NFIC

Functionⁱ

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	1 – 195	CTF/NF-IPROSITE-ProRule annotationAdd BLAST		195

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
- 1524678
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 1524678
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 1524678

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA replication Source: UniProtKB-KW
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 19706729
odontogenesis of dentin-containing tooth Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 19706729
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 8710515

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	DNA replication, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-73980 RNA Polymerase III Transcription Termination R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
SignaLinkⁱ	P08651
SIGNORⁱ	P08651

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear factor 1 C-type Short name: NF1-C Short name: Nuclear factor 1/C Alternative name(s): CCAAT-box-binding transcription factor Short name: CTF Nuclear factor I/C Short name: NF-I/C Short name: NFI-C TGGCA-binding protein
Gene namesⁱ	Name:NFIC Synonyms:NFI
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000141905.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7786 NFIC
MIMⁱ	600729 gene
neXtProtⁱ	NX_P08651

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4782
Open Targets More...OpenTargetsⁱ	ENSG00000141905
PharmGKBⁱ	PA31592

Polymorphism and mutation databases

BioMutaⁱ	NFIC
DMDMⁱ	14195672

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000100199	1 – 508	Nuclear factor 1 C-typeAdd BLAST		508

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	194	PhosphoserineCombined sources	1
Modified residueⁱ	294	PhosphoserineCombined sources	1
Modified residueⁱ	300	PhosphotyrosineBy similarity	1
Modified residueⁱ	302	PhosphoserineBy similarity	1
Modified residueⁱ	304	PhosphoserineCombined sources	1
Modified residueⁱ	305	PhosphoserineCombined sources	1
Modified residueⁱ	323	PhosphoserineCombined sources	1
Modified residueⁱ	333	PhosphoserineCombined sources	1
Modified residueⁱ	337	PhosphoserineCombined sources	1
Modified residueⁱ	339	PhosphoserineCombined sources	1
Modified residueⁱ	343	PhosphoserineCombined sources	1
Modified residueⁱ	365	Asymmetric dimethylarginine; alternateCombined sources	1
Modified residueⁱ	365	Omega-N-methylarginine; alternateCombined sources	1
Modified residueⁱ	395	Asymmetric dimethylarginineCombined sources	1
Modified residueⁱ	451	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	475	PhosphoserineCombined sources	1
Modified residueⁱ	477	PhosphoserineCombined sources	1
Modified residueⁱ	487	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	P08651
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08651
PaxDbⁱ	P08651
PeptideAtlas More...PeptideAtlasⁱ	P08651
PRIDEⁱ	P08651
ProteomicsDBⁱ	52148 52149 [P08651-2] 52150 [P08651-3] 52151 [P08651-4] 52152 [P08651-5]

PTM databases

iPTMnetⁱ	P08651
PhosphoSitePlusⁱ	P08651

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000141905 Expressed in 236 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_NFIC
ExpressionAtlasⁱ	P08651 baseline and differential
Genevisibleⁱ	P08651 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004300 CAB004674 HPA052625

HPAⁱ

CAB004300
CAB004674
HPA052625

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homodimer.

Protein-protein interaction databases

BioGridⁱ	110854, 23 interactors
Database of interacting proteins More...DIPⁱ	DIP-44692N
IntActⁱ	P08651, 22 interactors
Molecular INTeraction database More...MINTⁱ	P08651
STRINGⁱ	9606.ENSP00000465655

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P08651
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CTF/NF-I family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3663 Eukaryota ENOG410Y16G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009905
HOGENOMⁱ	HOG000013028
HOVERGENⁱ	HBG006561
InParanoidⁱ	P08651
KEGG Orthology (KO) More...KOⁱ	K09170
OMAⁱ	ACDPANQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HVY
PhylomeDBⁱ	P08651

