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UniProtKB - P08620 (FGF4_HUMAN)

Entry version 195 (25 May 2022)
Sequence version 1 (01 Aug 1988)
Previous versions | rss
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Protein

Fibroblast growth factor 4

Gene

FGF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processDifferentiation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08620

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-109704, PI3K Cascade
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-1839122, Signaling by activated point mutants of FGFR1
R-HSA-1839130, Signaling by activated point mutants of FGFR3
R-HSA-190322, FGFR4 ligand binding and activation
R-HSA-190372, FGFR3c ligand binding and activation
R-HSA-190373, FGFR1c ligand binding and activation
R-HSA-190375, FGFR2c ligand binding and activation
R-HSA-2033514, FGFR3 mutant receptor activation
R-HSA-2033519, Activated point mutants of FGFR2
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219, Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221, Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227, Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228, Phospholipase C-mediated cascade, FGFR4
R-HSA-5654687, Downstream signaling of activated FGFR1
R-HSA-5654688, SHC-mediated cascade:FGFR1
R-HSA-5654689, PI-3K cascade:FGFR1
R-HSA-5654693, FRS-mediated FGFR1 signaling
R-HSA-5654695, PI-3K cascade:FGFR2
R-HSA-5654699, SHC-mediated cascade:FGFR2
R-HSA-5654700, FRS-mediated FGFR2 signaling
R-HSA-5654704, SHC-mediated cascade:FGFR3
R-HSA-5654706, FRS-mediated FGFR3 signaling
R-HSA-5654710, PI-3K cascade:FGFR3
R-HSA-5654712, FRS-mediated FGFR4 signaling
R-HSA-5654719, SHC-mediated cascade:FGFR4
R-HSA-5654720, PI-3K cascade:FGFR4
R-HSA-5654726, Negative regulation of FGFR1 signaling
R-HSA-5654727, Negative regulation of FGFR2 signaling
R-HSA-5654732, Negative regulation of FGFR3 signaling
R-HSA-5654733, Negative regulation of FGFR4 signaling
R-HSA-5655253, Signaling by FGFR2 in disease
R-HSA-5655302, Signaling by FGFR1 in disease
R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853338, Signaling by FGFR3 point mutants in cancer

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P08620

SIGNOR Signaling Network Open Resource

More...SIGNORi		P08620

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibroblast growth factor 4
Short name:
FGF-4
Alternative name(s):
Heparin secretory-transforming protein 1
Short name:
HST
Short name:
HST-1
Short name:
HSTF-1
Heparin-binding growth factor 4
Short name:
HBGF-4
Transforming protein KS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGF4
Synonyms:HST, HSTF1, KS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3682, FGF4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164980, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08620

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000075388

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		2249

Open Targets

More...OpenTargetsi		ENSG00000075388

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28121

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08620, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3286072

Drug and drug target database

More...DrugBanki		DB01109, Heparin
DB00686, Pentosan polysulfate
DB05309, TP-508

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FGF4

Domain mapping of disease mutations (DMDM)

More...DMDMi		122750

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000895331 – 206Fibroblast growth factor 4Add BLAST176

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P08620

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08620

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08620

PeptideAtlas

More...PeptideAtlasi		P08620

PRoteomics IDEntifications database

More...PRIDEi		P08620

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08620

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08620

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000075388, Expressed in skeletal muscle tissue and 32 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08620, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000075388, Not detected

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108540, 41 interactors

Database of interacting proteins

More...DIPi		DIP-4017N

Protein interaction database and analysis system

More...IntActi		P08620, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000168712

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P08620

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08620, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P08620

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08620

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P08620

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the heparin-binding growth factors family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3885, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158825

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_081609_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08620

Identification of Orthologs from Complete Genome Data

More...OMAi		YESHTYP

Database of Orthologous Groups

More...OrthoDBi		1183051at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08620

TreeFam database of animal gene trees

More...TreeFami		TF317805

Family and domain databases

Conserved Domains Database

More...CDDi		cd00058, FGF, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028239, FGF4
IPR002209, Fibroblast_GF_fam
IPR008996, IL1/FGF

The PANTHER Classification System

More...PANTHERi		PTHR11486, PTHR11486, 1 hit
PTHR11486:SF31, PTHR11486:SF31, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00167, FGF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00263, HBGFFGF

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00442, FGF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50353, SSF50353, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00247, HBGF_FGF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P08620-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL 
        60         70         80         90        100
VALSLARLPV AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP 
       110        120        130        140        150
DGRIGGAHAD TRDSLLELSP VERGVVSIFG VASRFFVAMS SKGKLYGSPF 
       160        170        180        190        200
FTDECTFKEI LLPNNYNAYE SYKYPGMFIA LSKNGKTKKG NRVSPTMKVT 

HFLPRL
Length:206
Mass (Da):22,048
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7FD54A0272A1569
GO
Isoform 2 (identifier: P08620-2) [UniParc]FASTAAdd to basket
Also known as: FGF4si

The sequence of this isoform differs from the canonical sequence as follows:
     114-206: SLLELSPVER...MKVTHFLPRL → TLLHR

Note: Antagonist of isoform 1, shutting down FGF4-induced Erk1/2 phosphorylation.Curated
Show »
Length:118
Mass (Da):12,237
Checksum:iAAA97FBB8C667D7F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053541114 – 206SLLEL…FLPRL → TLLHR in isoform 2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FJ456981 mRNA Translation: ACJ68447.1
J02986 Genomic DNA Translation: AAB59555.1
M17446 mRNA Translation: AAA59473.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8194.1 [P08620-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A28417, TVHUHS

