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Protein

Cadherin-1

Gene

CDH1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha-E/beta-7.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi263Calcium 1By similarity1
Metal bindingi263Calcium 2By similarity1
Metal bindingi294Calcium 3By similarity1

GO - Molecular functioni

  • cadherin binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-1
Alternative name(s):
Epithelial cadherin
Short name:
E-cadherin
Liver cell adhesion molecule
Short name:
L-CAM
Gene namesi
Name:CDH1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini161 – 714ExtracellularSequence analysisAdd BLAST554
Transmembranei715 – 735HelicalSequence analysisAdd BLAST21
Topological domaini736 – 887CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000000372127 – 160Add BLAST134
ChainiPRO_0000003722161 – 887Cadherin-1Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi291N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi346N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi564N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi643N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PRIDEiP08641

PTM databases

iPTMnetiP08641

Expressioni

Tissue specificityi

Non-neural epithelial tissues.

Interactioni

Subunit structurei

Homodimer. Interacts with CTNNA2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP08641, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliP08641
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 268Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini269 – 381Cadherin 2PROSITE-ProRule annotationAdd BLAST113
Domaini382 – 493Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini494 – 599Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini600 – 704Cadherin 5PROSITE-ProRule annotationAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi844 – 855Ser-richAdd BLAST12

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000231254
HOVERGENiHBG106438
InParanoidiP08641
KOiK05689
PhylomeDBiP08641

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PF08758 Cadherin_pro, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SM01055 Cadherin_pro, 1 hit
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08641-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRRWGSPAL QRFPVLVLLL LLQVCGRRCD EAAPCQPGFA AETFSFSVPQ
60 70 80 90 100
DSVAAGRELG RVSFAACSGR PWAVYVPTDT RFKVNGDGVV STKRPLTLYG
110 120 130 140 150
RKISFTIYAQ DAMGKRHSAR VTVGRHRHRR HHHNHHLQDT TPAVLTFPKH
160 170 180 190 200
DPGFLRRQKR DWVIPPISCL ENHRGPYPMR LVQIKSNKDK ESKVYYSITG
210 220 230 240 250
QGADSPPVGI FIIERETGWL EVTEQLDREK IDRYTLLSHA VSASGQPVED
260 270 280 290 300
PMEIIITVMD QNDNKPVFIK EVFVGYIEEN AKPGTSVMTV NATDADDAVN
310 320 330 340 350
TDNGIVSYSI VSQQPPRPHP QMFTIDPAKG IISVLGTGLD RETTPNYTLI
360 370 380 390 400
VQATDQEGKG LSNTATAIIE VTDANDNIPI FNPTMYEGVV EENKPGTEVA
410 420 430 440 450
RLTVTDQDAP GSPAWQAVYH IKSGNLDGAF SIITDPSTNN GILKTAKGLD
460 470 480 490 500
YETKSRYDLV VTVENKVPLS VPITLSTASV LVTVLDVNEP PVFVPPIKRV
510 520 530 540 550
GVPEDLPVGQ QVTSYTAQDP DRDMRQKITY RMGSDPAGWL YIHPENGIVT
560 570 580 590 600
ATQPLDRESV HAINSTYKAI ILAVDNGIPD TTGTGTLLLL LQDVNDNGPT
610 620 630 640 650
PEPRSFEICS RQPEKQILSI VDKDLPPHTY PFKAALEHGS SNNWTVEIRG
660 670 680 690 700
QDELAMGLKK ELEPGEYNIF VKLTDSQGKA QVTQVKAQVC ECEGTAKNCE
710 720 730 740 750
RRSYIVGGLG VPAILGILGG ILALLILLLL LLLFARRRKV EKEPLLPPED
760 770 780 790 800
DMRDNVYNYD EEGGGEEDQD YDLSQLHRGL DARPEVIRND VAPPLMAAPQ
810 820 830 840 850
YRPRPANPDE IGNFIDENLK AADTDPTAPP YDSLLVFDYE GGGSEATSLS
860 870 880
SLNSSASDQD QDYDYLNEWG NRFKKLAELY GGGEDDE
Length:887
Mass (Da):97,783
Last modified:February 1, 1991 - v2
Checksum:iF56A8A9779A94A40
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140T → M in AAA82572 (PubMed:3174655).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22190
, M22180, M22181, M22182, M22186, M22183, M22194, M22184, M22185, M22189, M22193, M22187, M22192, M22191, M22195 Genomic DNA Translation: AAA82572.1
M16260 mRNA Translation: AAA82573.1
PIRiA30201 IJCHCL
RefSeqiNP_001034347.2, NM_001039258.2
UniGeneiGga.2982

Genome annotation databases

GeneIDi415860
KEGGigga:415860

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22190
, M22180, M22181, M22182, M22186, M22183, M22194, M22184, M22185, M22189, M22193, M22187, M22192, M22191, M22195 Genomic DNA Translation: AAA82572.1
M16260 mRNA Translation: AAA82573.1
PIRiA30201 IJCHCL
RefSeqiNP_001034347.2, NM_001039258.2
UniGeneiGga.2982

3D structure databases

ProteinModelPortaliP08641
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08641, 2 interactors

PTM databases

iPTMnetiP08641

Proteomic databases

PRIDEiP08641

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi415860
KEGGigga:415860

Organism-specific databases

CTDi999

Phylogenomic databases

HOGENOMiHOG000231254
HOVERGENiHBG106438
InParanoidiP08641
KOiK05689
PhylomeDBiP08641

Miscellaneous databases

PROiPR:P08641

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR014868 Cadherin_pro_dom
IPR027397 Catenin_binding_dom_sf
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PF08758 Cadherin_pro, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SM01055 Cadherin_pro, 1 hit
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 3 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCADH1_CHICK
AccessioniPrimary (citable) accession number: P08641
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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