Kras

Functionⁱ

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation (PubMed:3110778). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity).By similarity1 Publication

Activity regulationⁱ

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interaction with SOS1 promotes exchange of bound GDP by GTP.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	10 – 18	GTPBy similarity	9
Nucleotide bindingⁱ	29 – 35	GTPBy similarity	7
Nucleotide bindingⁱ	59 – 60	GTPBy similarity	2
Nucleotide bindingⁱ	116 – 119	GTPBy similarity	4

GO - Molecular functionⁱ

GDP binding
Source: RGD
Inferred from direct assayⁱ
- 12594205
GMP binding
Source: RGD
Inferred from direct assayⁱ
- 12594205
GTPase activity Source: Ensembl
GTP binding Source: UniProtKB-KW
LRR domain binding
Source: RGD
Inferred from direct assayⁱ
- 12594205
protein-containing complex binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization Source: Ensembl
cytokine-mediated signaling pathway
Source: RGD
Inferred from mutant phenotypeⁱ
- 14576830
endocrine signaling Source: Ensembl
epithelial tube branching involved in lung morphogenesis Source: Ensembl
female pregnancy
Source: RGD
Inferred from expression patternⁱ
- 1570348
forebrain astrocyte development Source: Ensembl
homeostasis of number of cells within a tissue Source: Ensembl
liver development
Source: RGD
Inferred from expression patternⁱ
- 1526114
negative regulation of cell differentiation Source: Ensembl
negative regulation of neuron apoptotic process Source: Ensembl
positive regulation of cell proliferation Source: UniProtKB
positive regulation of cellular senescence
Source: RGD
Inferred from mutant phenotypeⁱ
- 17706954
positive regulation of gene expression Source: Ensembl
positive regulation of MAP kinase activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 10969813
positive regulation of NF-kappaB transcription factor activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 14576830
positive regulation of nitric-oxide synthase activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 14576830
positive regulation of Rac protein signal transduction Source: Ensembl
Ras protein signal transduction Source: Ensembl
regulation of long-term neuronal synaptic plasticity Source: Ensembl
regulation of protein stability Source: UniProtKB
regulation of synaptic transmission, GABAergic Source: Ensembl
response to glucocorticoid
Source: RGD
Inferred from expression patternⁱ
- 1420288
- 16543373
response to isolation stress
Source: RGD
Inferred from expression patternⁱ
- 19616040
response to mineralocorticoid
Source: RGD
Inferred from expression patternⁱ
- 16543373
striated muscle cell differentiation Source: Ensembl
visual learning Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-RNO-1169092 Activation of RAS in B cells R-RNO-1250347 SHC1 events in ERBB4 signaling R-RNO-1433557 Signaling by SCF-KIT R-RNO-171007 p38MAPK events R-RNO-179812 GRB2 events in EGFR signaling R-RNO-180336 SHC1 events in EGFR signaling R-RNO-186763 Downstream signal transduction R-RNO-1963640 GRB2 events in ERBB2 signaling R-RNO-210993 Tie2 Signaling R-RNO-2179392 EGFR Transactivation by Gastrin R-RNO-2424491 DAP12 signaling R-RNO-2871796 FCERI mediated MAPK activation R-RNO-375165 NCAM signaling for neurite out-growth R-RNO-5218921 VEGFR2 mediated cell proliferation R-RNO-5621575 CD209 (DC-SIGN) signaling R-RNO-5654688 SHC-mediated cascade:FGFR1 R-RNO-5654693 FRS-mediated FGFR1 signaling R-RNO-5654699 SHC-mediated cascade:FGFR2 R-RNO-5654700 FRS-mediated FGFR2 signaling R-RNO-5654704 SHC-mediated cascade:FGFR3 R-RNO-5654706 FRS-mediated FGFR3 signaling R-RNO-5654712 FRS-mediated FGFR4 signaling R-RNO-5654719 SHC-mediated cascade:FGFR4 R-RNO-5658442 Regulation of RAS by GAPs R-RNO-5673000 RAF activation R-RNO-5673001 RAF/MAP kinase cascade R-RNO-5674135 MAP2K and MAPK activation R-RNO-5675221 Negative regulation of MAPK pathway R-RNO-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-RNO-8851805 MET activates RAS signaling R-RNO-8951936 RUNX3 regulates p14-ARF

