UniProtKB - P08651 (NFIC_HUMAN)
Nuclear factor 1 C-type
NFIC
Functioni
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 1 – 195 | CTF/NF-IPROSITE-ProRule annotationAdd BLAST | 195 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- DNA replication Source: UniProtKB-KW
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription by RNA polymerase II Source: ProtInc
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | DNA replication, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P08651 |
Reactomei | R-HSA-73980, RNA Polymerase III Transcription Termination R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation |
SignaLinki | P08651 |
SIGNORi | P08651 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear factor 1 C-typeShort name: NF1-C Short name: Nuclear factor 1/C Alternative name(s): CCAAT-box-binding transcription factor Short name: CTF Nuclear factor I/C Short name: NF-I/C Short name: NFI-C TGGCA-binding protein |
Gene namesi | Name:NFIC Synonyms:NFI |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7786, NFIC |
MIMi | 600729, gene |
neXtProti | NX_P08651 |
VEuPathDBi | HostDB:ENSG00000141905 |
Subcellular locationi
Nucleus
Nucleus
- fibrillar center Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 4782 |
OpenTargetsi | ENSG00000141905 |
PharmGKBi | PA31592 |
Miscellaneous databases
Pharosi | P08651, Tbio |
Genetic variation databases
BioMutai | NFIC |
DMDMi | 14195672 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000100199 | 1 – 508 | Nuclear factor 1 C-typeAdd BLAST | 508 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 194 | PhosphoserineCombined sources | 1 | |
Modified residuei | 294 | PhosphoserineCombined sources | 1 | |
Modified residuei | 300 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 302 | PhosphoserineBy similarity | 1 | |
Modified residuei | 304 | PhosphoserineCombined sources | 1 | |
Modified residuei | 305 | PhosphoserineCombined sources | 1 | |
Modified residuei | 323 | PhosphoserineCombined sources | 1 | |
Modified residuei | 333 | PhosphoserineCombined sources | 1 | |
Modified residuei | 337 | PhosphoserineCombined sources | 1 | |
Modified residuei | 339 | PhosphoserineCombined sources | 1 | |
Modified residuei | 343 | PhosphoserineCombined sources | 1 | |
Modified residuei | 365 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 365 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 395 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 451 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 475 | PhosphoserineCombined sources | 1 | |
Modified residuei | 477 | PhosphoserineCombined sources | 1 | |
Modified residuei | 487 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | P08651 |
jPOSTi | P08651 |
MassIVEi | P08651 |
MaxQBi | P08651 |
PaxDbi | P08651 |
PeptideAtlasi | P08651 |
PRIDEi | P08651 |
ProteomicsDBi | 52148 [P08651-1] 52149 [P08651-2] 52150 [P08651-3] 52151 [P08651-4] 52152 [P08651-5] |
PTM databases
GlyGeni | P08651, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P08651 |
PhosphoSitePlusi | P08651 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141905, Expressed in parotid gland and 247 other tissues |
ExpressionAtlasi | P08651, baseline and differential |
Genevisiblei | P08651, HS |
Organism-specific databases
HPAi | ENSG00000141905, Tissue enriched (skeletal) |
Interactioni
Subunit structurei
Binds DNA as a homodimer.
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 110854, 61 interactors |
DIPi | DIP-44692N |
IntActi | P08651, 29 interactors |
MINTi | P08651 |
STRINGi | 9606.ENSP00000396843 |
Miscellaneous databases
RNActi | P08651, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 190 – 209 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 267 – 348 | DisorderedSequence analysisAdd BLAST | 82 | |
Regioni | 438 – 495 | DisorderedSequence analysisAdd BLAST | 58 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 404 – 412 | 9aaTAD1 Publication | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 194 – 209 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 267 – 281 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 297 – 317 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 329 – 348 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 462 – 484 | Polar residuesSequence analysisAdd BLAST | 23 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3663, Eukaryota |
GeneTreei | ENSGT00950000182916 |
HOGENOMi | CLU_012576_3_0_1 |
InParanoidi | P08651 |
OMAi | YFVRERX |
OrthoDBi | 967862at2759 |
PhylomeDBi | P08651 |
Family and domain databases
InterProi | View protein in InterPro IPR000647, CTF/NFI IPR020604, CTF/NFI_DNA-bd-dom IPR019739, CTF/NFI_DNA-bd_CS IPR019548, CTF/NFI_DNA-bd_N IPR003619, MAD_homology1_Dwarfin-type |
PANTHERi | PTHR11492, PTHR11492, 1 hit |
Pfami | View protein in Pfam PF00859, CTF_NFI, 1 hit PF03165, MH1, 1 hit PF10524, NfI_DNAbd_pre-N, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit |
PROSITEi | View protein in PROSITE PS00349, CTF_NFI_1, 1 hit PS51080, CTF_NFI_2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS
60 70 80 90 100
KDEERAVKDE LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK
110 120 130 140 150
APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER
160 170 180 190 200
LVKAAQCGHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSGSPRTGMG
210 220 230 240 250
SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG
260 270 280 290 300
ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY
310 320 330 340 350
TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT
360 370 380 390 400
QHHRPVIAVH SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL
410 420 430 440 450
NPQDPLKDLV SLACDPASQQ PGPLNGSGQL KMPSHCLSAQ MLAPPPPGLP
460 470 480 490 500
RLALPPATKP ATTSEGGATS PTSPSYSPPD TSPANRSFVG LGPRDPAGIY
QAQSWYLG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A286YEX4 | A0A286YEX4_HUMAN | Nuclear factor 1 | NFIC | 530 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 130 | L → P in BAH12681 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 212 | D → V in CAA63440 (PubMed:8710515).Curated | 1 | |
Sequence conflicti | 329 | E → K in BAH12681 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 353 | H → Y in BAH12681 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057656 | 417 | A → S. Corresponds to variant dbSNP:rs10412720Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003552 | 1 – 10 | MYSSPLCLTQ → M in isoform 1, isoform 2 and isoform 3. 2 Publications | 10 | |
Alternative sequenceiVSP_003553 | 188 – 211 | Missing in isoform 3. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_047539 | 424 – 508 | LNGSG…SWYLG → PTLRPTRPLQTVPLWD in isoform 6. 1 PublicationAdd BLAST | 85 | |
Alternative sequenceiVSP_003554 | 424 – 503 | Missing in isoform 5. 2 PublicationsAdd BLAST | 80 | |
Alternative sequenceiVSP_003555 | 424 – 439 | LNGSG…HCLSA → PTLRPTRPLQTVPLWD in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 16 | |
Alternative sequenceiVSP_003556 | 440 – 508 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 69 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000341919; ENSP00000342194; ENSG00000141905 [P08651-5] ENST00000395111; ENSP00000378543; ENSG00000141905 [P08651-3] ENST00000443272; ENSP00000396843; ENSG00000141905 ENST00000586919; ENSP00000465177; ENSG00000141905 [P08651-4] ENST00000589123; ENSP00000465655; ENSG00000141905 [P08651-2] ENST00000590282; ENSP00000466647; ENSG00000141905 [P08651-6] |
GeneIDi | 4782 |
KEGGi | hsa:4782 |
MANE-Selecti | ENST00000443272.3; ENSP00000396843.2; NM_001245002.2; NP_001231931.1 |
UCSCi | uc002lxo.3, human [P08651-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 110854, 61 interactors |
DIPi | DIP-44692N |
IntActi | P08651, 29 interactors |
MINTi | P08651 |
STRINGi | 9606.ENSP00000396843 |
PTM databases
GlyGeni | P08651, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P08651 |
PhosphoSitePlusi | P08651 |
Genetic variation databases
BioMutai | NFIC |
DMDMi | 14195672 |
Proteomic databases
EPDi | P08651 |
jPOSTi | P08651 |
MassIVEi | P08651 |
MaxQBi | P08651 |
PaxDbi | P08651 |
PeptideAtlasi | P08651 |
PRIDEi | P08651 |
ProteomicsDBi | 52148 [P08651-1] 52149 [P08651-2] 52150 [P08651-3] 52151 [P08651-4] 52152 [P08651-5] |
Protocols and materials databases
Antibodypediai | 23195, 298 antibodies from 31 providers |
DNASUi | 4782 |
Genome annotation databases
Ensembli | ENST00000341919; ENSP00000342194; ENSG00000141905 [P08651-5] ENST00000395111; ENSP00000378543; ENSG00000141905 [P08651-3] ENST00000443272; ENSP00000396843; ENSG00000141905 ENST00000586919; ENSP00000465177; ENSG00000141905 [P08651-4] ENST00000589123; ENSP00000465655; ENSG00000141905 [P08651-2] ENST00000590282; ENSP00000466647; ENSG00000141905 [P08651-6] |
GeneIDi | 4782 |
KEGGi | hsa:4782 |
MANE-Selecti | ENST00000443272.3; ENSP00000396843.2; NM_001245002.2; NP_001231931.1 |
UCSCi | uc002lxo.3, human [P08651-1] |
Organism-specific databases
CTDi | 4782 |
DisGeNETi | 4782 |
GeneCardsi | NFIC |
HGNCi | HGNC:7786, NFIC |
HPAi | ENSG00000141905, Tissue enriched (skeletal) |
MIMi | 600729, gene |
neXtProti | NX_P08651 |
OpenTargetsi | ENSG00000141905 |
PharmGKBi | PA31592 |
VEuPathDBi | HostDB:ENSG00000141905 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3663, Eukaryota |
GeneTreei | ENSGT00950000182916 |
HOGENOMi | CLU_012576_3_0_1 |
InParanoidi | P08651 |
OMAi | YFVRERX |
OrthoDBi | 967862at2759 |
PhylomeDBi | P08651 |
Enzyme and pathway databases
PathwayCommonsi | P08651 |
Reactomei | R-HSA-73980, RNA Polymerase III Transcription Termination R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation |
SignaLinki | P08651 |
SIGNORi | P08651 |
Miscellaneous databases
BioGRID-ORCSi | 4782, 18 hits in 1071 CRISPR screens |
ChiTaRSi | NFIC, human |
GeneWikii | NFIC_(gene) |
GenomeRNAii | 4782 |
Pharosi | P08651, Tbio |
PROi | PR:P08651 |
RNActi | P08651, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141905, Expressed in parotid gland and 247 other tissues |
ExpressionAtlasi | P08651, baseline and differential |
Genevisiblei | P08651, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000647, CTF/NFI IPR020604, CTF/NFI_DNA-bd-dom IPR019739, CTF/NFI_DNA-bd_CS IPR019548, CTF/NFI_DNA-bd_N IPR003619, MAD_homology1_Dwarfin-type |
PANTHERi | PTHR11492, PTHR11492, 1 hit |
Pfami | View protein in Pfam PF00859, CTF_NFI, 1 hit PF03165, MH1, 1 hit PF10524, NfI_DNAbd_pre-N, 1 hit |
SMARTi | View protein in SMART SM00523, DWA, 1 hit |
PROSITEi | View protein in PROSITE PS00349, CTF_NFI_1, 1 hit PS51080, CTF_NFI_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NFIC_HUMAN | |
Accessioni | P08651Primary (citable) accession number: P08651 Secondary accession number(s): A8K1H0 Q9UPK1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 211 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families