Family and domain databases

InterProⁱ	View protein in InterPro IPR000647 CTF/NFI IPR020604 CTF/NFI_DNA-bd-dom IPR019739 CTF/NFI_DNA-bd_CS IPR019548 CTF/NFI_DNA-bd_N IPR003619 MAD_homology1_Dwarfin-type
PANTHERⁱ	PTHR11492 PTHR11492, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00859 CTF_NFI, 1 hit PF03165 MH1, 1 hit PF10524 NfI_DNAbd_pre-N, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00349 CTF_NFI_1, 1 hit PS51080 CTF_NFI_2, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 4 (identifier: P08651-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS 
        60         70         80         90        100
KDEERAVKDE LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK 
       110        120        130        140        150
APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER 
       160        170        180        190        200
LVKAAQCGHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSGSPRTGMG 
       210        220        230        240        250
SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG 
       260        270        280        290        300
ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY 
       310        320        330        340        350
TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT 
       360        370        380        390        400
QHHRPVIAVH SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL 
       410        420        430        440        450
NPQDPLKDLV SLACDPASQQ PGPLNGSGQL KMPSHCLSAQ MLAPPPPGLP 
       460        470        480        490        500
RLALPPATKP ATTSEGGATS PTSPSYSPPD TSPANRSFVG LGPRDPAGIY 

QAQSWYLG

Length:508

Mass (Da):55,675

Last modified:June 1, 2001 - v2

Checksum:ⁱ3D0F97DA0F3AF992

GO

Isoform 1 (identifier: P08651-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-10: MYSSPLCLTQ → M

« Hide

        10         20         30         40         50
MDEFHPFIEA LLPHVRAFAY TWFNLQARKR KYFKKHEKRM SKDEERAVKD 
        60         70         80         90        100
ELLGEKPEVK QKWASRLLAK LRKDIRPECR EDFVLSITGK KAPGCVLSNP 
       110        120        130        140        150
DQKGKMRRID CLRQADKVWR LDLVMVILFK GIPLESTDGE RLVKAAQCGH 
       160        170        180        190        200
PVLCVQPHHI GVAVKELDLY LAYFVRERDA EQSGSPRTGM GSDQEDSKPI 
       210        220        230        240        250
TLDTTDFQES FVTSGVFSVT ELIQVSRTPV VTGTGPNFSL GELQGHLAYD 
       260        270        280        290        300
LNPASTGLRR TLPSTSSSGS KRHKSGSMEE DVDTSPGGDY YTSPSSPTSS 
       310        320        330        340        350
SRNWTEDMEG GISSPVKKTE MDKSPFNSPS PQDSPRLSSF TQHHRPVIAV 
       360        370        380        390        400
HSGIARSPHP SSALHFPTTS ILPQTASTYF PHTAIRYPPH LNPQDPLKDL 
       410        420        430        440        450
VSLACDPASQ QPGPLNGSGQ LKMPSHCLSA QMLAPPPPGL PRLALPPATK 
       460        470        480        490 
PATTSEGGAT SPTSPSYSPP DTSPANRSFV GLGPRDPAGI YQAQSWYLG

Show »

Length:499

Mass (Da):54,682

Checksum:ⁱB6A59BD10B4B6D1B

GO

Isoform 2 (identifier: P08651-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

« Hide

        10         20         30         40         50
MDEFHPFIEA LLPHVRAFAY TWFNLQARKR KYFKKHEKRM SKDEERAVKD 
        60         70         80         90        100
ELLGEKPEVK QKWASRLLAK LRKDIRPECR EDFVLSITGK KAPGCVLSNP 
       110        120        130        140        150
DQKGKMRRID CLRQADKVWR LDLVMVILFK GIPLESTDGE RLVKAAQCGH 
       160        170        180        190        200
PVLCVQPHHI GVAVKELDLY LAYFVRERDA EQSGSPRTGM GSDQEDSKPI 
       210        220        230        240        250
TLDTTDFQES FVTSGVFSVT ELIQVSRTPV VTGTGPNFSL GELQGHLAYD 
       260        270        280        290        300
LNPASTGLRR TLPSTSSSGS KRHKSGSMEE DVDTSPGGDY YTSPSSPTSS 
       310        320        330        340        350
SRNWTEDMEG GISSPVKKTE MDKSPFNSPS PQDSPRLSSF TQHHRPVIAV 
       360        370        380        390        400
HSGIARSPHP SSALHFPTTS ILPQTASTYF PHTAIRYPPH LNPQDPLKDL 
       410        420        430
VSLACDPASQ QPGPPTLRPT RPLQTVPLWD

Show »

Length:430

Mass (Da):47,901

Checksum:ⁱ99820E6484D655B3

GO

Isoform 3 (identifier: P08651-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     188-211: Missing.
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

« Hide

        10         20         30         40         50
MDEFHPFIEA LLPHVRAFAY TWFNLQARKR KYFKKHEKRM SKDEERAVKD 
        60         70         80         90        100
ELLGEKPEVK QKWASRLLAK LRKDIRPECR EDFVLSITGK KAPGCVLSNP 
       110        120        130        140        150
DQKGKMRRID CLRQADKVWR LDLVMVILFK GIPLESTDGE RLVKAAQCGH 
       160        170        180        190        200
PVLCVQPHHI GVAVKELDLY LAYFVRERDT TDFQESFVTS GVFSVTELIQ 
       210        220        230        240        250
VSRTPVVTGT GPNFSLGELQ GHLAYDLNPA STGLRRTLPS TSSSGSKRHK 
       260        270        280        290        300
SGSMEEDVDT SPGGDYYTSP SSPTSSSRNW TEDMEGGISS PVKKTEMDKS 
       310        320        330        340        350
PFNSPSPQDS PRLSSFTQHH RPVIAVHSGI ARSPHPSSAL HFPTTSILPQ 
       360        370        380        390        400
TASTYFPHTA IRYPPHLNPQ DPLKDLVSLA CDPASQQPGP PTLRPTRPLQ 

TVPLWD

Show »

Length:406

Mass (Da):45,413

Checksum:ⁱEA00A93762A9FAC1

GO

Isoform 5 (identifier: P08651-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
424-503: Missing.

« Hide

        10         20         30         40         50
MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS 
        60         70         80         90        100
KDEERAVKDE LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK 
       110        120        130        140        150
APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER 
       160        170        180        190        200
LVKAAQCGHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSGSPRTGMG 
       210        220        230        240        250
SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG 
       260        270        280        290        300
ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY 
       310        320        330        340        350
TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT 
       360        370        380        390        400
QHHRPVIAVH SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL 
       410        420 
NPQDPLKDLV SLACDPASQQ PGPSWYLG

Show »

Length:428

Mass (Da):47,629

Checksum:ⁱ239F7A15BBEA2539

GO

Isoform 6 (identifier: P08651-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
424-508: LNGSGQLKMP...IYQAQSWYLG → PTLRPTRPLQTVPLWD

« Hide

        10         20         30         40         50
MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS 
        60         70         80         90        100
KDEERAVKDE LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK 
       110        120        130        140        150
APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER 
       160        170        180        190        200
LVKAAQCGHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSGSPRTGMG 
       210        220        230        240        250
SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG 
       260        270        280        290        300
ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY 
       310        320        330        340        350
TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT 
       360        370        380        390        400
QHHRPVIAVH SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL 
       410        420        430 
NPQDPLKDLV SLACDPASQQ PGPPTLRPTR PLQTVPLWD

Note: No experimental confirmation available.

Show »

Length:439

Mass (Da):48,894

Checksum:ⁱ5A9A6B88FAF84891

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A286YEX4	A0A286YEX4_HUMAN		Nuclear factor 1 Nuclear factor 1	NFIC	530	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	130	L → P in BAH12681 (PubMed:14702039).Curated	1
Sequence conflictⁱ	212	D → V in CAA63440 (PubMed:8710515).Curated	1
Sequence conflictⁱ	329	E → K in BAH12681 (PubMed:14702039).Curated	1
Sequence conflictⁱ	353	H → Y in BAH12681 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_057656	417	A → S. Corresponds to variant dbSNP:rs10412720Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_003552	1 – 10	MYSSPLCLTQ → M in isoform 1, isoform 2 and isoform 3. 2 Publications	10
Alternative sequenceⁱVSP_003553	188 – 211	Missing in isoform 3. 1 PublicationAdd BLAST	24
Alternative sequenceⁱVSP_047539	424 – 508	LNGSG…SWYLG → PTLRPTRPLQTVPLWD in isoform 6. 1 PublicationAdd BLAST	85
Alternative sequenceⁱVSP_003554	424 – 503	Missing in isoform 5. 2 PublicationsAdd BLAST	80
Alternative sequenceⁱVSP_003555	424 – 439	LNGSG…HCLSA → PTLRPTRPLQTVPLWD in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	16
Alternative sequenceⁱVSP_003556	440 – 508	Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	69