Reactomeⁱ

R-RNO-1169092 Activation of RAS in B cells
R-RNO-1250347 SHC1 events in ERBB4 signaling
R-RNO-1433557 Signaling by SCF-KIT
R-RNO-171007 p38MAPK events
R-RNO-179812 GRB2 events in EGFR signaling
R-RNO-180336 SHC1 events in EGFR signaling
R-RNO-186763 Downstream signal transduction
R-RNO-1963640 GRB2 events in ERBB2 signaling
R-RNO-210993 Tie2 Signaling
R-RNO-2179392 EGFR Transactivation by Gastrin
R-RNO-2424491 DAP12 signaling
R-RNO-2871796 FCERI mediated MAPK activation
R-RNO-375165 NCAM signaling for neurite out-growth
R-RNO-5218921 VEGFR2 mediated cell proliferation
R-RNO-5621575 CD209 (DC-SIGN) signaling
R-RNO-5654688 SHC-mediated cascade:FGFR1
R-RNO-5654693 FRS-mediated FGFR1 signaling
R-RNO-5654699 SHC-mediated cascade:FGFR2
R-RNO-5654700 FRS-mediated FGFR2 signaling
R-RNO-5654704 SHC-mediated cascade:FGFR3
R-RNO-5654706 FRS-mediated FGFR3 signaling
R-RNO-5654712 FRS-mediated FGFR4 signaling
R-RNO-5654719 SHC-mediated cascade:FGFR4
R-RNO-5658442 Regulation of RAS by GAPs
R-RNO-5673000 RAF activation
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-5674135 MAP2K and MAPK activation
R-RNO-5675221 Negative regulation of MAPK pathway
R-RNO-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-RNO-8851805 MET activates RAS signaling
R-RNO-8951936 RUNX3 regulates p14-ARF

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: GTPase KRas Alternative name(s): K-Ras 2 Ki-Ras c-K-ras c-Ki-ras Cleaved into the following chain: GTPase KRas, N-terminally processed
Gene namesⁱ	Name:Kras Synonyms:Kras2
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 4

Organism-specific databases

Rat genome database More...RGDⁱ	2981 Kras

RGDⁱ

2981 Kras

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000326483	1 – 186	GTPase KRasAdd BLAST	186
Initiator methionineⁱ		Removed; alternateBy similarity
ChainⁱPRO_0000082644	2 – 186	GTPase KRas, N-terminally processedAdd BLAST	185
PropeptideⁱPRO_0000281294	187 – 189	Removed in mature formBy similarity	3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	2	N-acetylthreonine; in GTPase KRas, N-terminally processedBy similarity	1
Modified residueⁱ	104	N6-acetyllysineBy similarity	1
Lipidationⁱ	180	S-palmitoyl cysteineBy similarity	1
Modified residueⁱ	186	Cysteine methyl esterBy similarity	1
Lipidationⁱ	186	S-farnesyl cysteineBy similarity	1

Post-translational modificationⁱ

Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).By similarity

Keywords - PTMⁱ

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbⁱ	P08644
PRIDEⁱ	P08644

PTM databases

iPTMnetⁱ	P08644
PhosphoSitePlusⁱ	P08644
SwissPalmⁱ	P08644

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000009338 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	P08644 baseline and differential
Genevisibleⁱ	P08644 RN

Interactionⁱ

Subunit structureⁱ

Interacts with SOS1 (By similarity). Interacts (when farnesylated) with PDE6D; this promotes dissociation from the cell membrane (By similarity). Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14.By similarity2 Publications

GO - Molecular functionⁱ

LRR domain binding
Source: RGD
Inferred from direct assayⁱ
- 12594205

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	246680, 9 interactors
STRINGⁱ	10116.ENSRNOP00000012588

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P08644
SMRⁱ	P08644
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	166 – 185	Hypervariable regionAdd BLAST		20

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	32 – 40	Effector region		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133672
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	P08644
KEGG Orthology (KO) More...KOⁱ	K07827
OMAⁱ	MSKEGKK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UAU
PhylomeDBⁱ	P08644
TreeFamⁱ	TF312796

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Isoforms differ in the C-terminal region which is encoded by two alternative exons (IVA and IVB).

