SNRNP70

Functionⁱ

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158).3 Publications

Isoform 3: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.1 Publication

Isoform 4: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.1 Publication

Miscellaneous

Major ribonucleoprotein antigen recognized by the sera from patients with autoimmune diseases, such as systemic lupus erythematosus.

GO - Molecular functionⁱ

mRNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 2467746
U1 snRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21113136
- 25555158

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 9531537
negative regulation of chaperone-mediated autophagy
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 25719862
negative regulation of protein refolding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 25719862
positive regulation of mRNA splicing, via spliceosome Source: Ensembl
regulation of ATPase activity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 25719862
regulation of RNA splicing
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 2467746

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding
Biological process	mRNA processing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Protein family/group databases

MoonDBⁱ	P08621 Predicted

MoonDBⁱ

P08621 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: U1 small nuclear ribonucleoprotein 70 kDa Short name: U1 snRNP 70 kDa1 Publication Short name: U1-70K2 Publications Short name: snRNP70
Gene namesⁱ	Name:SNRNP70 Synonyms:RNPU1Z, RPU1, SNRP70, U1AP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104852.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11150 SNRNP70
MIMⁱ	180740 gene
neXtProtⁱ	NX_P08621

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6625
Open Targets More...OpenTargetsⁱ	ENSG00000104852
PharmGKBⁱ	PA35992

Polymorphism and mutation databases

BioMutaⁱ	SNRNP70
DMDMⁱ	13635663

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000081880	2 – 437	U1 small nuclear ribonucleoprotein 70 kDaAdd BLAST		436

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylthreonineCombined sources	1
Modified residueⁱ	118	N6-acetyllysineCombined sources	1
Modified residueⁱ	126	PhosphotyrosineCombined sources	1
Modified residueⁱ	226	PhosphoserineCombined sources	1
Modified residueⁱ	268	PhosphoserineCombined sources	1
Modified residueⁱ	320	PhosphoserineCombined sources	1
Cross-linkⁱ	346	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	410	PhosphoserineCombined sources	1

Post-translational modificationⁱ

The N-terminus is blocked.

Extensively phosphorylated on serine residues in the C-terminal region.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P08621
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08621
PaxDbⁱ	P08621
PeptideAtlas More...PeptideAtlasⁱ	P08621
PRIDEⁱ	P08621
ProteomicsDBⁱ	52138 52139 [P08621-2] 52140 [P08621-3] 52141 [P08621-4]

PTM databases

iPTMnetⁱ	P08621
PhosphoSitePlusⁱ	P08621
SwissPalmⁱ	P08621

Miscellaneous databases

PMAP-CutDBⁱ	P08621

PMAP-CutDBⁱ

P08621

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000104852 Expressed in 231 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasⁱ	P08621 baseline and differential
Genevisibleⁱ	P08621 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB001718 HPA042050 HPA043516

HPAⁱ

CAB001718
HPA042050
HPA043516

Interactionⁱ

Subunit structureⁱ

Component of the U1 snRNP (PubMed:19325628, PubMed:21113136, PubMed:25555158). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (PubMed:19325628, PubMed:21113136, PubMed:25555158). Interacts with SCNM1 (By similarity). Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2 (PubMed:9531537). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10 (PubMed:10339552). Interacts with dephosphorylated SFRS13A and SFPQ (PubMed:11514619, PubMed:14765198). Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2 (PubMed:14561889, PubMed:11448987, PubMed:9447963). Interacts with GEMIN5 (PubMed:25911097).By similarity11 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CLK2	P49760	4	EBI-1049228,EBI-750020
SMN2	Q16637	4	EBI-1049228,EBI-395421
SRPK2	P78362	3	EBI-1049228,EBI-593303
SRSF1	Q07955	3	EBI-1049228,EBI-398920
SRSF2	Q01130	2	EBI-1049228,EBI-627047

Protein-protein interaction databases

BioGridⁱ	112509, 218 interactors
CORUMⁱ	P08621
Database of interacting proteins More...DIPⁱ	DIP-29406N
ELMⁱ	P08621
IntActⁱ	P08621, 79 interactors
Molecular INTeraction database More...MINTⁱ	P08621
STRINGⁱ	9606.ENSP00000472998

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	7 – 10	Combined sources	4
Helixⁱ	29 – 31	Combined sources	3
Helixⁱ	42 – 47	Combined sources	6
Helixⁱ	51 – 53	Combined sources	3
Helixⁱ	63 – 86	Combined sources	24
Helixⁱ	91 – 93	Combined sources	3
Helixⁱ	101 – 103	Combined sources	3
Beta strandⁱ	104 – 109	Combined sources	6
Helixⁱ	116 – 124	Combined sources	9
Beta strandⁱ	129 – 136	Combined sources	8
Turnⁱ	138 – 140	Combined sources	3
Beta strandⁱ	143 – 153	Combined sources	11
Helixⁱ	154 – 163	Combined sources	10
Beta strandⁱ	175 – 178	Combined sources	4
Turnⁱ	181 – 183	Combined sources	3
Helixⁱ	190 – 192	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P08621
SMRⁱ	P08621
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P08621

EvolutionaryTraceⁱ

P08621

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	103 – 181	RRMPROSITE-ProRule annotationAdd BLAST		79

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	92 – 202	Required for interaction with U1 RNA1 PublicationAdd BLAST		111

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	231 – 310	Arg/Glu-rich (mixed charge)CuratedAdd BLAST	80
Compositional biasⁱ	311 – 314	Poly-Gly	4
Compositional biasⁱ	344 – 393	Arg/Asp/Glu-rich (mixed charge)CuratedAdd BLAST	50
Compositional biasⁱ	394 – 398	Poly-Gly	5

Domainⁱ

The RRM domain mediates interaction with U1 RNA.2 Publications

Phylogenomic databases

eggNOGⁱ	KOG0113 Eukaryota COG0724 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063750
InParanoidⁱ	P08621
KEGG Orthology (KO) More...KOⁱ	K11093
OMAⁱ	NDVNIKH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R0Z
PhylomeDBⁱ	P08621
TreeFamⁱ	TF314215

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12236 RRM_snRNP70, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR034143 snRNP70_RRM IPR022023 U1snRNP70_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit PF12220 U1snRNP70_N, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P08621-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED 
        60         70         80         90        100
PRDAPPPTRA ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD 
       110        120        130        140        150
AFKTLFVARV NYDTTESKLR REFEVYGPIK RIHMVYSKRS GKPRGYAFIE 
       160        170        180        190        200
YEHERDMHSA YKHADGKKID GRRVLVDVER GRTVKGWRPR RLGGGLGGTR 
       210        220        230        240        250
RGGADVNIRH SGRDDTSRYD ERPGPSPLPH RDRDRDRERE RRERSRERDK 
       260        270        280        290        300
ERERRRSRSR DRRRRSRSRD KEERRRSRER SKDKDRDRKR RSSRSRERAR 
       310        320        330        340        350
RERERKEELR GGGGDMAEPS EAGDAPPDDG PPGELGPDGP DGPEEKGRDR 
       360        370        380        390        400
DRERRRSHRS ERERRRDRDR DRDRDREHKR GERGSERGRD EARGGGGGQD 
       410        420        430 
NGLEGLGNDS RDMYMESEGG DGYLAPENGY LMEAAPE

Length:437

Mass (Da):51,557

Last modified:August 1, 1988 - v2

Checksum:ⁱF1020BF5C40CF97D

GO

Isoform 2 (identifier: P08621-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
223-231: Missing.

« Hide

        10         20         30         40         50
MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED 
        60         70         80         90        100
PRDAPPPTRA ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD 
       110        120        130        140        150
AFKTLFVARV NYDTTESKLR REFEVYGPIK RIHMVYSKRS GKPRGYAFIE 
       160        170        180        190        200
YEHERDMHSA YKHADGKKID GRRVLVDVER GRTVKGWRPR RLGGGLGGTR 
       210        220        230        240        250
RGGADVNIRH SGRDDTSRYD ERDRDRDRER ERRERSRERD KERERRRSRS 
       260        270        280        290        300
RDRRRRSRSR DKEERRRSRE RSKDKDRDRK RRSSRSRERA RRERERKEEL 
       310        320        330        340        350
RGGGGDMAEP SEAGDAPPDD GPPGELGPDG PDGPEEKGRD RDRERRRSHR 
       360        370        380        390        400
SERERRRDRD RDRDRDREHK RGERGSERGR DEARGGGGGQ DNGLEGLGND 
       410        420 
SRDMYMESEG GDGYLAPENG YLMEAAPE

Show »

Length:428

Mass (Da):50,618

Checksum:ⁱEEBC1CE4E8B9DBDA

GO

Isoform 3 (identifier: P08621-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
160-166: AYKHADG → TTQLACS
167-437: Missing.

« Hide

        10         20         30         40         50
MTQFLPPNLL ALFAPRDPIP YLPPLEKLPH EKHHNQPYCG IAPYIREFED 
        60         70         80         90        100
PRDAPPPTRA ETREERMERK RREKIERRQQ EVETELKMWD PHNDPNAQGD 
       110        120        130        140        150
AFKTLFVARV NYDTTESKLR REFEVYGPIK RIHMVYSKRS GKPRGYAFIE 
       160 
YEHERDMHST TQLACS

Show »

Length:166

Mass (Da):19,790

Checksum:ⁱE90F034A08D3E79C

GO

Isoform 4 (identifier: P08621-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-159: MTQFLPPNLL...EYEHERDMHS → MEQALHRFGR...PLPLPTSVTA

« Hide

        10         20         30         40         50
MEQALHRFGR GLVWLSVAWL SVGRVRVRDD GDTGRGFCRA GPVLTRGPSG 
        60         70         80         90        100
DSSPLPLPTS VTAAYKHADG KKIDGRRVLV DVERGRTVKG WRPRRLGGGL 
       110        120        130        140        150
GGTRRGGADV NIRHSGRDDT SRYDERPGPS PLPHRDRDRD RERERRERSR 
       160        170        180        190        200
ERDKERERRR SRSRDRRRRS RSRDKEERRR SRERSKDKDR DRKRRSSRSR 
       210        220        230        240        250
ERARRERERK EELRGGGGDM AEPSEAGDAP PDDGPPGELG PDGPDGPEEK 
       260        270        280        290        300
GRDRDRERRR SHRSERERRR DRDRDRDRDR EHKRGERGSE RGRDEARGGG 
       310        320        330        340 
GGQDNGLEGL GNDSRDMYME SEGGDGYLAP ENGYLMEAAP E

Show »

Length:341

Mass (Da):39,191

Checksum:ⁱ390967CC272E50E9

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0QYR1	M0QYR1_HUMAN	U1 small nuclear ribonucleoprotein ... U1 small nuclear ribonucleoprotein 70 kDa	SNRNP70	94	Annotation score:
M0QX04	M0QX04_HUMAN	U1 small nuclear ribonucleoprotein ... U1 small nuclear ribonucleoprotein 70 kDa	SNRNP70	33	Annotation score:

Sequence cautionⁱ

The sequence CAA28352 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAA29964 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAA29966 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_005847	1 – 159	MTQFL…RDMHS → MEQALHRFGRGLVWLSVAWL SVGRVRVRDDGDTGRGFCRA GPVLTRGPSGDSSPLPLPTS VTA in isoform 4. 1 PublicationAdd BLAST	159
Alternative sequenceⁱVSP_005848	160 – 166	AYKHADG → TTQLACS in isoform 3. 1 Publication	7
Alternative sequenceⁱVSP_005849	167 – 437	Missing in isoform 3. 1 PublicationAdd BLAST	271
Alternative sequenceⁱVSP_005850	223 – 231	Missing in isoform 2. Curated	9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04654 mRNA Translation: CAA28352.1 Different initiation. X06814 mRNA Translation: CAA29963.1 X06815 mRNA Translation: CAA29964.1 Different initiation. X06817 mRNA Translation: CAA29966.1 Different initiation. X07402 mRNA Translation: CAA30304.1 X06816 mRNA Translation: CAA29965.1 X06812 mRNA Translation: CAA29961.1 X06811 mRNA Translation: CAA29960.1 X07401 mRNA Translation: CAA30303.1 X07403 mRNA Translation: CAA30305.1 M22636 mRNA Translation: AAA03001.1 M57939 M57937 Genomic DNA Translation: AAA36572.1 M57939 M57937 Genomic DNA Translation: AAA36573.1 M57935 , M57929, M57930, M57932, M57934 Genomic DNA Translation: AAA36571.1 AK096783 mRNA Translation: BAG53365.1 X84841 mRNA Translation: CAA59278.1 AL117507 mRNA Translation: CAB55969.1 CH471177 Genomic DNA Translation: EAW52449.1 BC001315 mRNA Translation: AAH01315.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12756.1 [P08621-1] CCDS74417.1 [P08621-2]
PIRⁱ	A25707 S00674
NCBI Reference Sequences More...RefSeqⁱ	NP_001287998.1, NM_001301069.1 [P08621-2] NP_003080.2, NM_003089.5 [P08621-1]
UniGeneⁱ	Hs.467097

Genome annotation databases

Ensemblⁱ	ENST00000221448; ENSP00000221448; ENSG00000104852 [P08621-2] ENST00000401730; ENSP00000385077; ENSG00000104852 [P08621-3] ENST00000595231; ENSP00000471006; ENSG00000104852 [P08621-3] ENST00000598441; ENSP00000472998; ENSG00000104852 [P08621-1] ENST00000601065; ENSP00000468952; ENSG00000104852 [P08621-3]
GeneIDⁱ	6625
KEGGⁱ	hsa:6625
UCSC genome browser More...UCSCⁱ	uc002pmk.4 human [P08621-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08621	Small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen), isoform CRA_b		HUMAN		437	UniRef100_P08621
SNRNP70 isoform 3		PANTR		437
U1 small nuclear ribonucleoprotein 70 kDa		MACMU		437
SNRNP70 isoform 3		PONAB		437
Uncharacterized protein		CERAT		437
+9
P08621-2	U1 small nuclear ribonucleoprotein 70 kDa		MACMU		428	UniRef100_H9FYT4
SNRNP70 isoform 6		PONAB		428
SNRNP70 isoform 6		PANTR		428
Uncharacterized protein		CHLSB		428
UPI00062ABED1		NOMLE		362
P08621-3	Snrnp70 protein		MOUSE		166	UniRef100_Q6ZWP0
SNRNP70 isoform 1		PANTR		166
Uncharacterized protein		PIG		166
SNRNP70 isoform 1		PONAB		166
Small nuclear ribonucleoprotein U1 subunit 70		SAIBB		166
+15

Protein	Similar proteins		Species	Score	Length	Source
P08621	U1 small nuclear ribonucleoprotein 70 kDa		BOVIN		439	UniRef90_P08621
Small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen), isoform CRA_b		HUMAN		437
SNRNP70 isoform 3		PANTR		437
U1 small nuclear ribonucleoprotein 70 kDa		MACMU		437
SNRNP70 isoform 3		PONAB		437
+132
P08621-3	Snrnp70 protein		MOUSE		166	UniRef90_Q6ZWP0
SNRNP70 isoform 1		PANTR		166
Uncharacterized protein		PIG		166
SNRNP70 isoform 1		PONAB		166
Small nuclear ribonucleoprotein U1 subunit 70		SAIBB		166
+20
P08621-4	cDNA FLJ32246 fis, clone PROST1000097, highly similar to U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 kDa		HUMAN		341	UniRef90_P08621-4
UPI000624FB40		AOTNA		383
UPI000809B3E8		Cebus capucinus imitator		342
UPI000625A54B		AOTNA		374
UPI000809FAFE		Cebus capucinus imitator		333

Protein	Similar proteins		Species	Score	Length	Source
P08621	U1 small nuclear ribonucleoprotein 70 kDa		BOVIN		439	UniRef50_P08621
Small nuclear ribonucleoprotein 70kDa polypeptide (RNP antigen), isoform CRA_b		HUMAN		437
SNRNP70 isoform 3		PANTR		437
U1 small nuclear ribonucleoprotein 70 kDa		MACMU		437
SNRNP70 isoform 3		PONAB		437
+152
P08621-3	Uncharacterized protein		Patagioenas fasciata monilis		227	UniRef50_A0A1V4JT33
U1 small nuclear ribonucleoprotein 70 kDa (Fragment)		MOUSE		168
Uncharacterized protein		Amazon coral snake		178
SNRNP70 isoform 1		PANTR		166
Uncharacterized protein		PIG		166
+21
P08621-4	cDNA FLJ32246 fis, clone PROST1000097, highly similar to U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 kDa		HUMAN		341	UniRef50_P08621-4
Uncharacterized protein		PIG		377
Uncharacterized protein		COLAP		347
Small nuclear ribonucleoprotein U1 subunit 70		CALJA		347
Small nuclear ribonucleoprotein U1 subunit 70		SAIBB		347
+20

