLTQ → M in isoform 1, isoform 2 and isoform 3. 2 Publications10
Alternative sequenceiVSP_003553188 – 211Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_047539424 – 508LNGSG…SWYLG → PTLRPTRPLQTVPLWD in isoform 6. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_003554424 – 503Missing in isoform 5. 2 PublicationsAdd BLAST80
Alternative sequenceiVSP_003555424 – 439LNGSG…HCLSA → PTLRPTRPLQTVPLWD in isoform 2 and isoform 3. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_003556440 – 508Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X12492 mRNA Translation: CAA31012.1
X92857 mRNA Translation: CAA63440.1
AK289885 mRNA Translation: BAF82574.1
AK297867 mRNA Translation: BAH12681.1
AK304816 mRNA Translation: BAH14259.1
AC005514 Genomic DNA Translation: AAC32593.1
AC005514 Genomic DNA Translation: AAC32594.1
AC005551 Genomic DNA Translation: AAC33190.1
AC005551 Genomic DNA Translation: AAC33191.1
AC005551 Genomic DNA Translation: AAC33192.1
AC005778 Genomic DNA Translation: AAC62842.1
CH471139 Genomic DNA Translation: EAW69325.1
CH471139 Genomic DNA Translation: EAW69326.1
BC012120 mRNA Translation: AAH12120.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12107.1 [P08651-5]
CCDS45914.1 [P08651-2]
CCDS58640.1 [P08651-3]
CCDS59330.1 [P08651-1]
CCDS59331.1 [P08651-6]

Protein sequence database of the Protein Information Resource

More...PIRi		B33416
S01038

NCBI Reference Sequences

More...RefSeqi		NP_001231931.1, NM_001245002.1 [P08651-1]
NP_001231933.1, NM_001245004.1 [P08651-6]
NP_001231934.1, NM_001245005.1 [P08651-3]
NP_005588.2, NM_005597.3 [P08651-5]
NP_995315.1, NM_205843.2 [P08651-2]
XP_016882324.1, XM_017026835.1 [P08651-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341919; ENSP00000342194; ENSG00000141905 [P08651-5]
ENST00000395111; ENSP00000378543; ENSG00000141905 [P08651-3]
ENST00000443272; ENSP00000396843; ENSG00000141905
ENST00000586919; ENSP00000465177; ENSG00000141905 [P08651-4]
ENST00000589123; ENSP00000465655; ENSG00000141905 [P08651-2]
ENST00000590282; ENSP00000466647; ENSG00000141905 [P08651-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4782

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000443272.3; ENSP00000396843.2; NM_001245002.2; NP_001231931.1

UCSC genome browser

More...UCSCi		uc002lxo.3, human [P08651-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12492 mRNA Translation: CAA31012.1
X92857 mRNA Translation: CAA63440.1
AK289885 mRNA Translation: BAF82574.1
AK297867 mRNA Translation: BAH12681.1
AK304816 mRNA Translation: BAH14259.1
AC005514 Genomic DNA Translation: AAC32593.1
AC005514 Genomic DNA Translation: AAC32594.1
AC005551 Genomic DNA Translation: AAC33190.1
AC005551 Genomic DNA Translation: AAC33191.1
AC005551 Genomic DNA Translation: AAC33192.1
AC005778 Genomic DNA Translation: AAC62842.1
CH471139 Genomic DNA Translation: EAW69325.1
CH471139 Genomic DNA Translation: EAW69326.1
BC012120 mRNA Translation: AAH12120.1
CCDSiCCDS12107.1 [P08651-5]
CCDS45914.1 [P08651-2]
CCDS58640.1 [P08651-3]
CCDS59330.1 [P08651-1]
CCDS59331.1 [P08651-6]
PIRiB33416
S01038
RefSeqiNP_001231931.1, NM_001245002.1 [P08651-1]
NP_001231933.1, NM_001245004.1 [P08651-6]
NP_001231934.1, NM_001245005.1 [P08651-3]
NP_005588.2, NM_005597.3 [P08651-5]
NP_995315.1, NM_205843.2 [P08651-2]
XP_016882324.1, XM_017026835.1 [P08651-6]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi110854, 61 interactors
DIPiDIP-44692N
IntActiP08651, 29 interactors
MINTiP08651
STRINGi9606.ENSP00000396843

