Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTPase HRas

Gene

HRAS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Activity regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTP8
Nucleotide bindingi57 – 61GTP5
Nucleotide bindingi116 – 119GTP4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-1169092 Activation of RAS in B cells
R-GGA-1250347 SHC1 events in ERBB4 signaling
R-GGA-1433557 Signaling by SCF-KIT
R-GGA-171007 p38MAPK events
R-GGA-179812 GRB2 events in EGFR signaling
R-GGA-180336 SHC1 events in EGFR signaling
R-GGA-186763 Downstream signal transduction
R-GGA-1963640 GRB2 events in ERBB2 signaling
R-GGA-210993 Tie2 Signaling
R-GGA-2179392 EGFR Transactivation by Gastrin
R-GGA-2424491 DAP12 signaling
R-GGA-2871796 FCERI mediated MAPK activation
R-GGA-375165 NCAM signaling for neurite out-growth
R-GGA-3928662 EPHB-mediated forward signaling
R-GGA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-GGA-5218921 VEGFR2 mediated cell proliferation
R-GGA-5621575 CD209 (DC-SIGN) signaling
R-GGA-5654688 SHC-mediated cascade:FGFR1
R-GGA-5654693 FRS-mediated FGFR1 signaling
R-GGA-5654699 SHC-mediated cascade:FGFR2
R-GGA-5654700 FRS-mediated FGFR2 signaling
R-GGA-5654704 SHC-mediated cascade:FGFR3
R-GGA-5654706 FRS-mediated FGFR3 signaling
R-GGA-5654712 FRS-mediated FGFR4 signaling
R-GGA-5654719 SHC-mediated cascade:FGFR4
R-GGA-5658442 Regulation of RAS by GAPs
R-GGA-5673000 RAF activation
R-GGA-5673001 RAF/MAP kinase cascade
R-GGA-5674135 MAP2K and MAPK activation
R-GGA-5675221 Negative regulation of MAPK pathway
R-GGA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-GGA-8851805 MET activates RAS signaling

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase HRas
Alternative name(s):
H-Ras-1
Transforming protein p21
c-H-ras
p21ras
Cleaved into the following chain:
Gene namesi
Name:HRAS
Synonyms:HRAS1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi164R → A: Loss of GTP-binding activity. 1 Publication1

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004343071 – 186GTPase HRasAdd BLAST186
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00000430022 – 186GTPase HRas, N-terminally processedAdd BLAST185
PropeptideiPRO_0000043003187 – 189Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in GTPase HRas, N-terminally processedBy similarity1
Modified residuei118S-nitrosocysteineBy similarity1
Lipidationi181S-palmitoyl cysteineBy similarity1
Lipidationi184S-palmitoyl cysteineBy similarity1
Modified residuei186Cysteine methyl esterBy similarity1
Lipidationi186S-farnesyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation, S-nitrosylation

Proteomic databases

PaxDbiP08642
PRIDEiP08642

Expressioni

Gene expression databases

BgeeiENSGALG00000006885 Expressed in 11 organ(s), highest expression level in brain
ExpressionAtlasiP08642 baseline

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038222

Structurei

3D structure databases

ProteinModelPortaliP08642
SMRiP08642
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 185Hypervariable regionAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiP08642
KOiK02833
OMAiDCMNCKC
OrthoDBiEOG091G0UAU
PhylomeDBiP08642
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08642-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHQYREQI
110 120 130 140 150
KRVKDSDDVP MVLVGNKCDL PARTVETRQA QDLARSYGIP YIETSAKTRQ
160 170 180
GVEDAFYTLV REIRQHKLRK LNPPDESGPG CMNCKCVIS
Length:189
Mass (Da):21,365
Last modified:August 13, 1987 - v1
Checksum:i0E7BA6C929482387
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03578 mRNA Translation: CAA27258.1
PIRiA24617 TVCHRS
RefSeqiNP_990623.1, NM_205292.1
UniGeneiGga.3849

Genome annotation databases

EnsembliENSGALT00000061350; ENSGALP00000051306; ENSGALG00000029260
ENSGALT00000079859; ENSGALP00000056118; ENSGALG00000034526
GeneIDi396229
KEGGigga:396229

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03578 mRNA Translation: CAA27258.1
PIRiA24617 TVCHRS
RefSeqiNP_990623.1, NM_205292.1
UniGeneiGga.3849

3D structure databases

ProteinModelPortaliP08642
SMRiP08642
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038222

Proteomic databases

PaxDbiP08642
PRIDEiP08642

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000061350; ENSGALP00000051306; ENSGALG00000029260
ENSGALT00000079859; ENSGALP00000056118; ENSGALG00000034526
GeneIDi396229
KEGGigga:396229

Organism-specific databases

CTDi3265

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiP08642
KOiK02833
OMAiDCMNCKC
OrthoDBiEOG091G0UAU
PhylomeDBiP08642
TreeFamiTF312796

Enzyme and pathway databases

ReactomeiR-GGA-1169092 Activation of RAS in B cells
R-GGA-1250347 SHC1 events in ERBB4 signaling
R-GGA-1433557 Signaling by SCF-KIT
R-GGA-171007 p38MAPK events
R-GGA-179812 GRB2 events in EGFR signaling
R-GGA-180336 SHC1 events in EGFR signaling
R-GGA-186763 Downstream signal transduction
R-GGA-1963640 GRB2 events in ERBB2 signaling
R-GGA-210993 Tie2 Signaling
R-GGA-2179392 EGFR Transactivation by Gastrin
R-GGA-2424491 DAP12 signaling
R-GGA-2871796 FCERI mediated MAPK activation
R-GGA-375165 NCAM signaling for neurite out-growth
R-GGA-3928662 EPHB-mediated forward signaling
R-GGA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-GGA-5218921 VEGFR2 mediated cell proliferation
R-GGA-5621575 CD209 (DC-SIGN) signaling
R-GGA-5654688 SHC-mediated cascade:FGFR1
R-GGA-5654693 FRS-mediated FGFR1 signaling
R-GGA-5654699 SHC-mediated cascade:FGFR2
R-GGA-5654700 FRS-mediated FGFR2 signaling
R-GGA-5654704 SHC-mediated cascade:FGFR3
R-GGA-5654706 FRS-mediated FGFR3 signaling
R-GGA-5654712 FRS-mediated FGFR4 signaling
R-GGA-5654719 SHC-mediated cascade:FGFR4
R-GGA-5658442 Regulation of RAS by GAPs
R-GGA-5673000 RAF activation
R-GGA-5673001 RAF/MAP kinase cascade
R-GGA-5674135 MAP2K and MAPK activation
R-GGA-5675221 Negative regulation of MAPK pathway
R-GGA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-GGA-8851805 MET activates RAS signaling

Miscellaneous databases

PROiPR:P08642

Gene expression databases

BgeeiENSGALG00000006885 Expressed in 11 organ(s), highest expression level in brain
ExpressionAtlasiP08642 baseline

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASH_CHICK
AccessioniPrimary (citable) accession number: P08642
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 12, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again