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X04654 mRNA Translation: CAA28352.1 Different initiation. X06814 mRNA Translation: CAA29963.1 X06815 mRNA Translation: CAA29964.1 Different initiation. X06817 mRNA Translation: CAA29966.1 Different initiation. X07402 mRNA Translation: CAA30304.1 X06816 mRNA Translation: CAA29965.1 X06812 mRNA Translation: CAA29961.1 X06811 mRNA Translation: CAA29960.1 X07401 mRNA Translation: CAA30303.1 X07403 mRNA Translation: CAA30305.1 M22636 mRNA Translation: AAA03001.1 M57939 M57937 Genomic DNA Translation: AAA36572.1 M57939 M57937 Genomic DNA Translation: AAA36573.1 M57935 , M57929, M57930, M57932, M57934 Genomic DNA Translation: AAA36571.1 AK096783 mRNA Translation: BAG53365.1 X84841 mRNA Translation: CAA59278.1 AL117507 mRNA Translation: CAB55969.1 CH471177 Genomic DNA Translation: EAW52449.1 BC001315 mRNA Translation: AAH01315.1
CCDSⁱ	CCDS12756.1 [P08621-1] CCDS74417.1 [P08621-2]
PIRⁱ	A25707 S00674
RefSeqⁱ	NP_001287998.1, NM_001301069.1 [P08621-2] NP_003080.2, NM_003089.5 [P08621-1]
UniGeneⁱ	Hs.467097

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2L5I	NMR	-	A	131-151	[»]
	2L5J	NMR	-	A	131-151	[»]
	3CW1	X-ray	5.49	6/7/8/K	1-216	[»]
	3PGW	X-ray	4.40	L/S	1-437	[»]
	4PJO	X-ray	3.30	K/N/k/n	2-60	[»]
	4PKD	X-ray	2.50	B	60-215	[»]
ProteinModelPortalⁱ	P08621
SMRⁱ	P08621
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112509, 218 interactors
CORUMⁱ	P08621
DIPⁱ	DIP-29406N
ELMⁱ	P08621
IntActⁱ	P08621, 79 interactors
MINTⁱ	P08621
STRINGⁱ	9606.ENSP00000472998

Protein family/group databases

MoonDBⁱ	P08621 Predicted

MoonDBⁱ

P08621 Predicted

PTM databases

iPTMnetⁱ	P08621
PhosphoSitePlusⁱ	P08621
SwissPalmⁱ	P08621

Polymorphism and mutation databases

BioMutaⁱ	SNRNP70
DMDMⁱ	13635663

Proteomic databases

EPDⁱ	P08621
MaxQBⁱ	P08621
PaxDbⁱ	P08621
PeptideAtlasⁱ	P08621
PRIDEⁱ	P08621
ProteomicsDBⁱ	52138 52139 [P08621-2] 52140 [P08621-3] 52141 [P08621-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000221448; ENSP00000221448; ENSG00000104852 [P08621-2] ENST00000401730; ENSP00000385077; ENSG00000104852 [P08621-3] ENST00000595231; ENSP00000471006; ENSG00000104852 [P08621-3] ENST00000598441; ENSP00000472998; ENSG00000104852 [P08621-1] ENST00000601065; ENSP00000468952; ENSG00000104852 [P08621-3]
GeneIDⁱ	6625
KEGGⁱ	hsa:6625
UCSCⁱ	uc002pmk.4 human [P08621-1]

Organism-specific databases

CTDⁱ	6625
DisGeNETⁱ	6625
EuPathDBⁱ	HostDB:ENSG00000104852.14
GeneCardsⁱ	SNRNP70
HGNCⁱ	HGNC:11150 SNRNP70
HPAⁱ	CAB001718 HPA042050 HPA043516
MIMⁱ	180740 gene
neXtProtⁱ	NX_P08621
OpenTargetsⁱ	ENSG00000104852
PharmGKBⁱ	PA35992
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0113 Eukaryota COG0724 LUCA
GeneTreeⁱ	ENSGT00530000063750
InParanoidⁱ	P08621
KOⁱ	K11093
OMAⁱ	NDVNIKH
OrthoDBⁱ	EOG091G0R0Z
PhylomeDBⁱ	P08621
TreeFamⁱ	TF314215

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSⁱ	SNRNP70 human
EvolutionaryTraceⁱ	P08621
GeneWikiⁱ	SnRNP70
GenomeRNAiⁱ	6625
PMAP-CutDBⁱ	P08621
Protein Ontology More...PROⁱ	PR:P08621
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000104852 Expressed in 231 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasⁱ	P08621 baseline and differential
Genevisibleⁱ	P08621 HS

Family and domain databases

CDDⁱ	cd12236 RRM_snRNP70, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR034143 snRNP70_RRM IPR022023 U1snRNP70_N
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit PF12220 U1snRNP70_N, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RU17_HUMAN
Accessionⁱ	P08621Primary (citable) accession number: P08621 Secondary accession number(s): B3KUA3 Q9UFQ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	August 1, 1988
	Last modified:	November 7, 2018
	This is version 213 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P08621 (RU17_HUMAN)

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U1 small nuclear ribonucleoprotein 70 kDa

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

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Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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