UniProtKB - P08560 (UL18_HCMVA)
Protein
Glycoprotein UL18
Gene
H301
Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Functioni
Plays a role in the protection against host NK cell cytotoxicity by interacting with and modulating the activity of the host inhibitory leukocyte Ig-like receptor 1/LILRB1, which is expressed on monocytes, dendritic cells, as well as subsets of T and NK cells. UL18 exerts an inhibitory effect on LIR-1+ NK cells, while it stimulates LIR-1- NK cell. These modulations prevent lysis of the infected cells by NK cells.1 Publication
GO - Biological processi
- antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
- evasion by virus of host natural killer cell activity Source: UniProtKB-KW
- negative regulation of interferon-gamma production Source: UniProtKB
- receptor internalization Source: UniProtKB
Keywordsi
Biological process | Host-virus interaction, Immunity, Modulation of host NK-cell activity by virus, Viral immunoevasion |
Names & Taxonomyi
Protein namesi | Recommended name: Glycoprotein UL18 |
Gene namesi | Name:H301 Synonyms:UL18 |
Organismi | Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) |
Taxonomic identifieri | 10360 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Betaherpesvirinae › Cytomegalovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host membrane Curated; Single-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 321 – 342 | HelicalSequence analysisAdd BLAST | 22 |
GO - Cellular componenti
- host cell membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
- MHC class I protein complex Source: UniProtKB-KW
Keywords - Cellular componenti
Host membrane, Membrane, MHC IPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000037452 | 19 – 368 | Glycoprotein UL18Add BLAST | 350 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 56 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 66 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 74 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 95 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 123 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 127 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 150 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 167 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 177 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 193 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 240 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 282 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 291 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 |
Keywords - PTMi
GlycoproteinInteractioni
Subunit structurei
Interacts with host LILRB1.
1 PublicationProtein-protein interaction databases
DIPi | DIP-46164N |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P08560 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08560 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 19 – 114 | Alpha-1-likeAdd BLAST | 96 | |
Regioni | 115 – 208 | Alpha-2-likeAdd BLAST | 94 | |
Regioni | 209 – 303 | Alpha-3-likeAdd BLAST | 95 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P08560-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMTMWCLTLF VLWMLRVVGM HVLRYGYTGI FDDTSHMTLT VVGIFDGQHF
60 70 80 90 100
FTYHVNSSDK ASSRANGTIS WMANVSAAYP TYLDGERAKG DLIFNQTEQN
110 120 130 140 150
LLELEIALGY RSQSVLTWTH ECNTTENGSF VAGYEGFGWD GETLMELKDN
160 170 180 190 200
LTLWTGPNYE ISWLKQNKTY IDGKIKNISE GDTTIQRNYL KGNCTQWSVI
210 220 230 240 250
YSGFQPPVTH PVVKGGVRNQ NDNRAEAFCT SYGFFPGEIN ITFIHYGDKV
260 270 280 290 300
PEDSEPQCNP LLPTLDGTFH QGCYVAIFCN QNYTCRVTHG NWTVEIPISV
310 320 330 340 350
TSPDDSSSGE VPDHPTANKR YNTMTISSVL LALLLCALLF AFLHYFTTLK
360
QYLRNLAFAW RYRKVRSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00293 Genomic DNA Translation: CAA68399.1 X17403 Genomic DNA Translation: CAA35417.1 BK000394 Genomic DNA Translation: DAA00121.1 |
PIRi | S09781, HLBECM |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00293 Genomic DNA Translation: CAA68399.1 X17403 Genomic DNA Translation: CAA35417.1 BK000394 Genomic DNA Translation: DAA00121.1 |
PIRi | S09781, HLBECM |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3D2U | X-ray | 2.21 | A/E | 21-301 | [»] | |
SMRi | P08560 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-46164N |
Miscellaneous databases
EvolutionaryTracei | P08560 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UL18_HCMVA | |
Accessioni | P08560Primary (citable) accession number: P08560 Secondary accession number(s): Q7M6R5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1988 | |
Last modified: | August 12, 2020 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references