PTM databases

GlyGeniP08651, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP08651
PhosphoSitePlusiP08651

Genetic variation databases

BioMutaiNFIC
DMDMi14195672

Proteomic databases

EPDiP08651
jPOSTiP08651
MassIVEiP08651
MaxQBiP08651
PaxDbiP08651
PeptideAtlasiP08651
PRIDEiP08651
ProteomicsDBi52148 [P08651-1]
52149 [P08651-2]
52150 [P08651-3]
52151 [P08651-4]
52152 [P08651-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23195, 298 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		4782

Genome annotation databases

EnsembliENST00000341919; ENSP00000342194; ENSG00000141905 [P08651-5]
ENST00000395111; ENSP00000378543; ENSG00000141905 [P08651-3]
ENST00000443272; ENSP00000396843; ENSG00000141905
ENST00000586919; ENSP00000465177; ENSG00000141905 [P08651-4]
ENST00000589123; ENSP00000465655; ENSG00000141905 [P08651-2]
ENST00000590282; ENSP00000466647; ENSG00000141905 [P08651-6]
GeneIDi4782
KEGGihsa:4782
MANE-SelectiENST00000443272.3; ENSP00000396843.2; NM_001245002.2; NP_001231931.1
UCSCiuc002lxo.3, human [P08651-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4782
DisGeNETi4782

GeneCards: human genes, protein and diseases

More...GeneCardsi		NFIC
HGNCiHGNC:7786, NFIC
HPAiENSG00000141905, Tissue enriched (skeletal)
MIMi600729, gene
neXtProtiNX_P08651
OpenTargetsiENSG00000141905
PharmGKBiPA31592
VEuPathDBiHostDB:ENSG00000141905

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3663, Eukaryota
GeneTreeiENSGT00950000182916
HOGENOMiCLU_012576_3_0_1
InParanoidiP08651
OMAiYFVRERX
OrthoDBi967862at2759
PhylomeDBiP08651

Enzyme and pathway databases

PathwayCommonsiP08651
ReactomeiR-HSA-73980, RNA Polymerase III Transcription Termination
R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
SignaLinkiP08651
SIGNORiP08651

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4782, 18 hits in 1071 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NFIC, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NFIC_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4782
PharosiP08651, Tbio

Protein Ontology

More...PROi		PR:P08651
RNActiP08651, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000141905, Expressed in parotid gland and 247 other tissues
ExpressionAtlasiP08651, baseline and differential
GenevisibleiP08651, HS

Family and domain databases

InterProiView protein in InterPro
IPR000647, CTF/NFI
IPR020604, CTF/NFI_DNA-bd-dom
IPR019739, CTF/NFI_DNA-bd_CS
IPR019548, CTF/NFI_DNA-bd_N
IPR003619, MAD_homology1_Dwarfin-type
PANTHERiPTHR11492, PTHR11492, 1 hit
PfamiView protein in Pfam
PF00859, CTF_NFI, 1 hit
PF03165, MH1, 1 hit
PF10524, NfI_DNAbd_pre-N, 1 hit
SMARTiView protein in SMART
SM00523, DWA, 1 hit
PROSITEiView protein in PROSITE
PS00349, CTF_NFI_1, 1 hit
PS51080, CTF_NFI_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFIC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08651
Secondary accession number(s): A8K1H0
, B7Z4U5, B7Z9C3, K7EMU1, P08652, Q14932, Q9UPJ3, Q9UPJ9, Q9UPK0, Q9UPK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 1, 2001
Last modified: February 23, 2022
This is version 211 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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