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Entry version 154 (13 Nov 2019)
Sequence version 3 (25 Mar 2003)
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Protein

Complement C4

Gene

C4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes (By similarity).By similarity
Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory processes. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Miscellaneous

C4 is a major histocompatibility complex class-III protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement pathway, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-166663 Initial triggering of complement
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation
R-RNO-977606 Regulation of Complement cascade

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P08649

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.951

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement C4
Cleaved into the following 4 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C4
Synonyms:C4a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
620005 C4a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Secreted, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000597920 – 673Complement C4 beta chainBy similarityAdd BLAST654
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000005980674 – 677By similarity4
ChainiPRO_0000005981678 – 1442Complement C4 alpha chainBy similarityAdd BLAST765
ChainiPRO_0000005982678 – 753C4a anaphylatoxinAdd BLAST76
PropeptideiPRO_00000059831443 – 1446By similarity4
ChainiPRO_00000059841447 – 1737Complement C4 gamma chainBy similarityAdd BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi664N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi700 ↔ 726By similarity
Disulfide bondi701 ↔ 733By similarity
Disulfide bondi714 ↔ 734By similarity
Glycosylationi743N-linked (GlcNAc...) asparagine1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1005 ↔ 1008Isoglutamyl cysteine thioester (Cys-Gln)By similarity
Glycosylationi1323N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1386N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1412SulfotyrosineBy similarity1
Modified residuei1414SulfotyrosineBy similarity1
Modified residuei1416SulfotyrosineBy similarity1
Disulfide bondi1588 ↔ 1666By similarity
Disulfide bondi1611 ↔ 1735By similarity
Modified residuei1676SulfotyrosineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Sulfation, Thioester bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P08649

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08649

PRoteomics IDEntifications database

More...
PRIDEi
P08649

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08649

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08649

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P08649

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in hepatic stellate cells by iron overload and by gamma-interferon.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

This protein is synthesized as a single-chain precursor and, prior to secretion, is enzymatically cleaved to form a trimer of non-identical chains alpha, beta and gamma.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
246420, 1 interactor

Protein interaction database and analysis system

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IntActi
P08649, 1 interactor

Molecular INTeraction database

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MINTi
P08649

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000037902

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P08649

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini700 – 734Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST35
Domaini1588 – 1735NTRPROSITE-ProRule annotationAdd BLAST148

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1366 Eukaryota
ENOG410XRED LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290712

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P08649

KEGG Orthology (KO)

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KOi
K03989

Database of Orthologous Groups

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OrthoDBi
28894at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P08649

Family and domain databases

Conserved Domains Database

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CDDi
cd00017 ANATO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR011626 Alpha-macroglobulin_TED
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR001840 Anaphylatoxn_comp_syst_dom
IPR037569 Complement_C4A
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR040839 MG4
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold

The PANTHER Classification System

More...
PANTHERi
PTHR11412:SF86 PTHR11412:SF86, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF17789 MG4, 1 hit
PF01759 NTR, 1 hit
PF07678 TED_complement, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00004 ANAPHYLATOXN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit
PS01177 ANAPHYLATOXIN_1, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P08649-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLWGLAWA FSFFASSLQK PRLLLFSPSV VNLGTPLSVG VQLLDAPAGQ
60 70 80 90 100
EVKGSVYLRN PTSGPCSPKK DFKLSSGNDF VLLRLEVPLK DVRSCGLFGL
110 120 130 140 150
RRAPHIQLVA HSPWLKNTAS KATETQGVNL LFSSRRGHIF VQTDQPIYNP
160 170 180 190 200
GQRVRYRVFA LDQKMRPSTD TLTVTVENSH GLRVRKKEVF APTSIFQDDF
210 220 230 240 250
IIPDISEPGT WKISARFSDG LESNRSTHFE VKKYVLPNFE VKLTPWKPYI
260 270 280 290 300
LTVPSYREEI QLDVQARYVY GKPVQGVAYT RFALMDEQGK KSFLRGLETQ
310 320 330 340 350
TKLVEGQTHI SISRDQFQAA LGKVNTEIGD LEGLRLYAAV AVIESPGGEM
360 370 380 390 400
EEAELTSWPF VSSAFSLDLS HTKQHLVPGA PFLLQALVRE MSGSEASDVP
410 420 430 440 450
VKVSATLLSG SDSKVLDFQQ NTNGIGQVSF SIHVPPTITE LRLLVSAGSL
460 470 480 490 500
YPAVAKLTVQ APPSRGPGFL SIEPLDLRSP RVGDTFVLSL RTVGIPMPTF
510 520 530 540 550
SHYYYMIISR GQIMAMSREP RRALTSISVL VDHHLAPSFY FVAYFYHQGL
560 570 580 590 600
PVANSLLINV QPGDCEGKLE LKVDGAKEYR NGDSMKLQLQ TDSEALVALG
610 620 630 640 650
AVDTALYAVG GRSHKPLDMS KVFEVMNSYN LGCGPGGGDD ALQVFQTAGL
660 670 680 690 700
AFSDGDRLTQ TKENLSCPKE KKSRQKRNVN FQKAISEKLG QYSSPDTKRC
710 720 730 740 750
CQDGMTKLPM ARTCEQRAAR VPQPACREPF LSCCKFAEDL RRNQTRSQAG
760 770 780 790 800
LARAQDMLQE EDLIDEDDIL VRSFFPENWL WRVEPVDRSK LLTVWLPDSL
810 820 830 840 850
TTWEIHGVSL SKSKGLCVAK PTRVRVFREF HLHLRLPISV RRFEQLELRP
860 870 880 890 900
VLYNYLSEDV TVSVHVSPVE GLCLAGGGLL AQQVSVPAGS ARPVAFSVVP
910 920 930 940 950
TAAASIPLKV VARGSFTIGD AVSKILQIEK EGAIHREEIV YNLDPLNNLG
960 970 980 990 1000
RSLEIPGSSD PNVIPDGDFS SFVRVTASEP LETLGSEGAL SPGGVASLLR
1010 1020 1030 1040 1050
LPRGCAEQTM IYLAPTLTAS HYLDRTEQWS KLPPETKDHA VDLIQKGHMR
1060 1070 1080 1090 1100
IQQFRKKDGS FGAWLHRDSS TWLTAFVLKI LSLAQEQIGD SPEKLQETAG
1110 1120 1130 1140 1150
WLLGQQLDDG SFHDPCPVIH RGMQGGLVGT DETVALTAFV VIALHHGLAV
1160 1170 1180 1190 1200
FQDENSQQLK KRVEASITKA NSFLGQKASA GLLGAHASAI TAYALTLTKA
1210 1220 1230 1240 1250
SEDLQNVAHN SLMAMAEETG ENLYWGSAIG SQDNVVSSTP APRNPSEPVP
1260 1270 1280 1290 1300
QAPALWIETT AYGLLHLLLR EGKGEMADKV ATWLTHQGSF QGGFRSTQDT
1310 1320 1330 1340 1350
VVTLDALSAY WIASHTTEEK ALNVTLSSMG RNGYKSHLLQ LNNHQVKGLE
1360 1370 1380 1390 1400
EELKFSLGST INVKVGGNSK GTLKILRTYN VLDMKNTTCQ DLRIEVTVTG
1410 1420 1430 1440 1450
YVEYTREANE DYEYDYDMPA ADDPSVHSQP VTPLQLFEGR RSRRRREAPK
1460 1470 1480 1490 1500
AADEQESRVQ YTVCIWRNGN LGLSGMAIAD ITLLSGFQAL RADLEKLTSL
1510 1520 1530 1540 1550
SDRYVSHFET DGPHVLLYFD SVPTTRECVG FGALQEVAVG LVQPASAVLY
1560 1570 1580 1590 1600
DYYSPDHKCS VFYAAPTKSK LLSTLCSADV CQCAEGKCPR QRRSLERGVE
1610 1620 1630 1640 1650
DKDGYRMKFA CYYPRVEYGF QVKVLREDSR AAFRLFETKI TQVLHFTKDA
1660 1670 1680 1690 1700
KASIGQTRNF LVRASCRLRL EPSKEYLIMG MDGVTSDLKG DPQYLLDSNT
1710 1720 1730
WIEEMPSERL CRSTRQRAAC GQLNDFLQEY SSQGCQV
Length:1,737
Mass (Da):192,163
Last modified:March 25, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67FA7BFA27A3DDFA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0RB00M0RB00_RAT
Complement C4A
C4a
1,734Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JV52A0A0G2JV52_RAT
Complement C4A
C4a
1,374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JT52A0A0G2JT52_RAT
Complement C4A
C4a
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA91231 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti706T → A AA sequence (Ref. 5) Curated1
Sequence conflicti1700T → S in AAA91231 (PubMed:8805663).Curated1
Sequence conflicti1709R → H in AAA91231 (PubMed:8805663).Curated1
Sequence conflicti1731S → R in AAA91231 (PubMed:8805663).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY149995 mRNA Translation: AAN72415.1
AY091787 Genomic DNA Translation: AAM14719.1
U42719 mRNA Translation: AAA91231.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...
PIRi
JL0036

NCBI Reference Sequences

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RefSeqi
NP_113692.2, NM_031504.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
24233

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:24233

UCSC genome browser

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UCSCi
RGD:620005 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149995 mRNA Translation: AAN72415.1
AY091787 Genomic DNA Translation: AAM14719.1
U42719 mRNA Translation: AAA91231.1 Frameshift.
PIRiJL0036
RefSeqiNP_113692.2, NM_031504.3

3D structure databases

SMRiP08649
ModBaseiSearch...

Protein-protein interaction databases

BioGridi246420, 1 interactor
IntActiP08649, 1 interactor
MINTiP08649
STRINGi10116.ENSRNOP00000037902

Protein family/group databases

MEROPSiI39.951

PTM databases

iPTMnetiP08649
PhosphoSitePlusiP08649

Proteomic databases

jPOSTiP08649
PaxDbiP08649
PRIDEiP08649

Genome annotation databases

GeneIDi24233
KEGGirno:24233
UCSCiRGD:620005 rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
720
RGDi620005 C4a

Phylogenomic databases

eggNOGiKOG1366 Eukaryota
ENOG410XRED LUCA
HOGENOMiHOG000290712
InParanoidiP08649
KOiK03989
OrthoDBi28894at2759
PhylomeDBiP08649

Enzyme and pathway databases

ReactomeiR-RNO-166663 Initial triggering of complement
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation
R-RNO-977606 Regulation of Complement cascade
SABIO-RKiP08649

Miscellaneous databases

PMAP-CutDBiP08649

Protein Ontology

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PROi
PR:P08649

Family and domain databases

CDDicd00017 ANATO, 1 hit
Gene3Di2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR011626 Alpha-macroglobulin_TED
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR001840 Anaphylatoxn_comp_syst_dom
IPR037569 Complement_C4A
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR040839 MG4
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11412:SF86 PTHR11412:SF86, 1 hit
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF17789 MG4, 1 hit
PF01759 NTR, 1 hit
PF07678 TED_complement, 1 hit
PRINTSiPR00004 ANAPHYLATOXN
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit
SUPFAMiSSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit
PS01177 ANAPHYLATOXIN_1, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO4_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08649
Secondary accession number(s): Q62895, Q8R403
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: March 25, 2003
Last modified: November 13, 2019
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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