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UniProtKB - P08621 (RU17_HUMAN)

Entry version 229 (07 Oct 2020)
Sequence version 2 (01 Aug 1988)
Previous versions | rss
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Protein

U1 small nuclear ribonucleoprotein 70 kDa

Gene

SNRNP70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158).3 Publications
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.1 Publication
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.1 Publication

Miscellaneous

Major ribonucleoprotein antigen recognized by the sera from patients with autoimmune diseases, such as systemic lupus erythematosus.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • snRNA binding Source: GO_Central
  • U1 snRNA binding Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08621

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72163, mRNA Splicing - Major Pathway

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P08621, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein 70 kDa
Short name:
U1 snRNP 70 kDa1 Publication
Short name:
U1-70K2 Publications
Short name:
snRNP70
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNRNP70
Synonyms:RNPU1Z, RPU1, SNRP70, U1AP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000104852.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:11150, SNRNP70

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		180740, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08621

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6625

Open Targets

More...OpenTargetsi		ENSG00000104852

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35992

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08621, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SNRNP70

Domain mapping of disease mutations (DMDM)

More...DMDMi		13635663

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818802 – 437U1 small nuclear ribonucleoprotein 70 kDaAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonineCombined sources1
Modified residuei118N6-acetyllysineCombined sources1
Modified residuei126PhosphotyrosineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki346Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei410PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.
Extensively phosphorylated on serine residues in the C-terminal region.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1007

Encyclopedia of Proteome Dynamics

More...EPDi		P08621

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P08621

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08621

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08621

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08621

PeptideAtlas

More...PeptideAtlasi		P08621

PRoteomics IDEntifications database

More...PRIDEi		P08621

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52138 [P08621-1]
52139 [P08621-2]
52140 [P08621-3]
52141 [P08621-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08621

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08621

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P08621

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000104852, Expressed in right hemisphere of cerebellum and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P08621, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08621, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000104852, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the U1 snRNP (PubMed:19325628, PubMed:21113136, PubMed:25555158). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (PubMed:19325628, PubMed:21113136, PubMed:25555158).

Interacts with SCNM1 (By similarity).

Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2 (PubMed:9531537).

Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10 (PubMed:10339552).

Interacts with dephosphorylated SFRS13A and SFPQ (PubMed:11514619, PubMed:14765198).

Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2 (PubMed:14561889, PubMed:11448987, PubMed:9447963).

Interacts with GEMIN5 (PubMed:25911097).

Interacts with FUS.

By similarity12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112509, 851 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P08621

Database of interacting proteins

More...DIPi		DIP-29406N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P08621

Protein interaction database and analysis system

More...IntActi		P08621, 196 interactors

Molecular INTeraction database

More...MINTi		P08621

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000472998

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08621, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08621

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P08621

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 181RRMPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni92 – 202Required for interaction with U1 RNA1 PublicationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi231 – 310Arg/Glu-rich (mixed charge)CuratedAdd BLAST80
Compositional biasi311 – 314Poly-Gly4
Compositional biasi344 – 393Arg/Asp/Glu-rich (mixed charge)CuratedAdd BLAST50
Compositional biasi394 – 398Poly-Gly5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RRM domain mediates interaction with U1 RNA.2 Publications

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0113, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160292

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_045151_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08621

KEGG Orthology (KO)

More...KOi		K11093

Identification of Orthologs from Complete Genome Data

More...OMAi		NDVNIKH

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08621

TreeFam database of animal gene trees

More...TreeFami		TF314215

Family and domain databases

Conserved Domains Database

More...CDDi		cd12236, RRM_snRNP70, 1 hit

Database of protein disorder

More...DisProti		DP02171

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00138

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034143, snRNP70_RRM
IPR022023, U1snRNP70_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 1 hit
PF12220, U1snRNP70_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P08621-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED 
        60         70         80         90        100
PRDAPPPTRA ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD 
       110        120        130        140        150
AFKTLFVARV NYDTTESKLR REFEVYGPIK RIHMVYSKRS GKPRGYAFIE 
       160        170        180        190        200
YEHERDMHSA YKHADGKKID GRRVLVDVER GRTVKGWRPR RLGGGLGGTR 
       210        220        230        240        250
RGGADVNIRH SGRDDTSRYD ERPGPSPLPH RDRDRDRERE RRERSRERDK 
       260        270        280        290        300
ERERRRSRSR DRRRRSRSRD KEERRRSRER SKDKDRDRKR RSSRSRERAR 
       310        320        330        340        350
RERERKEELR GGGGDMAEPS EAGDAPPDDG PPGELGPDGP DGPEEKGRDR 
       360        370        380        390        400
DRERRRSHRS ERERRRDRDR DRDRDREHKR GERGSERGRD EARGGGGGQD 
       410        420        430 
NGLEGLGNDS RDMYMESEGG DGYLAPENGY LMEAAPE
Length:437
Mass (Da):51,557
Last modified:August 1, 1988 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1020BF5C40CF97D
GO
Isoform 2 (identifier: P08621-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-231: Missing.

