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UniProtKB - P08631 (HCK_HUMAN)

Entry version 261 (25 May 2022)
Sequence version 5 (23 Jan 2007)
Previous versions | rss
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Protein

Tyrosine-protein kinase HCK

Gene

HCK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.

19 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Subject to autoinhibition, mediated by intramolecular interactions involving the SH2 and SH3 domains. Kinase activity is also regulated by phosphorylation at regulatory tyrosine residues. Phosphorylation at Tyr-411 is required for optimal activity. Phosphorylation at Tyr-522 inhibits kinase activity. Inhibited by PP1 and A-770041.9 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei290ATP1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei381Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi268 – 276ATP9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
Biological processExocytosis, Host-virus interaction, Immunity, Inflammatory response, Innate immunity, Phagocytosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.10.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08631

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-164944, Nef and signal transduction
R-HSA-2029481, FCGR activation
R-HSA-912631, Regulation of signaling by CBL
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-9674555, Signaling by CSF3 (G-CSF)
R-HSA-9705462, Inactivation of CSF3 (G-CSF) signaling
R-HSA-9706374, FLT3 signaling through SRC family kinases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P08631

SIGNOR Signaling Network Open Resource

More...SIGNORi		P08631

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein kinase HCK (EC:2.7.10.2)
Alternative name(s):
Hematopoietic cell kinase
Hemopoietic cell kinase
p59-HCK/p60-HCK
p59Hck
p61Hck
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HCK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4840, HCK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142370, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08631

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000101336

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Lysosome, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Aberrant activation of HCK by HIV-1 protein Nef enhances HIV-1 replication and contributes to HIV-1 pathogenicity.
Aberrant activation of HCK, e.g. by the BCR-ABL fusion protein, promotes cancer cell proliferation.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi3G → C: Slight palmitoylation, cytoplasmic and caveolar localization; in isoform 1;. 2 Publications1
Mutagenesisi3G → S: Abolishes palmitoylation and localization at the cell membrane. 2 Publications1
Mutagenesisi23G → A: Myristoylation and palmitoylation are abolished, leading to entirely cytoplasmic localization; in isoform 2. 1 Publication1
Mutagenesisi24C → S: Palmitoylation is abolished, some cytoplasmic and no calveolar localization; in isoform 2. 1 Publication1
Mutagenesisi290K → E: Loss of kinase activity. 1 Publication1
Mutagenesisi305E → A: Loss of kinase activity. 1 Publication1
Mutagenesisi381D → E: Loss of kinase activity. 1 Publication1
Mutagenesisi411Y → A: Reduced catalytic activity and higher affinity for target peptides. 1 Publication1
Mutagenesisi522Y → F: Constitutively activated kinase, leading to cellular transformation. 2 Publications1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		3055

Open Targets

More...OpenTargetsi		ENSG00000101336

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29216

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08631, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3234

Drug and drug target database

More...DrugBanki		DB01809, 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
DB06616, Bosutinib
DB12010, Fostamatinib
DB01962, Phosphonotyrosine
DB04216, Quercetin

DrugCentral

More...DrugCentrali		P08631

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2032

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HCK

Domain mapping of disease mutations (DMDM)

More...DMDMi		20141296

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000244332 – 526Tyrosine-protein kinase HCKAdd BLAST525
Isoform 2 (identifier: P08631-2)
Initiator methionineiRemovedCurated

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei36PhosphothreonineCombined sources1
Modified residuei51Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei202PhosphothreonineCombined sources1
Modified residuei209PhosphotyrosineBy similarity1
Modified residuei411Phosphotyrosine; by autocatalysis2 Publications1
Modified residuei462PhosphoserineCombined sources1
Modified residuei522Phosphotyrosine5 Publications1
Isoform 2 (identifier: P08631-2)
Lipidationi2N-myristoyl glycine1 Publication1
Lipidationi3S-palmitoyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on several tyrosine residues. Autophosphorylated. Becomes rapidly phosphorylated upon activation of the immunoglobulin receptors FCGR1A and FCGR2A. Phosphorylation by the BCR-ABL fusion protein mediates activation of HCK. Phosphorylation at Tyr-411 increases kinase activity. Phosphorylation at Tyr-522 inhibits kinase activity. Kinase activity is not required for phosphorylation at Tyr-522, suggesting that this site is a target of other kinases.9 Publications
Ubiquitinated by CBL, leading to its degradation via the proteasome.1 Publication
Isoform 2 palmitoylation at position 2 requires prior myristoylation. Palmitoylation at position 3 is required for caveolar localization of isoform 2.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P08631

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P08631

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08631

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08631

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08631

PeptideAtlas

More...PeptideAtlasi		P08631

PRoteomics IDEntifications database

More...PRIDEi		P08631

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52142 [P08631-1]
52143 [P08631-2]
52144 [P08631-3]
52145 [P08631-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P08631, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08631

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08631

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P08631

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during myeloid cell differentiation. The highest levels are detected in fully differentiated phagocytes. Up-regulated by IL2.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000101336, Expressed in blood and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P08631, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08631, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000101336, Tissue enhanced (bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated).

Interacts with VAV1, WAS and RAPGEF1 (By similarity). This interaction stimulates its tyrosine-kinase activity.

Interacts with ARRB1 and ARRB2.

Interacts with ADAM15.

Interacts with FASLG.

Interacts with CBL.

Interacts with FCGR1A; the interaction may be indirect.

Interacts with IL6ST.

Interacts (via SH3 domain) with ELMO1.

Interacts (via SH3 domain) with TP73.

Interacts with YAP1.

Interacts with ABL1 and ITGB1, and thereby recruits ABL1 to activated ITGB1.

Interacts (via SH3 domain) with WDCP.

By similarity19 Publications

(Microbial infection) Interacts (via SH3 domain) with HEV ORF3 protein.

1 Publication

(Microbial infection) Interacts (via SH3 domain) with HIV-1 Nef and Vif.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P08631
With#Exp.IntAct
ADAM10 [O14672]2EBI-346340,EBI-1536151
ADAM12 [O43184]2EBI-346340,EBI-2625825
ADAM15 [Q13444]4EBI-346340,EBI-77818
ALOX5 [P09917]2EBI-346340,EBI-79934
ASAP1 [Q9ULH1]2EBI-346340,EBI-346622
EGFR [P00533]3EBI-346340,EBI-297353
ELMO1 [Q92556]4EBI-346340,EBI-346417
ERBB3 [P21860]2EBI-346340,EBI-720706
GOPC [Q9HD26]3EBI-346340,EBI-349832
HSP90AB1 [P08238]4EBI-346340,EBI-352572
KHDRBS1 [Q07666]4EBI-346340,EBI-1364
KIT [P10721]2EBI-346340,EBI-1379503
KRT40 [Q6A162]3EBI-346340,EBI-10171697
KRTAP10-9 [P60411]3EBI-346340,EBI-10172052
MTUS2 [Q5JR59]3EBI-346340,EBI-742948
NLRP12 [P59046]4EBI-346340,EBI-6374637
NOTCH2NLA [Q7Z3S9]3EBI-346340,EBI-945833
PAK2 [Q13177]2EBI-346340,EBI-1045887
PDCD6IP [Q8WUM4]4EBI-346340,EBI-310624
SOS1 [Q07889]4EBI-346340,EBI-297487
WAS [P42768]9EBI-346340,EBI-346375
WIPF1 [O43516]3EBI-346340,EBI-346356
nef [P03406] from Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI).2EBI-346340,EBI-15672419
nef [Q90VU7] from Human immunodeficiency virus 1.2EBI-346340,EBI-7460704
vif [P12504] from Human immunodeficiency virus type 1 group M subtype B (isolate NY5).3EBI-346340,EBI-779991
O92972 from Hepatitis C virus genotype 1b (strain HC-J4).2EBI-346340,EBI-710506
P27958 from Hepatitis C virus genotype 1a (isolate H77).5EBI-346340,EBI-706378
Isoform 2 [P08631-2]
With#Exp.IntAct
AGR2 [O95994]3EBI-9834454,EBI-712648
BPIFA1 [Q9NP55]3EBI-9834454,EBI-953896
CBL [P22681]2EBI-9834454,EBI-518228
CCDC88B [A6NC98]3EBI-9834454,EBI-347573
CTAG1B [P78358]3EBI-9834454,EBI-1188472
CYB5D2 [Q8WUJ1]3EBI-9834454,EBI-19113794
CYSRT1 [A8MQ03]3EBI-9834454,EBI-3867333
FHL5 [Q5TD97]3EBI-9834454,EBI-750641
FRS3 [O43559]2EBI-9834454,EBI-725515
GOPC - isoform 2 [Q9HD26-2]3EBI-9834454,EBI-11102276
HSF2BP [O75031]3EBI-9834454,EBI-7116203
INCA1 [Q0VD86]3EBI-9834454,EBI-6509505
KPRP [Q5T749]3EBI-9834454,EBI-10981970
KRT31 [Q15323]3EBI-9834454,EBI-948001
KRT34 [O76011]3EBI-9834454,EBI-1047093
KRT35 [Q92764]3EBI-9834454,EBI-1058674
KRT36 - isoform 2 [O76013-2]3EBI-9834454,EBI-11958506
KRT40 [Q6A162]3EBI-9834454,EBI-10171697
KRTAP1-1 [Q07627]3EBI-9834454,EBI-11959885
KRTAP1-3 [Q8IUG1]3EBI-9834454,EBI-11749135
KRTAP10-7 [P60409]3EBI-9834454,EBI-10172290
KRTAP10-8 [P60410]3EBI-9834454,EBI-10171774
KRTAP10-9 [P60411]3EBI-9834454,EBI-10172052
KRTAP3-1 [Q9BYR8]3EBI-9834454,EBI-9996449
MDK [P21741]3EBI-9834454,EBI-722444
MID2 - isoform 2 [Q9UJV3-2]3EBI-9834454,EBI-10172526
MKRN3 [Q13064]3EBI-9834454,EBI-2340269
MTUS2 - isoform 2 [Q5JR59-3]3EBI-9834454,EBI-11522433
NOTCH2NLC [P0DPK4]3EBI-9834454,EBI-22310682
OLIG1 [Q8TAK6]2EBI-9834454,EBI-3867416
PIK3R3 [Q92569]4EBI-9834454,EBI-79893
PLEKHG4 [Q58EX7]3EBI-9834454,EBI-949255
PNMA1 [Q8ND90]3EBI-9834454,EBI-302345
PTK2 [Q05397]2EBI-9834454,EBI-702142
RBPMS - isoform C [Q93062-3]3EBI-9834454,EBI-740343
SH2B2 - isoform 2 [O14492-2]3EBI-9834454,EBI-19952306
TEKT4 [Q8WW24]3EBI-9834454,EBI-750487
TEPSIN [Q96N21]3EBI-9834454,EBI-11139477
TOX2 - isoform 3 [Q96NM4-3]3EBI-9834454,EBI-12815137
TRIM27 [P14373]3EBI-9834454,EBI-719493
TRIP6 [Q15654]3EBI-9834454,EBI-742327
WFS1 [O76024]3EBI-9834454,EBI-720609
ZSCAN4 [Q8NAM6]3EBI-9834454,EBI-7252920

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109305, 153 interactors

Database of interacting proteins

More...DIPi		DIP-1051N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P08631

Protein interaction database and analysis system

More...IntActi		P08631, 155 interactors

Molecular INTeraction database

More...MINTi		P08631

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000444986

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P08631

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08631, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1526
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P08631

Biological Magnetic Resonance Data Bank

More...BMRBi		P08631

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08631

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P08631

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 138SH3PROSITE-ProRule annotationAdd BLAST61
Domaini144 – 241SH2PROSITE-ProRule annotationAdd BLAST98
Domaini262 – 515Protein kinasePROSITE-ProRule annotationAdd BLAST254

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH3 domain mediates binding to HIV-1 Nef.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0197, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_7_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08631

Identification of Orthologs from Complete Genome Data

More...OMAi		QKLTFPC

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08631

Family and domain databases

Conserved Domains Database

More...CDDi		cd10363, SH2_Src_HCK, 1 hit

Database of protein disorder

More...DisProti		DP02383

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035851, HCK_SH2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF00017, SH2, 1 hit
PF00018, SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00401, SH2DOMAIN
PR00452, SH3DOMAIN
PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 1 hit
SM00219, TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 1 hit
SSF55550, SSF55550, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50001, SH2, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P08631-1) [UniParc]FASTAAdd to basket
Also known as: p60-HCK, p61Hck

