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UniProtKB - P08572 (CO4A2_HUMAN)

Protein

Collagen alpha-2(IV) chain

Gene

COL4A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processAngiogenesis

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474244 Extracellular matrix organization
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-2214320 Anchoring fibril formation
R-HSA-2243919 Crosslinking of collagen fibrils
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-419037 NCAM1 interactions
R-HSA-8948216 Collagen chain trimerization
SIGNORiP08572

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-2(IV) chain
Cleaved into the following chain:
Canstatin
Gene namesi
Name:COL4A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000134871.17
HGNCiHGNC:2203 COL4A2
MIMi120090 gene
neXtProtiNX_P08572

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Porencephaly 2 (POREN2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurologic disorder characterized by a fluid-filled cysts or cavities within the cerebral hemispheres. Affected individuals typically have hemiplegia, seizures, and intellectual disability. Porencephaly type 2, or schizencephalic porencephaly, is usually symmetric and represents a primary defect in the development of the cerebral ventricles.
See also OMIM:614483
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0678371037G → E in POREN2. 1 PublicationCorresponds to variant dbSNP:rs387906603EnsemblClinVar.1
Natural variantiVAR_0678381152G → D in POREN2; incomplete penetrance. 1 PublicationCorresponds to variant dbSNP:rs387906602EnsemblClinVar.1
Intracerebral hemorrhage (ICH)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke.
See also OMIM:614519

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi1284
MalaCardsiCOL4A2
MIMi614483 phenotype
614519 phenotype
OpenTargetsiENSG00000134871
Orphaneti99810 Familial porencephaly
PharmGKBiPA26718

Chemistry databases

ChEMBLiCHEMBL2364188

Polymorphism and mutation databases

BioMutaiCOL4A2
DMDMi143811377

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
PropeptideiPRO_000000582426 – 183N-terminal propeptide (7S domain)Add BLAST158
ChainiPRO_0000005825184 – 1712Collagen alpha-2(IV) chainAdd BLAST1529
ChainiPRO_00002837751486 – 1712CanstatinAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi138N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1504 ↔ 1593
Disulfide bondi1537 ↔ 1590
Disulfide bondi1549 ↔ 1555
Disulfide bondi1612 ↔ 1708
Disulfide bondi1646 ↔ 1705
Disulfide bondi1658 ↔ 1665

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.By similarity
Proteolytic processing produces the C-terminal NC1 peptide, canstatin.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

EPDiP08572
MaxQBiP08572
PaxDbiP08572
PeptideAtlasiP08572
PRIDEiP08572
ProteomicsDBi52123

PTM databases

iPTMnetiP08572
PhosphoSitePlusiP08572
SwissPalmiP08572

Miscellaneous databases

PMAP-CutDBiP08572

Expressioni

Gene expression databases

BgeeiENSG00000134871 Expressed in 238 organ(s), highest expression level in placenta
CleanExiHS_COL4A2
ExpressionAtlasiP08572 baseline and differential
GenevisibleiP08572 HS

Organism-specific databases

HPAiCAB010751
HPA029118

Interactioni

Subunit structurei

There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.

Binary interactionsi

WithEntry#Exp.IntActNotes
COL4A1P024622EBI-2432506,EBI-2432478

Protein-protein interaction databases

BioGridi107681, 40 interactors
ComplexPortaliCPX-1723 Collagen type IV trimer variant 1
IntActiP08572, 21 interactors
MINTiP08572
STRINGi9606.ENSP00000353654

Structurei

Secondary structure

11712
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08572
SMRiP08572
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08572

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1489 – 1712Collagen IV NC1PROSITE-ProRule annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni184 – 1484Triple-helical regionAdd BLAST1301

Domaini

Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.

Sequence similaritiesi

Belongs to the type IV collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140804
HOGENOMiHOG000085652
HOVERGENiHBG004933
InParanoidiP08572
KOiK06237
OMAiNPGTKGW
OrthoDBiEOG091G0613
PhylomeDBiP08572
TreeFamiTF344135

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 17 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P08572-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRDQRAVAG PALRRWLLLG TVTVGFLAQS VLAGVKKFDV PCGGRDCSGG 
        60         70         80         90        100
CQCYPEKGGR GQPGPVGPQG YNGPPGLQGF PGLQGRKGDK GERGAPGVTG 
       110        120        130        140        150
PKGDVGARGV SGFPGADGIP GHPGQGGPRG RPGYDGCNGT QGDSGPQGPP 
       160        170        180        190        200
GSEGFTGPPG PQGPKGQKGE PYALPKEERD RYRGEPGEPG LVGFQGPPGR 
       210        220        230        240        250
PGHVGQMGPV GAPGRPGPPG PPGPKGQQGN RGLGFYGVKG EKGDVGQPGP 
       260        270        280        290        300
NGIPSDTLHP IIAPTGVTFH PDQYKGEKGS EGEPGIRGIS LKGEEGIMGF 
       310        320        330        340        350
PGLRGYPGLS GEKGSPGQKG SRGLDGYQGP DGPRGPKGEA GDPGPPGLPA 
       360        370        380        390        400
YSPHPSLAKG ARGDPGFPGA QGEPGSQGEP GDPGLPGPPG LSIGDGDQRR 
       410        420        430        440        450
GLPGEMGPKG FIGDPGIPAL YGGPPGPDGK RGPPGPPGLP GPPGPDGFLF 
       460        470        480        490        500
GLKGAKGRAG FPGLPGSPGA RGPKGWKGDA GECRCTEGDE AIKGLPGLPG 
       510        520        530        540        550
PKGFAGINGE PGRKGDRGDP GQHGLPGFPG LKGVPGNIGA PGPKGAKGDS 
       560        570        580        590        600
RTITTKGERG QPGVPGVPGM KGDDGSPGRD GLDGFPGLPG PPGDGIKGPP 
       610        620        630        640        650
GDPGYPGIPG TKGTPGEMGP PGLGLPGLKG QRGFPGDAGL PGPPGFLGPP 
       660        670        680        690        700
GPAGTPGQID CDTDVKRAVG GDRQEAIQPG CIGGPKGLPG LPGPPGPTGA 
       710        720        730        740        750
KGLRGIPGFA GADGGPGPRG LPGDAGREGF PGPPGFIGPR GSKGAVGLPG 
       760        770        780        790        800
PDGSPGPIGL PGPDGPPGER GLPGEVLGAQ PGPRGDAGVP GQPGLKGLPG 
       810        820        830        840        850
DRGPPGFRGS QGMPGMPGLK GQPGLPGPSG QPGLYGPPGL HGFPGAPGQE 
       860        870        880        890        900
GPLGLPGIPG REGLPGDRGD PGDTGAPGPV GMKGLSGDRG DAGFTGEQGH 
       910        920        930        940        950
PGSPGFKGID GMPGTPGLKG DRGSPGMDGF QGMPGLKGRP GFPGSKGEAG 
       960        970        980        990       1000
FFGIPGLKGL AGEPGFKGSR GDPGPPGPPP VILPGMKDIK GEKGDEGPMG 
      1010       1020       1030       1040       1050
LKGYLGAKGI QGMPGIPGLS GIPGLPGRPG HIKGVKGDIG VPGIPGLPGF 
      1060       1070       1080       1090       1100
PGVAGPPGIT GFPGFIGSRG DKGAPGRAGL YGEIGATGDF GDIGDTINLP 
      1110       1120       1130       1140       1150
GRPGLKGERG TTGIPGLKGF FGEKGTEGDI GFPGITGVTG VQGPPGLKGQ 
      1160       1170       1180       1190       1200
TGFPGLTGPP GSQGELGRIG LPGGKGDDGW PGAPGLPGFP GLRGIRGLHG 
      1210       1220       1230       1240       1250
LPGTKGFPGS PGSDIHGDPG FPGPPGERGD PGEANTLPGP VGVPGQKGDQ 
      1260       1270       1280       1290       1300
GAPGERGPPG SPGLQGFPGI TPPSNISGAP GDKGAPGIFG LKGYRGPPGP 
      1310       1320       1330       1340       1350
PGSAALPGSK GDTGNPGAPG TPGTKGWAGD SGPQGRPGVF GLPGEKGPRG 
      1360       1370       1380       1390       1400
EQGFMGNTGP TGAVGDRGPK GPKGDPGFPG APGTVGAPGI AGIPQKIAVQ 
      1410       1420       1430       1440       1450
PGTVGPQGRR GPPGAPGEMG PQGPPGEPGF RGAPGKAGPQ GRGGVSAVPG 
      1460       1470       1480       1490       1500
FRGDEGPIGH QGPIGQEGAP GRPGSPGLPG MPGRSVSIGY LLVKHSQTDQ 
      1510       1520       1530       1540       1550
EPMCPVGMNK LWSGYSLLYF EGQEKAHNQD LGLAGSCLAR FSTMPFLYCN 
      1560       1570       1580       1590       1600
PGDVCYYASR NDKSYWLSTT APLPMMPVAE DEIKPYISRC SVCEAPAIAI 
      1610       1620       1630       1640       1650
AVHSQDVSIP HCPAGWRSLW IGYSFLMHTA AGDEGGGQSL VSPGSCLEDF 
      1660       1670       1680       1690       1700
RATPFIECNG GRGTCHYYAN KYSFWLTTIP EQSFQGSPSA DTLKAGLIRT 
      1710 
HISRCQVCMK NL
Length:1,712
Mass (Da):167,553
