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Protein

Myosin light chain 3

Gene

MYL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory light chain of myosin. Does not bind calcium.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin monomer binding Source: BHF-UCL
  • calcium ion binding Source: InterPro
  • motor activity Source: Ensembl
  • myosin II heavy chain binding Source: BHF-UCL
  • structural constituent of muscle Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390522 Striated Muscle Contraction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin light chain 3Curated
Alternative name(s):
Cardiac myosin light chain 11 Publication
Short name:
CMLC11 Publication
Myosin light chain 1, slow-twitch muscle B/ventricular isoformCurated
Short name:
MLC1SB
Ventricular myosin alkali light chain1 Publication
Ventricular myosin light chain 11 Publication
Short name:
VLCl1 Publication
Ventricular/slow twitch myosin alkali light chain1 Publication
Short name:
MLC-lV/sb1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYL3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160808.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7584 MYL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
160790 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08590

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cardiomyopathy, familial hypertrophic 8 (CMH8)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
See also OMIM:608751
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01984256E → G in CMH8. 1 PublicationCorresponds to variant dbSNP:rs199474702EnsemblClinVar.1
Natural variantiVAR_019843143E → K in CMH8; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs104893750EnsemblClinVar.1
Natural variantiVAR_004599149M → V in CMH8; with mid-left ventricular chamber thickening. 1 PublicationCorresponds to variant dbSNP:rs104893748EnsemblClinVar.1
Natural variantiVAR_004600154R → H in CMH8; with mid-left ventricular chamber thickening. 1 PublicationCorresponds to variant dbSNP:rs104893749EnsemblClinVar.1
Natural variantiVAR_073726177E → G in CMH8. 1 PublicationCorresponds to variant dbSNP:rs193922391EnsemblClinVar.1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4634

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
MYL3

MalaCards human disease database

More...
MalaCardsi
MYL3
MIMi608751 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000160808

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31381

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3831286

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
127149

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001986962 – 195Myosin light chain 3Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N,N,N-trimethylalanine1 Publication1
Modified residuei88PhosphothreonineBy similarity1
Modified residuei127PhosphothreonineBy similarity1
Modified residuei129PhosphothreonineBy similarity1
Modified residuei130PhosphotyrosineBy similarity1
Modified residuei179PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.
N-terminus is methylated by METTL11A/NTM1.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P08590

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P08590

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08590

PeptideAtlas

More...
PeptideAtlasi
P08590

PRoteomics IDEntifications database

More...
PRIDEi
P08590

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52134

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P08590

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08590

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08590

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P08590

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160808 Expressed in 131 organ(s), highest expression level in heart left ventricle

CleanEx database of gene expression profiles

More...
CleanExi
HS_MYL3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P08590 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08590 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB018662
HPA016564
HPA046859
HPA063034

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110718, 12 interactors

Protein interaction database and analysis system

More...
IntActi
P08590, 5 interactors

Molecular INTeraction database

More...
MINTi
P08590

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000292327

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P08590

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P08590

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 86EF-hand 1PROSITE-ProRule annotationAdd BLAST38
Domaini128 – 163EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini163 – 195EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0030 Eukaryota
COG5126 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153812

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233018

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG012180

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08590

KEGG Orthology (KO)

More...
KOi
K12749

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSKMIDF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0TQL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08590

