UniProtKB - P08641 (CADH1_CHICK)
Protein
Cadherin-1
Gene
CDH1
Organism
Gallus gallus (Chicken)
Status
Functioni
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha-E/beta-7.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 263 | Calcium 1By similarity | 1 | |
Metal bindingi | 263 | Calcium 2By similarity | 1 | |
Metal bindingi | 294 | Calcium 3By similarity | 1 |
GO - Molecular functioni
- cadherin binding Source: GO_Central
- calcium ion binding Source: GO_Central
GO - Biological processi
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- synapse assembly Source: GO_Central
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-1Alternative name(s): Epithelial cadherin Short name: E-cadherin Liver cell adhesion molecule Short name: L-CAM |
Gene namesi | Name:CDH1 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- catenin complex Source: GO_Central
- flotillin complex Source: GO_Central
Other locations
- apical junction complex Source: GO_Central
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 161 – 714 | ExtracellularSequence analysisAdd BLAST | 554 | |
Transmembranei | 715 – 735 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 736 – 887 | CytoplasmicSequence analysisAdd BLAST | 152 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
PropeptideiPRO_0000003721 | 27 – 160 | Add BLAST | 134 | |
ChainiPRO_0000003722 | 161 – 887 | Cadherin-1Add BLAST | 727 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 291 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 346 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 564 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 643 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, GlycoproteinProteomic databases
PRIDEi | P08641 |
PTM databases
iPTMneti | P08641 |
Expressioni
Tissue specificityi
Non-neural epithelial tissues.
Interactioni
Subunit structurei
Homodimer.
Interacts with CTNNA2.
1 PublicationGO - Molecular functioni
- cadherin binding Source: GO_Central
Protein-protein interaction databases
IntActi | P08641, 2 interactors |
STRINGi | 9031.ENSGALP00000000855 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 161 – 268 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 269 – 381 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 113 | |
Domaini | 382 – 493 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 494 – 599 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 600 – 704 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 105 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 844 – 855 | Ser-richAdd BLAST | 12 |
Domaini
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
InParanoidi | P08641 |
OrthoDBi | 182239at2759 |
PhylomeDBi | P08641 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin_binding_dom_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P08641-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRRWGSPAL QRFPVLVLLL LLQVCGRRCD EAAPCQPGFA AETFSFSVPQ
60 70 80 90 100
DSVAAGRELG RVSFAACSGR PWAVYVPTDT RFKVNGDGVV STKRPLTLYG
110 120 130 140 150
RKISFTIYAQ DAMGKRHSAR VTVGRHRHRR HHHNHHLQDT TPAVLTFPKH
160 170 180 190 200
DPGFLRRQKR DWVIPPISCL ENHRGPYPMR LVQIKSNKDK ESKVYYSITG
210 220 230 240 250
QGADSPPVGI FIIERETGWL EVTEQLDREK IDRYTLLSHA VSASGQPVED
260 270 280 290 300
PMEIIITVMD QNDNKPVFIK EVFVGYIEEN AKPGTSVMTV NATDADDAVN
310 320 330 340 350
TDNGIVSYSI VSQQPPRPHP QMFTIDPAKG IISVLGTGLD RETTPNYTLI
360 370 380 390 400
VQATDQEGKG LSNTATAIIE VTDANDNIPI FNPTMYEGVV EENKPGTEVA
410 420 430 440 450
RLTVTDQDAP GSPAWQAVYH IKSGNLDGAF SIITDPSTNN GILKTAKGLD
460 470 480 490 500
YETKSRYDLV VTVENKVPLS VPITLSTASV LVTVLDVNEP PVFVPPIKRV
510 520 530 540 550
GVPEDLPVGQ QVTSYTAQDP DRDMRQKITY RMGSDPAGWL YIHPENGIVT
560 570 580 590 600
ATQPLDRESV HAINSTYKAI ILAVDNGIPD TTGTGTLLLL LQDVNDNGPT
610 620 630 640 650
PEPRSFEICS RQPEKQILSI VDKDLPPHTY PFKAALEHGS SNNWTVEIRG
660 670 680 690 700
QDELAMGLKK ELEPGEYNIF VKLTDSQGKA QVTQVKAQVC ECEGTAKNCE
710 720 730 740 750
RRSYIVGGLG VPAILGILGG ILALLILLLL LLLFARRRKV EKEPLLPPED
760 770 780 790 800
DMRDNVYNYD EEGGGEEDQD YDLSQLHRGL DARPEVIRND VAPPLMAAPQ
810 820 830 840 850
YRPRPANPDE IGNFIDENLK AADTDPTAPP YDSLLVFDYE GGGSEATSLS
860 870 880
SLNSSASDQD QDYDYLNEWG NRFKKLAELY GGGEDDE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 140 | T → M in AAA82572 (PubMed:3174655).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22190 , M22180, M22181, M22182, M22186, M22183, M22194, M22184, M22185, M22189, M22193, M22187, M22192, M22191, M22195 Genomic DNA Translation: AAA82572.1 M16260 mRNA Translation: AAA82573.1 |
PIRi | A30201, IJCHCL |
RefSeqi | NP_001034347.2, NM_001039258.2 |
Genome annotation databases
GeneIDi | 415860 |
KEGGi | gga:415860 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22190 , M22180, M22181, M22182, M22186, M22183, M22194, M22184, M22185, M22189, M22193, M22187, M22192, M22191, M22195 Genomic DNA Translation: AAA82572.1 M16260 mRNA Translation: AAA82573.1 |
PIRi | A30201, IJCHCL |
RefSeqi | NP_001034347.2, NM_001039258.2 |
3D structure databases
SMRi | P08641 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P08641, 2 interactors |
STRINGi | 9031.ENSGALP00000000855 |
PTM databases
iPTMneti | P08641 |
Proteomic databases
PRIDEi | P08641 |
Genome annotation databases
GeneIDi | 415860 |
KEGGi | gga:415860 |
Organism-specific databases
CTDi | 999 |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
InParanoidi | P08641 |
OrthoDBi | 182239at2759 |
PhylomeDBi | P08641 |
Miscellaneous databases
PROi | PR:P08641 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin_binding_dom_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CADH1_CHICK | |
Accessioni | P08641Primary (citable) accession number: P08641 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | February 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |