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Protein

Receptor-type tyrosine-protein phosphatase C

Gene

PTPRC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).By similarity2 Publications
(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.1 Publication

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei821SubstrateBy similarity1
Active sitei853Phosphocysteine intermediate1
Binding sitei897SubstrateBy similarity1
Active sitei1169Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-416700 Other semaphorin interactions
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP08575
SIGNORiP08575

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase CCurated (EC:3.1.3.48)
Alternative name(s):
Leukocyte common antigen
Short name:
L-CA
T200
CD_antigen: CD45
Gene namesi
Name:PTPRCImported
Synonyms:CD45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000081237.18
HGNCiHGNC:9666 PTPRC
MIMi151460 gene
neXtProtiNX_P08575

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 577ExtracellularSequence analysisAdd BLAST552
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 1306CytoplasmicSequence analysisAdd BLAST708

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
See also OMIM:608971
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021205364 – 365Missing in T(-)B(+)NK(+) SCID; associated with lack of surface expression. 1 Publication2
Multiple sclerosis (MS)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
See also OMIM:126200

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi853C → S: Loss of activity. Abolishes interaction with SKAP1. 1 Publication1

Keywords - Diseasei

Disease mutation, SCID

Organism-specific databases

DisGeNETi5788
MalaCardsiPTPRC
MIMi126200 phenotype
608971 phenotype
OpenTargetsiENSG00000081237
Orphaneti169157 T-B+ severe combined immunodeficiency due to CD45 deficiency
PharmGKBiPA34011

Chemistry databases

ChEMBLiCHEMBL3243

Polymorphism and mutation databases

BioMutaiPTPRC
DMDMi33112650

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000002547026 – 1306Receptor-type tyrosine-protein phosphatase CAdd BLAST1281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi286N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi337N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi421N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi490N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei683PhosphotyrosineBy similarity1
Modified residuei975PhosphoserineCombined sources1
Modified residuei994PhosphoserineCombined sources1
Modified residuei997PhosphoserineBy similarity1
Modified residuei1001PhosphoserineBy similarity1
Modified residuei1004PhosphoserineBy similarity1
Modified residuei1005PhosphoserineBy similarity1
Modified residuei1009PhosphoserineBy similarity1
Modified residuei1299PhosphoserineCombined sources1

Post-translational modificationi

Heavily N- and O-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP08575
MaxQBiP08575
PaxDbiP08575
PeptideAtlasiP08575
PRIDEiP08575
ProteomicsDBi52125

PTM databases

DEPODiP08575
GlyConnecti1706
339
iPTMnetiP08575
PhosphoSitePlusiP08575
SwissPalmiP08575
UniCarbKBiP08575

Expressioni

Tissue specificityi

Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.1 Publication

Developmental stagei

Isoform 1: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 2: During T-cell development, expressed at low levels at the CD3-CD4-CD8- and CD3-CD4+CD8- stages but up-regulated at the CD3+CD4+CD8+ and CD3+CD4+CD8- stages. Isoform 3: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 5: During T-cell development, expressed at the CD3-CD4-CD8- and CD3+CD4+CD8- stages but barely detectable at the CD3-CD4+CD8+ stage. Isoform 7: Consistently expressed at high levels at all stages of T-cell development.1 Publication

Gene expression databases

BgeeiENSG00000081237 Expressed in 219 organ(s), highest expression level in blood
CleanExiHS_PTPRC

Organism-specific databases

HPAiHPA000440

Interactioni

Subunit structurei

Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1 (PubMed:11909961). Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (PubMed:12676959).By similarity2 Publications
(Microbial infection) Interacts with human cytomegalovirus protein UL11; the interaction is required for binding of UL11 to T-cells.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111752, 24 interactors
DIPiDIP-224N
IntActiP08575, 40 interactors
MINTiP08575
STRINGi9606.ENSP00000356346

Chemistry databases

BindingDBiP08575

Structurei

Secondary structure

11306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08575
SMRiP08575
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08575

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini391 – 483Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini484 – 576Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini653 – 912Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST260
Domaini944 – 1228Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST285

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni853 – 859Substrate bindingBy similarity7

Domaini

The first PTPase domain interacts with SKAP1.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOGENOMiHOG000049064
HOVERGENiHBG000066
InParanoidiP08575
KOiK06478
OMAiQYQYNNW
OrthoDBiEOG091G015A
PhylomeDBiP08575
TreeFamiTF351829

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR024739 PTP_recept_N
IPR000242 PTPase_domain
IPR016335 Ptprc
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF12567 CD45, 1 hit
PF00041 fn3, 2 hits
PF12453 PTP_N, 1 hit
PF00102 Y_phosphatase, 2 hits
PIRSFiPIRSF002004 Leukocyte_common_antigen, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (8+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P08575-3) [UniParc]FASTAAdd to basket
Also known as: CD45RABC1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTMYLWLKLL AFGFAFLDTE VFVTGQSPTP SPTGLTTAKM PSVPLSSDPL
60 70 80 90 100
PTHTTAFSPA STFERENDFS ETTTSLSPDN TSTQVSPDSL DNASAFNTTG
110 120 130 140 150
VSSVQTPHLP THADSQTPSA GTDTQTFSGS AANAKLNPTP GSNAISDVPG
160 170 180 190 200
ERSTASTFPT DPVSPLTTTL SLAHHSSAAL PARTSNTTIT ANTSDAYLNA
210 220 230 240 250
SETTTLSPSG SAVISTTTIA TTPSKPTCDE KYANITVDYL YNKETKLFTA
260 270 280 290 300
KLNVNENVEC GNNTCTNNEV HNLTECKNAS VSISHNSCTA PDKTLILDVP
310 320 330 340 350
PGVEKFQLHD CTQVEKADTT ICLKWKNIET FTCDTQNITY RFQCGNMIFD
360 370 380 390 400
NKEIKLENLE PEHEYKCDSE ILYNNHKFTN ASKIIKTDFG SPGEPQIIFC
410 420 430 440 450
RSEAAHQGVI TWNPPQRSFH NFTLCYIKET EKDCLNLDKN LIKYDLQNLK
460 470 480 490 500
PYTKYVLSLH AYIIAKVQRN GSAAMCHFTT KSAPPSQVWN MTVSMTSDNS
510 520 530 540 550
MHVKCRPPRD RNGPHERYHL EVEAGNTLVR NESHKNCDFR VKDLQYSTDY
560 570 580 590 600
TFKAYFHNGD YPGEPFILHH STSYNSKALI AFLAFLIIVT SIALLVVLYK
610 620 630 640 650
IYDLHKKRSC NLDEQQELVE RDDEKQLMNV EPIHADILLE TYKRKIADEG
660 670 680 690 700
RLFLAEFQSI PRVFSKFPIK EARKPFNQNK NRYVDILPYD YNRVELSEIN
710 720 730 740 750
GDAGSNYINA SYIDGFKEPR KYIAAQGPRD ETVDDFWRMI WEQKATVIVM
760 770 780 790 800
VTRCEEGNRN KCAEYWPSME EGTRAFGDVV VKINQHKRCP DYIIQKLNIV
810 820 830 840 850
NKKEKATGRE VTHIQFTSWP DHGVPEDPHL LLKLRRRVNA FSNFFSGPIV
860 870 880 890 900
VHCSAGVGRT GTYIGIDAML EGLEAENKVD VYGYVVKLRR QRCLMVQVEA
910 920 930 940 950
QYILIHQALV EYNQFGETEV NLSELHPYLH NMKKRDPPSE PSPLEAEFQR
960 970 980 990 1000
LPSYRSWRTQ HIGNQEENKS KNRNSNVIPY DYNRVPLKHE LEMSKESEHD
1010 1020 1030 1040 1050
SDESSDDDSD SEEPSKYINA SFIMSYWKPE VMIAAQGPLK ETIGDFWQMI
1060 1070 1080 1090 1100
FQRKVKVIVM LTELKHGDQE ICAQYWGEGK QTYGDIEVDL KDTDKSSTYT
1110 1120 1130 1140 1150
LRVFELRHSK RKDSRTVYQY QYTNWSVEQL PAEPKELISM IQVVKQKLPQ
1160 1170 1180 1190 1200
KNSSEGNKHH KSTPLLIHCR DGSQQTGIFC ALLNLLESAE TEEVVDIFQV
1210 1220 1230 1240 1250
VKALRKARPG MVSTFEQYQF LYDVIASTYP AQNGQVKKNN HQEDKIEFDN
1260 1270 1280 1290 1300
EVDKVKQDAN CVNPLGAPEK LPEAKEQAEG SEPTSGTEGP EHSVNGPASP

ALNQGS
Length:1,306
Mass (Da):147,486
Last modified:March 28, 2018 - v3
Checksum:i6E942E2BF6B17AC5
GO
Isoform 2 (identifier: P08575-4) [UniParc]FASTAAdd to basket
Also known as: CD45R01 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     34-194: Missing.

Show »
Length:1,145
Mass (Da):131,130
Checksum:iD3CB364EF4243384
GO
Isoform 3 (identifier: P08575-5) [UniParc]FASTAAdd to basket
Also known as: CD45RAB1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     147-194: Missing.

Show »
Length:1,258
Mass (Da):142,623
Checksum:iEA40BE995CD98F7C
GO
Isoform 4 (identifier: P08575-6) [UniParc]FASTAAdd to basket
Also known as: CD45RAC1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     100-146: Missing.