Show »
Length:428
Mass (Da):50,618
Checksum:iEEBC1CE4E8B9DBDA
GO
Isoform 3 (identifier: P08621-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-166: AYKHADG → TTQLACS
     167-437: Missing.

Show »
Length:166
Mass (Da):19,790
Checksum:iE90F034A08D3E79C
GO
Isoform 4 (identifier: P08621-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: MTQFLPPNLL...EYEHERDMHS → MEQALHRFGR...PLPLPTSVTA

Show »
Length:341
Mass (Da):39,191
Checksum:i390967CC272E50E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QX04M0QX04_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRNP70
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYR1M0QYR1_HUMAN
U1 small nuclear ribonucleoprotein ...
SNRNP70
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA28352 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA29964 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA29966 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0058471 – 159MTQFL…RDMHS → MEQALHRFGRGLVWLSVAWL SVGRVRVRDDGDTGRGFCRA GPVLTRGPSGDSSPLPLPTS VTA in isoform 4. 1 PublicationAdd BLAST159
Alternative sequenceiVSP_005848160 – 166AYKHADG → TTQLACS in isoform 3. 1 Publication7
Alternative sequenceiVSP_005849167 – 437Missing in isoform 3. 1 PublicationAdd BLAST271
Alternative sequenceiVSP_005850223 – 231Missing in isoform 2. Curated9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X04654 mRNA Translation: CAA28352.1 Different initiation.
X06814 mRNA Translation: CAA29963.1
X06815 mRNA Translation: CAA29964.1 Different initiation.
X06817 mRNA Translation: CAA29966.1 Different initiation.
X07402 mRNA Translation: CAA30304.1
X06816 mRNA Translation: CAA29965.1
X06812 mRNA Translation: CAA29961.1
X06811 mRNA Translation: CAA29960.1
X07401 mRNA Translation: CAA30303.1
X07403 mRNA Translation: CAA30305.1
M22636 mRNA Translation: AAA03001.1
M57939 M57937 Genomic DNA Translation: AAA36572.1
M57939 M57937 Genomic DNA Translation: AAA36573.1
M57935 M57934 Genomic DNA Translation: AAA36571.1
AK096783 mRNA Translation: BAG53365.1
X84841 mRNA Translation: CAA59278.1
AL117507 mRNA Translation: CAB55969.1
CH471177 Genomic DNA Translation: EAW52449.1
BC001315 mRNA Translation: AAH01315.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12756.1 [P08621-1]
CCDS74417.1 [P08621-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A25707
S00674

NCBI Reference Sequences

More...RefSeqi		NP_001287998.1, NM_001301069.1 [P08621-2]
NP_003080.2, NM_003089.5 [P08621-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000221448; ENSP00000221448; ENSG00000104852 [P08621-2]
ENST00000401730; ENSP00000385077; ENSG00000104852 [P08621-3]
ENST00000595231; ENSP00000471006; ENSG00000104852 [P08621-3]
ENST00000598441; ENSP00000472998; ENSG00000104852 [P08621-1]
ENST00000601065; ENSP00000468952; ENSG00000104852 [P08621-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6625

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6625

UCSC genome browser

More...UCSCi		uc002pmk.4, human [P08621-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04654 mRNA Translation: CAA28352.1 Different initiation.
X06814 mRNA Translation: CAA29963.1
X06815 mRNA Translation: CAA29964.1 Different initiation.
X06817 mRNA Translation: CAA29966.1 Different initiation.
X07402 mRNA Translation: CAA30304.1
X06816 mRNA Translation: CAA29965.1
X06812 mRNA Translation: CAA29961.1
X06811 mRNA Translation: CAA29960.1
X07401 mRNA Translation: CAA30303.1
X07403 mRNA Translation: CAA30305.1
M22636 mRNA Translation: AAA03001.1
M57939 M57937 Genomic DNA Translation: AAA36572.1
M57939 M57937 Genomic DNA Translation: AAA36573.1
M57935 M57934 Genomic DNA Translation: AAA36571.1
AK096783 mRNA Translation: BAG53365.1
X84841 mRNA Translation: CAA59278.1
AL117507 mRNA Translation: CAB55969.1
CH471177 Genomic DNA Translation: EAW52449.1
BC001315 mRNA Translation: AAH01315.1
CCDSiCCDS12756.1 [P08621-1]
CCDS74417.1 [P08621-2]
PIRiA25707
S00674
RefSeqiNP_001287998.1, NM_001301069.1 [P08621-2]
NP_003080.2, NM_003089.5 [P08621-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L5INMR-A131-151[»]
2L5JNMR-A131-151[»]
3CW1X-ray5.496/7/8/K1-216[»]
3PGWX-ray4.40L/S1-437[»]
4PJOX-ray3.30K/N/k/n2-60[»]
4PKDX-ray2.50B60-215[»]
6QX9electron microscopy3.281K1-437[»]
SMRiP08621
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112509, 851 interactors
CORUMiP08621
DIPiDIP-29406N
ELMiP08621
IntActiP08621, 196 interactors
MINTiP08621
STRINGi9606.ENSP00000472998

Protein family/group databases

MoonDBiP08621, Predicted

PTM databases

iPTMnetiP08621
PhosphoSitePlusiP08621
SwissPalmiP08621

Polymorphism and mutation databases

BioMutaiSNRNP70
DMDMi13635663

Proteomic databases

CPTACiCPTAC-1007
EPDiP08621
jPOSTiP08621
MassIVEiP08621
MaxQBiP08621
PaxDbiP08621
PeptideAtlasiP08621
PRIDEiP08621
ProteomicsDBi52138 [P08621-1]
52139 [P08621-2]
52140 [P08621-3]
52141 [P08621-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3444, 186 antibodies

Genome annotation databases

EnsembliENST00000221448; ENSP00000221448; ENSG00000104852 [P08621-2]
ENST00000401730; ENSP00000385077; ENSG00000104852 [P08621-3]
ENST00000595231; ENSP00000471006; ENSG00000104852 [P08621-3]
ENST00000598441; ENSP00000472998; ENSG00000104852 [P08621-1]
ENST00000601065; ENSP00000468952; ENSG00000104852 [P08621-3]
GeneIDi6625
KEGGihsa:6625
UCSCiuc002pmk.4, human [P08621-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6625
DisGeNETi6625
EuPathDBiHostDB:ENSG00000104852.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		SNRNP70
HGNCiHGNC:11150, SNRNP70
HPAiENSG00000104852, Low tissue specificity
MIMi180740, gene
neXtProtiNX_P08621
OpenTargetsiENSG00000104852
PharmGKBiPA35992

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0113, Eukaryota
GeneTreeiENSGT00940000160292
HOGENOMiCLU_045151_5_1_1
InParanoidiP08621
KOiK11093
OMAiNDVNIKH
PhylomeDBiP08621
TreeFamiTF314215

Enzyme and pathway databases

PathwayCommonsiP08621
ReactomeiR-HSA-72163, mRNA Splicing - Major Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6625, 742 hits in 884 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SNRNP70, human
EvolutionaryTraceiP08621

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SnRNP70

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6625
PharosiP08621, Tbio

Protein Ontology

More...PROi		PR:P08621
RNActiP08621, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000104852, Expressed in right hemisphere of cerebellum and 243 other tissues
ExpressionAtlasiP08621, baseline and differential
GenevisibleiP08621, HS

Family and domain databases

CDDicd12236, RRM_snRNP70, 1 hit
DisProtiDP02171
Gene3Di3.30.70.330, 1 hit
IDEALiIID00138
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034143, snRNP70_RRM
IPR022023, U1snRNP70_N
PfamiView protein in Pfam
PF00076, RRM_1, 1 hit
PF12220, U1snRNP70_N, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRU17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08621
Secondary accession number(s): B3KUA3
, P78493, P78494, Q15364, Q15686, Q15687, Q15689, Q99377, Q9UE45, Q9UE46, Q9UE47, Q9UE48, Q9UFQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 7, 2020
This is version 229 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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