Isoform 2A (identifier: P08644-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET 
        60         70         80         90        100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI 
       110        120        130        140        150
KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QELARSYGIP FIETSAKTRQ 
       160        170        180 
RVEDAFYTLV REIRQYRLKK ISKEEKTPGC VKIKKCVIM

Length:189

Mass (Da):21,656

Last modified:July 19, 2004 - v3

Checksum:ⁱ97345422E01D2C81

GO

Isoform 2B (identifier: P08644-2) [UniParc] [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
151-153: RVE → GVD
165-189: QYRLKKISKEEKTPGCVKIKKCVIM → KHKEKMSKDGKKKKKKSRTRCIVM

« Hide

        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET 
        60         70         80         90        100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI 
       110        120        130        140        150
KRVKDSEDVP MVLVGNKCDL PSRTVDTKQA QELARSYGIP FIETSAKTRQ 
       160        170        180 
GVDDAFYTLV REIRKHKEKM SKDGKKKKKK SRTRCIVM

Show »

Length:188

Mass (Da):21,495

Checksum:ⁱB0A55318AD158F51

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	12	G → C in AAA42011 (PubMed:3023884).Curated		1
Sequence conflictⁱ	47	D → H in AAA42011 (PubMed:3023884).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011144	151 – 153	RVE → GVD in isoform 2B. 1 Publication		3
Alternative sequenceⁱVSP_011145	165 – 189	QYRLK…KCVIM → KHKEKMSKDGKKKKKKSRTR CIVM in isoform 2B. 1 PublicationAdd BLAST		25

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09793 mRNA Translation: AAB60458.1 AABR03032592 Genomic DNA No translation available. M12260, M12259 Genomic DNA Translation: AAA42011.1 M54870 Genomic DNA Translation: AAA40937.1 M16970 Genomic DNA Translation: AAA41494.1
PIRⁱ	I58402
NCBI Reference Sequences More...RefSeqⁱ	NP_113703.1, NM_031515.3 [P08644-2] XP_008761576.1, XM_008763354.2 [P08644-2] XP_017447931.1, XM_017592442.1 [P08644-1] XP_017447932.1, XM_017592443.1 [P08644-1]
UniGeneⁱ	Rn.24554

Genome annotation databases

Ensemblⁱ	ENSRNOT00000012588; ENSRNOP00000012588; ENSRNOG00000009338 [P08644-1] ENSRNOT00000012887; ENSRNOP00000012887; ENSRNOG00000009338 [P08644-2]
GeneIDⁱ	24525
KEGGⁱ	rno:24525
UCSC genome browser More...UCSCⁱ	RGD:2981 rat [P08644-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08644	GTPase KRas		MOUSE		189	UniRef100_P32883
Kras protein		MOUSE		189
UPI0003D713F5		MOUSE		227
P08644-2	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog		RAT		188	UniRef100_A0JN17

Protein	Similar proteins		Species	Score	Length	Source
P08644	GTPase KRas		MOUSE		189	UniRef90_P32883
GTPase KRas isoform X1		ERIEU		227
GTPase KRas isoform X3		Florida manatee		227
GTPase KRas isoform X3		Yangtze finless porpoise		227
GTPase KRas isoform X3		MESAU		227
+90
P08644-2	GTPase KRas		MONDO		188	UniRef90_Q07983
GTPase KRas		MELGA		188
GTPase KRas		ORYLA		188
GTPase KRas		KRYMA		188
GTPase KRas		CYPCA		188
+154

Protein	Similar proteins		Species	Score	Length	Source
P08644	GTPase NRas	)	HUMAN		189	UniRef50_P01111
GTPase NRas		PIG		189
GTPase NRas		XENLA		189
GTPase HRas		MSVMO		189
GTPase HRas		MSVNS		189
+616

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09793 mRNA Translation: AAB60458.1 AABR03032592 Genomic DNA No translation available. M12260, M12259 Genomic DNA Translation: AAA42011.1 M54870 Genomic DNA Translation: AAA40937.1 M16970 Genomic DNA Translation: AAA41494.1
PIRⁱ	I58402
RefSeqⁱ	NP_113703.1, NM_031515.3 [P08644-2] XP_008761576.1, XM_008763354.2 [P08644-2] XP_017447931.1, XM_017592442.1 [P08644-1] XP_017447932.1, XM_017592443.1 [P08644-1]
UniGeneⁱ	Rn.24554

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1N4S	X-ray	2.60	M/N/O/P/Q/R	185-188	[»]
ProteinModelPortalⁱ	P08644
SMRⁱ	P08644
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	246680, 9 interactors
STRINGⁱ	10116.ENSRNOP00000012588

PTM databases

iPTMnetⁱ	P08644
PhosphoSitePlusⁱ	P08644
SwissPalmⁱ	P08644

Proteomic databases

PaxDbⁱ	P08644
PRIDEⁱ	P08644

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000012588; ENSRNOP00000012588; ENSRNOG00000009338 [P08644-1] ENSRNOT00000012887; ENSRNOP00000012887; ENSRNOG00000009338 [P08644-2]
GeneIDⁱ	24525
KEGGⁱ	rno:24525
UCSCⁱ	RGD:2981 rat [P08644-1]

