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Entry version 197 (31 Jul 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Pleckstrin

Gene

PLEK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major protein kinase C substrate of platelets.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P08567

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin
Alternative name(s):
Platelet 47 kDa protein
Short name:
p47
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEK
Synonyms:P47
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9070 PLEK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
173570 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08567

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5341

Open Targets

More...
OpenTargetsi
ENSG00000115956

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33400

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLEK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373523

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000538591 – 350PleckstrinAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64N6-acetyllysineCombined sources1
Modified residuei113Phosphoserine; by PKC1 Publication1
Modified residuei117Phosphoserine; by PKCCombined sources1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P08567

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P08567

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P08567

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08567

PeptideAtlas

More...
PeptideAtlasi
P08567

PRoteomics IDEntifications database

More...
PRIDEi
P08567

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52121

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P08567

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08567

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08567

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115956 Expressed in 191 organ(s), highest expression level in leukocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08567 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031838
HPA057341

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111357, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P08567, 10 interactors

Molecular INTeraction database

More...
MINTi
P08567

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000234313

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1350
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P08567

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P08567

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 101PH 1PROSITE-ProRule annotationAdd BLAST98
Domaini136 – 221DEPPROSITE-ProRule annotationAdd BLAST86
Domaini244 – 347PH 2PROSITE-ProRule annotationAdd BLAST104

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFJ7 Eukaryota
ENOG410ZY9B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157885

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294078

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08567

KEGG Orthology (KO)

More...
KOi
K19993

Identification of Orthologs from Complete Genome Data

More...
OMAi
FCEGYSS

Database of Orthologous Groups

More...
OrthoDBi
717547at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08567

TreeFam database of animal gene trees

More...
TreeFami
TF332246

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04445 DEP_PLEK1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000591 DEP_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037370 Pleckstrin
IPR037371 PLEK1_DEP
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12092 PTHR12092, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610 DEP, 1 hit
PF00169 PH, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049 DEP, 1 hit
SM00233 PH, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186 DEP, 1 hit
PS50003 PH_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P08567-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPKRIREGY LVKKGSVFNT WKPMWVVLLE DGIEFYKKKS DNSPKGMIPL
60 70 80 90 100
KGSTLTSPCQ DFGKRMFVFK ITTTKQQDHF FQAAFLEERD AWVRDIKKAI
110 120 130 140 150
KCIEGGQKFA RKSTRRSIRL PETIDLGALY LSMKDTEKGI KELNLEKDKK
160 170 180 190 200
IFNHCFTGNC VIDWLVSNQS VRNRQEGLMI ASSLLNEGYL QPAGDMSKSA
210 220 230 240 250
VDGTAENPFL DNPDAFYYFP DSGFFCEENS SDDDVILKEE FRGVIIKQGC
260 270 280 290 300
LLKQGHRRKN WKVRKFILRE DPAYLHYYDP AGAEDPLGAI HLRGCVVTSV
310 320 330 340 350
ESNSNGRKSE EENLFEIITA DEVHYFLQAA TPKERTEWIR AIQMASRTGK
Length:350
Mass (Da):40,125
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E292CB18B533261
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti284E → G in CAG46876 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0277975R → W. Corresponds to variant dbSNP:rs17035364Ensembl.1
Natural variantiVAR_00552492W → R. 1
Natural variantiVAR_02779897K → N2 PublicationsCorresponds to variant dbSNP:rs3816281Ensembl.1
Natural variantiVAR_056666108K → Q. Corresponds to variant dbSNP:rs34515106Ensembl.1
Natural variantiVAR_027799340R → K4 PublicationsCorresponds to variant dbSNP:rs1063479Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X07743 mRNA Translation: CAA30564.1
CR542056 mRNA Translation: CAG46853.1
CR542079 mRNA Translation: CAG46876.1
AK313756 mRNA Translation: BAG36495.1
AC015969 Genomic DNA Translation: AAX93121.1
CH471053 Genomic DNA Translation: EAW99876.1
BC018549 mRNA Translation: AAH18549.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1887.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S00755

NCBI Reference Sequences

More...
RefSeqi
NP_002655.2, NM_002664.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000234313; ENSP00000234313; ENSG00000115956

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5341

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5341

UCSC genome browser

More...
UCSCi
uc002sen.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07743 mRNA Translation: CAA30564.1
CR542056 mRNA Translation: CAG46853.1
CR542079 mRNA Translation: CAG46876.1
AK313756 mRNA Translation: BAG36495.1
AC015969 Genomic DNA Translation: AAX93121.1
CH471053 Genomic DNA Translation: EAW99876.1
BC018549 mRNA Translation: AAH18549.1
CCDSiCCDS1887.1
PIRiS00755
RefSeqiNP_002655.2, NM_002664.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PLSNMR-A1-105[»]
1W4MNMR-A121-223[»]
1X05NMR-A235-350[»]
1XX0NMR-A234-350[»]
1ZM0X-ray2.10A/B240-350[»]
2CSONMR-A116-229[»]
2I5CX-ray1.75A/B/C244-347[»]
2I5FX-ray1.35A244-347[»]
SMRiP08567
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111357, 3 interactors
IntActiP08567, 10 interactors
MINTiP08567
STRINGi9606.ENSP00000234313

PTM databases

iPTMnetiP08567
PhosphoSitePlusiP08567

Polymorphism and mutation databases

BioMutaiPLEK
DMDMi317373523

2D gel databases

OGPiP08567

Proteomic databases

EPDiP08567
jPOSTiP08567
MaxQBiP08567
PaxDbiP08567
PeptideAtlasiP08567
PRIDEiP08567
ProteomicsDBi52121

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5341
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234313; ENSP00000234313; ENSG00000115956
GeneIDi5341
KEGGihsa:5341
UCSCiuc002sen.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5341
DisGeNETi5341

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLEK
HGNCiHGNC:9070 PLEK
HPAiHPA031838
HPA057341
MIMi173570 gene
neXtProtiNX_P08567
OpenTargetsiENSG00000115956
PharmGKBiPA33400

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFJ7 Eukaryota
ENOG410ZY9B LUCA
GeneTreeiENSGT00940000157885
HOGENOMiHOG000294078
InParanoidiP08567
KOiK19993
OMAiFCEGYSS
OrthoDBi717547at2759
PhylomeDBiP08567
TreeFamiTF332246

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
SIGNORiP08567

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLEK human
EvolutionaryTraceiP08567

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5341

Protein Ontology

More...
PROi
PR:P08567

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115956 Expressed in 191 organ(s), highest expression level in leukocyte
GenevisibleiP08567 HS

Family and domain databases

CDDicd04445 DEP_PLEK1, 1 hit
Gene3Di1.10.10.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037370 Pleckstrin
IPR037371 PLEK1_DEP
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12092 PTHR12092, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00169 PH, 2 hits
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50003 PH_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLEK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08567
Secondary accession number(s): B2R9E8
, Q53SU8, Q6FGM8, Q6FGQ1, Q8WV81
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 11, 2011
Last modified: July 31, 2019
This is version 197 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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