UniProtKB - P08631 (HCK_HUMAN)
Tyrosine-protein kinase HCK
HCK
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation8 PublicationsEC:2.7.10.2PROSITE-ProRule annotation8 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 290 | ATP | 1 | |
Active sitei | 381 | Proton acceptor | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 268 – 276 | ATP | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: GO_Central
- phosphotyrosine residue binding Source: CAFA
- protein tyrosine kinase activity Source: UniProtKB
- signaling receptor binding Source: GO_Central
GO - Biological processi
- cell adhesion Source: UniProtKB
- cell differentiation Source: GO_Central
- cytokine-mediated signaling pathway Source: UniProtKB
- Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: GO_Central
- innate immune response-activating signal transduction Source: UniProtKB
- integrin-mediated signaling pathway Source: UniProtKB
- interferon-gamma-mediated signaling pathway Source: UniProtKB
- leukocyte degranulation Source: UniProtKB
- leukocyte migration involved in immune response Source: UniProtKB
- lipopolysaccharide-mediated signaling pathway Source: UniProtKB
- mesoderm development Source: ProtInc
- negative regulation of apoptotic process Source: UniProtKB
- peptidyl-tyrosine autophosphorylation Source: GO_Central
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of actin cytoskeleton reorganization Source: UniProtKB
- positive regulation of actin filament polymerization Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- protein phosphorylation Source: ProtInc
- regulation of cell population proliferation Source: GO_Central
- regulation of cell shape Source: UniProtKB
- regulation of defense response to virus by virus Source: Reactome
- regulation of DNA-binding transcription factor activity Source: UniProtKB
- regulation of inflammatory response Source: UniProtKB
- regulation of phagocytosis Source: UniProtKB
- regulation of podosome assembly Source: UniProtKB
- respiratory burst after phagocytosis Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Exocytosis, Host-virus interaction, Immunity, Inflammatory response, Innate immunity, Phagocytosis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P08631 |
Reactomei | R-HSA-164944, Nef and signal transduction R-HSA-2029481, FCGR activation R-HSA-912631, Regulation of signaling by CBL R-HSA-9607240, FLT3 Signaling R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis |
SignaLinki | P08631 |
SIGNORi | P08631 |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase HCK (EC:2.7.10.2)Alternative name(s): Hematopoietic cell kinase Hemopoietic cell kinase p59-HCK/p60-HCK p59Hck p61Hck |
Gene namesi | Name:HCK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000101336.12 |
HGNCi | HGNC:4840, HCK |
MIMi | 142370, gene |
neXtProti | NX_P08631 |
Subcellular locationi
Cytosol
Lysosome
Plasma membrane
Other locations
Note: Associated with specialized secretory lysosomes called azurophil granules. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated.
Golgi apparatus
- Golgi apparatus 1 Publication
Cytoskeleton
- cytoskeleton 1 Publication
Lysosome
- Lysosome 1 Publication
Nucleus
- Nucleus 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Lipid-anchor 1 Publication
Other locations
- caveola 1 Publication; Lipid-anchor 1 Publication
- focal adhesion 1 Publication
- Cytoplasmic vesicle 1 Publication
Note: 20% of this isoform is associated with caveolae. Localization at the cell membrane and at caveolae requires palmitoylation at Cys-3. Colocalizes with the actin cytoskeleton at focal adhesions.