Organism-specific databases

CTDⁱ	3845
RGDⁱ	2981 Kras

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
GeneTreeⁱ	ENSGT00860000133672
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	P08644
KOⁱ	K07827
OMAⁱ	MSKEGKK
OrthoDBⁱ	EOG091G0UAU
PhylomeDBⁱ	P08644
TreeFamⁱ	TF312796

Enzyme and pathway databases

Reactomeⁱ	R-RNO-1169092 Activation of RAS in B cells R-RNO-1250347 SHC1 events in ERBB4 signaling R-RNO-1433557 Signaling by SCF-KIT R-RNO-171007 p38MAPK events R-RNO-179812 GRB2 events in EGFR signaling R-RNO-180336 SHC1 events in EGFR signaling R-RNO-186763 Downstream signal transduction R-RNO-1963640 GRB2 events in ERBB2 signaling R-RNO-210993 Tie2 Signaling R-RNO-2179392 EGFR Transactivation by Gastrin R-RNO-2424491 DAP12 signaling R-RNO-2871796 FCERI mediated MAPK activation R-RNO-375165 NCAM signaling for neurite out-growth R-RNO-5218921 VEGFR2 mediated cell proliferation R-RNO-5621575 CD209 (DC-SIGN) signaling R-RNO-5654688 SHC-mediated cascade:FGFR1 R-RNO-5654693 FRS-mediated FGFR1 signaling R-RNO-5654699 SHC-mediated cascade:FGFR2 R-RNO-5654700 FRS-mediated FGFR2 signaling R-RNO-5654704 SHC-mediated cascade:FGFR3 R-RNO-5654706 FRS-mediated FGFR3 signaling R-RNO-5654712 FRS-mediated FGFR4 signaling R-RNO-5654719 SHC-mediated cascade:FGFR4 R-RNO-5658442 Regulation of RAS by GAPs R-RNO-5673000 RAF activation R-RNO-5673001 RAF/MAP kinase cascade R-RNO-5674135 MAP2K and MAPK activation R-RNO-5675221 Negative regulation of MAPK pathway R-RNO-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-RNO-8851805 MET activates RAS signaling R-RNO-8951936 RUNX3 regulates p14-ARF

Reactomeⁱ

R-RNO-1169092 Activation of RAS in B cells
R-RNO-1250347 SHC1 events in ERBB4 signaling
R-RNO-1433557 Signaling by SCF-KIT
R-RNO-171007 p38MAPK events
R-RNO-179812 GRB2 events in EGFR signaling
R-RNO-180336 SHC1 events in EGFR signaling
R-RNO-186763 Downstream signal transduction
R-RNO-1963640 GRB2 events in ERBB2 signaling
R-RNO-210993 Tie2 Signaling
R-RNO-2179392 EGFR Transactivation by Gastrin
R-RNO-2424491 DAP12 signaling
R-RNO-2871796 FCERI mediated MAPK activation
R-RNO-375165 NCAM signaling for neurite out-growth
R-RNO-5218921 VEGFR2 mediated cell proliferation
R-RNO-5621575 CD209 (DC-SIGN) signaling
R-RNO-5654688 SHC-mediated cascade:FGFR1
R-RNO-5654693 FRS-mediated FGFR1 signaling
R-RNO-5654699 SHC-mediated cascade:FGFR2
R-RNO-5654700 FRS-mediated FGFR2 signaling
R-RNO-5654704 SHC-mediated cascade:FGFR3
R-RNO-5654706 FRS-mediated FGFR3 signaling
R-RNO-5654712 FRS-mediated FGFR4 signaling
R-RNO-5654719 SHC-mediated cascade:FGFR4
R-RNO-5658442 Regulation of RAS by GAPs
R-RNO-5673000 RAF activation
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-5674135 MAP2K and MAPK activation
R-RNO-5675221 Negative regulation of MAPK pathway
R-RNO-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-RNO-8851805 MET activates RAS signaling
R-RNO-8951936 RUNX3 regulates p14-ARF

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P08644

PROⁱ

PR:P08644

Gene expression databases

Bgeeⁱ	ENSRNOG00000009338 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasⁱ	P08644 baseline and differential
Genevisibleⁱ	P08644 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RASK_RAT
Accessionⁱ	P08644Primary (citable) accession number: P08644 Secondary accession number(s): P46203, P97914
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	July 19, 2004
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P08644 (RASK_RAT)

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GTPase KRas

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Plasma membrane

Cytosol

Mitochondrion

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