Show »
Length:1,259
Mass (Da):142,898
Checksum:iF5829F82003481DA
GO
Isoform 5 (identifier: P08575-7) [UniParc]FASTAAdd to basket
Also known as: CD45RBC1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     34-99: Missing.

Show »
Length:1,240
Mass (Da):140,582
Checksum:iB307438FC715AFF4
GO
Isoform 6 (identifier: P08575-8) [UniParc]FASTAAdd to basket
Also known as: CD45RA1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     100-194: Missing.

Show »
Length:1,211
Mass (Da):138,034
Checksum:iF42C1FEC9EDE4BC0
GO
Isoform 7 (identifier: P08575-9) [UniParc]FASTAAdd to basket
Also known as: CD45RB1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     34-99: Missing.
     147-194: Missing.

Show »
Length:1,192
Mass (Da):135,719
Checksum:i745870037910C575
GO
Isoform 8 (identifier: P08575-10) [UniParc]FASTAAdd to basket
Also known as: CD45RC1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     34-146: Missing.

Show »
Length:1,193
Mass (Da):135,993
Checksum:iF92C874C9A114890
GO

Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M3ZCP1M3ZCP1_HUMAN
Receptor-type tyrosine-protein phos...
PTPRC
735Annotation score:
A0A075B788A0A075B788_HUMAN
Receptor-type tyrosine-protein phos...
PTPRC
753Annotation score:
E9PKH0E9PKH0_HUMAN
Receptor-type tyrosine-protein phos...
PTPRC
600Annotation score:
M9MMK9M9MMK9_HUMAN
Receptor-type tyrosine-protein phos...
PTPRC
148Annotation score:
A0A0G2JNW2A0A0G2JNW2_HUMAN
Receptor-type tyrosine-protein phos...
PTPRC
523Annotation score:
A0A140TA68A0A140TA68_HUMAN
Receptor-type tyrosine-protein phos...
PTPRC
505Annotation score:
A0A140TA77A0A140TA77_HUMAN
Receptor-type tyrosine-protein phos...
PTPRC
457Annotation score:
A0A140TA57A0A140TA57_HUMAN
Receptor-type tyrosine-protein phos...
PTPRC
146Annotation score:
A0A2R8YE81A0A2R8YE81_HUMAN
Receptor-type tyrosine-protein phos...
PTPRC
161Annotation score:
M9MML4M9MML4_HUMAN
Receptor-type tyrosine-protein phos...
PTPRC
87Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAF84820 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA68269 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA68669 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti652L → P in CAA68669 (PubMed:2824653).Curated1
Sequence conflicti1209P → L in CAA68669 (PubMed:2824653).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036860193T → A. Corresponds to variant dbSNP:rs4915154EnsemblClinVar.1
Natural variantiVAR_035653230E → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_051763296I → L. Corresponds to variant dbSNP:rs2230606EnsemblClinVar.1
Natural variantiVAR_021205364 – 365Missing in T(-)B(+)NK(+) SCID; associated with lack of surface expression. 1 Publication2
Natural variantiVAR_051764423T → I. Corresponds to variant dbSNP:rs6696162EnsemblClinVar.1
Natural variantiVAR_051765570H → Q. Corresponds to variant dbSNP:rs12136658EnsemblClinVar.1
Natural variantiVAR_035654865G → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0203031285S → R. Corresponds to variant dbSNP:rs2298872Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05940934 – 194Missing in isoform 2. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_05983334 – 146Missing in isoform 8. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_05983434 – 99Missing in isoform 5 and isoform 7. 2 PublicationsAdd BLAST66
Alternative sequenceiVSP_059835100 – 194Missing in isoform 6. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_059836100 – 146Missing in isoform 4. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_059837147 – 194Missing in isoform 3 and isoform 7. 2 PublicationsAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00638 mRNA Translation: CAA68669.1 Different initiation.
Y00062 mRNA Translation: CAA68269.1 Different initiation.
AK292131 mRNA Translation: BAF84820.1 Different initiation.
AL157402 Genomic DNA No translation available.
AL355988 Genomic DNA No translation available.
KF510707 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91303.1
M23492
, M23496, M23466, M23467, M23468, M23469, M23470, M23471, M23472, M23473, M23474, M23475, M23476, M23477, M23478, M23479, M23480, M23481, M23482, M23483, M23484, M23485, M23486, M23487, M23488, M23489, M23490, M23491 Genomic DNA Translation: AAD15273.2
CCDSiCCDS1397.2 [P08575-3]
CCDS1398.2 [P08575-4]
PIRiA46546
RefSeqiNP_002829.3, NM_002838.4 [P08575-3]
NP_563578.2, NM_080921.3 [P08575-4]
XP_006711535.1, XM_006711472.3
XP_006711536.1, XM_006711473.3
XP_006711537.1, XM_006711474.3
UniGeneiHs.654514

Genome annotation databases

EnsembliENST00000348564; ENSP00000306782; ENSG00000081237 [P08575-4]
ENST00000442510; ENSP00000411355; ENSG00000081237 [P08575-3]
ENST00000573477; ENSP00000461074; ENSG00000262418
ENST00000573679; ENSP00000458322; ENSG00000262418
GeneIDi5788
KEGGihsa:5788
UCSCiuc061fse.1 human [P08575-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

PTPRCbase

PTPRC mutation db

Wikipedia

CD45 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00638 mRNA Translation: CAA68669.1 Different initiation.
Y00062 mRNA Translation: CAA68269.1 Different initiation.
AK292131 mRNA Translation: BAF84820.1 Different initiation.
AL157402 Genomic DNA No translation available.
AL355988 Genomic DNA No translation available.
KF510707 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91303.1
M23492
, M23496, M23466, M23467, M23468, M23469, M23470, M23471, M23472, M23473, M23474, M23475, M23476, M23477, M23478, M23479, M23480, M23481, M23482, M23483, M23484, M23485, M23486, M23487, M23488, M23489, M23490, M23491 Genomic DNA Translation: AAD15273.2
CCDSiCCDS1397.2 [P08575-3]
CCDS1398.2 [P08575-4]
PIRiA46546
RefSeqiNP_002829.3, NM_002838.4 [P08575-3]
NP_563578.2, NM_080921.3 [P08575-4]
XP_006711535.1, XM_006711472.3
XP_006711536.1, XM_006711473.3
XP_006711537.1, XM_006711474.3
UniGeneiHs.654514

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YGRX-ray2.90A/B624-1233[»]
1YGUX-ray2.90A/B624-1233[»]
5FMVX-ray2.90A/B225-573[»]
5FN6X-ray3.30A225-481[»]
5FN7X-ray2.30A/B225-394[»]
ProteinModelPortaliP08575
SMRiP08575
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111752, 24 interactors
DIPiDIP-224N
IntActiP08575, 40 interactors
MINTiP08575
STRINGi9606.ENSP00000356346

Chemistry databases

BindingDBiP08575
ChEMBLiCHEMBL3243

PTM databases

DEPODiP08575
GlyConnecti1706
339
iPTMnetiP08575
PhosphoSitePlusiP08575
SwissPalmiP08575
UniCarbKBiP08575

Polymorphism and mutation databases

BioMutaiPTPRC
DMDMi33112650

Proteomic databases

EPDiP08575
MaxQBiP08575
PaxDbiP08575
PeptideAtlasiP08575
PRIDEiP08575
ProteomicsDBi52125

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348564; ENSP00000306782; ENSG00000081237 [P08575-4]
ENST00000442510; ENSP00000411355; ENSG00000081237 [P08575-3]
ENST00000573477; ENSP00000461074; ENSG00000262418
ENST00000573679; ENSP00000458322; ENSG00000262418
GeneIDi5788
KEGGihsa:5788
UCSCiuc061fse.1 human [P08575-3]

Organism-specific databases

CTDi5788
DisGeNETi5788
EuPathDBiHostDB:ENSG00000081237.18
GeneCardsiPTPRC
HGNCiHGNC:9666 PTPRC
HPAiHPA000440
MalaCardsiPTPRC
MIMi126200 phenotype
151460 gene
608971 phenotype
neXtProtiNX_P08575
OpenTargetsiENSG00000081237
Orphaneti169157 T-B+ severe combined immunodeficiency due to CD45 deficiency
PharmGKBiPA34011
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOGENOMiHOG000049064
HOVERGENiHBG000066
InParanoidiP08575
KOiK06478
OMAiQYQYNNW
OrthoDBiEOG091G015A
PhylomeDBiP08575
TreeFamiTF351829

Enzyme and pathway databases

ReactomeiR-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-416700 Other semaphorin interactions
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP08575
SIGNORiP08575

Miscellaneous databases

ChiTaRSiPTPRC human
EvolutionaryTraceiP08575
GeneWikiiPTPRC
GenomeRNAii5788
PROiPR:P08575
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000081237 Expressed in 219 organ(s), highest expression level in blood
CleanExiHS_PTPRC

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR024739 PTP_recept_N
IPR000242 PTPase_domain
IPR016335 Ptprc
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF12567 CD45, 1 hit
PF00041 fn3, 2 hits
PF12453 PTP_N, 1 hit
PF00102 Y_phosphatase, 2 hits
PIRSFiPIRSF002004 Leukocyte_common_antigen, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRC_HUMAN
AccessioniPrimary (citable) accession number: P08575
Secondary accession number(s): A0A0A0MT22
, A8K7W6, Q16614, Q9H0Y6, X6R433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 214 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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