Cytosol
Other locations
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Lysosome
- lysosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- caveola Source: UniProtKB
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
- plasma membrane Source: HPA
Other locations
- cell projection Source: UniProtKB-KW
- focal adhesion Source: UniProtKB
- transport vesicle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Lysosome, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 3 | G → C: Slight palmitoylation, cytoplasmic and caveolar localization; in isoform 1;. 2 Publications | 1 | |
Mutagenesisi | 3 | G → S: Abolishes palmitoylation and localization at the cell membrane. 2 Publications | 1 | |
Mutagenesisi | 23 | G → A: Myristoylation and palmitoylation are abolished, leading to entirely cytoplasmic localization; in isoform 2. 1 Publication | 1 | |
Mutagenesisi | 24 | C → S: Palmitoylation is abolished, some cytoplasmic and no calveolar localization; in isoform 2. 1 Publication | 1 | |
Mutagenesisi | 290 | K → E: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 305 | E → A: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 381 | D → E: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 411 | Y → A: Reduced catalytic activity and higher affinity for target peptides. 1 Publication | 1 | |
Mutagenesisi | 522 | Y → F: Constitutively activated kinase, leading to cellular transformation. 2 Publications | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 3055 |
OpenTargetsi | ENSG00000101336 |
PharmGKBi | PA29216 |
Miscellaneous databases
Pharosi | P08631, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3234 |
DrugBanki | DB01809, 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine DB06616, Bosutinib DB12010, Fostamatinib DB01962, Phosphonotyrosine DB04216, Quercetin |
DrugCentrali | P08631 |
GuidetoPHARMACOLOGYi | 2032 |
Polymorphism and mutation databases
BioMutai | HCK |
DMDMi | 20141296 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Initiator methioninei | Removed | ||||
ChainiPRO_0000024433 | 2 – 526 | Tyrosine-protein kinase HCKAdd BLAST | 525 | ||
Isoform 2 (identifier: P08631-2) | |||||
Initiator methioninei | RemovedCurated |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 | ||
Modified residuei | 36 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 51 | Phosphotyrosine; by autocatalysis1 Publication | 1 | ||
Modified residuei | 202 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 209 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 411 | Phosphotyrosine; by autocatalysis2 Publications | 1 | ||
Modified residuei | 462 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 522 | Phosphotyrosine5 Publications | 1 | ||
Isoform 2 (identifier: P08631-2) | |||||
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 | ||
Lipidationi | 3 | S-palmitoyl cysteine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Myristate, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P08631 |
MassIVEi | P08631 |
MaxQBi | P08631 |
PaxDbi | P08631 |
PeptideAtlasi | P08631 |
PRIDEi | P08631 |
ProteomicsDBi | 52142 [P08631-1] 52143 [P08631-2] 52144 [P08631-3] 52145 [P08631-4] |
PTM databases
iPTMneti | P08631 |
PhosphoSitePlusi | P08631 |
SwissPalmi | P08631 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000101336, Expressed in blood and 213 other tissues |
ExpressionAtlasi | P08631, baseline and differential |
Genevisiblei | P08631, HS |
Organism-specific databases
HPAi | ENSG00000101336, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated).
Interacts with VAV1, WAS and RAPGEF1 (By similarity). This interaction stimulates its tyrosine-kinase activity.
Interacts with ARRB1 and ARRB2.
Interacts with ADAM15.
Interacts with FASLG.
Interacts with CBL.
Interacts with FCGR1A; the interaction may be indirect.
Interacts with IL6ST.
Interacts (via SH3 domain) with ELMO1.
Interacts (via SH3 domain) with TP73.
Interacts with YAP1.
Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1.
Interacts (via SH3 domain) with WDCP.
By similarity19 Publications(Microbial infection) Interacts (via SH3 domain) with HEV ORF3 protein.
1 Publication(Microbial infection) Interacts (via SH3 domain) with HIV-1 Nef and Vif.
