UniProtKB - P08621 (RU17_HUMAN)
U1 small nuclear ribonucleoprotein 70 kDa
SNRNP70
Functioni
Miscellaneous
GO - Molecular functioni
- mRNA binding Source: GO_Central
- RNA binding Source: UniProtKB
- snRNA binding Source: GO_Central
- U1 snRNA binding Source: UniProtKB
GO - Biological processi
- mRNA splicing, via spliceosome Source: UniProtKB
- negative regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
- negative regulation of protein refolding Source: ParkinsonsUK-UCL
- positive regulation of mRNA splicing, via spliceosome Source: Ensembl
- regulation of ATPase activity Source: ParkinsonsUK-UCL
- regulation of RNA splicing Source: UniProtKB
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing |
Enzyme and pathway databases
PathwayCommonsi | P08621 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Protein family/group databases
MoonDBi | P08621, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: U1 small nuclear ribonucleoprotein 70 kDaShort name: U1 snRNP 70 kDa1 Publication Short name: U1-70K2 Publications Short name: snRNP70 |
Gene namesi | Name:SNRNP70 Synonyms:RNPU1Z, RPU1, SNRP70, U1AP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104852.14 |
HGNCi | HGNC:11150, SNRNP70 |
MIMi | 180740, gene |
neXtProti | NX_P08621 |
Subcellular locationi
Nucleus
- Nucleus speckle 1 Publication
- nucleoplasm 2 Publications
Note: Colocalizes with SCNM1 and LUC7L2 in nuclear speckles.By similarity
Nucleus
- nuclear speck Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- spliceosomal complex Source: UniProtKB
- U1 snRNP Source: UniProtKB
- U2-type prespliceosome Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6625 |
OpenTargetsi | ENSG00000104852 |
PharmGKBi | PA35992 |
Miscellaneous databases
Pharosi | P08621, Tbio |
Polymorphism and mutation databases
BioMutai | SNRNP70 |
DMDMi | 13635663 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000081880 | 2 – 437 | U1 small nuclear ribonucleoprotein 70 kDaAdd BLAST | 436 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonineCombined sources | 1 | |
Modified residuei | 118 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 126 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 226 | PhosphoserineCombined sources | 1 | |
Modified residuei | 268 | PhosphoserineCombined sources | 1 | |
Modified residuei | 320 | PhosphoserineCombined sources | 1 | |
Cross-linki | 346 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 410 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1007 |
EPDi | P08621 |
jPOSTi | P08621 |
MassIVEi | P08621 |
MaxQBi | P08621 |
PaxDbi | P08621 |
PeptideAtlasi | P08621 |
PRIDEi | P08621 |
ProteomicsDBi | 52138 [P08621-1] 52139 [P08621-2] 52140 [P08621-3] 52141 [P08621-4] |
PTM databases
iPTMneti | P08621 |
PhosphoSitePlusi | P08621 |
SwissPalmi | P08621 |
Expressioni
Gene expression databases
Bgeei | ENSG00000104852, Expressed in right hemisphere of cerebellum and 243 other tissues |
ExpressionAtlasi | P08621, baseline and differential |
Genevisiblei | P08621, HS |
Organism-specific databases
HPAi | ENSG00000104852, Low tissue specificity |
Interactioni
Subunit structurei
Component of the U1 snRNP (PubMed:19325628, PubMed:21113136, PubMed:25555158). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (PubMed:19325628, PubMed:21113136, PubMed:25555158).
Interacts with SCNM1 (By similarity).
Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2 (PubMed:9531537).
Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10 (PubMed:10339552).
Interacts with dephosphorylated SFRS13A and SFPQ (PubMed:11514619, PubMed:14765198).
Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2 (PubMed:14561889, PubMed:11448987, PubMed:9447963).
Interacts with GEMIN5 (PubMed:25911097).
Interacts with FUS.