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGRSSCEDP GCPRDEERAP RMGCMKSKFL QVGGNTFSKT ETSASPHCPV 
        60         70         80         90        100
YVPDPTSTIK PGPNSHNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ 
       110        120        130        140        150
KGDQMVVLEE SGEWWKARSL ATRKEGYIPS NYVARVDSLE TEEWFFKGIS 
       160        170        180        190        200
RKDAERQLLA PGNMLGSFMI RDSETTKGSY SLSVRDYDPR QGDTVKHYKI 
       210        220        230        240        250
RTLDNGGFYI SPRSTFSTLQ ELVDHYKKGN DGLCQKLSVP CMSSKPQKPW 
       260        270        280        290        300
EKDAWEIPRE SLKLEKKLGA GQFGEVWMAT YNKHTKVAVK TMKPGSMSVE 
       310        320        330        340        350
AFLAEANVMK TLQHDKLVKL HAVVTKEPIY IITEFMAKGS LLDFLKSDEG 
       360        370        380        390        400
SKQPLPKLID FSAQIAEGMA FIEQRNYIHR DLRAANILVS ASLVCKIADF 
       410        420        430        440        450
GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGSFTIKSDV WSFGILLMEI 
       460        470        480        490        500
VTYGRIPYPG MSNPEVIRAL ERGYRMPRPE NCPEELYNIM MRCWKNRPEE 
       510        520 
RPTFEYIQSV LDDFYTATES QYQQQP
Note: Initiates from a CTG codon.
Length:526
Mass (Da):59,600
Last modified:January 23, 2007 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i847E877A0A641725
GO
Isoform 2 (identifier: P08631-2) [UniParc]FASTAAdd to basket
Also known as: p59-HCK, p59Hck

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:505
Mass (Da):57,312
Checksum:i4F1EC1E8F3EDF9CA
GO
Isoform 3 (identifier: P08631-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     76-76: Missing.

Show »
Length:504
Mass (Da):57,241
Checksum:iC07FF5B8D3C1B862
GO
Isoform 4 (identifier: P08631-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-76: Missing.

Note: Initiates from a CTG codon.Curated
Show »
Length:525
Mass (Da):59,529
Checksum:i803967415A2F57FC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y3C5H0Y3C5_HUMAN
Tyrosine-protein kinase
HCK
525Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KPD6J3KPD6_HUMAN
Tyrosine-protein kinase
HCK
526Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXG4H7BXG4_HUMAN
Tyrosine-protein kinase HCK
HCK
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5P9H7C5P9_HUMAN
Tyrosine-protein kinase HCK
HCK
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA52643 differs from that shown. Reason: Frameshift.Curated
The sequence BAF82585 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24C → S in AAA52643 (PubMed:3496523).Curated1
Sequence conflicti69N → D in BAF82585 (PubMed:14702039).Curated1
Sequence conflicti144W → R in BAB15482 (PubMed:14702039).Curated1
Sequence conflicti168F → Y in BAF82585 (PubMed:14702039).Curated1
Sequence conflicti378I → T in AAI13855 (PubMed:15489334).Curated1
Sequence conflicti488N → S in BAF82585 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04170744A → T1 PublicationCorresponds to variant dbSNP:rs56029200Ensembl.1
Natural variantiVAR_041708105M → L2 PublicationsCorresponds to variant dbSNP:rs55722810Ensembl.1
Natural variantiVAR_041709399D → G in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_033836502P → Q. Corresponds to variant dbSNP:rs17093828Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0188581 – 21Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST21
Alternative sequenceiVSP_04192676Missing in isoform 3 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M16591 mRNA Translation: AAA52643.1 Frameshift.
M16592 mRNA Translation: AAA52644.1
AK026432 mRNA Translation: BAB15482.1
AK289896 mRNA Translation: BAF82585.1 Different initiation.
AK298726 mRNA Translation: BAG60878.1
AL353092, AL049539 Genomic DNA Translation: CAI19694.1
AL353092, AL049539 Genomic DNA Translation: CAI19695.1
AL049539, AL353092 Genomic DNA Translation: CAI22966.1
AL049539, AL353092 Genomic DNA Translation: CAI22967.1
CH471077 Genomic DNA Translation: EAW76392.1
CH471077 Genomic DNA Translation: EAW76393.1
BC014435 mRNA Translation: AAH14435.2
BC094847 mRNA Translation: AAH94847.2
BC108930 mRNA Translation: AAI08931.2
BC108931 mRNA Translation: AAI08932.2
BC113854 mRNA Translation: AAI13855.2
BC114463 mRNA Translation: AAI14464.2
X58741, X58742, X58743 Genomic DNA Translation: CAA41565.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33460.1 [P08631-1]
CCDS54453.1 [P08631-4]
CCDS54455.1 [P08631-2]
CCDS54456.1 [P08631-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A27811, TVHUHC
A41263