5 PublicationsBinary interactionsi
P08631
Isoform 2 [P08631-2]
GO - Molecular functioni
- phosphotyrosine residue binding Source: CAFA
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 109305, 105 interactors |
DIPi | DIP-1051N |
ELMi | P08631 |
IntActi | P08631, 145 interactors |
MINTi | P08631 |
STRINGi | 9606.ENSP00000444986 |
Chemistry databases
BindingDBi | P08631 |
Miscellaneous databases
RNActi | P08631, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P08631 |
SMRi | P08631 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08631 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 138 | SH3PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 144 – 241 | SH2PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 262 – 515 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 254 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000158738 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | P08631 |
PhylomeDBi | P08631 |
Family and domain databases
CDDi | cd10363, SH2_Src_HCK, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035851, HCK_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGGRSSCEDP GCPRDEERAP RMGCMKSKFL QVGGNTFSKT ETSASPHCPV
60 70 80 90 100
YVPDPTSTIK PGPNSHNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ
110 120 130 140 150
KGDQMVVLEE SGEWWKARSL ATRKEGYIPS NYVARVDSLE TEEWFFKGIS
160 170 180 190 200
RKDAERQLLA PGNMLGSFMI RDSETTKGSY SLSVRDYDPR QGDTVKHYKI
210 220 230 240 250
RTLDNGGFYI SPRSTFSTLQ ELVDHYKKGN DGLCQKLSVP CMSSKPQKPW
260 270 280 290 300
EKDAWEIPRE SLKLEKKLGA GQFGEVWMAT YNKHTKVAVK TMKPGSMSVE
310 320 330 340 350
AFLAEANVMK TLQHDKLVKL HAVVTKEPIY IITEFMAKGS LLDFLKSDEG
360 370 380 390 400
SKQPLPKLID FSAQIAEGMA FIEQRNYIHR DLRAANILVS ASLVCKIADF
410 420 430 440 450
GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGSFTIKSDV WSFGILLMEI
460 470 480 490 500
VTYGRIPYPG MSNPEVIRAL ERGYRMPRPE NCPEELYNIM MRCWKNRPEE
510 520
RPTFEYIQSV LDDFYTATES QYQQQP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y3C5 | H0Y3C5_HUMAN | Tyrosine-protein kinase | HCK | 525 | Annotation score: | ||
J3KPD6 | J3KPD6_HUMAN | Tyrosine-protein kinase | HCK | 526 | Annotation score: | ||
H7C5P9 | H7C5P9_HUMAN | Tyrosine-protein kinase HCK | HCK | 61 | Annotation score: | ||
H7BXG4 | H7BXG4_HUMAN | Tyrosine-protein kinase HCK | HCK | 41 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 | C → S in AAA52643 (PubMed:3496523).Curated | 1 | |
Sequence conflicti | 69 | N → D in BAF82585 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 144 | W → R in BAB15482 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 168 | F → Y in BAF82585 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 378 | I → T in AAI13855 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 488 | N → S in BAF82585 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041707 | 44 | A → T1 PublicationCorresponds to variant dbSNP:rs56029200Ensembl. | 1 | |
Natural variantiVAR_041708 | 105 | M → L2 PublicationsCorresponds to variant dbSNP:rs55722810Ensembl. | 1 | |
Natural variantiVAR_041709 | 399 | D → G in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_033836 | 502 | P → Q. Corresponds to variant dbSNP:rs17093828Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018858 | 1 – 21 | Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_041926 | 76 | Missing in isoform 3 and isoform 4. 2 Publications | 1 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000518730; ENSP00000427757; ENSG00000101336 [P08631-3] ENST00000520553; ENSP00000429848; ENSG00000101336 [P08631-2] ENST00000538448; ENSP00000441169; ENSG00000101336 [P08631-2] ENST00000629881; ENSP00000486627; ENSG00000101336 [P08631-2] |
GeneIDi | 3055 |
KEGGi | hsa:3055 |
UCSCi | uc002wxi.4, human [P08631-1] |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AD5 | X-ray | 2.60 | A/B | 79-526 | [»] | |
1BU1 | X-ray | 2.60 | A/B/C/D/E/F | 81-137 | [»] | |
1QCF | X-ray | 2.00 | A | 81-526 | [»] | |
2C0I | X-ray | 2.30 | A/B | 81-526 | [»] | |
2C0O | X-ray | 2.85 | A/B | 81-526 | [»] | |
2C0T | X-ray | 2.15 | A/B | 81-526 | [»] | |
2HCK | X-ray | 3.00 | A/B | 79-526 | [»] | |
2HK5 | X-ray | 2.00 | A | 247-514 | [»] | |
2OI3 | NMR | - | A | 61-141 | [»] | |
