Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

U2 small nuclear ribonucleoprotein B''

Gene

SNRPB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128).5 Publications

Miscellaneous

Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins.

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U2 small nuclear ribonucleoprotein B''
Short name:
U2 snRNP B''
Gene namesi
Name:SNRPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125870.10
HGNCiHGNC:11155 SNRPB2
MIMi603520 gene
neXtProtiNX_P08579

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125870
PharmGKBiPA35996

Polymorphism and mutation databases

BioMutaiSNRPB2
DMDMi134095

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818921 – 225U2 small nuclear ribonucleoprotein B''Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111N6-acetyllysine; alternateBy similarity1
Cross-linki111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei151PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP08579
MaxQBiP08579
PaxDbiP08579
PeptideAtlasiP08579
PRIDEiP08579
ProteomicsDBi52127
TopDownProteomicsiP08579

PTM databases

iPTMnetiP08579
PhosphoSitePlusiP08579

Expressioni

Gene expression databases

BgeeiENSG00000125870 Expressed in 241 organ(s), highest expression level in oocyte
CleanExiHS_SNRPB2
GenevisibleiP08579 HS

Organism-specific databases

HPAiHPA050814
HPA076104

Interactioni

Subunit structurei

Identified in the spliceosome B complex (PubMed:28781166). Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:28076346). Present in a spliceosome complex assembled in vitro, and composed of SNRPB2, HPRP8BP and CRNKL1 (PubMed:12084575). Contributes to the binding of stem loop IV of U2 snRNA with SNRPP1 (PubMed:9716128).6 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi112513, 111 interactors
CORUMiP08579
IntActiP08579, 37 interactors
MINTiP08579
STRINGi9606.ENSP00000246071

Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08579
SMRiP08579
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08579

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 86RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini151 – 225RRM 2PROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the RRM U1 A/B'' family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4206 Eukaryota
ENOG410XPZI LUCA
GeneTreeiENSGT00390000007046
HOGENOMiHOG000217519
HOVERGENiHBG000895
KOiK11094
OMAiQGFPFYN
OrthoDBiEOG091G0NFU
PhylomeDBiP08579
TreeFamiTF313834

Family and domain databases

CDDicd12478 RRM1_U2B, 1 hit
cd12481 RRM2_U2B, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034564 U2B''_RRM1
IPR034562 U2B''_RRM2
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequencei

Sequence statusi: Complete.

P08579-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIRPNHTIY INNMNDKIKK EELKRSLYAL FSQFGHVVDI VALKTMKMRG
60 70 80 90 100
QAFVIFKELG SSTNALRQLQ GFPFYGKPMR IQYAKTDSDI ISKMRGTFAD
110 120 130 140 150
KEKKKEKKKA KTVEQTATTT NKKPGQGTPN SANTQGNSTP NPQVPDYPPN
160 170 180 190 200
YILFLNNLPE ETNEMMLSML FNQFPGFKEV RLVPGRHDIA FVEFENDGQA
210 220
GAARDALQGF KITPSHAMKI TYAKK
Length:225
Mass (Da):25,486
Last modified:August 1, 1988 - v1
Checksum:i67C949CC7E14A92A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03548719K → Q in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15841 mRNA Translation: AAA36796.1
AK313004 mRNA Translation: BAG35840.1
AL034428 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10284.1
CH471133 Genomic DNA Translation: EAX10285.1
BC018022 mRNA Translation: AAH18022.1
BC036737 mRNA Translation: AAH36737.1
CCDSiCCDS13123.1
PIRiA25910
RefSeqiNP_003083.1, NM_003092.4
NP_937863.1, NM_198220.2
UniGeneiHs.280378

Genome annotation databases

EnsembliENST00000246071; ENSP00000246071; ENSG00000125870
ENST00000377943; ENSP00000367178; ENSG00000125870
GeneIDi6629
KEGGihsa:6629
UCSCiuc002wph.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15841 mRNA Translation: AAA36796.1
AK313004 mRNA Translation: BAG35840.1
AL034428 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10284.1
CH471133 Genomic DNA Translation: EAX10285.1
BC018022 mRNA Translation: AAH18022.1
BC036737 mRNA Translation: AAH36737.1
CCDSiCCDS13123.1
PIRiA25910
RefSeqiNP_003083.1, NM_003092.4
NP_937863.1, NM_198220.2
UniGeneiHs.280378

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9NX-ray2.38B/D1-96[»]
5MQFelectron microscopy5.90X1-225[»]
5O9Zelectron microscopy4.5011-225[»]
5XJCelectron microscopy3.60p1-225[»]
5YZGelectron microscopy4.10p1-225[»]
ProteinModelPortaliP08579
SMRiP08579
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112513, 111 interactors
CORUMiP08579
IntActiP08579, 37 interactors
MINTiP08579
STRINGi9606.ENSP00000246071

PTM databases

iPTMnetiP08579
PhosphoSitePlusiP08579

Polymorphism and mutation databases

BioMutaiSNRPB2
DMDMi134095

Proteomic databases

EPDiP08579
MaxQBiP08579
PaxDbiP08579
PeptideAtlasiP08579
PRIDEiP08579
ProteomicsDBi52127
TopDownProteomicsiP08579

Protocols and materials databases

DNASUi6629
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246071; ENSP00000246071; ENSG00000125870
ENST00000377943; ENSP00000367178; ENSG00000125870
GeneIDi6629
KEGGihsa:6629
UCSCiuc002wph.3 human

Organism-specific databases

CTDi6629
EuPathDBiHostDB:ENSG00000125870.10
GeneCardsiSNRPB2
HGNCiHGNC:11155 SNRPB2
HPAiHPA050814
HPA076104
MIMi603520 gene
neXtProtiNX_P08579
OpenTargetsiENSG00000125870
PharmGKBiPA35996
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4206 Eukaryota
ENOG410XPZI LUCA
GeneTreeiENSGT00390000007046
HOGENOMiHOG000217519
HOVERGENiHBG000895
KOiK11094
OMAiQGFPFYN
OrthoDBiEOG091G0NFU
PhylomeDBiP08579
TreeFamiTF313834

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiSNRPB2 human
EvolutionaryTraceiP08579
GeneWikiiSNRPB2
GenomeRNAii6629
PROiPR:P08579
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125870 Expressed in 241 organ(s), highest expression level in oocyte
CleanExiHS_SNRPB2
GenevisibleiP08579 HS

Family and domain databases

CDDicd12478 RRM1_U2B, 1 hit
cd12481 RRM2_U2B, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034564 U2B''_RRM1
IPR034562 U2B''_RRM2
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRU2B_HUMAN
AccessioniPrimary (citable) accession number: P08579
Secondary accession number(s): B2R7J3, D3DW21, Q9UJD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 10, 2018
This is version 195 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again