NCBI Reference Sequences

More...RefSeqi		NP_001165600.1, NM_001172129.1 [P08631-2]
NP_001165601.1, NM_001172130.1 [P08631-4]
NP_001165602.1, NM_001172131.1 [P08631-3]
NP_001165604.1, NM_001172133.1 [P08631-2]
NP_002101.2, NM_002110.3 [P08631-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000375852.5; ENSP00000365012.3; ENSG00000101336.18
ENST00000375862.7; ENSP00000365022.3; ENSG00000101336.18 [P08631-4]
ENST00000518730.5; ENSP00000427757.1; ENSG00000101336.18 [P08631-3]
ENST00000520553.5; ENSP00000429848.1; ENSG00000101336.18 [P08631-2]
ENST00000629881.2; ENSP00000486627.1; ENSG00000101336.18 [P08631-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3055

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3055

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000375852.5; ENSP00000365012.3; NM_002110.5; NP_002101.2

UCSC genome browser

More...UCSCi		uc002wxi.4, human [P08631-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16591 mRNA Translation: AAA52643.1 Frameshift.
M16592 mRNA Translation: AAA52644.1
AK026432 mRNA Translation: BAB15482.1
AK289896 mRNA Translation: BAF82585.1 Different initiation.
AK298726 mRNA Translation: BAG60878.1
AL353092, AL049539 Genomic DNA Translation: CAI19694.1
AL353092, AL049539 Genomic DNA Translation: CAI19695.1
AL049539, AL353092 Genomic DNA Translation: CAI22966.1
AL049539, AL353092 Genomic DNA Translation: CAI22967.1
CH471077 Genomic DNA Translation: EAW76392.1
CH471077 Genomic DNA Translation: EAW76393.1
BC014435 mRNA Translation: AAH14435.2
BC094847 mRNA Translation: AAH94847.2
BC108930 mRNA Translation: AAI08931.2
BC108931 mRNA Translation: AAI08932.2
BC113854 mRNA Translation: AAI13855.2
BC114463 mRNA Translation: AAI14464.2
X58741, X58742, X58743 Genomic DNA Translation: CAA41565.2
CCDSiCCDS33460.1 [P08631-1]
CCDS54453.1 [P08631-4]
CCDS54455.1 [P08631-2]
CCDS54456.1 [P08631-3]
PIRiA27811, TVHUHC
A41263
RefSeqiNP_001165600.1, NM_001172129.1 [P08631-2]
NP_001165601.1, NM_001172130.1 [P08631-4]
NP_001165602.1, NM_001172131.1 [P08631-3]
NP_001165604.1, NM_001172133.1 [P08631-2]
NP_002101.2, NM_002110.3 [P08631-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AD5X-ray2.60A/B79-526[»]
1BU1X-ray2.60A/B/C/D/E/F81-137[»]
1QCFX-ray2.00A81-526[»]
2C0IX-ray2.30A/B81-526[»]
2C0OX-ray2.85A/B81-526[»]
2C0TX-ray2.15A/B81-526[»]
2HCKX-ray3.00A/B79-526[»]
2HK5X-ray2.00A247-514[»]
2OI3NMR-A61-141[»]
2OJ2NMR-A61-141[»]
3HCKNMR-A140-245[»]
3NHNX-ray2.61A72-256[»]
3RBBX-ray2.35B/D79-138[»]
3REAX-ray2.00B/D79-138[»]
3REBX-ray3.45B/D79-138[»]
3VRYX-ray2.48A/B81-526[»]
3VRZX-ray2.22A/B81-526[»]
3VS0X-ray2.93A/B81-526[»]
3VS1X-ray2.46A/B81-526[»]
3VS2X-ray2.61A/B81-526[»]
3VS3X-ray2.17A/B81-526[»]
3VS4X-ray2.75A/B81-526[»]
3VS5X-ray2.85A/B81-526[»]
3VS6X-ray2.37A/B81-526[»]
3VS7X-ray3.00A/B81-526[»]
4HCKNMR-A72-143[»]
4LUDX-ray2.85A/B81-526[»]
4LUEX-ray3.04A/B81-526[»]
4ORZX-ray2.00A77-138[»]
4U5WX-ray1.86B/D72-242[»]
5H09X-ray1.95A81-526[»]
5H0BX-ray1.65A81-526[»]
5H0EX-ray2.10A81-526[»]
5H0GX-ray1.80A81-526[»]
5H0HX-ray1.72A81-526[»]
5HCKNMR-A72-143[»]
5NUHX-ray2.78C/D79-138[»]
5ZJ6X-ray1.70A/B242-521[»]
AlphaFoldDBiP08631
BMRBiP08631
SMRiP08631
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109305, 153 interactors
DIPiDIP-1051N
ELMiP08631
IntActiP08631, 155 interactors
MINTiP08631
STRINGi9606.ENSP00000444986

Chemistry databases

BindingDBiP08631
ChEMBLiCHEMBL3234
DrugBankiDB01809, 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
DB06616, Bosutinib
DB12010, Fostamatinib
DB01962, Phosphonotyrosine
DB04216, Quercetin
DrugCentraliP08631
GuidetoPHARMACOLOGYi2032

PTM databases

GlyGeniP08631, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiP08631
PhosphoSitePlusiP08631
SwissPalmiP08631

Genetic variation databases

BioMutaiHCK
DMDMi20141296

Proteomic databases

EPDiP08631
jPOSTiP08631
MassIVEiP08631
MaxQBiP08631
PaxDbiP08631
PeptideAtlasiP08631
PRIDEiP08631
ProteomicsDBi52142 [P08631-1]
52143 [P08631-2]
52144 [P08631-3]
52145 [P08631-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3921, 600 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		3055

Genome annotation databases

EnsembliENST00000375852.5; ENSP00000365012.3; ENSG00000101336.18
ENST00000375862.7; ENSP00000365022.3; ENSG00000101336.18 [P08631-4]
ENST00000518730.5; ENSP00000427757.1; ENSG00000101336.18 [P08631-3]
ENST00000520553.5; ENSP00000429848.1; ENSG00000101336.18 [P08631-2]
ENST00000629881.2; ENSP00000486627.1; ENSG00000101336.18 [P08631-2]
GeneIDi3055
KEGGihsa:3055
MANE-SelectiENST00000375852.5; ENSP00000365012.3; NM_002110.5; NP_002101.2
UCSCiuc002wxi.4, human [P08631-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3055
DisGeNETi3055

GeneCards: human genes, protein and diseases

More...GeneCardsi		HCK
HGNCiHGNC:4840, HCK
HPAiENSG00000101336, Tissue enhanced (bone marrow, lymphoid tissue)
MIMi142370, gene
neXtProtiNX_P08631
OpenTargetsiENSG00000101336
PharmGKBiPA29216
VEuPathDBiHostDB:ENSG00000101336

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0197, Eukaryota
GeneTreeiENSGT00940000158738
HOGENOMiCLU_000288_7_2_1
InParanoidiP08631
OMAiQKLTFPC
PhylomeDBiP08631

Enzyme and pathway databases

BRENDAi2.7.10.2, 2681
PathwayCommonsiP08631
ReactomeiR-HSA-164944, Nef and signal transduction
R-HSA-2029481, FCGR activation
R-HSA-912631, Regulation of signaling by CBL
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-9674555, Signaling by CSF3 (G-CSF)
R-HSA-9705462, Inactivation of CSF3 (G-CSF) signaling
R-HSA-9706374, FLT3 signaling through SRC family kinases
SignaLinkiP08631
SIGNORiP08631

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3055, 12 hits in 1101 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HCK, human
EvolutionaryTraceiP08631

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HCK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3055
PharosiP08631, Tclin

Protein Ontology

More...PROi		PR:P08631
RNActiP08631, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000101336, Expressed in blood and 214 other tissues
ExpressionAtlasiP08631, baseline and differential
GenevisibleiP08631, HS

Family and domain databases

CDDicd10363, SH2_Src_HCK, 1 hit
DisProtiDP02383
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035851, HCK_SH2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF00017, SH2, 1 hit
PF00018, SH3_1, 1 hit
PRINTSiPR00401, SH2DOMAIN
PR00452, SH3DOMAIN
PR00109, TYRKINASE
SMARTiView protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 1 hit
SM00219, TyrKc, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
SSF55550, SSF55550, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50001, SH2, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08631
Secondary accession number(s): A8K1I1
, B4DQB6, E1P5M2, Q29RX1, Q2VPE2, Q504R5, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 261 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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