2OJ2 | NMR | - | A | 61-141 | [»] | |
3HCK | NMR | - | A | 140-245 | [»] | |
3NHN | X-ray | 2.61 | A | 72-256 | [»] | |
3RBB | X-ray | 2.35 | B/D | 79-138 | [»] | |
3REA | X-ray | 2.00 | B/D | 79-138 | [»] | |
3REB | X-ray | 3.45 | B/D | 79-138 | [»] | |
3VRY | X-ray | 2.48 | A/B | 81-526 | [»] | |
3VRZ | X-ray | 2.22 | A/B | 81-526 | [»] | |
3VS0 | X-ray | 2.93 | A/B | 81-526 | [»] | |
3VS1 | X-ray | 2.46 | A/B | 81-526 | [»] | |
3VS2 | X-ray | 2.61 | A/B | 81-526 | [»] | |
3VS3 | X-ray | 2.17 | A/B | 81-526 | [»] | |
3VS4 | X-ray | 2.75 | A/B | 81-526 | [»] | |
3VS5 | X-ray | 2.85 | A/B | 81-526 | [»] | |
3VS6 | X-ray | 2.37 | A/B | 81-526 | [»] | |
3VS7 | X-ray | 3.00 | A/B | 81-526 | [»] | |
4HCK | NMR | - | A | 72-143 | [»] | |
4LUD | X-ray | 2.85 | A/B | 81-526 | [»] | |
4LUE | X-ray | 3.04 | A/B | 81-526 | [»] | |
4ORZ | X-ray | 2.00 | A | 77-138 | [»] | |
4U5W | X-ray | 1.86 | B/D | 72-242 | [»] | |
5H09 | X-ray | 1.95 | A | 81-526 | [»] | |
5H0B | X-ray | 1.65 | A | 81-526 | [»] | |
5H0E | X-ray | 2.10 | A | 81-526 | [»] | |
5H0G | X-ray | 1.80 | A | 81-526 | [»] | |
5H0H | X-ray | 1.72 | A | 81-526 | [»] | |
5HCK | NMR | - | A | 72-143 | [»] | |
5NUH | X-ray | 2.78 | C/D | 79-138 | [»] | |
5ZJ6 | X-ray | 1.70 | A/B | 242-521 | [»] | |
BMRBi | P08631 | |||||
SMRi | P08631 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109305, 105 interactors |
DIPi | DIP-1051N |
ELMi | P08631 |
IntActi | P08631, 145 interactors |
MINTi | P08631 |
STRINGi | 9606.ENSP00000444986 |
Chemistry databases
BindingDBi | P08631 |
ChEMBLi | CHEMBL3234 |
DrugBanki | DB01809, 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine DB06616, Bosutinib DB12010, Fostamatinib DB01962, Phosphonotyrosine DB04216, Quercetin |
DrugCentrali | P08631 |
GuidetoPHARMACOLOGYi | 2032 |
PTM databases
iPTMneti | P08631 |
PhosphoSitePlusi | P08631 |
SwissPalmi | P08631 |
Polymorphism and mutation databases
BioMutai | HCK |
DMDMi | 20141296 |
Proteomic databases
jPOSTi | P08631 |
MassIVEi | P08631 |
MaxQBi | P08631 |
PaxDbi | P08631 |
PeptideAtlasi | P08631 |
PRIDEi | P08631 |
ProteomicsDBi | 52142 [P08631-1] 52143 [P08631-2] 52144 [P08631-3] 52145 [P08631-4] |
Protocols and materials databases
Antibodypediai | 3921, 569 antibodies |
DNASUi | 3055 |
Genome annotation databases
Ensembli | ENST00000518730; ENSP00000427757; ENSG00000101336 [P08631-3] ENST00000520553; ENSP00000429848; ENSG00000101336 [P08631-2] ENST00000538448; ENSP00000441169; ENSG00000101336 [P08631-2] ENST00000629881; ENSP00000486627; ENSG00000101336 [P08631-2] |
GeneIDi | 3055 |
KEGGi | hsa:3055 |
UCSCi | uc002wxi.4, human [P08631-1] |
Organism-specific databases
CTDi | 3055 |
DisGeNETi | 3055 |
EuPathDBi | HostDB:ENSG00000101336.12 |
GeneCardsi | HCK |
HGNCi | HGNC:4840, HCK |
HPAi | ENSG00000101336, Group enriched (blood, lymphoid tissue) |
MIMi | 142370, gene |
neXtProti | NX_P08631 |
OpenTargetsi | ENSG00000101336 |
PharmGKBi | PA29216 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000158738 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | P08631 |
PhylomeDBi | P08631 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P08631 |
Reactomei | R-HSA-164944, Nef and signal transduction R-HSA-2029481, FCGR activation R-HSA-912631, Regulation of signaling by CBL R-HSA-9607240, FLT3 Signaling R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis |
SignaLinki | P08631 |
SIGNORi | P08631 |
Miscellaneous databases
BioGRID-ORCSi | 3055, 6 hits in 874 CRISPR screens |
ChiTaRSi | HCK, human |
EvolutionaryTracei | P08631 |
GeneWikii | HCK |
GenomeRNAii | 3055 |
Pharosi | P08631, Tclin |
PROi | PR:P08631 |
RNActi | P08631, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101336, Expressed in blood and 213 other tissues |
ExpressionAtlasi | P08631, baseline and differential |
Genevisiblei | P08631, HS |
Family and domain databases
CDDi | cd10363, SH2_Src_HCK, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035851, HCK_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HCK_HUMAN | |
Accessioni | P08631Primary (citable) accession number: P08631 Secondary accession number(s): A8K1I1 Q9UMJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 255 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index