By similarity12 PublicationsBinary interactionsi
Hide detailsP08621
Protein-protein interaction databases
BioGRIDi | 112509, 857 interactors |
CORUMi | P08621 |
DIPi | DIP-29406N |
ELMi | P08621 |
IntActi | P08621, 196 interactors |
MINTi | P08621 |
STRINGi | 9606.ENSP00000472998 |
Miscellaneous databases
RNActi | P08621, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P08621 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08621 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 181 | RRMPROSITE-ProRule annotationAdd BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 92 – 202 | Required for interaction with U1 RNA1 PublicationAdd BLAST | 111 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 231 – 310 | Arg/Glu-rich (mixed charge)CuratedAdd BLAST | 80 | |
Compositional biasi | 311 – 314 | Poly-Gly | 4 | |
Compositional biasi | 344 – 393 | Arg/Asp/Glu-rich (mixed charge)CuratedAdd BLAST | 50 | |
Compositional biasi | 394 – 398 | Poly-Gly | 5 |
Domaini
Phylogenomic databases
eggNOGi | KOG0113, Eukaryota |
GeneTreei | ENSGT00940000160292 |
HOGENOMi | CLU_045151_5_1_1 |
InParanoidi | P08621 |
OMAi | NDVNIKH |
PhylomeDBi | P08621 |
TreeFami | TF314215 |
Family and domain databases
CDDi | cd12236, RRM_snRNP70, 1 hit |
DisProti | DP02171 |
Gene3Di | 3.30.70.330, 1 hit |
IDEALi | IID00138 |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034143, snRNP70_RRM IPR022023, U1snRNP70_N |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF12220, U1snRNP70_N, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED
60 70 80 90 100
PRDAPPPTRA ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD
110 120 130 140 150
AFKTLFVARV NYDTTESKLR REFEVYGPIK RIHMVYSKRS GKPRGYAFIE
160 170 180 190 200
YEHERDMHSA YKHADGKKID GRRVLVDVER GRTVKGWRPR RLGGGLGGTR
210 220 230 240 250
RGGADVNIRH SGRDDTSRYD ERPGPSPLPH RDRDRDRERE RRERSRERDK
260 270 280 290 300
ERERRRSRSR DRRRRSRSRD KEERRRSRER SKDKDRDRKR RSSRSRERAR
310 320 330 340 350
RERERKEELR GGGGDMAEPS EAGDAPPDDG PPGELGPDGP DGPEEKGRDR
360 370 380 390 400
DRERRRSHRS ERERRRDRDR DRDRDREHKR GERGSERGRD EARGGGGGQD
410 420 430
NGLEGLGNDS RDMYMESEGG DGYLAPENGY LMEAAPE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QX04 | M0QX04_HUMAN | U1 small nuclear ribonucleoprotein ... | SNRNP70 | 33 | Annotation score: | ||
M0QYR1 | M0QYR1_HUMAN | U1 small nuclear ribonucleoprotein ... | SNRNP70 | 94 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005847 | 1 – 159 | MTQFL…RDMHS → MEQALHRFGRGLVWLSVAWL SVGRVRVRDDGDTGRGFCRA GPVLTRGPSGDSSPLPLPTS VTA in isoform 4. 1 PublicationAdd BLAST | 159 | |
Alternative sequenceiVSP_005848 | 160 – 166 | AYKHADG → TTQLACS in isoform 3. 1 Publication | 7 | |
Alternative sequenceiVSP_005849 | 167 – 437 | Missing in isoform 3. 1 PublicationAdd BLAST | 271 | |
Alternative sequenceiVSP_005850 | 223 – 231 | Missing in isoform 2. Curated | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04654 mRNA Translation: CAA28352.1 Different initiation. X06814 mRNA Translation: CAA29963.1 X06815 mRNA Translation: CAA29964.1 Different initiation. X06817 mRNA Translation: CAA29966.1 Different initiation. X07402 mRNA Translation: CAA30304.1 X06816 mRNA Translation: CAA29965.1 X06812 mRNA Translation: CAA29961.1 X06811 mRNA Translation: CAA29960.1 X07401 mRNA Translation: CAA30303.1 X07403 mRNA Translation: CAA30305.1 M22636 mRNA Translation: AAA03001.1 M57939 , M57929, M57930, M57932, M57934, M57937 Genomic DNA Translation: AAA36572.1 M57939 , M57929, M57930, M57932, M57934, M57937 Genomic DNA Translation: AAA36573.1 M57935 , M57929, M57930, M57932, M57934 Genomic DNA Translation: AAA36571.1 AK096783 mRNA Translation: BAG53365.1 X84841 mRNA Translation: CAA59278.1 AL117507 mRNA Translation: CAB55969.1 CH471177 Genomic DNA Translation: EAW52449.1 BC001315 mRNA Translation: AAH01315.1 |
CCDSi | CCDS12756.1 [P08621-1] CCDS74417.1 [P08621-2] |
PIRi | A25707 S00674 |
RefSeqi | NP_001287998.1, NM_001301069.1 [P08621-2] NP_003080.2, NM_003089.5 [P08621-1] |
Genome annotation databases
Ensembli | ENST00000221448; ENSP00000221448; ENSG00000104852 [P08621-2] ENST00000401730; ENSP00000385077; ENSG00000104852 [P08621-3] ENST00000595231; ENSP00000471006; ENSG00000104852 [P08621-3] ENST00000598441; ENSP00000472998; ENSG00000104852 [P08621-1] ENST00000601065; ENSP00000468952; ENSG00000104852 [P08621-3] |
GeneIDi | 6625 |
KEGGi | hsa:6625 |
