UniProtKB - P08620 (FGF4_HUMAN)
Fibroblast growth factor 4
FGF4
Functioni
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
1 PublicationGO - Molecular functioni
- fibroblast growth factor receptor binding Source: GO_Central
- growth factor activity Source: GO_Central
- heparin binding Source: UniProtKB-KW
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- apoptotic process involved in morphogenesis Source: Ensembl
- cartilage condensation Source: Ensembl
- cell-cell signaling Source: ProtInc
- cell differentiation Source: GO_Central
- cellular response to leukemia inhibitory factor Source: Ensembl
- chondroblast differentiation Source: UniProtKB
- cranial suture morphogenesis Source: Ensembl
- embryonic hindlimb morphogenesis Source: Ensembl
- fibroblast growth factor receptor signaling pathway Source: MGI
- mesenchymal cell proliferation Source: UniProtKB
- negative regulation of apoptotic process Source: Ensembl
- odontogenesis of dentin-containing tooth Source: Ensembl
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell population proliferation Source: MGI
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of gene expression Source: GO_Central
- positive regulation of protein phosphorylation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of cell migration Source: GO_Central
- regulation of endothelial cell chemotaxis to fibroblast growth factor Source: UniProtKB
- signal transduction Source: ProtInc
- stem cell population maintenance Source: Ensembl
Keywordsi
Molecular function | Developmental protein, Growth factor, Heparin-binding, Mitogen |
Biological process | Differentiation |
Enzyme and pathway databases
PathwayCommonsi | P08620 |
Reactomei | R-HSA-109704, PI3K Cascade R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1839122, Signaling by activated point mutants of FGFR1 R-HSA-1839130, Signaling by activated point mutants of FGFR3 R-HSA-190322, FGFR4 ligand binding and activation R-HSA-190372, FGFR3c ligand binding and activation R-HSA-190373, FGFR1c ligand binding and activation R-HSA-190375, FGFR2c ligand binding and activation R-HSA-2033514, FGFR3 mutant receptor activation R-HSA-2033519, Activated point mutants of FGFR2 R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5654219, Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221, Phospholipase C-mediated cascade, FGFR2 R-HSA-5654227, Phospholipase C-mediated cascade, FGFR3 R-HSA-5654228, Phospholipase C-mediated cascade, FGFR4 R-HSA-5654687, Downstream signaling of activated FGFR1 R-HSA-5654688, SHC-mediated cascade:FGFR1 R-HSA-5654689, PI-3K cascade:FGFR1 R-HSA-5654693, FRS-mediated FGFR1 signaling R-HSA-5654695, PI-3K cascade:FGFR2 R-HSA-5654699, SHC-mediated cascade:FGFR2 R-HSA-5654700, FRS-mediated FGFR2 signaling R-HSA-5654704, SHC-mediated cascade:FGFR3 R-HSA-5654706, FRS-mediated FGFR3 signaling R-HSA-5654710, PI-3K cascade:FGFR3 R-HSA-5654712, FRS-mediated FGFR4 signaling R-HSA-5654719, SHC-mediated cascade:FGFR4 R-HSA-5654720, PI-3K cascade:FGFR4 R-HSA-5654726, Negative regulation of FGFR1 signaling R-HSA-5654727, Negative regulation of FGFR2 signaling R-HSA-5654732, Negative regulation of FGFR3 signaling R-HSA-5654733, Negative regulation of FGFR4 signaling R-HSA-5655253, Signaling by FGFR2 in disease R-HSA-5655302, Signaling by FGFR1 in disease R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8853338, Signaling by FGFR3 point mutants in cancer |
SignaLinki | P08620 |
SIGNORi | P08620 |
Names & Taxonomyi
Protein namesi | Recommended name: Fibroblast growth factor 4Short name: FGF-4 Alternative name(s): Heparin secretory-transforming protein 1 Short name: HST Short name: HST-1 Short name: HSTF-1 Heparin-binding growth factor 4 Short name: HBGF-4 Transforming protein KS3 |
Gene namesi | Name:FGF4 Synonyms:HST, HSTF1, KS3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3682, FGF4 |
MIMi | 164980, gene |
neXtProti | NX_P08620 |
VEuPathDBi | HostDB:ENSG00000075388 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 2249 |
OpenTargetsi | ENSG00000075388 |
PharmGKBi | PA28121 |
Miscellaneous databases
Pharosi | P08620, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3286072 |
DrugBanki | DB01109, Heparin DB00686, Pentosan polysulfate DB05309, TP-508 |
Genetic variation databases
BioMutai | FGF4 |
DMDMi | 122750 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000008953 | 31 – 206 | Fibroblast growth factor 4Add BLAST | 176 |
Proteomic databases
jPOSTi | P08620 |
MassIVEi | P08620 |
PaxDbi | P08620 |
PeptideAtlasi | P08620 |
PRIDEi | P08620 |
PTM databases
iPTMneti | P08620 |
PhosphoSitePlusi | P08620 |
Expressioni
Gene expression databases
Bgeei | ENSG00000075388, Expressed in skeletal muscle tissue and 32 other tissues |
Genevisiblei | P08620, HS |
Organism-specific databases
HPAi | ENSG00000075388, Not detected |
Interactioni
Subunit structurei
Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
1 PublicationGO - Molecular functioni
- fibroblast growth factor receptor binding Source: GO_Central
- growth factor activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 108540, 41 interactors |
DIPi | DIP-4017N |
IntActi | P08620, 2 interactors |
STRINGi | 9606.ENSP00000168712 |
Chemistry databases
BindingDBi | P08620 |
Miscellaneous databases
RNActi | P08620, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P08620 |
SMRi | P08620 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08620 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3885, Eukaryota |
GeneTreei | ENSGT00940000158825 |
HOGENOMi | CLU_081609_4_1_1 |
InParanoidi | P08620 |
OMAi | YESHTYP |
OrthoDBi | 1183051at2759 |
PhylomeDBi | P08620 |
TreeFami | TF317805 |
Family and domain databases
CDDi | cd00058, FGF, 1 hit |
InterProi | View protein in InterPro IPR028239, FGF4 IPR002209, Fibroblast_GF_fam IPR008996, IL1/FGF |
PANTHERi | PTHR11486, PTHR11486, 1 hit PTHR11486:SF31, PTHR11486:SF31, 1 hit |
Pfami | View protein in Pfam PF00167, FGF, 1 hit |
PRINTSi | PR00263, HBGFFGF |
SMARTi | View protein in SMART SM00442, FGF, 1 hit |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247, HBGF_FGF, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL
60 70 80 90 100
VALSLARLPV AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP
110 120 130 140 150
DGRIGGAHAD TRDSLLELSP VERGVVSIFG VASRFFVAMS SKGKLYGSPF
160 170 180 190 200
FTDECTFKEI LLPNNYNAYE SYKYPGMFIA LSKNGKTKKG NRVSPTMKVT
HFLPRL
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053541 | 114 – 206 | SLLEL…FLPRL → TLLHR in isoform 2. 1 PublicationAdd BLAST | 93 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ456981 mRNA Translation: ACJ68447.1 J02986 Genomic DNA Translation: AAB59555.1 M17446 mRNA Translation: AAA59473.1 |
CCDSi | CCDS8194.1 [P08620-1] |
PIRi | A28417, TVHUHS |
RefSeqi | NP_001998.1, NM_002007.2 [P08620-1] XP_005273904.1, XM_005273847.1 |
Genome annotation databases
Ensembli | ENST00000168712.3; ENSP00000168712.1; ENSG00000075388.4 |
GeneIDi | 2249 |
KEGGi | hsa:2249 |
MANE-Selecti | ENST00000168712.3; ENSP00000168712.1; NM_002007.4; NP_001998.1 |
UCSCi | uc001opg.2, human [P08620-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ456981 mRNA Translation: ACJ68447.1 J02986 Genomic DNA Translation: AAB59555.1 M17446 mRNA Translation: AAA59473.1 |
CCDSi | CCDS8194.1 [P08620-1] |
PIRi | A28417, TVHUHS |
RefSeqi | NP_001998.1, NM_002007.2 [P08620-1] XP_005273904.1, XM_005273847.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IJT | X-ray | 1.80 | A | 79-206 | [»] | |
AlphaFoldDBi | P08620 | |||||
SMRi | P08620 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108540, 41 interactors |
DIPi | DIP-4017N |
IntActi | P08620, 2 interactors |
STRINGi | 9606.ENSP00000168712 |
Chemistry databases
BindingDBi | P08620 |
ChEMBLi | CHEMBL3286072 |
DrugBanki | DB01109, Heparin DB00686, Pentosan polysulfate DB05309, TP-508 |
PTM databases
iPTMneti | P08620 |
PhosphoSitePlusi | P08620 |
Genetic variation databases
BioMutai | FGF4 |
DMDMi | 122750 |
Proteomic databases
jPOSTi | P08620 |
MassIVEi | P08620 |
PaxDbi | P08620 |
PeptideAtlasi | P08620 |
PRIDEi | P08620 |
Protocols and materials databases
Antibodypediai | 2159, 448 antibodies from 38 providers |
DNASUi | 2249 |
Genome annotation databases
Ensembli | ENST00000168712.3; ENSP00000168712.1; ENSG00000075388.4 |
GeneIDi | 2249 |
KEGGi | hsa:2249 |
MANE-Selecti | ENST00000168712.3; ENSP00000168712.1; NM_002007.4; NP_001998.1 |
UCSCi | uc001opg.2, human [P08620-1] |
Organism-specific databases
CTDi | 2249 |
DisGeNETi | 2249 |
GeneCardsi | FGF4 |
HGNCi | HGNC:3682, FGF4 |
HPAi | ENSG00000075388, Not detected |
MIMi | 164980, gene |
neXtProti | NX_P08620 |
OpenTargetsi | ENSG00000075388 |
PharmGKBi | PA28121 |
VEuPathDBi | HostDB:ENSG00000075388 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3885, Eukaryota |
GeneTreei | ENSGT00940000158825 |
HOGENOMi | CLU_081609_4_1_1 |
InParanoidi | P08620 |
OMAi | YESHTYP |
OrthoDBi | 1183051at2759 |
PhylomeDBi | P08620 |
TreeFami | TF317805 |
Enzyme and pathway databases
PathwayCommonsi | P08620 |
Reactomei | R-HSA-109704, PI3K Cascade R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1839122, Signaling by activated point mutants of FGFR1 R-HSA-1839130, Signaling by activated point mutants of FGFR3 R-HSA-190322, FGFR4 ligand binding and activation R-HSA-190372, FGFR3c ligand binding and activation R-HSA-190373, FGFR1c ligand binding and activation R-HSA-190375, FGFR2c ligand binding and activation R-HSA-2033514, FGFR3 mutant receptor activation R-HSA-2033519, Activated point mutants of FGFR2 R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5654219, Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221, Phospholipase C-mediated cascade, FGFR2 R-HSA-5654227, Phospholipase C-mediated cascade, FGFR3 R-HSA-5654228, Phospholipase C-mediated cascade, FGFR4 R-HSA-5654687, Downstream signaling of activated FGFR1 R-HSA-5654688, SHC-mediated cascade:FGFR1 R-HSA-5654689, PI-3K cascade:FGFR1 R-HSA-5654693, FRS-mediated FGFR1 signaling R-HSA-5654695, PI-3K cascade:FGFR2 R-HSA-5654699, SHC-mediated cascade:FGFR2 R-HSA-5654700, FRS-mediated FGFR2 signaling R-HSA-5654704, SHC-mediated cascade:FGFR3 R-HSA-5654706, FRS-mediated FGFR3 signaling R-HSA-5654710, PI-3K cascade:FGFR3 R-HSA-5654712, FRS-mediated FGFR4 signaling R-HSA-5654719, SHC-mediated cascade:FGFR4 R-HSA-5654720, PI-3K cascade:FGFR4 R-HSA-5654726, Negative regulation of FGFR1 signaling R-HSA-5654727, Negative regulation of FGFR2 signaling R-HSA-5654732, Negative regulation of FGFR3 signaling R-HSA-5654733, Negative regulation of FGFR4 signaling R-HSA-5655253, Signaling by FGFR2 in disease R-HSA-5655302, Signaling by FGFR1 in disease R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8853338, Signaling by FGFR3 point mutants in cancer |
SignaLinki | P08620 |
SIGNORi | P08620 |
Miscellaneous databases
BioGRID-ORCSi | 2249, 11 hits in 1073 CRISPR screens |
EvolutionaryTracei | P08620 |
GeneWikii | FGF4 |
GenomeRNAii | 2249 |
Pharosi | P08620, Tbio |
PROi | PR:P08620 |
RNActi | P08620, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000075388, Expressed in skeletal muscle tissue and 32 other tissues |
Genevisiblei | P08620, HS |
Family and domain databases
CDDi | cd00058, FGF, 1 hit |
InterProi | View protein in InterPro IPR028239, FGF4 IPR002209, Fibroblast_GF_fam IPR008996, IL1/FGF |
PANTHERi | PTHR11486, PTHR11486, 1 hit PTHR11486:SF31, PTHR11486:SF31, 1 hit |
Pfami | View protein in Pfam PF00167, FGF, 1 hit |
PRINTSi | PR00263, HBGFFGF |
SMARTi | View protein in SMART SM00442, FGF, 1 hit |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247, HBGF_FGF, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FGF4_HUMAN | |
Accessioni | P08620Primary (citable) accession number: P08620 Secondary accession number(s): B7U994 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1988 | |
Last modified: | May 25, 2022 | |
This is version 195 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families