NCBI Reference Sequences

More...RefSeqi		NP_001998.1, NM_002007.2 [P08620-1]
XP_005273904.1, XM_005273847.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000168712.3; ENSP00000168712.1; ENSG00000075388.4

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2249

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2249

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000168712.3; ENSP00000168712.1; NM_002007.4; NP_001998.1

UCSC genome browser

More...UCSCi		uc001opg.2, human [P08620-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ456981 mRNA Translation: ACJ68447.1
J02986 Genomic DNA Translation: AAB59555.1
M17446 mRNA Translation: AAA59473.1
CCDSiCCDS8194.1 [P08620-1]
PIRiA28417, TVHUHS
RefSeqiNP_001998.1, NM_002007.2 [P08620-1]
XP_005273904.1, XM_005273847.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IJTX-ray1.80A79-206[»]
AlphaFoldDBiP08620
SMRiP08620
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108540, 41 interactors
DIPiDIP-4017N
IntActiP08620, 2 interactors
STRINGi9606.ENSP00000168712

Chemistry databases

BindingDBiP08620
ChEMBLiCHEMBL3286072
DrugBankiDB01109, Heparin
DB00686, Pentosan polysulfate
DB05309, TP-508

PTM databases

iPTMnetiP08620
PhosphoSitePlusiP08620

Genetic variation databases

BioMutaiFGF4
DMDMi122750

Proteomic databases

jPOSTiP08620
MassIVEiP08620
PaxDbiP08620
PeptideAtlasiP08620
PRIDEiP08620

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2159, 448 antibodies from 38 providers

The DNASU plasmid repository

More...DNASUi		2249

Genome annotation databases

EnsembliENST00000168712.3; ENSP00000168712.1; ENSG00000075388.4
GeneIDi2249
KEGGihsa:2249
MANE-SelectiENST00000168712.3; ENSP00000168712.1; NM_002007.4; NP_001998.1
UCSCiuc001opg.2, human [P08620-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2249
DisGeNETi2249

GeneCards: human genes, protein and diseases

More...GeneCardsi		FGF4
HGNCiHGNC:3682, FGF4
HPAiENSG00000075388, Not detected
MIMi164980, gene
neXtProtiNX_P08620
OpenTargetsiENSG00000075388
PharmGKBiPA28121
VEuPathDBiHostDB:ENSG00000075388

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3885, Eukaryota
GeneTreeiENSGT00940000158825
HOGENOMiCLU_081609_4_1_1
InParanoidiP08620
OMAiYESHTYP
OrthoDBi1183051at2759
PhylomeDBiP08620
TreeFamiTF317805

Enzyme and pathway databases

PathwayCommonsiP08620
ReactomeiR-HSA-109704, PI3K Cascade
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-1839122, Signaling by activated point mutants of FGFR1
R-HSA-1839130, Signaling by activated point mutants of FGFR3
R-HSA-190322, FGFR4 ligand binding and activation
R-HSA-190372, FGFR3c ligand binding and activation
R-HSA-190373, FGFR1c ligand binding and activation
R-HSA-190375, FGFR2c ligand binding and activation
R-HSA-2033514, FGFR3 mutant receptor activation
R-HSA-2033519, Activated point mutants of FGFR2
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219, Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221, Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227, Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228, Phospholipase C-mediated cascade, FGFR4
R-HSA-5654687, Downstream signaling of activated FGFR1
R-HSA-5654688, SHC-mediated cascade:FGFR1
R-HSA-5654689, PI-3K cascade:FGFR1
R-HSA-5654693, FRS-mediated FGFR1 signaling
R-HSA-5654695, PI-3K cascade:FGFR2
R-HSA-5654699, SHC-mediated cascade:FGFR2
R-HSA-5654700, FRS-mediated FGFR2 signaling
R-HSA-5654704, SHC-mediated cascade:FGFR3
R-HSA-5654706, FRS-mediated FGFR3 signaling
R-HSA-5654710, PI-3K cascade:FGFR3
R-HSA-5654712, FRS-mediated FGFR4 signaling
R-HSA-5654719, SHC-mediated cascade:FGFR4
R-HSA-5654720, PI-3K cascade:FGFR4
R-HSA-5654726, Negative regulation of FGFR1 signaling
R-HSA-5654727, Negative regulation of FGFR2 signaling
R-HSA-5654732, Negative regulation of FGFR3 signaling
R-HSA-5654733, Negative regulation of FGFR4 signaling
R-HSA-5655253, Signaling by FGFR2 in disease
R-HSA-5655302, Signaling by FGFR1 in disease
R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853338, Signaling by FGFR3 point mutants in cancer
SignaLinkiP08620
SIGNORiP08620

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2249, 11 hits in 1073 CRISPR screens
EvolutionaryTraceiP08620

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FGF4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2249
PharosiP08620, Tbio

Protein Ontology

More...PROi		PR:P08620
RNActiP08620, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000075388, Expressed in skeletal muscle tissue and 32 other tissues
GenevisibleiP08620, HS

Family and domain databases

CDDicd00058, FGF, 1 hit
InterProiView protein in InterPro
IPR028239, FGF4
IPR002209, Fibroblast_GF_fam
IPR008996, IL1/FGF
PANTHERiPTHR11486, PTHR11486, 1 hit
PTHR11486:SF31, PTHR11486:SF31, 1 hit
PfamiView protein in Pfam
PF00167, FGF, 1 hit
PRINTSiPR00263, HBGFFGF
SMARTiView protein in SMART
SM00442, FGF, 1 hit
SUPFAMiSSF50353, SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247, HBGF_FGF, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGF4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08620
Secondary accession number(s): B7U994
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 25, 2022
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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