UCSCi | uc002pmk.4, human [P08621-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04654 mRNA Translation: CAA28352.1 Different initiation. X06814 mRNA Translation: CAA29963.1 X06815 mRNA Translation: CAA29964.1 Different initiation. X06817 mRNA Translation: CAA29966.1 Different initiation. X07402 mRNA Translation: CAA30304.1 X06816 mRNA Translation: CAA29965.1 X06812 mRNA Translation: CAA29961.1 X06811 mRNA Translation: CAA29960.1 X07401 mRNA Translation: CAA30303.1 X07403 mRNA Translation: CAA30305.1 M22636 mRNA Translation: AAA03001.1 M57939 , M57929, M57930, M57932, M57934, M57937 Genomic DNA Translation: AAA36572.1 M57939 , M57929, M57930, M57932, M57934, M57937 Genomic DNA Translation: AAA36573.1 M57935 , M57929, M57930, M57932, M57934 Genomic DNA Translation: AAA36571.1 AK096783 mRNA Translation: BAG53365.1 X84841 mRNA Translation: CAA59278.1 AL117507 mRNA Translation: CAB55969.1 CH471177 Genomic DNA Translation: EAW52449.1 BC001315 mRNA Translation: AAH01315.1 |
CCDSi | CCDS12756.1 [P08621-1] CCDS74417.1 [P08621-2] |
PIRi | A25707 S00674 |
RefSeqi | NP_001287998.1, NM_001301069.1 [P08621-2] NP_003080.2, NM_003089.5 [P08621-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2L5I | NMR | - | A | 131-151 | [»] | |
2L5J | NMR | - | A | 131-151 | [»] | |
3CW1 | X-ray | 5.49 | 6/7/8/K | 1-216 | [»] | |
3PGW | X-ray | 4.40 | L/S | 1-437 | [»] | |
4PJO | X-ray | 3.30 | K/N/k/n | 2-60 | [»] | |
4PKD | X-ray | 2.50 | B | 60-215 | [»] | |
6QX9 | electron microscopy | 3.28 | 1K | 1-437 | [»] | |
SMRi | P08621 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112509, 857 interactors |
CORUMi | P08621 |
DIPi | DIP-29406N |
ELMi | P08621 |
IntActi | P08621, 196 interactors |
MINTi | P08621 |
STRINGi | 9606.ENSP00000472998 |
Protein family/group databases
MoonDBi | P08621, Predicted |
PTM databases
iPTMneti | P08621 |
PhosphoSitePlusi | P08621 |
SwissPalmi | P08621 |
Polymorphism and mutation databases
BioMutai | SNRNP70 |
DMDMi | 13635663 |
Proteomic databases
CPTACi | CPTAC-1007 |
EPDi | P08621 |
jPOSTi | P08621 |
MassIVEi | P08621 |
MaxQBi | P08621 |
PaxDbi | P08621 |
PeptideAtlasi | P08621 |
PRIDEi | P08621 |
ProteomicsDBi | 52138 [P08621-1] 52139 [P08621-2] 52140 [P08621-3] 52141 [P08621-4] |
Protocols and materials databases
Antibodypediai | 3444, 186 antibodies |
Genome annotation databases
Ensembli | ENST00000221448; ENSP00000221448; ENSG00000104852 [P08621-2] ENST00000401730; ENSP00000385077; ENSG00000104852 [P08621-3] ENST00000595231; ENSP00000471006; ENSG00000104852 [P08621-3] ENST00000598441; ENSP00000472998; ENSG00000104852 [P08621-1] ENST00000601065; ENSP00000468952; ENSG00000104852 [P08621-3] |
GeneIDi | 6625 |
KEGGi | hsa:6625 |
UCSCi | uc002pmk.4, human [P08621-1] |
Organism-specific databases
CTDi | 6625 |
DisGeNETi | 6625 |
EuPathDBi | HostDB:ENSG00000104852.14 |
GeneCardsi | SNRNP70 |
HGNCi | HGNC:11150, SNRNP70 |
HPAi | ENSG00000104852, Low tissue specificity |
MIMi | 180740, gene |
neXtProti | NX_P08621 |
OpenTargetsi | ENSG00000104852 |
PharmGKBi | PA35992 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0113, Eukaryota |
GeneTreei | ENSGT00940000160292 |
HOGENOMi | CLU_045151_5_1_1 |
InParanoidi | P08621 |
OMAi | NDVNIKH |
PhylomeDBi | P08621 |
TreeFami | TF314215 |
Enzyme and pathway databases
PathwayCommonsi | P08621 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
BioGRID-ORCSi | 6625, 742 hits in 856 CRISPR screens |
ChiTaRSi | SNRNP70, human |
EvolutionaryTracei | P08621 |
GeneWikii | SnRNP70 |
GenomeRNAii | 6625 |
Pharosi | P08621, Tbio |
PROi | PR:P08621 |
RNActi | P08621, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104852, Expressed in right hemisphere of cerebellum and 243 other tissues |
ExpressionAtlasi | P08621, baseline and differential |
Genevisiblei | P08621, HS |
Family and domain databases
CDDi | cd12236, RRM_snRNP70, 1 hit |
DisProti | DP02171 |
Gene3Di | 3.30.70.330, 1 hit |
IDEALi | IID00138 |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034143, snRNP70_RRM IPR022023, U1snRNP70_N |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF12220, U1snRNP70_N, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RU17_HUMAN | |
Accessioni | P08621Primary (citable) accession number: P08621 Secondary accession number(s): B3KUA3 Q9UFQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1988 | |
Last modified: | December 2, 2020 | |
This is version 230 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM