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UniProtKB - P08616 (TKN2_UPERU)
Protein
Rugosauperolein-2
Gene
N/A
Organism
Uperoleia rugosa (Wrinkled toadlet) (Pseudophryne rugosa)
Status
Functioni
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
GO - Biological processi
- defense response Source: UniProtKB-KW
- neuropeptide signaling pathway Source: UniProtKB-KW
- tachykinin receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | Amphibian defense peptide, Neuropeptide |
Names & Taxonomyi
Protein namesi | Recommended name: Rugosauperolein-2Alternative name(s): Rugosauperolein II [Lys5,Thr6]-physalaemin |
Organismi | Uperoleia rugosa (Wrinkled toadlet) (Pseudophryne rugosa) |
Taxonomic identifieri | 8368 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Myobatrachoidea › Myobatrachidae › Myobatrachinae › Uperoleia |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000044415 | 1 – 11 | Rugosauperolein-2Add BLAST | 11 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Modified residuei | 11 | Methionine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Pyrrolidone carboxylic acidExpressioni
Tissue specificityi
Expressed by the skin glands.
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the tachykinin family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR013055, Tachy_Neuro_lke_CS IPR008215, Tachykinin_dom |
Pfami | View protein in Pfam PF02202, Tachykinin, 1 hit |
PROSITEi | View protein in PROSITE PS00267, TACHYKININ, 1 hit |
i Sequence
Sequence statusi: Complete.
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
InterProi | View protein in InterPro IPR013055, Tachy_Neuro_lke_CS IPR008215, Tachykinin_dom |
Pfami | View protein in Pfam PF02202, Tachykinin, 1 hit |
PROSITEi | View protein in PROSITE PS00267, TACHYKININ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TKN2_UPERU | |
Accessioni | P08616Primary (citable) accession number: P08616 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | February 1, 1994 | |
Last modified: | September 29, 2021 | |
This is version 70 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families