TreeFam database of animal gene trees

More...
TreeFami
TF351553

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P08590-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKKPEPKK DDAKAAPKAA PAPAPPPEPE RPKEVEFDAS KIKIEFTPEQ
60 70 80 90 100
IEEFKEAFML FDRTPKCEMK ITYGQCGDVL RALGQNPTQA EVLRVLGKPR
110 120 130 140 150
QEELNTKMMD FETFLPMLQH ISKNKDTGTY EDFVEGLRVF DKEGNGTVMG
160 170 180 190
AELRHVLATL GERLTEDEVE KLMAGQEDSN GCINYEAFVK HIMSS
Length:195
Mass (Da):21,932
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i306CF328841729DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGV7E9PGV7_HUMAN
Myosin light chain 3
MYL3
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171K → R in AAF91089 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01984256E → G in CMH8. 1 PublicationCorresponds to variant dbSNP:rs199474702EnsemblClinVar.1
Natural variantiVAR_019843143E → K in CMH8; autosomal recessive. 1 PublicationCorresponds to variant dbSNP:rs104893750EnsemblClinVar.1
Natural variantiVAR_004599149M → V in CMH8; with mid-left ventricular chamber thickening. 1 PublicationCorresponds to variant dbSNP:rs104893748EnsemblClinVar.1
Natural variantiVAR_004600154R → H in CMH8; with mid-left ventricular chamber thickening. 1 PublicationCorresponds to variant dbSNP:rs104893749EnsemblClinVar.1
Natural variantiVAR_073726177E → G in CMH8. 1 PublicationCorresponds to variant dbSNP:rs193922391EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M24122 mRNA Translation: AAA59895.1
X07373 mRNA Translation: CAA30292.1
M24247
, M24242, M24243, M24244, M24245, M24246 Genomic DNA Translation: AAA59851.1
AF174483 mRNA Translation: AAF91089.1
AK312044 mRNA Translation: BAG34981.1
CH471055 Genomic DNA Translation: EAW64791.1
BC009790 mRNA Translation: AAH09790.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2746.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B30881 MOHU3V

NCBI Reference Sequences

More...
RefSeqi
NP_000249.1, NM_000258.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.517939

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292327; ENSP00000292327; ENSG00000160808
ENST00000395869; ENSP00000379210; ENSG00000160808

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4634

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4634

UCSC genome browser

More...
UCSCi
uc003cql.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24122 mRNA Translation: AAA59895.1
X07373 mRNA Translation: CAA30292.1
M24247
, M24242, M24243, M24244, M24245, M24246 Genomic DNA Translation: AAA59851.1
AF174483 mRNA Translation: AAF91089.1
AK312044 mRNA Translation: BAG34981.1
CH471055 Genomic DNA Translation: EAW64791.1
BC009790 mRNA Translation: AAH09790.1
CCDSiCCDS2746.1
PIRiB30881 MOHU3V
RefSeqiNP_000249.1, NM_000258.2
UniGeneiHs.517939

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5TBYelectron microscopy20.00C/D1-195[»]
ProteinModelPortaliP08590
SMRiP08590
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110718, 12 interactors
IntActiP08590, 5 interactors
MINTiP08590
STRINGi9606.ENSP00000292327

Chemistry databases

ChEMBLiCHEMBL3831286

PTM databases

iPTMnetiP08590
PhosphoSitePlusiP08590

Polymorphism and mutation databases

BioMutaiMYL3
DMDMi127149

2D gel databases

UCD-2DPAGEiP08590

Proteomic databases

EPDiP08590
MaxQBiP08590
PaxDbiP08590
PeptideAtlasiP08590
PRIDEiP08590
ProteomicsDBi52134

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4634
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292327; ENSP00000292327; ENSG00000160808
ENST00000395869; ENSP00000379210; ENSG00000160808
GeneIDi4634
KEGGihsa:4634
UCSCiuc003cql.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4634
DisGeNETi4634
EuPathDBiHostDB:ENSG00000160808.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYL3
GeneReviewsiMYL3
HGNCiHGNC:7584 MYL3
HPAiCAB018662
HPA016564
HPA046859
HPA063034
MalaCardsiMYL3
MIMi160790 gene
608751 phenotype
neXtProtiNX_P08590
OpenTargetsiENSG00000160808
Orphaneti155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
PharmGKBiPA31381

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00940000153812
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP08590
KOiK12749
OMAiNSKMIDF
OrthoDBiEOG091G0TQL
PhylomeDBiP08590
TreeFamiTF351553

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MYL3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MYL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4634
PMAP-CutDBiP08590

Protein Ontology

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PROi
PR:P08590

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000160808 Expressed in 131 organ(s), highest expression level in heart left ventricle
CleanExiHS_MYL3
ExpressionAtlasiP08590 baseline and differential
GenevisibleiP08590 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08590
Secondary accession number(s): B2R534, Q9NRS8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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