Last modified:April 3, 2007 - v4
Checksum:iE0DABEEAB349D8AF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A352A2A352_HUMAN
Collagen alpha-2(IV) chain
COL4A2
105Annotation score:
A0A087WY39A0A087WY39_HUMAN
Collagen alpha-2(IV) chain
COL4A2
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti471R → P in CAA29076 (PubMed:3345760).Curated1
Sequence conflicti1041V → L in AAA52043 (PubMed:3692475).Curated1
Sequence conflicti1419M → I in CAA29098 (PubMed:3582677).Curated1
Sequence conflicti1575M → I in AAA58422 (PubMed:2439508).Curated1
Sequence conflicti1636G → V in AAA52043 (PubMed:3692475).Curated1
Sequence conflicti1663G → H AA sequence (PubMed:2844531).Curated1
Sequence conflicti1701H → G AA sequence (PubMed:2844531).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067551192V → F Polymorphism; does not affect COL4A2 and COL4A1 secretion. 2 PublicationsCorresponds to variant dbSNP:rs62621885EnsemblClinVar.1
Natural variantiVAR_048796517R → K3 PublicationsCorresponds to variant dbSNP:rs7990383EnsemblClinVar.1
Natural variantiVAR_048797683G → A3 PublicationsCorresponds to variant dbSNP:rs3803230EnsemblClinVar.1
Natural variantiVAR_067552701K → R Polymorphism; does not affect COL4A2 and COL4A1 secretion. 2 PublicationsCorresponds to variant dbSNP:rs78829338EnsemblClinVar.1
Natural variantiVAR_067836718P → S Polymorphism; does not affect COL4A2 and COL4A1 secretion. 2 PublicationsCorresponds to variant dbSNP:rs9583500EnsemblClinVar.1
Natural variantiVAR_0678371037G → E in POREN2. 1 PublicationCorresponds to variant dbSNP:rs387906603EnsemblClinVar.1
Natural variantiVAR_0675531109R → Q Polymorphism; does not affect COL4A2 and COL4A1 secretion. 1 PublicationCorresponds to variant dbSNP:rs184812559EnsemblClinVar.1
Natural variantiVAR_0675541123E → G Associated with ICH susceptibility; results in a significantly decreased extracellular-to-intracellular ratio of COL4A2 and COL4A1 proteins, indicating interference with the proper secretion of both these proteins. 1 PublicationCorresponds to variant dbSNP:rs117412802EnsemblClinVar.1
Natural variantiVAR_0675551150Q → K Associated with ICH susceptibility; results in a significantly decreased extracellular-to-intracellular ratio of COL4A2 and COL4A1 proteins, indicating interference with the proper secretion of both these proteins. 1 PublicationCorresponds to variant dbSNP:rs62621875EnsemblClinVar.1
Natural variantiVAR_0678381152G → D in POREN2; incomplete penetrance. 1 PublicationCorresponds to variant dbSNP:rs387906602EnsemblClinVar.1
Natural variantiVAR_0675561389G → R Probable disease-associated mutation found in a family with porencephaly and small-vessel disease in the form of scattered white matter lesions; impairs COL4A2 and COL4A1 secretion; the mutant protein is retained in the endoplasmic reticulum. 1 Publication1
Natural variantiVAR_0675571399V → I2 PublicationsCorresponds to variant dbSNP:rs45520539EnsemblClinVar.1
Natural variantiVAR_0675581690A → T Associated with ICH susceptibility; results in a significantly decreased extracellular-to-intracellular ratio of COL4A2 and COL4A1 proteins, indicating interference with the proper secretion of both these proteins. 1 PublicationCorresponds to variant dbSNP:rs201105747EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139385 Genomic DNA No translation available.
AL159153 Genomic DNA No translation available.
AL161773 Genomic DNA No translation available.
X05562 mRNA Translation: CAA29076.1
M36963 Genomic DNA Translation: AAA53099.1
J04217 Genomic DNA Translation: AAA53097.1
X12784 Genomic DNA Translation: CAA31275.1
M24766 mRNA Translation: AAA52043.1
X05610 mRNA Translation: CAA29098.1
BC080644 mRNA Translation: AAH80644.1
J02760 mRNA Translation: AAA58422.1
AF258350 mRNA Translation: AAF72631.1
AF400430 mRNA Translation: AAK92479.1
AY450357 mRNA Translation: AAR20245.1
AY455978 mRNA Translation: AAR18250.1
CCDSiCCDS41907.1
PIRiA32024 CGHU2B
RefSeqiNP_001837.2, NM_001846.3
UniGeneiHs.508716

Genome annotation databases

EnsembliENST00000360467; ENSP00000353654; ENSG00000134871
GeneIDi1284
KEGGihsa:1284
UCSCiuc001vqx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139385 Genomic DNA No translation available.
AL159153 Genomic DNA No translation available.
AL161773 Genomic DNA No translation available.
X05562 mRNA Translation: CAA29076.1
M36963 Genomic DNA Translation: AAA53099.1
J04217 Genomic DNA Translation: AAA53097.1
X12784 Genomic DNA Translation: CAA31275.1
M24766 mRNA Translation: AAA52043.1
X05610 mRNA Translation: CAA29098.1
BC080644 mRNA Translation: AAH80644.1
J02760 mRNA Translation: AAA58422.1
AF258350 mRNA Translation: AAF72631.1
AF400430 mRNA Translation: AAK92479.1
AY450357 mRNA Translation: AAR20245.1
AY455978 mRNA Translation: AAR18250.1
CCDSiCCDS41907.1
PIRiA32024 CGHU2B
RefSeqiNP_001837.2, NM_001846.3
UniGeneiHs.508716

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LI1X-ray1.90C/F1485-1712[»]
5NAXX-ray2.82C/E1485-1712[»]
5NB2X-ray2.50A/B1485-1712[»]
ProteinModelPortaliP08572
SMRiP08572
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107681, 40 interactors
ComplexPortaliCPX-1723 Collagen type IV trimer variant 1
IntActiP08572, 21 interactors
MINTiP08572
STRINGi9606.ENSP00000353654

Chemistry databases

ChEMBLiCHEMBL2364188

PTM databases

iPTMnetiP08572
PhosphoSitePlusiP08572
SwissPalmiP08572

Polymorphism and mutation databases

BioMutaiCOL4A2
DMDMi143811377

Proteomic databases

EPDiP08572
MaxQBiP08572
PaxDbiP08572
PeptideAtlasiP08572
PRIDEiP08572
ProteomicsDBi52123

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360467; ENSP00000353654; ENSG00000134871
GeneIDi1284
KEGGihsa:1284
UCSCiuc001vqx.4 human

Organism-specific databases

CTDi1284
DisGeNETi1284
EuPathDBiHostDB:ENSG00000134871.17
GeneCardsiCOL4A2
H-InvDBiHIX0011454
HGNCiHGNC:2203 COL4A2
HPAiCAB010751
HPA029118
MalaCardsiCOL4A2
MIMi120090 gene
614483 phenotype
614519 phenotype
neXtProtiNX_P08572
OpenTargetsiENSG00000134871
Orphaneti99810 Familial porencephaly
PharmGKBiPA26718
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140804
HOGENOMiHOG000085652
HOVERGENiHBG004933
InParanoidiP08572
KOiK06237
OMAiNPGTKGW
OrthoDBiEOG091G0613
PhylomeDBiP08572
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474244 Extracellular matrix organization
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-2214320 Anchoring fibril formation
R-HSA-2243919 Crosslinking of collagen fibrils
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-419037 NCAM1 interactions
R-HSA-8948216 Collagen chain trimerization
SIGNORiP08572

Miscellaneous databases

ChiTaRSiCOL4A2 human
EvolutionaryTraceiP08572
GeneWikiiCOL4A2
GenomeRNAii1284
PMAP-CutDBiP08572
PROiPR:P08572
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134871 Expressed in 238 organ(s), highest expression level in placenta
CleanExiHS_COL4A2
ExpressionAtlasiP08572 baseline and differential
GenevisibleiP08572 HS

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 17 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCO4A2_HUMAN
AccessioniPrimary (citable) accession number: P08572
Secondary accession number(s): Q14052
, Q548C3, Q5VZA9, Q66K23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 203 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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