FGF4

Functionⁱ

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.1 Publication

GO - Molecular functionⁱ

1-phosphatidylinositol-3-kinase activity Source: Reactome
fibroblast growth factor receptor binding Source: InterPro
growth factor activity
Source: ProtInc
Traceable author statementⁱ
- 2959959
heparin binding Source: UniProtKB-KW
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
protein tyrosine kinase activity Source: Reactome
Ras guanyl-nucleotide exchange factor activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process involved in morphogenesis Source: Ensembl
cartilage condensation Source: Ensembl
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 2959959
cellular response to leukemia inhibitory factor Source: Ensembl
chondroblast differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 17167778
cranial suture morphogenesis Source: Ensembl
embryonic hindlimb morphogenesis Source: Ensembl
fibroblast growth factor receptor signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 8663044
MAPK cascade Source: Reactome
mesenchymal cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 11023873
negative regulation of apoptotic process Source: Ensembl
odontogenesis of dentin-containing tooth Source: Ensembl
positive regulation of cell division Source: UniProtKB-KW
positive regulation of cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 8663044
positive regulation of ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 17167778
positive regulation of protein kinase B signaling Source: Reactome
positive regulation of transcription by RNA polymerase II Source: Ensembl
regulation of endothelial cell chemotaxis to fibroblast growth factor
Source: UniProtKB
Inferred from direct assayⁱ
- 16756958
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 2959959
stem cell population maintenance Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Growth factor, Heparin-binding, Mitogen
Biological process	Differentiation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109704 PI3K Cascade R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1839122 Signaling by activated point mutants of FGFR1 R-HSA-1839130 Signaling by activated point mutants of FGFR3 R-HSA-190322 FGFR4 ligand binding and activation R-HSA-190372 FGFR3c ligand binding and activation R-HSA-190373 FGFR1c ligand binding and activation R-HSA-190375 FGFR2c ligand binding and activation R-HSA-2033514 FGFR3 mutant receptor activation R-HSA-2033519 Activated point mutants of FGFR2 R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2 R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3 R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4 R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654688 SHC-mediated cascade:FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654699 SHC-mediated cascade:FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654704 SHC-mediated cascade:FGFR3 R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654719 SHC-mediated cascade:FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654726 Negative regulation of FGFR1 signaling R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5654732 Negative regulation of FGFR3 signaling R-HSA-5654733 Negative regulation of FGFR4 signaling R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SignaLinkⁱ	P08620
SIGNORⁱ	P08620

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fibroblast growth factor 4 Short name: FGF-4 Alternative name(s): Heparin secretory-transforming protein 1 Short name: HST Short name: HST-1 Short name: HSTF-1 Heparin-binding growth factor 4 Short name: HBGF-4 Transforming protein KS3
Gene namesⁱ	Name:FGF4 Synonyms:HST, HSTF1, KS3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000075388.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3682 FGF4
MIMⁱ	164980 gene
neXtProtⁱ	NX_P08620

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2249
Open Targets More...OpenTargetsⁱ	ENSG00000075388
PharmGKBⁱ	PA28121

Chemistry databases

ChEMBLⁱ	CHEMBL3286072
Drug and drug target database More...DrugBankⁱ	DB00686 Pentosan Polysulfate DB05309 TP-508

Polymorphism and mutation databases

BioMutaⁱ	FGF4
DMDMⁱ	122750

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 30	Sequence analysisAdd BLAST		30
ChainⁱPRO_0000008953	31 – 206	Fibroblast growth factor 4Add BLAST		176

Proteomic databases

PaxDbⁱ	P08620
PRIDEⁱ	P08620
ProteomicsDBⁱ	52137

PTM databases

iPTMnetⁱ	P08620
PhosphoSitePlusⁱ	P08620

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000075388 Expressed in 26 organ(s), highest expression level in muscle tissue
CleanExⁱ	HS_FGF4
Genevisibleⁱ	P08620 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA011209

HPAⁱ

HPA011209

Interactionⁱ

Subunit structureⁱ

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.1 Publication

GO - Molecular functionⁱ

fibroblast growth factor receptor binding Source: InterPro
growth factor activity
Source: ProtInc
Traceable author statementⁱ
- 2959959
Ras guanyl-nucleotide exchange factor activity Source: Reactome

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108540, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-4017N
STRINGⁱ	9606.ENSP00000168712

Chemistry databases

BindingDBⁱ

P08620

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	82 – 88	Combined sources	7
Beta strandⁱ	94 – 98	Combined sources	5
Beta strandⁱ	104 – 109	Combined sources	6
Helixⁱ	112 – 114	Combined sources	3
Beta strandⁱ	116 – 122	Combined sources	7
Beta strandⁱ	125 – 130	Combined sources	6
Turnⁱ	131 – 134	Combined sources	4
Beta strandⁱ	135 – 139	Combined sources	5
Beta strandⁱ	145 – 150	Combined sources	6
Beta strandⁱ	155 – 161	Combined sources	7
Helixⁱ	163 – 165	Combined sources	3
Beta strandⁱ	167 – 174	Combined sources	8
Beta strandⁱ	185 – 187	Combined sources	3
Helixⁱ	190 – 192	Combined sources	3
Helixⁱ	198 – 200	Combined sources	3
Beta strandⁱ	202 – 205	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P08620
SMRⁱ	P08620
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P08620

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the heparin-binding growth factors family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3885 Eukaryota ENOG4111IPH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118859
HOGENOMⁱ	HOG000236341
HOVERGENⁱ	HBG007580
InParanoidⁱ	P08620
KEGG Orthology (KO) More...KOⁱ	K04358
OMAⁱ	HNENKYS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NAY
PhylomeDBⁱ	P08620
TreeFamⁱ	TF317805

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00058 FGF, 1 hit
InterProⁱ	View protein in InterPro IPR028239 FGF4 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF
PANTHERⁱ	PTHR11486 PTHR11486, 1 hit PTHR11486:SF31 PTHR11486:SF31, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00167 FGF, 1 hit
PRINTSⁱ	PR00263 HBGFFGF
SMARTⁱ	View protein in SMART SM00442 FGF, 1 hit
SUPFAMⁱ	SSF50353 SSF50353, 1 hit
PROSITEⁱ	View protein in PROSITE PS00247 HBGF_FGF, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P08620-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL 
        60         70         80         90        100
VALSLARLPV AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP 
       110        120        130        140        150
DGRIGGAHAD TRDSLLELSP VERGVVSIFG VASRFFVAMS SKGKLYGSPF 
       160        170        180        190        200
FTDECTFKEI LLPNNYNAYE SYKYPGMFIA LSKNGKTKKG NRVSPTMKVT 

HFLPRL

Length:206

Mass (Da):22,048

Last modified:August 1, 1988 - v1

Checksum:ⁱC7FD54A0272A1569

GO

Isoform 2 (identifier: P08620-2) [UniParc]FASTA Add to basket

Also known as: FGF4si

The sequence of this isoform differs from the canonical sequence as follows:
114-206: SLLELSPVER...MKVTHFLPRL → TLLHR

« Hide

        10         20         30         40         50
MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL 
        60         70         80         90        100
VALSLARLPV AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP 
       110 
DGRIGGAHAD TRDTLLHR

Note: Antagonist of isoform 1, shutting down FGF4-induced Erk1/2 phosphorylation.

Show »

Length:118

Mass (Da):12,237

Checksum:ⁱAAA97FBB8C667D7F

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053541	114 – 206	SLLEL…FLPRL → TLLHR in isoform 2. 1 PublicationAdd BLAST		93

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FJ456981 mRNA Translation: ACJ68447.1 J02986 Genomic DNA Translation: AAB59555.1 M17446 mRNA Translation: AAA59473.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8194.1 [P08620-1]
PIRⁱ	A28417 TVHUHS
NCBI Reference Sequences More...RefSeqⁱ	NP_001998.1, NM_002007.2 [P08620-1] XP_005273904.1, XM_005273847.1
UniGeneⁱ	Hs.1755 Hs.362432

Genome annotation databases

Ensemblⁱ	ENST00000168712; ENSP00000168712; ENSG00000075388 [P08620-1]
GeneIDⁱ	2249
KEGGⁱ	hsa:2249
UCSC genome browser More...UCSCⁱ	uc001opg.2 human [P08620-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08620	Fibroblast growth factor 4		BOVIN		206	UniRef90_P08620
Fibroblast growth factor		PANTR		206
Fibroblast growth factor		GORGO		206
Fibroblast growth factor		PONAB		206
Fibroblast growth factor		ICTTR		206
+7

Protein	Similar proteins		Species	Score	Length	Source
P08620	Fibroblast growth factor 4		BOVIN		206	UniRef50_P08620
Fibroblast growth factor 4		MOUSE		202
Fibroblast growth factor		ICTTR		206
Fibroblast growth factor		PONAB		206
Fibroblast growth factor		PANTR		206
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FJ456981 mRNA Translation: ACJ68447.1 J02986 Genomic DNA Translation: AAB59555.1 M17446 mRNA Translation: AAA59473.1
CCDSⁱ	CCDS8194.1 [P08620-1]
PIRⁱ	A28417 TVHUHS
RefSeqⁱ	NP_001998.1, NM_002007.2 [P08620-1] XP_005273904.1, XM_005273847.1
UniGeneⁱ	Hs.1755 Hs.362432

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IJT	X-ray	1.80	A	79-206	[»]
ProteinModelPortalⁱ	P08620
SMRⁱ	P08620
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108540, 1 interactor
DIPⁱ	DIP-4017N
STRINGⁱ	9606.ENSP00000168712

Chemistry databases

BindingDBⁱ	P08620
ChEMBLⁱ	CHEMBL3286072
DrugBankⁱ	DB00686 Pentosan Polysulfate DB05309 TP-508

PTM databases

iPTMnetⁱ	P08620
PhosphoSitePlusⁱ	P08620

Polymorphism and mutation databases

BioMutaⁱ	FGF4
DMDMⁱ	122750

Proteomic databases

PaxDbⁱ	P08620
PRIDEⁱ	P08620
ProteomicsDBⁱ	52137

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2249
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000168712; ENSP00000168712; ENSG00000075388 [P08620-1]
GeneIDⁱ	2249
KEGGⁱ	hsa:2249
UCSCⁱ	uc001opg.2 human [P08620-1]

Organism-specific databases

CTDⁱ	2249
DisGeNETⁱ	2249
EuPathDBⁱ	HostDB:ENSG00000075388.3
GeneCardsⁱ	FGF4
HGNCⁱ	HGNC:3682 FGF4
HPAⁱ	HPA011209
MIMⁱ	164980 gene
neXtProtⁱ	NX_P08620
OpenTargetsⁱ	ENSG00000075388
PharmGKBⁱ	PA28121
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3885 Eukaryota ENOG4111IPH LUCA
GeneTreeⁱ	ENSGT00760000118859
HOGENOMⁱ	HOG000236341
HOVERGENⁱ	HBG007580
InParanoidⁱ	P08620
KOⁱ	K04358
OMAⁱ	HNENKYS
OrthoDBⁱ	EOG091G0NAY
PhylomeDBⁱ	P08620
TreeFamⁱ	TF317805

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109704 PI3K Cascade R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1839122 Signaling by activated point mutants of FGFR1 R-HSA-1839130 Signaling by activated point mutants of FGFR3 R-HSA-190322 FGFR4 ligand binding and activation R-HSA-190372 FGFR3c ligand binding and activation R-HSA-190373 FGFR1c ligand binding and activation R-HSA-190375 FGFR2c ligand binding and activation R-HSA-2033514 FGFR3 mutant receptor activation R-HSA-2033519 Activated point mutants of FGFR2 R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2 R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3 R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4 R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654688 SHC-mediated cascade:FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654699 SHC-mediated cascade:FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654704 SHC-mediated cascade:FGFR3 R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654719 SHC-mediated cascade:FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654726 Negative regulation of FGFR1 signaling R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5654732 Negative regulation of FGFR3 signaling R-HSA-5654733 Negative regulation of FGFR4 signaling R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SignaLinkⁱ	P08620
SIGNORⁱ	P08620

Miscellaneous databases

EvolutionaryTraceⁱ	P08620
GeneWikiⁱ	FGF4
GenomeRNAiⁱ	2249
Protein Ontology More...PROⁱ	PR:P08620
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000075388 Expressed in 26 organ(s), highest expression level in muscle tissue
CleanExⁱ	HS_FGF4
Genevisibleⁱ	P08620 HS

Family and domain databases

CDDⁱ	cd00058 FGF, 1 hit
InterProⁱ	View protein in InterPro IPR028239 FGF4 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF
PANTHERⁱ	PTHR11486 PTHR11486, 1 hit PTHR11486:SF31 PTHR11486:SF31, 1 hit
Pfamⁱ	View protein in Pfam PF00167 FGF, 1 hit
PRINTSⁱ	PR00263 HBGFFGF
SMARTⁱ	View protein in SMART SM00442 FGF, 1 hit
SUPFAMⁱ	SSF50353 SSF50353, 1 hit
PROSITEⁱ	View protein in PROSITE PS00247 HBGF_FGF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FGF4_HUMAN
Accessionⁱ	P08620Primary (citable) accession number: P08620 Secondary accession number(s): B7U994
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	August 1, 1988
	Last modified:	November 7, 2018
	This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - P08620 (FGF4_HUMAN)

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Fibroblast growth factor 4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