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12492 mRNA Translation: CAA31012.1 X92857 mRNA Translation: CAA63440.1 AK289885 mRNA Translation: BAF82574.1 AK297867 mRNA Translation: BAH12681.1 AK304816 mRNA Translation: BAH14259.1 AC005514 Genomic DNA Translation: AAC32593.1 AC005514 Genomic DNA Translation: AAC32594.1 AC005551 Genomic DNA Translation: AAC33190.1 AC005551 Genomic DNA Translation: AAC33191.1 AC005551 Genomic DNA Translation: AAC33192.1 AC005778 Genomic DNA Translation: AAC62842.1 CH471139 Genomic DNA Translation: EAW69325.1 CH471139 Genomic DNA Translation: EAW69326.1 BC012120 mRNA Translation: AAH12120.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12107.1 [P08651-5] CCDS45914.1 [P08651-2] CCDS58640.1 [P08651-3] CCDS59330.1 [P08651-1] CCDS59331.1 [P08651-6]
PIRⁱ	B33416 S01038
NCBI Reference Sequences More...RefSeqⁱ	NP_001231931.1, NM_001245002.1 [P08651-1] NP_001231933.1, NM_001245004.1 [P08651-6] NP_001231934.1, NM_001245005.1 [P08651-3] NP_005588.2, NM_005597.3 [P08651-5] NP_995315.1, NM_205843.2 [P08651-2] XP_016882324.1, XM_017026835.1 [P08651-6]
UniGeneⁱ	Hs.170131

Genome annotation databases

Ensemblⁱ	ENST00000341919; ENSP00000342194; ENSG00000141905 [P08651-5] ENST00000395111; ENSP00000378543; ENSG00000141905 [P08651-3] ENST00000443272; ENSP00000396843; ENSG00000141905 [P08651-1] ENST00000586919; ENSP00000465177; ENSG00000141905 [P08651-4] ENST00000589123; ENSP00000465655; ENSG00000141905 [P08651-2] ENST00000590282; ENSP00000466647; ENSG00000141905 [P08651-6]
GeneIDⁱ	4782
KEGGⁱ	hsa:4782
UCSC genome browser More...UCSCⁱ	uc002lxo.3 human [P08651-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08651	Nuclear factor 1		PONAB		508	UniRef100_P08651
P08651-2	Nuclear factor 1		HUMAN		530	UniRef100_A0A286YEX4
Nuclear factor 1		PONAB		530
Nuclear factor 1		GORGO		530
Nuclear factor 1		PONAB		499
P08651-3	Nuclear factor 1		PONAB		430	UniRef100_A0A2J8SBI2
P08651-4	Nuclear factor 1		PONAB		406	UniRef100_A0A2J8SBE7
Nuclear factor 1		CERAT		406
Nuclear factor 1		PAPAN		406
Nuclear factor 1		RHIRO		405
Nuclear factor 1		GORGO		405
P08651-5	Nuclear factor 1		PANTR		428	UniRef100_A0A2I3T2G9
Nuclear factor 1		PANPA		418
Nuclear factor 1		GORGO		418
P08651-6	Nuclear factor 1		PONAB		439	UniRef100_A0A2J8SBF3

Protein	Similar proteins		Species	Score	Length	Source
P08651	Nuclear factor 1		PONAB		508	UniRef90_P08651
Nuclear factor 1		PANTR		508
Nuclear factor 1		SAIBB		508
Nuclear factor 1		CALJA		508
Nuclear factor 1		CHLSB		508
+21
P08651-2	Nuclear factor 1		MACMU		508	UniRef90_A0A1D5RF27
Nuclear factor 1		MACFA		508
Nuclear factor 1		Cebus capucinus imitator		532
Nuclear factor 1		PAPAN		532
Nuclear factor 1		HUMAN		530
+83
P08651-3	Nuclear factor 1		BOVIN		428	UniRef90_Q4ZJ65
Nuclear factor 1		DELLE		428
Nuclear factor 1		PHYCD		428
Nuclear factor 1		LIPVE		428
Nuclear factor 1		PTEAL		495
+63
P08651-4	Nuclear factor 1		ODORO		415	UniRef90_A0A2U3VKG5
Nuclear factor 1		PANTR		406
Nuclear factor 1		PANPA		405
Nuclear factor 1		COLAP		327
Nuclear factor 1		PROCO		406
+10
P08651-5	Nuclear factor 1		BOVIN		428	UniRef90_Q4ZJ65
Nuclear factor 1		DELLE		428
Nuclear factor 1		PHYCD		428
Nuclear factor 1		LIPVE		428
Nuclear factor 1		PTEAL		495
+63
P08651-6	Nuclear factor 1 C-type		MOUSE		439	UniRef90_P70255
Nuclear factor 1		SAIBB		439
Nuclear factor 1		PONAB		439
Nuclear factor 1		Florida manatee		439
Nuclear factor 1		CALJA		439
+61

Protein	Similar proteins		Species	Score	Length	Source
P08651	Isoform 5 of Nuclear factor 1 A-type		MOUSE		466	UniRef50_Q02780-5
Nuclear factor 1 C-type		PIG		506
Nuclear factor 1 C-type		CHICK		439
Nuclear factor 1		ICTPU		546
Nuclear factor 1		Asian bonytongue		468
+600
P08651-3	Nuclear factor 1		DANRE		432	UniRef50_A0A0R4IU09
Nuclear factor 1		FUNHE		412
Nuclear factor 1		GASAC		465
Nuclear factor 1		TAKRU		508
Nuclear factor 1		MOUSE		391
+174
P08651-4	Isoform 4 of Nuclear factor 1 C-type		MOUSE		397	UniRef50_P70255-4
Nuclear factor 1		DIPOR		421
Nuclear factor 1		ICTTR		387
Nuclear factor 1		Bengalese finch		384
Nuclear factor 1		PIG		484
+44
P08651-5	Nuclear factor 1		DANRE		432	UniRef50_A0A0R4IU09
Nuclear factor 1		FUNHE		412
Nuclear factor 1		GASAC		465
Nuclear factor 1		TAKRU		508
Nuclear factor 1		MOUSE		391
+174

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12492 mRNA Translation: CAA31012.1 X92857 mRNA Translation: CAA63440.1 AK289885 mRNA Translation: BAF82574.1 AK297867 mRNA Translation: BAH12681.1 AK304816 mRNA Translation: BAH14259.1 AC005514 Genomic DNA Translation: AAC32593.1 AC005514 Genomic DNA Translation: AAC32594.1 AC005551 Genomic DNA Translation: AAC33190.1 AC005551 Genomic DNA Translation: AAC33191.1 AC005551 Genomic DNA Translation: AAC33192.1 AC005778 Genomic DNA Translation: AAC62842.1 CH471139 Genomic DNA Translation: EAW69325.1 CH471139 Genomic DNA Translation: EAW69326.1 BC012120 mRNA Translation: AAH12120.1
CCDSⁱ	CCDS12107.1 [P08651-5] CCDS45914.1 [P08651-2] CCDS58640.1 [P08651-3] CCDS59330.1 [P08651-1] CCDS59331.1 [P08651-6]
PIRⁱ	B33416 S01038
RefSeqⁱ	NP_001231931.1, NM_001245002.1 [P08651-1] NP_001231933.1, NM_001245004.1 [P08651-6] NP_001231934.1, NM_001245005.1 [P08651-3] NP_005588.2, NM_005597.3 [P08651-5] NP_995315.1, NM_205843.2 [P08651-2] XP_016882324.1, XM_017026835.1 [P08651-6]
UniGeneⁱ	Hs.170131

3D structure databases

ProteinModelPortalⁱ	P08651
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110854, 23 interactors
DIPⁱ	DIP-44692N
IntActⁱ	P08651, 22 interactors
MINTⁱ	P08651
STRINGⁱ	9606.ENSP00000465655

PTM databases

iPTMnetⁱ	P08651
PhosphoSitePlusⁱ	P08651

Polymorphism and mutation databases

BioMutaⁱ	NFIC
DMDMⁱ	14195672

Proteomic databases

EPDⁱ	P08651
MaxQBⁱ	P08651
PaxDbⁱ	P08651
PeptideAtlasⁱ	P08651
PRIDEⁱ	P08651
ProteomicsDBⁱ	52148 52149 [P08651-2] 52150 [P08651-3] 52151 [P08651-4] 52152 [P08651-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4782
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000341919; ENSP00000342194; ENSG00000141905 [P08651-5] ENST00000395111; ENSP00000378543; ENSG00000141905 [P08651-3] ENST00000443272; ENSP00000396843; ENSG00000141905 [P08651-1] ENST00000586919; ENSP00000465177; ENSG00000141905 [P08651-4] ENST00000589123; ENSP00000465655; ENSG00000141905 [P08651-2] ENST00000590282; ENSP00000466647; ENSG00000141905 [P08651-6]
GeneIDⁱ	4782
KEGGⁱ	hsa:4782
UCSCⁱ	uc002lxo.3 human [P08651-1]

Organism-specific databases

CTDⁱ	4782
DisGeNETⁱ	4782
EuPathDBⁱ	HostDB:ENSG00000141905.17
GeneCardsⁱ	NFIC
HGNCⁱ	HGNC:7786 NFIC
HPAⁱ	CAB004300 CAB004674 HPA052625
MIMⁱ	600729 gene
neXtProtⁱ	NX_P08651
OpenTargetsⁱ	ENSG00000141905
PharmGKBⁱ	PA31592
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3663 Eukaryota ENOG410Y16G LUCA
GeneTreeⁱ	ENSGT00390000009905
HOGENOMⁱ	HOG000013028
HOVERGENⁱ	HBG006561
InParanoidⁱ	P08651
KOⁱ	K09170
OMAⁱ	ACDPANQ
OrthoDBⁱ	EOG091G0HVY
PhylomeDBⁱ	P08651

Enzyme and pathway databases

Reactomeⁱ	R-HSA-73980 RNA Polymerase III Transcription Termination R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
SignaLinkⁱ	P08651
SIGNORⁱ	P08651

Miscellaneous databases

ChiTaRSⁱ	NFIC human
GeneWikiⁱ	NFIC_(gene)
GenomeRNAiⁱ	4782
Protein Ontology More...PROⁱ	PR:P08651
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000141905 Expressed in 236 organ(s), highest expression level in parotid gland
CleanExⁱ	HS_NFIC
ExpressionAtlasⁱ	P08651 baseline and differential
Genevisibleⁱ	P08651 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000647 CTF/NFI IPR020604 CTF/NFI_DNA-bd-dom IPR019739 CTF/NFI_DNA-bd_CS IPR019548 CTF/NFI_DNA-bd_N IPR003619 MAD_homology1_Dwarfin-type
PANTHERⁱ	PTHR11492 PTHR11492, 1 hit
Pfamⁱ	View protein in Pfam PF00859 CTF_NFI, 1 hit PF03165 MH1, 1 hit PF10524 NfI_DNAbd_pre-N, 1 hit
SMARTⁱ	View protein in SMART SM00523 DWA, 1 hit
PROSITEⁱ	View protein in PROSITE PS00349 CTF_NFI_1, 1 hit PS51080 CTF_NFI_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NFIC_HUMAN
Accessionⁱ	P08651Primary (citable) accession number: P08651 Secondary accession number(s): A8K1H0 Q9UPK1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - P08651 (NFIC_HUMAN)

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Nuclear factor 1 C-type

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