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Protein

Beta-1 adrenergic receptor

Gene

ADRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei138Agonist or antagonistBy similarity1
Binding sitei143Agonist or antagonistBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390696 Adrenoceptors
R-HSA-418555 G alpha (s) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P08588

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P08588

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.3.11 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-1 adrenergic receptor
Alternative name(s):
Beta-1 adrenoreceptor
Short name:
Beta-1 adrenoceptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADRB1
Synonyms:ADRB1R, B1AR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000043591.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:285 ADRB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
109630 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08588

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 55ExtracellularBy similarityAdd BLAST55
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei56 – 84Helical; Name=1By similarityAdd BLAST29
Topological domaini85 – 93CytoplasmicBy similarity9
Transmembranei94 – 120Helical; Name=2By similarityAdd BLAST27
Topological domaini121 – 132ExtracellularBy similarityAdd BLAST12
Transmembranei133 – 154Helical; Name=3By similarityAdd BLAST22
Topological domaini155 – 172CytoplasmicBy similarityAdd BLAST18
Transmembranei173 – 196Helical; Name=4By similarityAdd BLAST24
Topological domaini197 – 222ExtracellularBy similarityAdd BLAST26
Transmembranei223 – 248Helical; Name=5By similarityAdd BLAST26
Topological domaini249 – 319CytoplasmicBy similarityAdd BLAST71
Transmembranei320 – 349Helical; Name=6By similarityAdd BLAST30
Topological domaini350 – 354ExtracellularBy similarity5
Transmembranei355 – 377Helical; Name=7By similarityAdd BLAST23
Topological domaini378 – 477CytoplasmicBy similarityAdd BLAST100

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi474E → A or D: Loss of interaction with GOPC. 1 Publication1
Mutagenesisi474E → K: Loss of interaction with GOPC; when associated with A-477. 1 Publication1
Mutagenesisi475S → A: Loss of interaction with GOPC. Loss of interaction with RAPGEF2. Abolishes agonist-induced Ras activation. 2 Publications1
Mutagenesisi475S → D: Loss of interaction with RAPGEF2. 2 Publications1
Mutagenesisi475S → T: Partial loss of interaction with GOPC. 2 Publications1
Mutagenesisi476K → A: Partial loss of interaction with GOPC. 1 Publication1
Mutagenesisi477V → A, F, L, I or M: Loss of interaction with GOPC. 2 Publications1
Mutagenesisi477V → A: Loss of interaction with RAPGEF2. Abolishes agonist-induced Ras activation. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
153

MalaCards human disease database

More...
MalaCardsi
ADRB1
MIMi607276 phenotype

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL213

Drug and drug target database

More...
DrugBanki
DB08347 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile
DB01193 Acebutolol
DB00866 Alprenolol
DB01118 Amiodarone
DB00321 Amitriptyline
DB00182 Amphetamine
DB01102 Arbutamine
DB06216 Asenapine
DB00335 Atenolol
DB00195 Betaxolol
DB00217 Bethanidine
DB01295 Bevantolol
DB00612 Bisoprolol
DB08807 Bopindolol
DB06726 Bufuralol
DB08808 Bupranolol
DB00248 Cabergoline
DB00521 Carteolol
DB01136 Carvedilol
DB04846 Celiprolol
DB01407 Clenbuterol
DB01151 Desipramine
DB00841 Dobutamine
DB04855 Dronedarone
DB06262 Droxidopa
DB01363 Ephedra
DB00668 Epinephrine
DB00187 Esmolol
DB01288 Fenoterol
DB00221 Isoetarine
DB01064 Isoprenaline
DB00598 Labetalol
DB01210 Levobunolol
DB00408 Loxapine
DB01365 Mephentermine
DB01214 Metipranolol
DB00264 Metoprolol
DB00370 Mirtazapine
DB01203 Nadolol
DB04861 Nebivolol
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB01580 Oxprenolol
DB01359 Penbutolol
DB00397 Phenylpropanolamine
DB00960 Pindolol
DB01291 Pirbuterol
DB01297 Practolol
DB00571 Propranolol
DB00852 Pseudoephedrine
DB01001 Salbutamol
DB00489 Sotalol
DB00373 Timolol
DB00726 Trimipramine
DB09068 Vortioxetine

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
28

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADRB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48429211

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000691181 – 477Beta-1 adrenergic receptorAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi15N-linked (GlcNAc...) asparagineCurated1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi131 ↔ 216PROSITE-ProRule annotation
Disulfide bondi209 ↔ 215PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei312Phosphoserine; by PKASequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi392S-palmitoyl cysteineBy similarity1
Modified residuei412Phosphoserine; by PKASequence analysis1
Modified residuei428PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P08588

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08588

PeptideAtlas

More...
PeptideAtlasi
P08588

PRoteomics IDEntifications database

More...
PRIDEi
P08588

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52133

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08588

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08588

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P08588

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000043591 Expressed in 144 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_ADRB1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08588 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA067972

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus PDZ motif) with RAPGEF2; the interaction is direct. Interacts with GOPC, MAGI3 and DLG4.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106662, 8 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P08588

Database of interacting proteins

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DIPi
DIP-36294N

Protein interaction database and analysis system

More...
IntActi
P08588, 13 interactors

Molecular INTeraction database

More...
MINTi
P08588

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358301

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P08588

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1477
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LSQNMR-A197-221[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P08588

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P08588

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni218 – 232Agonist and antagonist bindingBy similarityAdd BLAST15
Regioni337 – 344Agonist and antagonist bindingBy similarity8
Regioni363 – 367Agonist and antagonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi474 – 477PDZ-Binding4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000239242

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106962

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08588

KEGG Orthology (KO)

More...
KOi
K04141

Database of Orthologous Groups

More...
OrthoDBi
1204439at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08588

TreeFam database of animal gene trees

More...
TreeFami
TF316350

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002233 ADR_fam
IPR000507 ADRB1_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01103 ADRENERGICR
PR00561 ADRENRGCB1AR
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P08588-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAGVLVLGA SEPGNLSSAA PLPDGAATAA RLLVPASPPA SLLPPASESP
60 70 80 90 100
EPLSQQWTAG MGLLMALIVL LIVAGNVLVI VAIAKTPRLQ TLTNLFIMSL
110 120 130 140 150
ASADLVMGLL VVPFGATIVV WGRWEYGSFF CELWTSVDVL CVTASIETLC
160 170 180 190 200
VIALDRYLAI TSPFRYQSLL TRARARGLVC TVWAISALVS FLPILMHWWR
210 220 230 240 250
AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM AFVYLRVFRE
260 270 280 290 300
AQKQVKKIDS CERRFLGGPA RPPSPSPSPV PAPAPPPGPP RPAAAAATAP
310 320 330 340 350
LANGRAGKRR PSRLVALREQ KALKTLGIIM GVFTLCWLPF FLANVVKAFH
360 370 380 390 400
RELVPDRLFV FFNWLGYANS AFNPIIYCRS PDFRKAFQRL LCCARRAARR
410 420 430 440 450
RHATHGDRPR ASGCLARPGP PPSPGAASDD DDDDVVGATP PARLLEPWAG
460 470
CNGGAAADSD SSLDEPCRPG FASESKV
Length:477
Mass (Da):51,323
Last modified:June 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0950F2684E4721B8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05590926A → V. Corresponds to variant dbSNP:rs34844626Ensembl.1
Natural variantiVAR_05591029A → T. Corresponds to variant dbSNP:rs35720093Ensembl.1
Natural variantiVAR_05591131R → Q. Corresponds to variant dbSNP:rs35230616Ensembl.1
Natural variantiVAR_00987949S → G Associated with high mean resting heart rate. 4 PublicationsCorresponds to variant dbSNP:rs1801252EnsemblClinVar.1
Natural variantiVAR_009880389R → G Reduced binding to G proteins. 4 PublicationsCorresponds to variant dbSNP:rs1801253Ensembl.1
Natural variantiVAR_018742389R → L1 Publication1
Natural variantiVAR_055912399R → H. Corresponds to variant dbSNP:rs36052953Ensembl.1
Natural variantiVAR_055913405H → Y. Corresponds to variant dbSNP:rs35705839Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03019 mRNA Translation: AAA51667.1
AF169006 Genomic DNA Translation: AAD53696.1
AF169007 Genomic DNA Translation: AAD53697.1
AY567837 Genomic DNA Translation: AAS66983.1
EU332832 Genomic DNA Translation: ABY87521.1
AL355543 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7586.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A39911 QRHUB1

NCBI Reference Sequences

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RefSeqi
NP_000675.1, NM_000684.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.99913

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000369295; ENSP00000358301; ENSG00000043591

Database of genes from NCBI RefSeq genomes

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GeneIDi
153

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:153

UCSC genome browser

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UCSCi
uc001lba.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03019 mRNA Translation: AAA51667.1
AF169006 Genomic DNA Translation: AAD53696.1
AF169007 Genomic DNA Translation: AAD53697.1
AY567837 Genomic DNA Translation: AAS66983.1
EU332832 Genomic DNA Translation: ABY87521.1
AL355543 Genomic DNA No translation available.
CCDSiCCDS7586.1
PIRiA39911 QRHUB1
RefSeqiNP_000675.1, NM_000684.2
UniGeneiHs.99913

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LSQNMR-A197-221[»]
ProteinModelPortaliP08588
SMRiP08588
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106662, 8 interactors
CORUMiP08588
DIPiDIP-36294N
IntActiP08588, 13 interactors
MINTiP08588
STRINGi9606.ENSP00000358301

Chemistry databases

BindingDBiP08588
ChEMBLiCHEMBL213
DrugBankiDB08347 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile
DB01193 Acebutolol
DB00866 Alprenolol
DB01118 Amiodarone
DB00321 Amitriptyline
DB00182 Amphetamine
DB01102 Arbutamine
DB06216 Asenapine
DB00335 Atenolol
DB00195 Betaxolol
DB00217 Bethanidine
DB01295 Bevantolol
DB00612 Bisoprolol
DB08807 Bopindolol
DB06726 Bufuralol
DB08808 Bupranolol
DB00248 Cabergoline
DB00521 Carteolol
DB01136 Carvedilol
DB04846 Celiprolol
DB01407 Clenbuterol
DB01151 Desipramine
DB00841 Dobutamine
DB04855 Dronedarone
DB06262 Droxidopa
DB01363 Ephedra
DB00668 Epinephrine
DB00187 Esmolol
DB01288 Fenoterol
DB00221 Isoetarine
DB01064 Isoprenaline
DB00598 Labetalol
DB01210 Levobunolol
DB00408 Loxapine
DB01365 Mephentermine
DB01214 Metipranolol
DB00264 Metoprolol
DB00370 Mirtazapine
DB01203 Nadolol
DB04861 Nebivolol
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB01580 Oxprenolol
DB01359 Penbutolol
DB00397 Phenylpropanolamine
DB00960 Pindolol
DB01291 Pirbuterol
DB01297 Practolol
DB00571 Propranolol
DB00852 Pseudoephedrine
DB01001 Salbutamol
DB00489 Sotalol
DB00373 Timolol
DB00726 Trimipramine
DB09068 Vortioxetine
GuidetoPHARMACOLOGYi28

Protein family/group databases

TCDBi9.A.14.3.11 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiP08588
PhosphoSitePlusiP08588
SwissPalmiP08588

Polymorphism and mutation databases

BioMutaiADRB1
DMDMi48429211

Proteomic databases

jPOSTiP08588
PaxDbiP08588
PeptideAtlasiP08588
PRIDEiP08588
ProteomicsDBi52133

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369295; ENSP00000358301; ENSG00000043591
GeneIDi153
KEGGihsa:153
UCSCiuc001lba.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
153
DisGeNETi153
EuPathDBiHostDB:ENSG00000043591.5

GeneCards: human genes, protein and diseases

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GeneCardsi
ADRB1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0035626
HGNCiHGNC:285 ADRB1
HPAiHPA067972
MalaCardsiADRB1
MIMi109630 gene
607276 phenotype
neXtProtiNX_P08588
PharmGKBiPA38

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP08588
KOiK04141
OrthoDBi1204439at2759
PhylomeDBiP08588
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-418555 G alpha (s) signalling events
SignaLinkiP08588
SIGNORiP08588

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Beta-1_adrenergic_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
153

Protein Ontology

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PROi
PR:P08588

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000043591 Expressed in 144 organ(s), highest expression level in placenta
CleanExiHS_ADRB1
GenevisibleiP08588 HS

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000507 ADRB1_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00561 ADRENRGCB1AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADRB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08588
Secondary accession number(s): B0LPE2
, Q5T5Y4, Q9UKG7, Q9UKG8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 7, 2004
Last modified: January 16, 2019
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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